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Roles of ER stress in renal pathophysiology and development of novel therapeutic approaches to kidney diseases

Research Project

Project/Area Number 20390235
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Yamanashi

Principal Investigator

KITAMURA Masanori  山梨大学, 大学院・医学工学総合研究部, 教授 (90333062)

Co-Investigator(Kenkyū-buntansha) YAO Jian  山梨大学, 大学院・医学工学総合研究部, 准教授 (50303128)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords小胞体ストレス / シグナル伝達 / 腎疾患 / 炎症 / アポトーシス / 細胞死(アポトーシス) / 3’-deoxyadenosine / 4-phenylbutyric acid / IRE1 / ATF6 / 腎尿細管障害 / 細胞死(アポトーシス) / Akt / mTOR / 3'-deoxyadenosine / 尿細管傷害 / 胞体ストレス / 腎臓病学 / 糸球体腎炎 / NF-κB / 尿細管細胞 / メサンギウム細胞 / 糸球体上皮細胞 / NF-kB / サイトカイン
Research Abstract

The unfolded protein response (UPR) has two different faces; an anti-inflammatory aspect (light side) and tissue damaging potential (dark side). Different branches of the UPR contribute to the dark and light sides following endoplasmic reticulum (ER) stress. By modulating selective arms of the UPR, it is feasible to attenuate inflammation and to inhibit tissue damage caused by ER stress. 3’-Deoxyadenosineand 4-phenylbutyric acid analogues may be potentially useful for the treatment of ER stress-related disorders.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (120 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (84 results) (of which Peer Reviewed: 69 results) Presentation (20 results) Book (6 results) Remarks (8 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Pathological in situ reprogramming of somatic cells by the unfolded protein response2013

    • Author(s)
      Johno H and Kitamura M
    • Journal Title

      Am J Pathol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] he unfolded protein response triggered by environmental factors2013

    • Author(s)
      Kitamura M
    • Journal Title

      Semin Immunopathol

      Volume: 35 Issue: 3 Pages: 259-275

    • DOI

      10.1007/s00281-013-0371-y

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2αand suppression of Sp12013

    • Author(s)
      Gu L,Johno H, Nakajima S, Yoshitomi T, Takahashi S, and Kitamura M
    • Journal Title

      Toxicol Sci

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eviprostat activates cAMP signaling pathway and suppresses bladder smooth muscle cell proliferation2013

    • Author(s)
      Li K, Yao J, Chi Y, Sawada N, Araki I, Kitamura M, and Takeda M
    • Journal Title

      Int J Mol Sci

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pleiotropic potential of DHMEQ for NF-κB suppression via reactive oxygen species and unfolded protein response2013

    • Author(s)
      Nakajima S, Kato H,Gu L, Takahashi S,Johno H, Umezawa K, and Kitamura M
    • Journal Title

      J Immunol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual regulation of cadmium-induced apoptosis by mTORC1 through selective induction of IRE1 branches in unfolded protein response2013

    • Author(s)
      Kato H, Katoh R, and Kitamura M
    • Journal Title

      PLoS One

      Volume: 8 Issue: 5 Pages: e64344-e64344

    • DOI

      10.1371/journal.pone.0064344

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Connexin43 hemichannel-mediated regulation of connexin432013

    • Author(s)
      Li K, Chi Y, Gao K, Yan Q, Matsue H, Takeda T, Kitamura M, and Yao J
    • Journal Title

      PLoS One

      Volume: 8 Issue: 2 Pages: e58057-e58057

    • DOI

      10.1371/journal.pone.0058057

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of Smad signaling by 3 '-deoxyadenosine: a mechanism for its anti-fibrotic potential2013

    • Author(s)
      Gu L, Johno H, Nakajima S, Kato H, Takahashi H, Katoh K, and Kitamura M
    • Journal Title

      Lab Invest

      Volume: 93 Issue: 4 Pages: 450-461

    • DOI

      10.1038/labinvest.2013.4

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation2013

    • Author(s)
      Sugiyama T, Kitamura M, Sugita K, Okuda T, Hisamoto M, and Nakao A
    • Journal Title

      Am J Enol Viticult

      Volume: (in press) Issue: 1 Pages: 146-151

    • DOI

      10.5344/ajev.2012.11131

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pleiotropic potential of DHMEQ for NF-κB suppression via reactive oxygen species and unfolded protein response2013

    • Author(s)
      Nakajima S
    • Journal Title

      J Immunol

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual regulation of cadmium-induced apoptosis by mTORC1 through selective induction of IRE1 branches in unfolded protein response2013

