Clarification of aquaporin-4 related molecular and cellular pathomechanism in neuromyelitis optica (Devic's disease)
| Project/Area Number |
20390241
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
FUJIHARA Kazuo 東北大学, 大学院・医学系研究科, 教授 (70280873)
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| Co-Investigator(Kenkyū-buntansha) |
ITOYAMA Yasuto 国立精神・神経医療研究センター, 病院, 病院長 (30136428)
MISU Tatsuro 東北大学, 大学院・医学系研究科, 助教 (00396491)
NAKASHIMA Ichiro 東北大学, 病院, 講師 (50333810)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 脳神経疾患 / 視神経脊髄炎 / デビック病 |
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| Research Abstract |
Neuromyelitis optica (NMO)is an intractable neurologic disease characterized by recurrent severe optic neuritis and transverse myelitis. The present study showed that the titers of aquaporin 4 (AQP4)antibody, an autoantibody unique to NMO, reflect disease activity. We also demonstrated that AQP4 antibody has a pathogenic potential in vitro and in vivo, and that NMO is a new clinical entity (immune-mediated astrocytopathy). Concerning therapy of NMO, we found therapeutic efficacy of long-term gradual steroid tapering in preventing early relapse of this disease.
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Report
(4 results)
Research Products
(153 results)
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[Journal Article] Diagnostic Criteria for Multiple Sclerosis : 2010 Revisions to the"McDonald Criteria"2011
Author(s)
Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O' Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS
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Journal Title
Ann Neurol
Volume: 69
Pages: 292-302
Related Report
Peer Reviewed
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[Journal Article] Three cases of neuromyelitis optica preceded by hyperCKemia episode2010
Author(s)
Suzuki N, Takahashi T, Aoki M, Misu T, Konohana S, Okumura T, Takahashi H, Kameya S, Yamaki K, Kumagai T, Fujihara K, Itoyama Y.
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Journal Title
Neurology
Volume: 74
Pages: 1543-1545
Related Report
Peer Reviewed
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[Journal Article] Neuromyelitis optica : pathogenicity of patient immunoglobulin in vivo2009
Author(s)
Bradl M, Misu T, Takahashi T, Watanabe M, Mader S, Reindl M, Adzemovic M, Bauer J, Berger T, Fujihara K, Itoyama Y, Lassmann H.
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Journal Title
Ann Neurol
Volume: 66
Pages: 630-643
Related Report
Peer Reviewed
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