Roles of ER stress in renal pathophysiology and development of novel therapeutic approaches to kidney diseases

• Project/Area Number: 20390235
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: University of Yamanashi
• Principal Investigator: KITAMURA Masanori 山梨大学, 大学院・医学工学総合研究部, 教授 (90333062)
• Co-Investigator(Kenkyū-buntansha): YAO Jian 山梨大学, 大学院・医学工学総合研究部, 准教授 (50303128)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
• Keywords: 小胞体ストレス / シグナル伝達 / 腎疾患 / 炎症 / アポトーシス / 細胞死（アポトーシス） / 3’-deoxyadenosine / 4-phenylbutyric acid / IRE1 / ATF6 / 腎尿細管障害 / 細胞死(アポトーシス) / Akt / mTOR / 3'-deoxyadenosine / 尿細管傷害 / 胞体ストレス / 腎臓病学 / 糸球体腎炎 / NF-κB / 尿細管細胞 / メサンギウム細胞 / 糸球体上皮細胞 / NF-kB / サイトカイン

Research Abstract

The unfolded protein response (UPR) has two different faces; an anti-inflammatory aspect (light side) and tissue damaging potential (dark side). Different branches of the UPR contribute to the dark and light sides following endoplasmic reticulum (ER) stress. By modulating selective arms of the UPR, it is feasible to attenuate inflammation and to inhibit tissue damage caused by ER stress. 3’-Deoxyadenosineand 4-phenylbutyric acid analogues may be potentially useful for the treatment of ER stress-related disorders.

Research Products

• [Journal Article] Pathological in situ reprogramming of somatic cells by the unfolded protein response (2013)
  • Author(s): Johno H and Kitamura M
  • Journal Title: Am J Pathol Volume: (in press)
  • Peer Reviewed
• [Journal Article] he unfolded protein response triggered by environmental factors (2013)
  • Author(s): Kitamura M
  • Journal Title: Semin Immunopathol Volume: 35 Issue: 3 Pages: 259-275
  • DOI: 10.1007/s00281-013-0371-y
  • Peer Reviewed
• [Journal Article] Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2αand suppression of Sp1 (2013)
  • Author(s): Gu L,Johno H, Nakajima S, Yoshitomi T, Takahashi S, and Kitamura M
  • Journal Title: Toxicol Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Eviprostat activates cAMP signaling pathway and suppresses bladder smooth muscle cell proliferation (2013)
  • Author(s): Li K, Yao J, Chi Y, Sawada N, Araki I, Kitamura M, and Takeda M
  • Journal Title: Int J Mol Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Pleiotropic potential of DHMEQ for NF-κB suppression via reactive oxygen species and unfolded protein response (2013)
  • Author(s): Nakajima S, Kato H,Gu L, Takahashi S,Johno H, Umezawa K, and Kitamura M
  • Journal Title: J Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Dual regulation of cadmium-induced apoptosis by mTORC1 through selective induction of IRE1 branches in unfolded protein response (2013)
  • Author(s): Kato H, Katoh R, and Kitamura M
  • Journal Title: PLoS One Volume: 8 Issue: 5 Pages: e64344-e64344
  • DOI: 10.1371/journal.pone.0064344
  • Peer Reviewed
• [Journal Article] Connexin43 hemichannel-mediated regulation of connexin43 (2013)
  • Author(s): Li K, Chi Y, Gao K, Yan Q, Matsue H, Takeda T, Kitamura M, and Yao J
  • Journal Title: PLoS One Volume: 8 Issue: 2 Pages: e58057-e58057
  • DOI: 10.1371/journal.pone.0058057
  • Peer Reviewed
• [Journal Article] Blockade of Smad signaling by 3 '-deoxyadenosine: a mechanism for its anti-fibrotic potential (2013)
  • Author(s): Gu L, Johno H, Nakajima S, Kato H, Takahashi H, Katoh K, and Kitamura M
  • Journal Title: Lab Invest Volume: 93 Issue: 4 Pages: 450-461
  • DOI: 10.1038/labinvest.2013.4
  • Peer Reviewed
• [Journal Article] Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation (2013)
  • Author(s): Sugiyama T, Kitamura M, Sugita K, Okuda T, Hisamoto M, and Nakao A
  • Journal Title: Am J Enol Viticult Volume: (in press) Issue: 1 Pages: 146-151
  • DOI: 10.5344/ajev.2012.11131
  • Peer Reviewed
• [Journal Article] Pleiotropic potential of DHMEQ for NF-κB suppression via reactive oxygen species and unfolded protein response (2013)
  • Author(s): Nakajima S
  • Journal Title: J Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Dual regulation of cadmium-induced apoptosis by mTORC1 through selective induction of IRE1 branches in unfolded protein response (2013)
  • Author(s): Kato H