    • Author(s)
      Kato H
    • Journal Title

      PLoS One

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay2012

    • Author(s)
      Gu L, and Kitamura M
    • Journal Title

      PLoS One

      Volume: 7 Issue: 12 Pages: e52305-e52305

    • DOI

      10.1371/journal.pone.0052305

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unfolded protein response causes a phenotypic shift of inflamed glomerular cells towards redifferentiation through dual blockade of Akt and Smad signaling pathways2012

    • Author(s)
      Johno H, Nakajima S,Kato H,Yao J, Paton AW, Paton JC, Katoh R, Shimizu F, and Kitamura M
    • Journal Title

      Am J Pathol

      Volume: 181 Issue: 6 Pages: 1977-1990

    • DOI

      10.1016/j.ajpath.2012.08.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] NADPH oxidase-mediated upregulation of connexin43 contributes to podocyte injury2012

    • Author(s)
      Yan Q, Gao K, Chi Y, Li K, Zhu Y, Wan Y,Sun W,Matsue H, Kitamura M, and Yao Y
    • Journal Title

      Free Rad Biol Med

      Volume: 53 Issue: 6 Pages: 1286-1297

    • DOI

      10.1016/j.freeradbiomed.2012.07.012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of adipocyte differentiation by cordycepin2012

    • Author(s)
      Takahashi S, Tamai T, Nakajima S, Kato H, Johno H, Nakamura T, and Kitamura M
    • Journal Title

      British J Pharmacol

      Volume: 167 Issue: 3 Pages: 561-575

    • DOI

      10.1111/j.1476-5381.2012.02005.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acidic stress - ER stress axis for blunted activation of NF-κB in mesothelial cells exposed to peritoneal dialysis fluid2012

    • Author(s)
      Johno H, Ogata R, Nakajima S, Hiramatsu N, Kobayashi T, Hara H, and Kitamura M
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27 Issue: 11 Pages: 4053-4060

    • DOI

      10.1093/ndt/gfs130

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cordycepin as a sensitizer to TNF-α- induced apoptosis through eIF2α- and mTORC1- mediated inhibition of NF-κB2012

    • Author(s)
      Kadomatsu M, Nakajima S, Kato H, Gu L, Chi Y, Yao J and Kitamura M
    • Journal Title

      Clin Exp Immunol

      Volume: 168 Issue: 3 Pages: 325-332

    • DOI

      10.1111/j.1365-2249.2012.04580.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-catenin signaling contributes to PDGF-elicited bladder smooth muscle cell contraction through up-regulation of Cx43 expression2012

    • Author(s)
      Li K, Yao J, Sawada N, Kitamura M, Andersson K-E, and Takeda M
    • Journal Title

      J Urol

      Volume: 188 Issue: 1 Pages: 307-332

    • DOI

      10.1016/j.juro.2012.02.2556

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway2012

    • Author(s)
      Kato H, Nakajima S, Saito Y, Takahashi S, Katoh R, and Kitamura M
    • Journal Title

      Cell Death Differ

      Volume: 19 Issue: 2 Pages: 310-320

    • DOI

      10.1038/cdd.2011.98

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of NF-κB and inflammation by the unfolded protein response2011

    • Author(s)
      Kitamura M
    • Journal Title

      Int Rev Immunol

      Volume: 30 Issue: 1 Pages: 4-15

    • DOI

      10.3109/08830185.2010.522281

    • Related Report
      2012 Final Research Report
  • [Journal Article] Real-time monitoring of ER stress in living cells and animals using ESTRAP assay2011

    • Author(s)
      Kitamura M, and Hiramatsu N
    • Journal Title

      Methods in Enzymology(UPR and Cell Stress)

      Volume: Vol. 490, Chapter 5 Pages: 93-106

    • DOI

      10.1016/b978-0-12-385114-7.00005-2

    • Related Report
      2012 Final Research Report
  • [Journal Article] 小胞体ストレスとメサンギウムの細胞応答2011

    • Author(s)
      北村正敬
    • Journal Title

      Annual Review 腎臓

      Pages: 30-37

    • Related Report
      2012 Final Research Report
  • [Journal Article] Aryl hydrocarbon receptor 経路4の活性化によるデキストラン硫酸ナトリウム誘導性大腸炎の抑制2011

    • Author(s)
      高村武之、原間大輔、下川直美、北村正敬、中尾篤人
    • Journal Title

      消化器と免疫

      Volume: 47 Pages: 76-79

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reciprocal regulation between proinflammatory cytokine-induced iNOS and connexin43 in bladder smooth muscle cells2011

