| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
The purpose of this study was to understand the physiological basis and whole picture of neuro-vascular-metabolic coupling from a microscopic and macroscopic point of view using rodent models.(1) Microscopic scale. Using two-photon microscopy and intraperitoneal injection of sulforhodamine 101, both cortical microvasculature and astroglia could be imaged with the lapse of time.(2) Macroscopic scale. Using acute/chronic cranial window techniques, neural-hemodynamic relationships were examined. The results indicate the relationships vary depending on cortical processing patterns. However, the analysis of temporal/spectral structure of local field potentials(LFPs) and application of the high-frequency(gamma frequency band) LFP components were effective ways to manage the diversity or nonlinearity inherent in neural-hemodynamic relationships.
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