  • Journal Title: PLoS One Volume: in press
  • Peer Reviewed
• [Journal Article] Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay (2012)
  • Author(s): Gu L, and Kitamura M
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: e52305-e52305
  • DOI: 10.1371/journal.pone.0052305
  • Peer Reviewed
• [Journal Article] Unfolded protein response causes a phenotypic shift of inflamed glomerular cells towards redifferentiation through dual blockade of Akt and Smad signaling pathways (2012)
  • Author(s): Johno H, Nakajima S,Kato H,Yao J, Paton AW, Paton JC, Katoh R, Shimizu F, and Kitamura M
  • Journal Title: Am J Pathol Volume: 181 Issue: 6 Pages: 1977-1990
  • DOI: 10.1016/j.ajpath.2012.08.015
  • Peer Reviewed
• [Journal Article] NADPH oxidase-mediated upregulation of connexin43 contributes to podocyte injury (2012)
  • Author(s): Yan Q, Gao K, Chi Y, Li K, Zhu Y, Wan Y,Sun W,Matsue H, Kitamura M, and Yao Y
  • Journal Title: Free Rad Biol Med Volume: 53 Issue: 6 Pages: 1286-1297
  • DOI: 10.1016/j.freeradbiomed.2012.07.012
  • Peer Reviewed
• [Journal Article] Blockade of adipocyte differentiation by cordycepin (2012)
  • Author(s): Takahashi S, Tamai T, Nakajima S, Kato H, Johno H, Nakamura T, and Kitamura M
  • Journal Title: British J Pharmacol Volume: 167 Issue: 3 Pages: 561-575
  • DOI: 10.1111/j.1476-5381.2012.02005.x
  • Peer Reviewed
• [Journal Article] Acidic stress - ER stress axis for blunted activation of NF-κB in mesothelial cells exposed to peritoneal dialysis fluid (2012)
  • Author(s): Johno H, Ogata R, Nakajima S, Hiramatsu N, Kobayashi T, Hara H, and Kitamura M
  • Journal Title: Nephrol Dial Transplant Volume: 27 Issue: 11 Pages: 4053-4060
  • DOI: 10.1093/ndt/gfs130
  • Peer Reviewed
• [Journal Article] Cordycepin as a sensitizer to TNF-α- induced apoptosis through eIF2α- and mTORC1- mediated inhibition of NF-κB (2012)
  • Author(s): Kadomatsu M, Nakajima S, Kato H, Gu L, Chi Y, Yao J and Kitamura M
  • Journal Title: Clin Exp Immunol Volume: 168 Issue: 3 Pages: 325-332
  • DOI: 10.1111/j.1365-2249.2012.04580.x
  • Peer Reviewed
• [Journal Article] β-catenin signaling contributes to PDGF-elicited bladder smooth muscle cell contraction through up-regulation of Cx43 expression (2012)
  • Author(s): Li K, Yao J, Sawada N, Kitamura M, Andersson K-E, and Takeda M
  • Journal Title: J Urol Volume: 188 Issue: 1 Pages: 307-332
  • DOI: 10.1016/j.juro.2012.02.2556
  • Peer Reviewed
• [Journal Article] mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway (2012)
  • Author(s): Kato H, Nakajima S, Saito Y, Takahashi S, Katoh R, and Kitamura M
  • Journal Title: Cell Death Differ Volume: 19 Issue: 2 Pages: 310-320
  • DOI: 10.1038/cdd.2011.98
  • Peer Reviewed
• [Journal Article] Control of NF-κB and inflammation by the unfolded protein response (2011)
  • Author(s): Kitamura M
  • Journal Title: Int Rev Immunol Volume: 30 Issue: 1 Pages: 4-15
  • DOI: 10.3109/08830185.2010.522281
• [Journal Article] Real-time monitoring of ER stress in living cells and animals using ESTRAP assay (2011)
  • Author(s): Kitamura M, and Hiramatsu N
  • Journal Title: Methods in Enzymology(UPR and Cell Stress) Volume: Vol. 490, Chapter 5 Pages: 93-106
  • DOI: 10.1016/b978-0-12-385114-7.00005-2
• [Journal Article] 小胞体ストレスとメサンギウムの細胞応答 (2011)
  • Author(s): 北村正敬
  • Journal Title: Annual Review 腎臓 Pages: 30-37
• [Journal Article] Aryl hydrocarbon receptor 経路4の活性化によるデキストラン硫酸ナトリウム誘導性大腸炎の抑制 (2011)
  • Author(s): 高村武之、原間大輔、下川直美、北村正敬、中尾篤人
  • Journal Title: 消化器と免疫 Volume: 47 Pages: 76-79
• [Journal Article] Reciprocal regulation between proinflammatory cytokine-induced iNOS and connexin43 in bladder smooth muscle cells (2011)
  • Author(s): Li K, Yao J, Shi L, Sawada N, Chi Y, Yan Q, Fukayama M, Zakohji H, Araki I, Kitamura Mand Takeda M
  • Journal Title: J Biol Chem Volume: 286 Issue: 48 Pages: 41552-41562
  • DOI: 10.1074/jbc.m111.274449
  • Peer Reviewed
• [Journal Article] Dysfunction of corneas and lacrimal glands in smoking model rat (2011)
  • Author(s): Higuchi A, Ito K, Dogru M, Kitamura M, Kawakita T, Ogawa Y, and Tsubota K
