Development of novel treatment for type 2 diabetes by regulating cellular stresses targeted to molecular chaperone.
| Project/Area Number |
20390259
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
ARAKI Eiichi Kumamoto University, 大学院・生命科学研究部, 教授 (10253733)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Tatsuya 熊本大学, 大学院・生命科学研究部, 助教 (70398204)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 糖尿病 / 分子シャペロン / Hsp72 / 小胞体ストレス / 細胞内ストレス / Bip |
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| Research Abstract |
Induction of molecular chaperones, such as Hsp72 or BiP contributes to improve glucose homeostasis in diabetes. Especially, these inductions can be expected to treat several types of diabetes, because these inductions were effective to diabetes originated from environmental, genetic or ER stress, respectively. We therefore conclude that induction of molecular chaperone, such as Hsp72 or BiP, decreases cellular stresses and chronic inflammation, resulting in improvement of insulin resistance.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Glucose uptake in rat skeletal muscle L6 cells is increased by low-intensity electrical current through the activation of the phosphatidylinositol-3-OH kinase (PI-3K)/Akt pathway.2011
Author(s)
Yano S, Morino-Koga S, Kondo T, Suico MA, Koga T, Shimauchi Y, Matsuyama S, Shuto T, Sato T, Araki E, Kai H.
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Journal Title
J Pharmacol Sci. 115(1)
Pages: 94-98
NAID
Related Report
Peer Reviewed
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[Journal Article] Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.2011
Author(s)
Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E.
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Journal Title
Biochem Biophys Res Commun. 404(1)
Pages: 339-344
Related Report
Peer Reviewed
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[Journal Article] Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects.2010
Author(s)
Kondo T, Sasaki K, Adachi H, Nakayama Y, Hatemura M, Matsuyama R, Tsuruzoe K, Furukawa N, Motoshima H, Morino (Koga) S, Yamashita Y, Miyamura N, Kai H, Araki E
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Journal Title
Obesity Research and Clinical Practice 4
NAID
Related Report
Peer Reviewed
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[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice.2010
Author(s)
Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
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Journal Title
Am J Physiol Endocrinol Metab 29(5)
Related Report
Peer Reviewed
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[Journal Article] Heat Shock Treatment with Mild Electrical Stimulation Safely Reduced Inflammatory Markers in Healthy Male Subjects2010
Author(s)
Kondo, T., Sasaki, K., Adachi, H., Nakayama, Y., Hatemura, M., Matsuyama, R., Tsuruzoe, K., Furukawa, N., Motoshima, H., Morino, S., Yamashita, Y., Miyamura, N., Kai, H., Araki, E.
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Journal Title
Obesity Research and Clinical Practice Vol.4 Issue 2
NAID
Related Report
Peer Reviewed
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