| Project/Area Number |
20390239
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
UMEMURA Satoshi Yokohama City University, 医学研究科, 教授 (00128589)
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| Co-Investigator(Kenkyū-buntansha) |
INOKO Hidetoshi 東海大学, 医学部, 教授 (10101932)
MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579)
HIRAWA Nobuhito 横浜市立大学, 市民総合医療センター, 准教授 (20315766)
TAMURA Koichi 横浜市立大学, 医学部, 准教授 (40285143)
OKA Akira 東海大学, 総合医学研究所, 講師 (80384866)
YATSU Keisuke 横浜市立大学, 市民総合医療センター, 助教 (10457856)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 本態性高血圧 / ゲノム多型 / バイオインフォマティクス / ノックアウトマウス / 遺伝子発現解析 |
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| Research Abstract |
We performed the genome-wide association analysis with using microsatellite markers for essential hypertension and reported the new candidate genes in 2007. For these three years, we studied the new three disease-susceptibility genes for essential hypertension. One of them is LPIN1 gene. The phenotype of the LPIN1 knockout mice showed the high blood pressure, but the mechanism of the lpin1-induced hypertension is still unknown. More works about the examination of the rest candidate genes are left. We were able to show the estimable result for the new candidate genes of essential hypertension, but it is left what we should do still more.
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