  • Journal Title: Free Rad Biol Med Volume: 51 Issue: 12 Pages: 2210-2216
  • DOI: 10.1016/j.freeradbiomed.2011.09.025
  • Peer Reviewed
• [Journal Article] Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMPK (2011)
  • Author(s): Chi Y, Li K, Yan Q, Koizumi S, Shi L, Takahashi S, Zhu Y, Matsue H, Takeda M, Kitamura M, Yao J
  • Journal Title: J Pharmacol Exp Ther Volume: 339 Issue: 1 Pages: 257-266
  • DOI: 10.1124/jpet.111.183020
  • Peer Reviewed
• [Journal Article] Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress (2011)
  • Author(s): Zhang H, Zhao Y,TianT, Paton AW, Paton JC, Kitamura M
  • Journal Title: Anal Biochem Volume: 417 Issue: 2 Pages: 292-294
  • DOI: 10.1016/j.ab.2011.06.025
  • Peer Reviewed
• [Journal Article] Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin (2011)
  • Author(s): Tian T, Zhao Y, Nakajima S, Huang T, Yao J, Paton AW, Paton JC and Kitamura M
  • Journal Title: Biochem Biophys Res Commun Volume: 410 Issue: 4 Pages: 852-858
  • DOI: 10.1016/j.bbrc.2011.06.078
  • Peer Reviewed
• [Journal Article] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion- triggered PERK - eIF2αpathway (2011)
  • Author(s): Tagawa Y, Hiramatsu N, Kato H, Sakoh T, Nakajima S, Hayakawa K, Saito Y, Johno H, Takahashi S, Gu L, Yao J, and Kitamura M
  • Journal Title: Toxicology Volume: 287 Issue: 1-3 Pages: 105-112
  • DOI: 10.1016/j.tox.2011.06.005
  • Peer Reviewed
• [Journal Article] Inhibition of NF-κB by MG132 through ER stress-mediated induction of LAP and LIP (2011)
  • Author(s): Nakajima S, Kato H, Takahashi S, Johno H, and Kitamura M
  • Journal Title: FEBS Lett Volume: 585 Issue: 14 Pages: 2249-2254
  • DOI: 10.1016/j.febslet.2011.05.047
  • Peer Reviewed
• [Journal Article] Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine (2011)
  • Author(s): Kitamura M, Kato H, Saito Y, Nakajima S, Takahashi S, Johno H, Gu L, and Katoh R
  • Journal Title: Cell Death Differ Volume: 18 Issue: 12 Pages: 1876-1888
  • DOI: 10.1038/cdd.2011.63
  • Peer Reviewed
• [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβand mTOR-dependent dephosphorylation of Akt (2011)
  • Author(s): Nakajima S, HiramatsuN, Hayakawa K, Saito Y, Kato H, Huang T, Yao J, Paton AW, Paton JC, and Kitamura M
  • Journal Title: Mol Cell Biol Volume: 31 Issue: 8 Pages: 1710-1718
  • DOI: 10.1128/mcb.00939-10
  • Peer Reviewed
• [Journal Article] Connexin43 hemichannels contribute to cadmium- induced oxidative stress and cell injury (2011)
  • Author(s): Fang X, Huang T, ZhuY, Jiang JX, Wang P, Kitamura Mand Yao J
  • Journal Title: Antioxid Redox Signal Volume: 14 Issue: 12 Pages: 2427-2439
  • DOI: 10.1089/ars.2010.3150
  • Peer Reviewed
• [Journal Article] Lactobacillus bulgaricusOLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis (2011)
  • Author(s): Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ohshima K, Ikegami S, Makino S, Kitamura M, and Nakao A
  • Journal Title: Immunol Cell Bioll Volume: 89 Issue: 7 Pages: 817-822
  • DOI: 10.1038/icb.2010.165
  • Peer Reviewed
• [Journal Article] Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response (2011)
  • Author(s): Zhao Y,Tian T, Huang T,Nakajima S, Saito Y, Takahashi S, Yao J, Paton AW, PatonJC, and Kitamura M
  • Journal Title: Toxicol Sci Volume: 120 Issue: 1 Pages: 79-86
  • DOI: 10.1093/toxsci/kfq368
  • Peer Reviewed
• [Journal Article] Impairment of MCP-1 expression in mesothelial cells exposed to PDF by osmotic stress and acidic stress (2011)
  • Author(s): Ogata R, Hiramatsu N, Hayakawa K, Nakajima S, Yao J, Kobayashi T, and Kitamura M
  • Journal Title: Perit Dial Int Volume: 31 Issue: 1 Pages: 80-89
  • DOI: 10.3747/pdi.2009.00159
  • Peer Reviewed
• [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR : involvement of C/EBPβand mTOR-dependent dephosphorylation of Akt. (2011)
  • Author(s): Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Kato H, Huang T, Yao J Paton AW, Paton JC, Kitamura M
  • Journal Title: Mol Cell Biol 31 Pages: 1710-1718
• [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR : involvement of C/EBPβand mTOR-dependent dephosphorylation of Akt. (2011)
  • Author(s): Nakajima S, et al.
