Development of risk assessment and prevention of cerebral amyloid angiopathy-related cerebral hemorrhages
| Project/Area Number |
20390242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHITA Mitsuhiro 金沢大学, 医学系, 協力研究員 (60361995)
内木 宏延 福井大学, 医学部, 教授 (10227704)
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| Co-Investigator(Renkei-kenkyūsha) |
NAIKI Hironobu 福井大学, 医学部, 教授 (10227704)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 脳アミロイドアンギオパチー / アミロイド / 脳内出血 / MRI / PET / アミロイドβ蛋白 / 実験モデル / 天然フェノール化合物 / 脳画像 / 診断マーカー / 試験管内モデル / 動物モデル |
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| Research Abstract |
We investigated cerebral amyloid angiopathy(CAA) and CAA-related hemorrhages to develop methods of risk assessment and prevention. We propose a table of biomarkers and risk factors to predict future development of CAA-related hemorrhages and other disorders. We established an in vitro model of CAA. We revealed that natural phenolic compounds inhibited fibril formation and oligomerization of amyloidβ-protein(Aβ) in in vitro and in vivo models.
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Report
(6 results)
Research Products
(52 results)
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[Journal Article] Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site specific binding2012
Author(s)
Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki JI, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M
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Journal Title
J Biol Cbem
Volume: (印刷中)
Issue: 18
Pages: 14631-14643
DOI
Related Report
Peer Reviewed
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[Journal Article] Phenolic compounds prevent amyloidβ-protein oligomerization and synaptic dysfunction by site specific binding
Author(s)
Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J-I, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M
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Journal Title
J Biol Chem
Volume: (in press)
Related Report
Peer Reviewed
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