Development of novel treatment for type 2 diabetes by regulating cellular stresses targeted to molecular chaperone.

• Project/Area Number: 20390259
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: ARAKI Eiichi Kumamoto University, 大学院・生命科学研究部, 教授 (10253733)
• Co-Investigator(Kenkyū-buntansha): KONDO Tatsuya 熊本大学, 大学院・生命科学研究部, 助教 (70398204)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 糖尿病 / 分子シャペロン / Hsp72 / 小胞体ストレス / 細胞内ストレス / Bip

Research Abstract

Induction of molecular chaperones, such as Hsp72 or BiP contributes to improve glucose homeostasis in diabetes. Especially, these inductions can be expected to treat several types of diabetes, because these inductions were effective to diabetes originated from environmental, genetic or ER stress, respectively. We therefore conclude that induction of molecular chaperone, such as Hsp72 or BiP, decreases cellular stresses and chronic inflammation, resulting in improvement of insulin resistance.

Research Products

• [Journal Article] Glucose uptake in rat skeletal muscle L6 cells is increased by low-intensity electrical current through the activation of the phosphatidylinositol-3-OH kinase (PI-3K)/Akt pathway. (2011)
  • Author(s): Yano S, Morino-Koga S, Kondo T, Suico MA, Koga T, Shimauchi Y, Matsuyama S, Shuto T, Sato T, Araki E, Kai H.
  • Journal Title: J Pharmacol Sci. 115(1) