Role of Neuronal Network System in Development of the Metabolic Syndrome

• Project/Area Number: 20390252
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Tohoku University
• Principal Investigator: KATAGIRI Hideki Tohoku University, 大学院・医学系研究科, 教授 (00344664)
• Co-Investigator(Kenkyū-buntansha): ISHIGAKI Yasushi 東北大学, 大学院・医学系研究科, 准教授 (50375002)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 糖尿病 / メタボリックシンドローム / 肥満 / 臓器間ネットワーク / インスリン / 膵β細胞

Research Abstract

We have recently discovered that neuronal networks among organs/tissues play important roles in maintaining metabolic homeostasis in the whole body. In this study, we examined how the inter-organ neuronal networks contribute to the development of the metabolic syndrome. First, we found that hepatic ERK activation induced insulin hypersecretion and pancreatic beta cell proliferation. This liver-to-pancreas coordination is mediated by a novel neuronal network, consisting the splanchnic afferents and vagal efferents. Furthermore, this neuronal network is involved in obesity-induced hyperinsulinemia. In addition, we have found that another neuronal network originating in hepatic PPARgamma expression causes hypertension associated with obesity. Thus, this study has revealed the mechanisms underlying obesity-induced hyperinsulinemia and hypertension, which are major features of the metabolic syndrome. The mechanisms involve two types of inter-organ metabolic networks, which are potential therapeutic targets for the metabolic syndrome.

Research Products

• [Journal Article] Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells : Potential Involvement of the PLC-IP3-Dependent Pathway. (2011)
  • Author(s): Suzuki T, Imai J, Yamada T, Ishigaki Y, Kaneko K, Uno K, Hasegawa Y, Ishihara H, Oka Y, Katagiri H.
  • Journal Title: Diabetes 60(2) Pages: 537-547
  • Peer Reviewed
• [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity. (2011)
  • Author(s): Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T.
  • Journal Title: Am J Physiol Cell Physiol. In Press
  • Peer Reviewed
• [Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse 1 iver. (2011)
  • Author(s): Onoyama I, Suzuki A, Matsumo to A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI
  • Journal Title: J Clin Invest Volume: 121(1) Pages: 342-354
  • Peer Reviewed
• [Journal Article] Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Panc reatic β-Cells : Potential Involvement of the PLC-IP3-Dependent Pathway. (2011)
  • Author(s): Suzuki T, Imai J, Yamada T, Ishigaki Y, Kaneko K, Uno K, Hasegawa Y, Ishihara H, Oka Y, Katagiri H.
  • Journal Title: Diabetes Volume: 60(2) Pages: 537-547
  • Peer Reviewed
• [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity. (2011)
  • Author(s): Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T.
  • Journal Title: Am J Physiol Cell PhysioL Volume: In Press
  • Peer Reviewed
• [Journal Article] Molecular Characterization of the Tumor Suppressor Candidate 5 Gene : Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans. (2010)
  • Author(s): Knotts TA, Lee HW, Kim JB, Oort PJ, McPherson R, Dent R, Tachibana K, Doi T, Yu S, Reddy JK, Uno K, Katagiri H, Pasarica M, Smith SR, Sears DD, Grino M, Adams SH.
  • Journal Title: PPAR Research Pages: 867678-867678
  • Peer Reviewed
• [Journal Article] Characterization of a novel murine preadipocyte line, AP-18, isolated from subcutaneous tissue : analysis of adipocyte-related gene expressions. (2010)
  • Author(s): Chen C, Takahashi K, Yoshida A, Takizawa Y, Lee Y, Nakui M, Doi H, Takebayashi Y, Fukumoto M, Yamada T, Katagiri H, Oka Y, Satoh J.
  • Journal Title: Cell Biol Int 34(3) Pages: 293-299
  • Peer Reviewed
• [Journal Article] The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic β cells under oxidative stress conditions. (2010)
  • Author(s): Tominaga R, Yamaguchi S, Satake C, Usui M, Tanji Y, Kondo K, Katagiri H, Oka Y, Ishihara H.
  • Journal Title: Cell Biochem Funct 28(5) Pages: 387-393
  • Peer Reviewed
• [Journal Article] Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. (2010)
  • Author(s): Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H, Nakayama KI.
  • Journal Title: J.Biol.CheJ.Chem 285(20) Pages: 15538-15547
  • Peer Reviewed
• [Journal Article] Pinl associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity. (2010)
  • Author(s): Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T.
  • Journal Title: J Biol Chem 285(43) Pages: 33018-33027
  • Peer Reviewed
• [Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. (2010)
  • Author(s): Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI.
  • Journal Title: J Clin Invest 121(1) Pages: 342-354
  • Peer Reviewed
• [Journal Article] Molecular Characterization of the Tumor Suppressor Candidate 5 Gene : Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans. (2010)
  • Author(s): Knotts TA, Lee HW, Kim JB, Oort PJ, McPherson R, Dent R, Tachibana K, Doi T, Yu S, Reddy JK, Uno K, Katagiri H, Pasarica M, Smith SR. Sears DD, Grino M, Adams SH.
  • Journal Title: PPAR Research Pages: 867678-867678
  • Peer Reviewed
• [Journal Article] Characterization of a novel murine preadipocyte line, AP-18, isolated from subcutaneous tissue : analysis of adipocyte-related gene expressions. (2010)
  • Author(s): Chen C, Takahashi K, Yoshida A, Takizawa Y, Lee Y, Nakui M, Doi H, Takebayashi Y, Fukumoto M, Yamada T, Katagiri H, Oka Y, Satoh J
  • Journal Title: Cell Biol Int Volume: 34(3) Pages: 293-299
  • Peer Reviewed
• [Journal Article] The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic β cells under oxidative stress conditions. (2010)
  • Author(s): Tominaga R, Yamaguchi S, Sateke C, Usui M, Tanji Y, Kondo K, Katagiri H, Oka Y, Ishihara H
  • Journal Title: Cell Biochem Funct Volume: 28(5) Pages: 387-393
  • Peer Reviewed
• [Journal Article] Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. (2010)
  • Author(s): Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H, Nakayama KI
  • Journal Title: J.Biol.Chem Volume: 285(20) Pages: 15538-15547
  • Peer Reviewed
• [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol thereby suppressing cAMP-responsive element transcriptional activity. (2010)
  • Author(s): Nakatsu Y, Sakoda H. Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T.
  • Journal Title: J Biol Chem Volume: 285(43) Pages: 33018-33027
  • NAID: 120006471211
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Tokita A, Ishigaki Y, Okimoto H, Hasegawa H, Koiwa Y, Kato M, Ishihara H, Hinokio Y, Katagiri H, Kanai H, Oka Y.
  • Journal Title: Atherosclerosis 206(1) Pages: 168-172
  • Peer Reviewed
• [Journal Article] Identification of a Novel Mechanism Regulating β Cell Mass : Neuronal relay from the Liver to Pancreatic β Cells. (2009)
  • Author(s): Imai J, Oka Y, Katagiri H.
  • Journal Title: Islets 1(1) Pages: 75-77
  • Peer Reviewed
• [Journal Article] Neural Relay from the Liver Induces Proliferation of Pancreatic β Cells : A Path to Regenerative Medicine using the Self-Renewal Capabilities. (2009)
  • Author(s): Katagiri H, Imai J, Oka Y.
  • Journal Title: Commun Integr Biol. 2 Pages: 425-427
  • Peer Reviewed
• [Journal Article] Peginterferon (PEG-IFN) plus Ribavirin Combination Therapy, but neither Interferon nor PGE-IFN Alone, Apparently Induced Type 1 Diabetes in a Patient with Chronic Hepatitis C. (2009)
  • Author(s): Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y.
  • Journal Title: Internal Medicine 48 Pages: 1387-1390
  • Peer Reviewed
• [Journal Article] Eradication of insulin resistance. (2009)
  • Author(s): Imai J, Yamada T, Saito T, Ishigaki Y, Hinokio Y, Kotake H, Oka Y, Katagiri H.
  • Journal Title: The Lancet 374 Pages: 264-264
  • Peer Reviewed
• [Journal Article] Circulating oxidized LDL-a biomarker and a pathogenic factor. (2009)
  • Author(s): Ishigaki Y, Oka Y, Katagiri H.
  • Journal Title: Curr Opin Lipidol 20(5) Pages: 363-369
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. (2009)
  • Author(s): Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Oike Y.
  • Journal Title: Cell Metab 10 Pages: 178-188
  • Peer Reviewed
• [Journal Article] Different Impacts of Saturated and Unsaturated Free Fatty Acids on COX-2 Expression in C2C12 Myotubes. (2009)
  • Author(s): Kadotani A, Tsuchiya Y, Hatakeyama H, Katagiri H, Kanzaki M.
  • Journal Title: Am J Physiol Endocrinol Metab 297(6)
  • Peer Reviewed
• [Journal Article] Adiponectin up-regulates Ferritin Heavy Chain in skeletal muscle cells. (2009)
  • Author(s): Ikegami Y, Inukai K, Imai K, Sakamoto Y, Katagiri H, Kurihara S, Awata T. Katayama S.
  • Journal Title: Diabetes 58 Pages: 61-70
  • Peer Reviewed
• [Journal Article] Obesity Alters Circadian Expressions of Molecular Clock Genes in the Brainstem. (2009)
  • Author(s): Kaneko K, Yamada T, Tsukita S, Takahashi K, Ishigaki Y, Oka Y, Katagiri H.
  • Journal Title: Brain Res 1263 Pages: 58-68
  • Peer Reviewed
• [Journal Article] Carotid arterial elasticity is a sensitive atherosclerosis value reflecting visceral fa taccumulation in obese subjects. (2009)
  • Author(s): Tokita A, Ishigaki Y, Okimoto H, Hasegawa H, Koiwa Y, Kato M, Ishihara H, Hinokio Y, Katagiri H, Kanai H, Oka Y.
  • Journal Title: Atherosclerosis 206(1) Pages: 168-172
  • Peer Reviewed
• [Journal Article] Peginterferon(PEG-IFN)plus Ribavirin Combination Therapy, but neither Interferon nor PGE-IFN Alone, Apparently Induced Type 1 Diabetes in a Patient with Chronic Hepatitis C. (2009)
  • Author(s): Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y.
  • Journal Title: Internal Medicine 48 Pages: 1387-1390
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance (2009)
  • Author(s): Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Oike Y.
  • Journal Title: Cell Metab 10 Pages: 178-188
  • Peer Reviewed
• [Journal Article] Adiponectin up-regulates Ferritin Heavy Chain in skeletal muscle cells (2009)
  • Author(s): Ikegami Y, Inukai K, Imai K, Sakamoto Y, Katagiri H, Kurihara S, Awata T, Katayama S
  • Journal Title: Diabetes 58 Pages: 61-70
  • Peer Reviewed
• [Journal Article] Obesity Alters Circadian Expressions of Molecular Clock Genes in the Brainstem (2009)
  • Author(s): Kaneko K, Yamada T, Tsukita S, Takahashi K, Ishigaki Y, Oka Y, Katagiri H
  • Journal Title: Brain Res (In press) Pages: 58-68
  • Peer Reviewed
• [Journal Article] Ambient Glucose Levels Qualify the Potency of Insulin Myogenic Actions by Regulating SIRT1 and FoxO3a in C2C12 myocytes. (2008)
  • Author(s): Nedachi T, Kadotani A, Ariga M, Katagiri H, Kanzaki M.
  • Journal Title: Am J Physiol Endocrinol Metab 294
  • Peer Reviewed
• [Journal Article] Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes. (2008)
  • Author(s): Ariga M, Nedachi T, Katagiri H, Kanzaki M.
  • Journal Title: J Biol Chem 283 Pages: 10208-10220
  • Peer Reviewed
• [Journal Article] Impact of Plasma Oxidized LDL Removal on Atherosclerosis. (2008)
  • Author(s): Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y.
  • Journal Title: Circulation 118 Pages: 75-83
  • Peer Reviewed
• [Journal Article] Regulation of Pancreatic β cell Mass by Neuronal Signals from the Liver. (2008)
  • Author(s): Imai J, Katagiri H, Yamada Y, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima A, Nakazato M, Asano T, Minokoshi Y, Oka Y.
  • Journal Title: Science 322 Pages: 1250-1254
  • Peer Reviewed
• [Journal Article] Ambient Glucose Levels Qualify the Potency of Insulin Myogenic Actions by Regulating SIRT1 and FoxO3a in C2C12 myocytes (2008)
  • Author(s): Nedachi T, Kadotani A, Ariga M, Katagiri H, Kanzaki M
  • Journal Title: Am J Physiol Endocrinol Metab. 294
  • Peer Reviewed
• [Journal Article] Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocyte (2008)
  • Author(s): Ariga M, Nedachi T, Katagiri H, Kanzaki M
  • Journal Title: J Biol Chem 283 Pages: 10208-20
  • Peer Reviewed
• [Journal Article] Impact of Plasma Oxidized LDL Removal on Atherosclerosis (2008)
  • Author(s): Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y
  • Journal Title: Circulation 118 Pages: 75-83
  • Peer Reviewed
• [Journal Article] Regulation of Pancreatic β cell Mass by Neuronal Signals from the Liver (2008)
  • Author(s): Imai J, Katagiri H, Yamada Y, Ishigaki Y, Suzuki T, Kudo H, Uno K, Hasegawa Y, Gao J, Kaneko K, Ishihara H, Niijima, A, Nakazato M, Asano T, Mino, Koshi Y, Oka Y
  • Journal Title: Science 322 Pages: 1250-4
  • Peer Reviewed
• [Presentation] 中枢と末梢のコーディネイト (2010)
  • Author(s): 片桐秀樹
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋
  • Year and Date: 2010-10-02
• [Presentation] 中枢と末梢のコーディネイル (2010)
  • Author(s): 片桐秀樹
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋
  • Year and Date: 2010-10-02
• [Presentation] Metabolic Harmony:自律神経による糖・エネルギー代謝に協調的調節 (2010)
  • Author(s): 片桐秀樹
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-28
• [Presentation] メタボリックシンドロームの最前線 -基礎から臨床- Neuronal Involvement in Inter-organ Metabolic Communication. (2010)
  • Author(s): 片桐秀樹
  • Organizer: 日本循環器病学会
  • Place of Presentation: 京都
• [Presentation] 神経ネットワークによる臓器間代謝調節 (2010)
  • Author(s): 片桐秀樹
  • Organizer: 第44回糖尿病学の進歩
  • Place of Presentation: 大阪
• [Presentation] (Invited Speaker) Symposium : Insulin resistance and tissue cross-talk. (2010)
  • Author(s): 片桐秀樹
  • Organizer: Metabolic Harmony via Neuronal Information Highways ~Coordinated Regulation of Systemic Metabolism~ 14^<th> International Congress of Endocrinology (ICE2010)
  • Place of Presentation: Kyoto Japan
• [Presentation] Interleukin-6 enhances glucose-stimulated insulin secretion from pancreatic β-cells through the PLC-IP_3-dependent pathway. (2010)
  • Author(s): Imai J, Suzuki T, Oka Y, Katagiri H.
  • Organizer: American Diabetes Association, 70th Scientific Sessions
  • Place of Presentation: Orlando, Florida, USA, USA
• [Presentation] The role of CHOP expressed in vascular and hematopoietic cells in vascular remodeling. (2010)
  • Author(s): Kondo K, Gao J, Ishigaki Y, Oka Y, Katagiri H.
  • Organizer: American Diabetes Association, 70th Scientific Sessions
  • Place of Presentation: Orlando, Florida, USA, USA
• [Presentation] Importance of the Endothelium in Vascular Remodeling and Aortic Aneurysm Formation through NF-kB Pathway. (2010)
  • Author(s): Saito T, Hasegawa Y, Oka Y, Katagiri H.
  • Organizer: American Diabetes Association, 70th Scientific Sessions
  • Place of Presentation: Orlando, Florida, USA,
• [Presentation] メタボリックシンドロームの最前線-基礎から臨床-Neuronal Involvement in Inter-organ Metabolic Communication (2010)
  • Author(s): 片桐秀樹
  • Organizer: 日本循環器病学会
  • Place of Presentation: 京都
• [Presentation] 肥満・糖尿病の成因とその対策 (2009)
  • Author(s): 片桐秀樹
  • Organizer: 日本内科学会東北地方会生涯教育講演会
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-20
• [Presentation] 肝臓からの神経シグナルによる糖・エネルギー代謝調節機構 (2009)
  • Author(s): 片桐秀樹
  • Organizer: 第43回糖尿病学の進歩
  • Place of Presentation: 松本
  • Year and Date: 2009-02-20
• [Presentation] ストレス応答の新機軸神経系による糖・エネルギー代謝の協調的調節 (2009)
  • Author(s): 片桐秀樹
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
• [Presentation] 膵β細胞の分化増殖と臨床展開 臓器間連関による膵β細胞再生機構 (2009)
  • Author(s): 片桐秀樹
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 前橋
• [Presentation] (Invited Speaker) Symposium Brain Signaling in Glucose and Fat Metabolism. (2009)
  • Author(s): 片桐秀樹
  • Organizer: Metabolic Pathways of Neurons. American Diabetes Association, 69th Scientific Sessions
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Obesity and Insulin Resistance Alter Circadian Expressions of Molecular Clock Genes in the Brainstem. (2009)
  • Author(s): Kaneko K, Yamada T, Oka Y, Katagiri H.
  • Organizer: American Diabetes Association, 69th Scientific Sessions
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] (Invited Speaker) Metabolic harmony via neuronal information highways. (2009)
  • Author(s): 片桐秀樹
  • Organizer: The 4th International Workshop on Cell Regulation in Division and Arrest
  • Place of Presentation: Okinawa, Japan
• [Presentation] Obesity induces pancreatic β cell proliferation with neuronal network originating in the liver. (2009)
  • Author(s): 片桐秀樹
  • Organizer: Tohoku University Global COE The 1st International Symposium ~Challenge to Medical Innovation~
  • Place of Presentation: Sendai, Japan
• [Presentation] ストレス応答の新機軸 神経系による糖・エネルギー代謝の協調的調節 (2009)
  • Author(s): 片桐秀樹
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
• [Presentation] 肥満症における肝臓の病態的意義S7-1肝からの神経を介した臓器間ネットワークとメタボリックシンドローム (2008)
  • Author(s): 宇野健司, 山田哲也, 岡芳知, 片桐秀樹
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
• [Presentation] 脂肪組織からの求心性神経シグナルによる食欲調節機構 (2008)
  • Author(s): 片桐秀樹
  • Organizer: 第50回歯科基礎医学会学術大会・総会
  • Place of Presentation: 東京
• [Presentation] 片桐秀樹肝からの神経による臓器間ネットワークとメタボリックシンドローム (2008)
  • Author(s): 宇野健司
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
• [Presentation] 自律神経による臓器間代謝情報ネットワークとメタボリックシンドローム (2008)
  • Author(s): 片桐秀樹
  • Organizer: 日本内分泌学会学術総会
  • Place of Presentation: 青森(国際学会)
• [Presentation] Impact of Plasma Oxidized LDL Removal on Atherosclerosis (2008)
  • Author(s): Ishigaki Y., Katagiri H., Gao J., Oka Y.
  • Organizer: American Diabetes Association, 68th Scientific Sessions
  • Place of Presentation: San Francisco, USA
• [Presentation] Metabolic Information Highway Uehara Memorial Foundation (2008)
  • Author(s): 片桐秀樹
  • Organizer: Symposium 2008 "Systems Biology : The Challenge of Complexity"
  • Place of Presentation: Tokyo, Japan
• [Presentation] Inter-Organ Metabolic Communication via Autonomic Nerve Circuits. (2008)
  • Author(s): 片桐秀樹
  • Organizer: The 39^<th> International Symposium of the Princess Takamatsu Cancer Research Fund "Metabolic Syndrome : Carcinogenesis and Prevention"
  • Place of Presentation: Tokyo Japan
• [Presentation] 自律神経による臓器間代謝情報ネットワークとメタボリックシンドローム (2008)
  • Author(s): 片桐秀樹
  • Organizer: 日本内分泌学会学術総会
  • Place of Presentation: 青森
• [Presentation] 肝からの神経による臓器間ネットワークとメタボリックシンドローム (2008)
  • Author(s): 宇野健司、片桐秀樹
  • Organizer: 第51回日本糖尿病学会
  • Place of Presentation: 東京
• [Presentation] Impact of Plasma Oxidized LDL Removal on Atherosclerosis American Diabetes Association (2008)
  • Author(s): Ishigaki Y., Katagiri H. Gao J., Oka Y
  • Organizer: 68th Scientific Sessions
  • Place of Presentation: San Francisco, USA
• [Presentation] Metabolic Information Highway Uehara Memorial Foundation Symposiu m 2008 (2008)
  • Author(s): Katagiri H
  • Organizer: Systems Biology : The Challenge of Complexity
  • Place of Presentation: Tokyo, Japan
• [Presentation] Inter-Organ Metabolic Communication via Autonomic Nerve Circuits (2008)
  • Author(s): Katagiri H
  • Organizer: The 39th International Symposium of the Princes s Takamatsu Cancer Research Fund "Metabolic Syndrome : Carcinoaenesis and Prevention
  • Place of Presentation: Tokyo, Japan
• [Patent(Industrial Property Rights)] Method for activating efferent sympathetic nerves innervating adipose tissue to improve obesity and symptoms associated therewith. (2010)
  • Inventor(s): 片桐秀樹, 岡芳知, Tetsuya Yamada, Kenji Uno
  • Industrial Property Rights Holder: Tohoku University
  • Acquisition Date: 2010-10-19
  • Overseas
• [Patent(Industrial Property Rights)] 膵β細胞増殖促進方法、血中インスリン濃度上昇方法、血糖値低下方法、及び糖尿病治療・予防方法 (2008)
  • Inventor(s): 片桐秀樹、岡芳知、今井淳太
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Filing Date: 2008-07-01
  • Overseas
• [Patent(Industrial Property Rights)] 膵β細胞増殖促進方法、血中インス. リン濃度上昇方法、血糖値低下方法、及び糖尿病治療・予防方法 (2008)
  • Inventor(s): 片桐秀樹岡芳知今井淳太
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Filing Date: 2008-07-01
  • Overseas