  • Journal Title: Mol Cell Biol Volume: 31 Pages: 1710-1718
  • Peer Reviewed
• [Journal Article] Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response. (2011)
  • Author(s): Zhao Y, et al.
  • Journal Title: Toxicol Sci Volume: 31 Pages: 79-86
  • Peer Reviewed
• [Journal Article] The oxidative stress - endoplasmic reticulum stress axis in cadmium toxicity (2010)
  • Author(s): itamura M, and Hiramatsu N
  • Journal Title: Biometals Volume: 23 Issue: 5 Pages: 941-950
  • DOI: 10.1007/s10534-010-9296-2
• [Journal Article] Induction of the unfolded protein response by calcineurin inhibitors: A double-edged sword in renal transplantation (2010)
  • Author(s): Kitamura M
  • Journal Title: Nephrol Dial Transplant Volume: 25 Issue: 1 Pages: 6-9
  • DOI: 10.1093/ndt/gfp516
  • Peer Reviewed
• [Journal Article] Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response (2010)
  • Author(s): Nakajima S,Saito Y, Takahashi S, Hiramatsu N, Kato H,Johno H, Yao J, Paton AW, Paton JC, and Kitamura M
  • Journal Title: Biochem Biophys Res Commun Volume: 397 Issue: 2 Pages: 176-180
  • DOI: 10.1016/j.bbrc.2010.05.069
  • Peer Reviewed
• [Journal Article] Selective deletion of adipocytes, but not preadipocytes, by TNF-α via C/EBP- and PPARγ-mediated suppression of NF-κB (2010)
  • Author(s): Tamai M, Shimada T, Hiramatsu N, Hayakawa K, Okamura M, Tagawa Y, Takahashi S, Nakajima S, Yao J, and Kitamura M
  • Journal Title: Lab Invest Volume: 90 Issue: 9 Pages: 1385-1395
  • DOI: 10.1038/labinvest.2010.118
  • Peer Reviewed
• [Journal Article] Disruption of gap junction attenuates aminoglycoside- elicited renal tubular cell injury (2010)
  • Author(s): Yao J, Huang T, Fang X, Chi Y, Zhu Y, Wan Y, Matsue H, and Kitamura M
  • Journal Title: Br J Pharmacol Volume: 160 Issue: 8 Pages: 2055-2068
  • DOI: 10.1111/j.1476-5381.2010.00860.x
  • Peer Reviewed
• [Journal Article] Suppression of nephrin expression by TNF-α via interfering with the cAMP - retinoic acid receptor pathway (2010)
  • Author(s): Saito Y, Okamura M, Nakajima S, Hayakawa K, Huang T, Yao J, and Kitamura M
  • Journal Title: Am J Physiol-Renal Volume: 298 Issue: 6 Pages: F1436-F1444
  • DOI: 10.1152/ajprenal.00512.2009
  • Peer Reviewed
• [Journal Article] Activation of the arylhydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice (2010)
  • Author(s): Takamura T, Harama D, Matsuoka S, Shimokawa N, Nakamura Y, Okumura K, Ogawa H, Kitamura M, and Nakao A
  • Journal Title: Immunol Cell Biol Volume: 88 Issue: 6 Pages: 685-689
  • DOI: 10.1038/icb.2010.35
  • Peer Reviewed
• [Journal Article] Influences of acidic conditions on formazan assay: A cautionary note (2010)
  • Author(s): Johno H, Takahashi S, and Kitamura M
  • Journal Title: Appl Biochem Biotech Volume: 162 Issue: 6 Pages: 1529-1535
  • DOI: 10.1007/s12010-010-8934-z
  • Peer Reviewed
• [Journal Article] Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis (2010)
  • Author(s): Huang T, Zhu Y, Fang X, Chi Y, Kitamura M, and Yao J
  • Journal Title: Cancer Sci Volume: 101 Issue: 3 Pages: 716-721
  • DOI: 10.1111/j.1349-7006.2009.01421.x
  • NAID: 10026589655
  • Peer Reviewed
• [Journal Article] ER stress depresses NF-κB activation in mesangial cells through preferential induction of C/EBPβ (2010)
  • Author(s): Hayakawa K, Nakajima S, Hiramatsu N, Okamura M, Huang T, Saito Y, Tagawa Y, Tamai M, Takahashi S, Yao J, and Kitamura M
  • Journal Title: J Am Soc Nephrol Volume: 21 Issue: 1 Pages: 73-81
  • DOI: 10.1681/asn.2009040432
  • Peer Reviewed
• [Journal Article] ER stress depresses NF-κB activation in mesangial cells through preferential induction of C/EBPβ. (2010)
  • Author(s): Hayakawa K, Nakajima S, Hiramatsu N, Okamura M, Huang T, Saito Y, Tagawa Y, Tamai M, Takahashi S, YaoJ, Kitamura M
  • Journal Title: J Am Soc Nephrol 21 Pages: 73-81
• [Journal Article] ER stress depresses NF-κB activation in mesangial cells through prefer ential induction of C/EBPβ. (2010)
  • Author(s): Hayakawa K, et al.
