Host factors affecting human illness with avian and human A influenza viruses

• Project/Area Number: 20390233
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Research Institute, International Medical Center of Japan
• Principal Investigator: KEICHO Naoto Research Institute, International Medical Center of Japan, 呼吸器疾患研究部, 部長 (80332386)
• Co-Investigator(Kenkyū-buntansha): HIJIKATA Minako 独立行政法人国立国際医療研究センター研究所, 呼吸器疾患研究部, ウイルス性呼吸器疾患研究室長 (90332387) ; SAKURADA Shinsaku 独立行政法人国立国際医療研究センター研究所, 呼吸器疾患研究部, 細菌性呼吸器疾患研究室長 (50178620)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 呼吸器感染症 / ウイルス / 遺伝子 / 感染症 / 内科 / 呼吸器

Research Abstract

The aim of the study was to elucidate host factors affecting illness with avian and human influenza A viruses. Expression of glycosyltransferase genes related to the synthesis of influenza virus receptors and antiviral genes was analyzed in human bronchial epithelial cells. A sialyltransferase gene expression was upregulated by an inflammatory stimulus. Expression of antiviral MxA gene in airway epithelial cells was related to genetic polymorphisms in the promoter region.

Research Products

• [Presentation] A Study on Molecular Pathogenesis of Avian Influenza Virus Infection in Human AirwayEpithelial Cells. (2011)
  • Author(s): Hainam Mai, Minako Hijikata, Ikumi Matsushita, Hideyuki Ito, Naoto Keicho.
  • Organizer: 第50回日本呼吸器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] A Study on Molecular Pathogenesis of Avian Influenza Virus Infection in Human Airway Epithelial Cells. (2011)
  • Author(s): Hainam Mai, Minako Hijikata, Ikumi Matsushita, Hideyuki Ito, Naoto Keicho
  • Organizer: 第51回日本呼吸器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] 抗ウイルス蛋白OAS1遺伝子のSNPとヒト気道上皮細胞におけるmRNA発現の解析 (2010)
  • Author(s): 土左美至圭,松下育美,濱野栄美,伊藤秀幸,慶長直人
  • Organizer: 第50回日本呼吸器学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-23