    • Author(s)
      Li K, Yao J, Shi L, Sawada N, Chi Y, Yan Q, Fukayama M, Zakohji H, Araki I, Kitamura Mand Takeda M
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 48 Pages: 41552-41562

    • DOI

      10.1074/jbc.m111.274449

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysfunction of corneas and lacrimal glands in smoking model rat2011

    • Author(s)
      Higuchi A, Ito K, Dogru M, Kitamura M, Kawakita T, Ogawa Y, and Tsubota K
    • Journal Title

      Free Rad Biol Med

      Volume: 51 Issue: 12 Pages: 2210-2216

    • DOI

      10.1016/j.freeradbiomed.2011.09.025

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMPK2011

    • Author(s)
      Chi Y, Li K, Yan Q, Koizumi S, Shi L, Takahashi S, Zhu Y, Matsue H, Takeda M, Kitamura M, Yao J
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 339 Issue: 1 Pages: 257-266

    • DOI

      10.1124/jpet.111.183020

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress2011

    • Author(s)
      Zhang H, Zhao Y,TianT, Paton AW, Paton JC, Kitamura M
    • Journal Title

      Anal Biochem

      Volume: 417 Issue: 2 Pages: 292-294

    • DOI

      10.1016/j.ab.2011.06.025

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin2011

    • Author(s)
      Tian T, Zhao Y, Nakajima S, Huang T, Yao J, Paton AW, Paton JC and Kitamura M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Issue: 4 Pages: 852-858

    • DOI

      10.1016/j.bbrc.2011.06.078

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion- triggered PERK - eIF2αpathway2011

    • Author(s)
      Tagawa Y, Hiramatsu N, Kato H, Sakoh T, Nakajima S, Hayakawa K, Saito Y, Johno H, Takahashi S, Gu L, Yao J, and Kitamura M
    • Journal Title

      Toxicology

      Volume: 287 Issue: 1-3 Pages: 105-112

    • DOI

      10.1016/j.tox.2011.06.005

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of NF-κB by MG132 through ER stress-mediated induction of LAP and LIP2011

    • Author(s)
      Nakajima S, Kato H, Takahashi S, Johno H, and Kitamura M
    • Journal Title

      FEBS Lett

      Volume: 585 Issue: 14 Pages: 2249-2254

    • DOI

      10.1016/j.febslet.2011.05.047

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine2011

    • Author(s)
      Kitamura M, Kato H, Saito Y, Nakajima S, Takahashi S, Johno H, Gu L, and Katoh R
    • Journal Title

      Cell Death Differ

      Volume: 18 Issue: 12 Pages: 1876-1888

    • DOI

      10.1038/cdd.2011.63

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβand mTOR-dependent dephosphorylation of Akt2011

    • Author(s)
      Nakajima S, HiramatsuN, Hayakawa K, Saito Y, Kato H, Huang T, Yao J, Paton AW, Paton JC, and Kitamura M
    • Journal Title

      Mol Cell Biol

      Volume: 31 Issue: 8 Pages: 1710-1718

    • DOI

      10.1128/mcb.00939-10

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Connexin43 hemichannels contribute to cadmium- induced oxidative stress and cell injury2011

    • Author(s)
      Fang X, Huang T, ZhuY, Jiang JX, Wang P, Kitamura Mand Yao J
    • Journal Title

      Antioxid Redox Signal

      Volume: 14 Issue: 12 Pages: 2427-2439

    • DOI

      10.1089/ars.2010.3150

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus bulgaricusOLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis2011

    • Author(s)
      Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ohshima K, Ikegami S, Makino S, Kitamura M, and Nakao A
    • Journal Title

      Immunol Cell Bioll

      Volume: 89 Issue: 7 Pages: 817-822

    • DOI

      10.1038/icb.2010.165

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response2011

    • Author(s)
      Zhao Y,Tian T, Huang T,Nakajima S, Saito Y, Takahashi S, Yao J, Paton AW, PatonJC, and Kitamura M
    • Journal Title

      Toxicol Sci

      Volume: 120 Issue: 1 Pages: 79-86

    • DOI

      10.1093/toxsci/kfq368

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of MCP-1 expression in mesothelial cells exposed to PDF by osmotic stress and acidic stress2011

    • Author(s)
      Ogata R, Hiramatsu N, Hayakawa K, Nakajima S, Yao J, Kobayashi T, and Kitamura M
    • Journal Title

      Perit Dial Int

      Volume: 31 Issue: 1 Pages: 80-89

    • DOI

      10.3747/pdi.2009.00159

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR : involvement of C/EBPβand mTOR-dependent dephosphorylation of Akt.2011

    • Author(s)
      Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Kato H, Huang T, Yao J Paton AW, Paton JC, Kitamura M
    • Journal Title

      Mol Cell Biol 31

      Pages: 1710-1718

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR : involvement of C/EBPβand mTOR-dependent dephosphorylation of Akt.2011

    • Author(s)
      Nakajima S, et al.
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 1710-1718

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response.2011

    • Author(s)
      Zhao Y, et al.
    • Journal Title

      Toxicol Sci

      Volume: 31 Pages: 79-86

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The oxidative stress - endoplasmic reticulum stress axis in cadmium toxicity2010

    • Author(s)
      itamura M, and Hiramatsu N
    • Journal Title

      Biometals

      Volume: 23 Issue: 5 Pages: 941-950

    • DOI

      10.1007/s10534-010-9296-2

    • Related Report
      2012 Final Research Report
  • [Journal Article] Induction of the unfolded protein response by calcineurin inhibitors: A double-edged sword in renal transplantation2010

    • Author(s)
      Kitamura M
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25 Issue: 1 Pages: 6-9

    • DOI

      10.1093/ndt/gfp516

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response2010

    • Author(s)
      Nakajima S,Saito Y, Takahashi S, Hiramatsu N, Kato H,Johno H, Yao J, Paton AW, Paton JC, and Kitamura M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 397 Issue: 2 Pages: 176-180

    • DOI

      10.1016/j.bbrc.2010.05.069

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective deletion of adipocytes, but not preadipocytes, by TNF-α via C/EBP- and PPARγ-mediated suppression of NF-κB2010

    • Author(s)
      Tamai M, Shimada T, Hiramatsu N, Hayakawa K, Okamura M, Tagawa Y, Takahashi S, Nakajima S, Yao J, and Kitamura M
    • Journal Title

      Lab Invest

      Volume: 90 Issue: 9 Pages: 1385-1395

    • DOI

      10.1038/labinvest.2010.118

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of gap junction attenuates aminoglycoside- elicited renal tubular cell injury2010

    • Author(s)
      Yao J, Huang T, Fang X, Chi Y, Zhu Y, Wan Y, Matsue H, and Kitamura M
    • Journal Title

      Br J Pharmacol

      Volume: 160 Issue: 8 Pages: 2055-2068

    • DOI

      10.1111/j.1476-5381.2010.00860.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of nephrin expression by TNF-α via interfering with the cAMP - retinoic acid receptor pathway2010

    • Author(s)
      Saito Y, Okamura M, Nakajima S, Hayakawa K, Huang T, Yao J, and Kitamura M
    • Journal Title

      Am J Physiol-Renal

      Volume: 298 Issue: 6 Pages: F1436-F1444

    • DOI

      10.1152/ajprenal.00512.2009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the arylhydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice2010

    • Author(s)
      Takamura T, Harama D, Matsuoka S, Shimokawa N, Nakamura Y, Okumura K, Ogawa H, Kitamura M, and Nakao A
    • Journal Title

      Immunol Cell Biol

      Volume: 88 Issue: 6 Pages: 685-689

    • DOI

      10.1038/icb.2010.35

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influences of acidic conditions on formazan assay: A cautionary note2010

    • Author(s)
      Johno H, Takahashi S, and Kitamura M
    • Journal Title

      Appl Biochem Biotech

      Volume: 162 Issue: 6 Pages: 1529-1535

    • DOI

      10.1007/s12010-010-8934-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis2010

    • Author(s)
      Huang T, Zhu Y, Fang X, Chi Y, Kitamura M, and Yao J
    • Journal Title

      Cancer Sci

      Volume: 101 Issue: 3 Pages: 716-721

    • DOI

      10.1111/j.1349-7006.2009.01421.x

    • NAID

      10026589655

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ER stress depresses NF-κB activation in mesangial cells through preferential induction of C/EBPβ2010

    • Author(s)
      Hayakawa K, Nakajima S, Hiramatsu N, Okamura M, Huang T, Saito Y, Tagawa Y, Tamai M, Takahashi S, Yao J, and Kitamura M
    • Journal Title

      J Am Soc Nephrol

      Volume: 21 Issue: 1 Pages: 73-81

    • DOI

      10.1681/asn.2009040432

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ER stress depresses NF-κB activation in mesangial cells through preferential induction of C/EBPβ.2010

    • Author(s)
      Hayakawa K, Nakajima S, Hiramatsu N, Okamura M, Huang T, Saito Y, Tagawa Y, Tamai M, Takahashi S, YaoJ, Kitamura M
    • Journal Title

      J Am Soc Nephrol 21

      Pages: 73-81

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] ER stress depresses NF-κB activation in mesangial cells through prefer ential induction of C/EBPβ.2010

    • Author(s)
      Hayakawa K, et al.
    • Journal Title

      J Am Soc Nephrol

      Volume: 21 Pages: 73-81

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum stress in glomerulonephritis: The bad guy turns good?2009

    • Author(s)
      Kitamura M
    • Journal Title

      J Am Soc Nephrol

      Volume: 20 Issue: 9 Pages: 1871-1873

    • DOI

      10.1089/ars.2008.2391

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gap junctional intercellular communication in the juxtaglomerular apparatus2009

    • Author(s)
      Yao J, Oite T and Kitamura M
    • Journal Title

      Am J Physiol - Renal

      Volume: 296 Issue: 5 Pages: F939-F946

    • DOI

      10.1152/ajprenal.90612.2008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gap Junction を介した細胞間情報伝達:メサンギウム細胞の動態制御に於ける役割2009

    • Author(s)
      姚建、北村正敬
    • Journal Title

      Annual Review 腎臓

      Pages: 14-19

    • Related Report
      2012 Final Research Report
  • [Journal Article] Preferential blockade of dioxin-induced activation of the aryl hydrocarbon receptor by Antrodia camphorata2009

    • Author(s)
      Mukai M, Hayakawa K, Okamura M, Tagawa Y, Nakajima S, Saito Y, Takahashi S, Yao J, Nishimura D, Sugi M, Matsunaga M, and Kitamura M
    • Journal Title

      Biol Pharm Bull32

      Volume: 32 Pages: 1510-1515

    • NAID

      130000117275

    • URL

      https://www.jstage.jst.go.jp/article/bpb/32/9/32_9_1510/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the Akt - NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response2009

    • Author(s)
      YamazakiH, Hiramatsu N, Hayakawa K, Tagawa Y, Okamura M, Ogata R, Huang T,Nakajima S, Yao J, Paton AW, Paton JC, andKitamura M
    • Journal Title

      J Immunol

      Volume: 183 Issue: 2 Pages: 1480-1487

    • DOI

      10.4049/jimmunol.0900017

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response2009

    • Author(s)
      Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y,Ogawa H,Matsuoka S, Paton AW,Paton JC, Kitamura M,and Nakao A
    • Journal Title

      Immunol

      Volume: 183 Issue: 2 Pages: 1368-1374

    • DOI

      10.4049/jimmunol.0804066

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor2009

    • Author(s)
      Okamura M, Takano Y, Saito Y, Yao J, and Kitamura M
    • Journal Title

      Nephrol Dial Transplant

      Volume: 24 Issue: 5 Pages: 3006-3012

    • DOI

      10.1152/ajprenal.00602.2007

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of gap junction expression and function by endoplasmic reticulum stress2009

    • Author(s)
      Huang T, Wan Y, Zhu Y, Fang X, Hiramatsu N, Hayakawa K, Paton A, Paton J, Kitamura M, and Yao J
    • Journal Title

      J Cell Biochem

      Volume: 107 Issue: 5 Pages: 973-983

    • DOI

      10.1002/jcb.22202

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response2009

    • Author(s)
      Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, Paton AW, Paton JC, and KitamuraM
    • Journal Title

      J Immunol

      Volume: 182 Issue: 11 Pages: 7201-7211

    • DOI

      10.4049/jimmunol.0801772

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual suppression of adipogenesis by cigarette smoke through activation of the aryl hydrocarbon receptor and induction of endoplasmic reticulum stress2009

    • Author(s)
      Shimada T, Hiramatsu N, Hayakawa K, Takahashi S, Kasai A, Tagawa Y, Mukai M, Yao J, Fujii-Kuriyama Y, and Kitamura M
    • Journal Title

      Am J Physiol-Endocrinol and Metab

      Volume: 296 Issue: 4 Pages: E721-E730

    • DOI

      10.1152/ajpendo.90829.2008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response: A mechanism for subsidence of inflammation2009

    • Author(s)
      Hayakawa K, Hiramatsu N, Okamura M, Yamazaki H, Nakajima S, Yao J, Paton AW, Paton JC, and Kitamura M
    • Journal Title