  • Journal Title: J Am Soc Nephrol Volume: 21 Pages: 73-81
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress in glomerulonephritis: The bad guy turns good? (2009)
  • Author(s): Kitamura M
  • Journal Title: J Am Soc Nephrol Volume: 20 Issue: 9 Pages: 1871-1873
  • DOI: 10.1089/ars.2008.2391
  • Peer Reviewed
• [Journal Article] Gap junctional intercellular communication in the juxtaglomerular apparatus (2009)
  • Author(s): Yao J, Oite T and Kitamura M
  • Journal Title: Am J Physiol - Renal Volume: 296 Issue: 5 Pages: F939-F946
  • DOI: 10.1152/ajprenal.90612.2008
  • Peer Reviewed
• [Journal Article] Gap Junction を介した細胞間情報伝達:メサンギウム細胞の動態制御に於ける役割 (2009)
  • Author(s): 姚建、北村正敬
  • Journal Title: Annual Review 腎臓 Pages: 14-19
• [Journal Article] Preferential blockade of dioxin-induced activation of the aryl hydrocarbon receptor by Antrodia camphorata (2009)
  • Author(s): Mukai M, Hayakawa K, Okamura M, Tagawa Y, Nakajima S, Saito Y, Takahashi S, Yao J, Nishimura D, Sugi M, Matsunaga M, and Kitamura M
  • Journal Title: Biol Pharm Bull32 Volume: 32 Pages: 1510-1515
  • NAID: 130000117275
  • URL: https://www.jstage.jst.go.jp/article/bpb/32/9/32_9_1510/_article
  • Peer Reviewed
• [Journal Article] Activation of the Akt - NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response (2009)
  • Author(s): YamazakiH, Hiramatsu N, Hayakawa K, Tagawa Y, Okamura M, Ogata R, Huang T,Nakajima S, Yao J, Paton AW, Paton JC, andKitamura M
  • Journal Title: J Immunol Volume: 183 Issue: 2 Pages: 1480-1487
  • DOI: 10.4049/jimmunol.0900017
  • Peer Reviewed
• [Journal Article] A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response (2009)
  • Author(s): Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y,Ogawa H,Matsuoka S, Paton AW,Paton JC, Kitamura M,and Nakao A
  • Journal Title: Immunol Volume: 183 Issue: 2 Pages: 1368-1374
  • DOI: 10.4049/jimmunol.0804066
  • Peer Reviewed
• [Journal Article] Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor (2009)
  • Author(s): Okamura M, Takano Y, Saito Y, Yao J, and Kitamura M
  • Journal Title: Nephrol Dial Transplant Volume: 24 Issue: 5 Pages: 3006-3012
  • DOI: 10.1152/ajprenal.00602.2007
  • Peer Reviewed
• [Journal Article] Downregulation of gap junction expression and function by endoplasmic reticulum stress (2009)
  • Author(s): Huang T, Wan Y, Zhu Y, Fang X, Hiramatsu N, Hayakawa K, Paton A, Paton J, Kitamura M, and Yao J
  • Journal Title: J Cell Biochem Volume: 107 Issue: 5 Pages: 973-983
  • DOI: 10.1002/jcb.22202
  • Peer Reviewed
• [Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response (2009)
  • Author(s): Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, Paton AW, Paton JC, and KitamuraM
  • Journal Title: J Immunol Volume: 182 Issue: 11 Pages: 7201-7211
  • DOI: 10.4049/jimmunol.0801772
  • Peer Reviewed
• [Journal Article] Dual suppression of adipogenesis by cigarette smoke through activation of the aryl hydrocarbon receptor and induction of endoplasmic reticulum stress (2009)
  • Author(s): Shimada T, Hiramatsu N, Hayakawa K, Takahashi S, Kasai A, Tagawa Y, Mukai M, Yao J, Fujii-Kuriyama Y, and Kitamura M
  • Journal Title: Am J Physiol-Endocrinol and Metab Volume: 296 Issue: 4 Pages: E721-E730
  • DOI: 10.1152/ajpendo.90829.2008
  • Peer Reviewed
• [Journal Article] Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response: A mechanism for subsidence of inflammation (2009)
  • Author(s): Hayakawa K, Hiramatsu N, Okamura M, Yamazaki H, Nakajima S, Yao J, Paton AW, Paton JC, and Kitamura M
  • Journal Title: J Immunol Volume: 182 Pages: 1182-1191
  • URL: http://www.jimmunol.org/content/182/2/1182.long
  • Peer Reviewed
• [Journal Article] A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. (2009)
  • Author(s): Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A
  • Journal Title: J Immunol 183 Pages: 1368-1374
• [Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family : Implication for unfolded protein response. (2009)
