| Project/Area Number |
20390232
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
KUROKI Yoshio Sapporo Medical University, 医学部, 教授 (70161784)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Motoko 札幌医科大学, 医学部, 准教授 (00303941)
SHIMIZU Takeyuki 札幌医科大学, 医学部, 講師 (10339137)
NISHITANI Chiaki 札幌医科大学, 医学部, 助教 (30381255)
ARIKI Shigeru 札幌医科大学, 医学部, 助教 (80464478)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
|---|
| Keywords | 肺サーファクタント蛋白質 / 肺胞マクロファージ / 肺胞II型細胞 / レジオネラ菌 / 非定型抗酸菌 / マトリックスメタロプロテアーゼ / SP-A / SP-D / SP-C / 肺コレクチン / MMP / 細胞内寄生菌 / コレクチン |
|---|
| Research Abstract |
Pulmonary surfactant is composed of lipids and proteins, and plays important roles in alveolar stability and in host defense of respiratory system. In this study, we made specific antibody against human SP-C, which can be used for clinical applications. In addition, SP-A and SP-D, pulmonary collectins, have been shown to directly bind to Legionella pneumophila and Mycobacterium avium, suppress their growth and inhibit cellular injuries caused by these bacteria. SP-D has been found to inhibit matrix metallo-proteinase activity in alveolar macrophages, These results established the molecular bases for clinical applications of the uses of surfactant proteins.
|