      J Immunol

      Volume: 182 Pages: 1182-1191

    • URL

      http://www.jimmunol.org/content/182/2/1182.long

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response.2009

    • Author(s)
      Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A
    • Journal Title

      J Immunol 183

      Pages: 1368-1374

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family : Implication for unfolded protein response.2009

    • Author(s)
      Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, Paton AW, Paton JC, Kitamura M
    • Journal Title

      J Immunol 182

      Pages: 7201-7211

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response : A mechanism for subsidence of inflammation.2009

    • Author(s)
      Hayakawa K, Hiramatsu N, Okamura M, Yamazaki H, Nakajima S, YaoJ, Paton AW, Paton JC, Kitamura M
    • Journal Title

      J Immunol 182

      Pages: 1182-1191

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response.2009

    • Author(s)
      Yamazaki H, et al.
    • Journal Title

      J Immunol 183

      Pages: 1480-1487

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response.2009

    • Author(s)
      Harama D, et al.
    • Journal Title

      J Immunol 183

      Pages: 1368-1374

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus(FK506)via induction of the C/EBP family : Implication for unfolded protein response.2009

    • Author(s)
      Du S, et al.
    • Journal Title

      J Immunol 182

      Pages: 7201-7211

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of anergy to proinflammatory cytokines in non-immune cells through endoplasmic reticulum stress response : A mechanism for subsidence of inflammation.2009

    • Author(s)
      Hayakawa K, et al.
    • Journal Title

      J Immunol 182

      Pages: 1182-1191

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Acquisition of anergy to proinflammatory cytokines in nonimmune cells through endoplasmic reticulum stress response : A mechanism for subsidence of inflammation.2009

    • Author(s)
      Hayakawa K, et al.
    • Journal Title

      J Immunol 182

      Pages: 1182-1191

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎における小胞体ストレス(ER stress)の意義2008

    • Author(s)
      北村正敬
    • Journal Title

      Annual Review 腎臓

      Pages: 22-30

    • Related Report
      2012 Final Research Report
  • [Journal Article] 糸球体メサンギウム細胞の細胞特性2008

    • Author(s)
      姚建、北村正敬、追手巌
    • Journal Title

      日本腎臓学会誌

      Volume: 50 Pages: 554-560

    • NAID

      10024900768

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endoplasmic reticulum stress in the kidney2008

    • Author(s)
      Kitamura M
    • Journal Title

      Clin Exp Nephrol

      Volume: 12 Issue: 5 Pages: 317-325

    • DOI

      10.1007/s10157-008-0060-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces2008

    • Author(s)
      Kitamura M
    • Journal Title

      Am J Physiol - Renal

      Volume: 295 Issue: 2 Pages: F323-F334

    • DOI

      10.1152/ajprenal.00050.2008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of adipocyte differentiation by Cordyceps militaris through activation of the aryl hydrocarbon receptor.2008

    • Author(s)
      Shimada T, Hiramatsu N, Kasai A, Mukai M, Okamura M, Yao J, Huang T, Tamai M, Takahashi S, Nakamura T, and Kitamura M
    • Journal Title

      Am J Physiol-Endocrinol and Metab

      Volume: 295 Issue: 4 Pages: E859-E867

    • DOI

      10.1152/ajpendo.90373.2008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of the aryl hydrocarbon receptor pathway triggered by dioxin, polycyclic aromatic hydrocarbons and cigarette smoke by Phellinus linteus2008

    • Author(s)
      Mukai M, Kasai A, Hiramatsu N, Hayakawa K, Okamura M, Tagawa Y, Yao J, Nakamura T, and Kitamura M
    • Journal Title

      Biol Pharm Bull

      Volume: 31 Pages: 1888-1893

    • NAID

      110006936328

    • URL

      https://www.jstage.jst.go.jp/article/bpb/31/10/31_10_1888/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] T cell receptor-mediated signaling induces GRP78 expression in T cells : The implications in maintaining T cell viability2008

    • Author(s)
      Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, and Nakao A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 371 Issue: 4 Pages: 762-766

    • DOI

      10.1016/j.bbrc.2008.04.132

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP)2008

    • Author(s)
      Tagawa Y, Hiramatsu N, Kasai A, Hayakawa K, Okamura M, Yao J, and Kitamura M
    • Journal Title