  • Author(s): Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, Paton AW, Paton JC, Kitamura M
  • Journal Title: J Immunol 182 Pages: 7201-7211
• [Journal Article] Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response : A mechanism for subsidence of inflammation. (2009)
  • Author(s): Hayakawa K, Hiramatsu N, Okamura M, Yamazaki H, Nakajima S, YaoJ, Paton AW, Paton JC, Kitamura M
  • Journal Title: J Immunol 182 Pages: 1182-1191
• [Journal Article] Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. (2009)
  • Author(s): Yamazaki H, et al.
  • Journal Title: J Immunol 183 Pages: 1480-1487
  • Peer Reviewed
• [Journal Article] A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. (2009)
  • Author(s): Harama D, et al.
  • Journal Title: J Immunol 183 Pages: 1368-1374
  • Peer Reviewed
• [Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus(FK506)via induction of the C/EBP family : Implication for unfolded protein response. (2009)
  • Author(s): Du S, et al.
  • Journal Title: J Immunol 182 Pages: 7201-7211
  • Peer Reviewed
• [Journal Article] Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response : A mechanism for subsidence of inflammation. (2009)
  • Author(s): Hayakawa K, et al.
  • Journal Title: J Immunol 182 Pages: 1182-1191
• [Journal Article] Acquisition of anergy to proinflammatory cytokines in nonimmune cells through endoplasmic reticulum stress response : A mechanism for subsidence of inflammation. (2009)
  • Author(s): Hayakawa K, et al.
  • Journal Title: J Immunol 182 Pages: 1182-1191
  • Peer Reviewed
• [Journal Article] 腎における小胞体ストレス(ER stress)の意義 (2008)
  • Author(s): 北村正敬
  • Journal Title: Annual Review 腎臓 Pages: 22-30
• [Journal Article] 糸球体メサンギウム細胞の細胞特性 (2008)
  • Author(s): 姚建、北村正敬、追手巌
  • Journal Title: 日本腎臓学会誌 Volume: 50 Pages: 554-560
  • NAID: 10024900768
• [Journal Article] Endoplasmic reticulum stress in the kidney (2008)
  • Author(s): Kitamura M
  • Journal Title: Clin Exp Nephrol Volume: 12 Issue: 5 Pages: 317-325
  • DOI: 10.1007/s10157-008-0060-7
• [Journal Article] Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces (2008)
  • Author(s): Kitamura M
  • Journal Title: Am J Physiol - Renal Volume: 295 Issue: 2 Pages: F323-F334
  • DOI: 10.1152/ajprenal.00050.2008
  • Peer Reviewed
• [Journal Article] Suppression of adipocyte differentiation by Cordyceps militaris through activation of the aryl hydrocarbon receptor. (2008)
  • Author(s): Shimada T, Hiramatsu N, Kasai A, Mukai M, Okamura M, Yao J, Huang T, Tamai M, Takahashi S, Nakamura T, and Kitamura M
  • Journal Title: Am J Physiol-Endocrinol and Metab Volume: 295 Issue: 4 Pages: E859-E867
  • DOI: 10.1152/ajpendo.90373.2008
  • Peer Reviewed
• [Journal Article] Blockade of the aryl hydrocarbon receptor pathway triggered by dioxin, polycyclic aromatic hydrocarbons and cigarette smoke by Phellinus linteus (2008)
  • Author(s): Mukai M, Kasai A, Hiramatsu N, Hayakawa K, Okamura M, Tagawa Y, Yao J, Nakamura T, and Kitamura M
  • Journal Title: Biol Pharm Bull Volume: 31 Pages: 1888-1893
  • NAID: 110006936328
  • URL: https://www.jstage.jst.go.jp/article/bpb/31/10/31_10_1888/_article
  • Peer Reviewed
• [Journal Article] T cell receptor-mediated signaling induces GRP78 expression in T cells : The implications in maintaining T cell viability (2008)
  • Author(s): Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, and Nakao A
  • Journal Title: Biochem Biophys Res Commun Volume: 371 Issue: 4 Pages: 762-766
  • DOI: 10.1016/j.bbrc.2008.04.132
  • Peer Reviewed
• [Journal Article] Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP) (2008)
  • Author(s): Tagawa Y, Hiramatsu N, Kasai A, Hayakawa K, Okamura M, Yao J, and Kitamura M
  • Journal Title: Free Radic Biol Med Volume: 45 Issue: 1 Pages: 50-59
  • DOI: 10.1016/j.freeradbiomed.2008.03.003
  • Peer Reviewed
• [Journal Article] Blockade of the dioxin pathway by herbal medicine Formula bupleuri minor: Identification of active entities for suppression of AhR activation (2008)
  • Author(s): Kasai A, Hiramatsu N, Hayakawa K, Yao J, and Kitamura M
  • Journal Title: Biol Pharm Bull Volume: 31 Pages: 838-846
  • NAID: 110006663938
  • Peer Reviewed
• [Journal Article] Involvement of hypoxia-triggered endoplasmic reticulum stress in outlet obstruction-induced apoptosis in the urinary bladder (2008)
  • Author(s): Sawada N, Yao J, Hiramatsu N, Hayakawa K, Araki I, Takeda M, and Kitamura M
  • Journal Title: Lab Invest Volume: 88 Issue: 5 Pages: 553-563
  • DOI: 10.1038/labinvest.2008.21
  • Peer Reviewed
• [Journal Article] Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response (2008)
  • Author(s): Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, Kasai A, Takano Y, Shitamura A, Shimada T, Yao J, and Kitamura M
  • Journal Title: J Biol Chem Volume: 283 Pages: 4252-4260
  • URL: http://www.jbc.org/content/283/7/4252.long
  • Peer Reviewed
• [Journal Article] Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrocarbons (2008)
  • Author(s): Kasai A, Hiramatsu N, Hayakawa K, Yao J, and Kitamura M
  • Journal Title: Environ Health Perspect Volume: 116 Issue: 3 Pages: 349-354
  • DOI: 10.1289/ehp.10722
  • Peer Reviewed
• [Journal Article] Suppression of cytokine responses by indomethacin in podocytes : a mechanism through induction of unfolded protein response. (2008)
  • Author(s): Okamura M, et al.
  • Journal Title: Am J Physiol-Renal Physiol 295
  • Peer Reviewed
• [Journal Article] Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. (2008)
  • Author(s): Yokouchi M, et al.
  • Journal Title: J Biol Chem 283 Pages: 4252-4260
  • Peer Reviewed
• [Presentation] 4-フェニル酪酸類縁体による小胞体ストレス応答の制御 (2013)
  • Author(s): 張卉
  • Organizer: 第93回日本化学会春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス（草津）
• [Presentation] ストレスが導く細胞のリプログラミング (2013)
  • Author(s): 城野悠志
  • Organizer: 第２回サイエンス・インカレ
  • Place of Presentation: 幕張メッセ国際会議場（幕張）
• [Presentation] Pleiotropic potential of DHMEQ for NF-κB suppression: Implications for oxidative stress and unfolded protein response (2012)
  • Author(s): Nakajima S
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡）
• [Presentation] Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay (2012)
  • Author(s): Gu L
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡）
• [Presentation] Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine (2011)
  • Author(s): Kitamura M, Kato H, Saito Y, Nakajima S, Takahashi S, Johno H, Gu L
  • Organizer: 第34回日本第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine (2011)
  • Author(s): Kitamura M, et al
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-16
• [Presentation] Anti-inflammatory potential of subtilase cytotoxin: Dual suppression of NF-κB via induction of C/EBPB and mTOR-mediated dephosphorylation of Akt. (2010)
  • Author(s): Nakajima S, et al.
  • Organizer: 43rd Annual Meeting of The American Society of Nephralogy
  • Place of Presentation: Denver, USA
  • Year and Date: 2010-11-18
• [Presentation] Anti-inflammatory potential of subtilase cytotoxin : Dual suppression of NF-κB via induction of C/EBPβand mTOR-mediated dephosphorylation of Akt. (2010)
  • Author(s): Nakajima S, Huang T, Yao J, Kitamura M
  • Organizer: 43rd Annual Meeting of The American Society of Nephrology.
  • Place of Presentation: Denver
• [Presentation] Subtilase cytotoxin suppresses TNF-α-induced activation of NF-κB via induction of C/EBPβand suppression of Akt. (2009)
  • Author(s): Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Huang T, Yao J, Kitamura M
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-08
• [Presentation] Subtilase cytotoxin suppresses TNF-α-induced activation of NF-κB via in duction of C/EBPβ and suppression of Akt. (2009)
  • Author(s): Nakajima S, et al.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Suppression of NF-B by cyclosporine A and tacrolimus (Fk506) via induction of the C/EBP family : Implication for unfolded protein response. (2008)
  • Author(s): Kitamura M, et al.