      Free Radic Biol Med

      Volume: 45 Issue: 1 Pages: 50-59

    • DOI

      10.1016/j.freeradbiomed.2008.03.003

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of the dioxin pathway by herbal medicine Formula bupleuri minor: Identification of active entities for suppression of AhR activation2008

    • Author(s)
      Kasai A, Hiramatsu N, Hayakawa K, Yao J, and Kitamura M
    • Journal Title

      Biol Pharm Bull

      Volume: 31 Pages: 838-846

    • NAID

      110006663938

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of hypoxia-triggered endoplasmic reticulum stress in outlet obstruction-induced apoptosis in the urinary bladder2008

    • Author(s)
      Sawada N, Yao J, Hiramatsu N, Hayakawa K, Araki I, Takeda M, and Kitamura M
    • Journal Title

      Lab Invest

      Volume: 88 Issue: 5 Pages: 553-563

    • DOI

      10.1038/labinvest.2008.21

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response2008

    • Author(s)
      Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, Kasai A, Takano Y, Shitamura A, Shimada T, Yao J, and Kitamura M
    • Journal Title

      J Biol Chem

      Volume: 283 Pages: 4252-4260

    • URL

      http://www.jbc.org/content/283/7/4252.long

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrocarbons2008

    • Author(s)
      Kasai A, Hiramatsu N, Hayakawa K, Yao J, and Kitamura M
    • Journal Title

      Environ Health Perspect

      Volume: 116 Issue: 3 Pages: 349-354

    • DOI

      10.1289/ehp.10722

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of cytokine responses by indomethacin in podocytes : a mechanism through induction of unfolded protein response.2008

    • Author(s)
      Okamura M, et al.
    • Journal Title

      Am J Physiol-Renal Physiol 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response.2008

    • Author(s)
      Yokouchi M, et al.
    • Journal Title

      J Biol Chem 283

      Pages: 4252-4260

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 4-フェニル酪酸類縁体による小胞体ストレス応答の制御2013

    • Author(s)
      張卉
    • Organizer
      第93回日本化学会春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(草津)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ストレスが導く細胞のリプログラミング2013

    • Author(s)
      城野悠志
    • Organizer
      第2回サイエンス・インカレ
    • Place of Presentation
      幕張メッセ国際会議場(幕張)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pleiotropic potential of DHMEQ for NF-κB suppression: Implications for oxidative stress and unfolded protein response2012

    • Author(s)
      Nakajima S
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay2012

    • Author(s)
      Gu L
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine2011

    • Author(s)
      Kitamura M, Kato H, Saito Y, Nakajima S, Takahashi S, Johno H, Gu L
    • Organizer
      第34回日本第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine2011

    • Author(s)
      Kitamura M, et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Anti-inflammatory potential of subtilase cytotoxin: Dual suppression of NF-κB via induction of C/EBPB and mTOR-mediated dephosphorylation of Akt.2010

    • Author(s)
      Nakajima S, et al.
    • Organizer
      43rd Annual Meeting of The American Society of Nephralogy
    • Place of Presentation
      Denver, USA
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anti-inflammatory potential of subtilase cytotoxin : Dual suppression of NF-κB via induction of C/EBPβand mTOR-mediated dephosphorylation of Akt.2010

    • Author(s)
      Nakajima S, Huang T, Yao J, Kitamura M
    • Organizer
      43rd Annual Meeting of The American Society of Nephrology.
    • Place of Presentation
      Denver
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Subtilase cytotoxin suppresses TNF-α-induced activation of NF-κB via induction of C/EBPβand suppression of Akt.2009

    • Author(s)
      Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Huang T, Yao J, Kitamura M
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-08
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Subtilase cytotoxin suppresses TNF-α-induced activation of NF-κB via in duction of C/EBPβ and suppression of Akt.2009

    • Author(s)
      Nakajima S, et al.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Suppression of NF-B by cyclosporine A and tacrolimus (Fk506) via induction of the C/EBP family : Implication for unfolded protein response.2008

    • Author(s)
      Kitamura M, et al.
    • Organizer
      41st Annual Meeting of The American Society of Nephrology
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Direct, continuous monitoring of air pollution by transgenic sensor mice responsive to halogenated and polycyclic aromatic hydrccarbons.2008

    • Author(s)
      Kitanmra M, Kasai A, Hiramatsu N, Hayakawa K, Yao J
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Suppression of NF-κB by cyclosporine A and tacroLimus (FK506) via induction of the C/EBP family : Implication for unfold protein response response.2008