  • Organizer: 41st Annual Meeting of The American Society of Nephrology
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2008-11-08
• [Presentation] Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrccarbons. (2008)
  • Author(s): Kitanmra M, Kasai A, Hiramatsu N, Hayakawa K, Yao J
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Suppression of NF-κB by cyclosporine A and tacroLimus (FK506) via induction of the C/EBP family : Implication for unfold protein response response. (2008)
  • Author(s): Hayakawa K, Du S, Hiramatsu N, Kasai A, Okamura M, Huang T,Yao J, Sawada N, Takeda M, Kitamura M
  • Organizer: 第31回日本分子生物学会年会/第82回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Suppression of NF-icB by cyclosporine A and tacrolimus(FK506)via inducrion of the GEB family : Implication for unfolded protein response. (2008)
  • Author(s): Kitamura M, Du S, Hiramatsu N, Hayakawa K, Okamura M, Huang T, Yao J, Takeda M
  • Organizer: 41st Annual Meeting of The American Society of Nephrology.
  • Place of Presentation: Philadelphia
• [Presentation] Connexin43 hemichannel-mediated release of ATP suppresses AMPK activation in renal tubular epithelial cells
  • Author(s): Chi Y
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] Dual regulation of cadmium-induced apoptosis by mTORC1 through induction of selective unfolded protein response
  • Author(s): Kato H
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] Blockade of Smad signaling by 3’-deoxyadenosine: A mechanism for the anti-fibrotic potential
  • Author(s): Gu L
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] Phenotypic shift of activated glomerular cells towards redifferentiation by the unfolded protein response
  • Author(s): Johno H
  • Organizer: 45th Annual Meeting of American Society of Nephrology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] NADPH oxidase-mediated up-regulation of connexin43 contributes to the oxidative stress-elicited podocyte injury
  • Author(s): Gao K
  • Organizer: 第55回日本腎臓学会総会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] β-catenin signaling contributes to PDGF-elicited bladder smooth muscle cell contraction through upregulation of Cx43 expression
  • Author(s): Li K
  • Organizer: 2012 Annual Meeting of American Urology Association
  • Place of Presentation: Georgia World Congress Center (Atlanta, USA)
• [Book] Methods in Enzymology (UPR and Cell Stress), Vol.490, Chapter 5 (2011)
  • Author(s): Kitamura M, Hiramatsu N
  • Total Pages: 14
  • Publisher: Real-time monitoring of ER stress in living cells and animalsusing ESTRAP assay
• [Book] Methods in Enzymology(UPR and Cell Stress)(Real-time monitoring of ER stress in living cells and animals using ESTRAP assay)(Vol.490, Chaoter 5) (2011)
  • Author(s): Kitamura M, Hiramatsu N
• [Book] Annual Review腎臓(小胞体ストレストメサンギウムの細胞応答) (2011)
  • Author(s): 北村正敬
• [Book] Annual Review腎臓(Gap Junctionを介した細胞間情報伝達メサンギウム細胞の動態制御に於ける役割) (2009)
  • Author(s): 姚建、北村正敬
• [Book] Annual Review腎臓(腎における小胞体ストレス(ER stress)の意義 (2008)
  • Author(s): 北村正敬
• [Book] Methods in Enzymology(UPR and Cell Stress)Vol. 490, Chapter 5 :Real-time monitornig of ER stress living cells and animals using ESTRAP assay.
  • Author(s): Kitamura M, Hiramatsu N
  • Publisher: Academic Press(Elsevier)
• [Remarks] 分子情報伝達学講座HP
  • URL: http://www.med.yamanashi.ac.jp/clinical/molecular/
• [Remarks] リエゾンアカデミーHP
  • URL: http://www.med.yamanashi.ac.jp/liaison/
• [Remarks] ライフサイエンス特進コースHP
  • URL: http://www.med.yamanashi.ac.jp/lifescience/
• [Remarks] 分子情報伝達学講座ホームページ
  • URL: http://www.med.yamanashi.ac.jp/clinical/molecular/
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/molecular/
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/molecular/
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/molecular/
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/molecular/
• [Patent(Industrial Property Rights)] 小胞体ストレス関連実験用試薬及び小胞体ストレス関連疾患治療薬 (2013)
  • Inventor(s): 北村 正敬
  • Industrial Property Rights Holder: 山梨大学
  • Filing Date: 2013
  • Overseas
• [Patent(Industrial Property Rights)] 特許Ｐ１５１３ＹＮＵ (2013)
  • Inventor(s): 北村正敬、新森英之
  • Industrial Property Rights Holder: 山梨大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-02-22