    • Author(s)
      Hayakawa K, Du S, Hiramatsu N, Kasai A, Okamura M, Huang T,Yao J, Sawada N, Takeda M, Kitamura M
    • Organizer
      第31回日本分子生物学会年会/第82回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Suppression of NF-icB by cyclosporine A and tacrolimus(FK506)via inducrion of the GEB family : Implication for unfolded protein response.2008

    • Author(s)
      Kitamura M, Du S, Hiramatsu N, Hayakawa K, Okamura M, Huang T, Yao J, Takeda M
    • Organizer
      41st Annual Meeting of The American Society of Nephrology.
    • Place of Presentation
      Philadelphia
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Connexin43 hemichannel-mediated release of ATP suppresses AMPK activation in renal tubular epithelial cells

    • Author(s)
      Chi Y
    • Organizer
      45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dual regulation of cadmium-induced apoptosis by mTORC1 through induction of selective unfolded protein response

    • Author(s)
      Kato H
    • Organizer
      45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Blockade of Smad signaling by 3’-deoxyadenosine: A mechanism for the anti-fibrotic potential

    • Author(s)
      Gu L
    • Organizer
      45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Phenotypic shift of activated glomerular cells towards redifferentiation by the unfolded protein response

    • Author(s)
      Johno H
    • Organizer
      45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] NADPH oxidase-mediated up-regulation of connexin43 contributes to the oxidative stress-elicited podocyte injury

    • Author(s)
      Gao K
    • Organizer
      第55回日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] β-catenin signaling contributes to PDGF-elicited bladder smooth muscle cell contraction through upregulation of Cx43 expression

    • Author(s)
      Li K
    • Organizer
      2012 Annual Meeting of American Urology Association
    • Place of Presentation
      Georgia World Congress Center (Atlanta, USA)
    • Related Report
      2012 Annual Research Report
  • [Book] Methods in Enzymology (UPR and Cell Stress), Vol.490, Chapter 52011

    • Author(s)
      Kitamura M, Hiramatsu N
    • Total Pages
      14
    • Publisher
      Real-time monitoring of ER stress in living cells and animalsusing ESTRAP assay
    • Related Report
      2011 Annual Research Report
  • [Book] Methods in Enzymology(UPR and Cell Stress)(Real-time monitoring of ER stress in living cells and animals using ESTRAP assay)(Vol.490, Chaoter 5)2011

    • Author(s)
      Kitamura M, Hiramatsu N
    • Related Report
      2010 Self-evaluation Report
  • [Book] Annual Review腎臓(小胞体ストレストメサンギウムの細胞応答)2011

    • Author(s)
      北村正敬
    • Related Report
      2010 Self-evaluation Report
  • [Book] Annual Review腎臓(Gap Junctionを介した細胞間情報伝達メサンギウム細胞の動態制御に於ける役割)2009

    • Author(s)
      姚建、北村正敬
    • Related Report
      2010 Self-evaluation Report
  • [Book] Annual Review腎臓(腎における小胞体ストレス(ER stress)の意義2008

    • Author(s)
      北村正敬
    • Related Report
      2010 Self-evaluation Report
  • [Book] Methods in Enzymology(UPR and Cell Stress)Vol. 490, Chapter 5 :Real-time monitornig of ER stress living cells and animals using ESTRAP assay.

    • Author(s)
      Kitamura M, Hiramatsu N
    • Publisher
      Academic Press(Elsevier)
    • Related Report
      2010 Annual Research Report
  • [Remarks] 分子情報伝達学講座HP

    • URL

      http://www.med.yamanashi.ac.jp/clinical/molecular/

    • Related Report
      2012 Final Research Report
  • [Remarks] リエゾンアカデミーHP

    • URL

      http://www.med.yamanashi.ac.jp/liaison/

    • Related Report
      2012 Final Research Report
  • [Remarks] ライフサイエンス特進コースHP

    • URL

      http://www.med.yamanashi.ac.jp/lifescience/

    • Related Report
      2012 Final Research Report
  • [Remarks] 分子情報伝達学講座ホームページ

    • URL

      http://www.med.yamanashi.ac.jp/clinical/molecular/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/molecular/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/molecular/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/molecular/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/molecular/

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 小胞体ストレス関連実験用試薬及び小胞体ストレス関連疾患治療薬2013

    • Inventor(s)
      北村 正敬
    • Industrial Property Rights Holder
      山梨大学
    • Filing Date
      2013
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許P1513YNU2013

    • Inventor(s)
      北村正敬、新森英之
    • Industrial Property Rights Holder
      山梨大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-02-22
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2019-07-29  

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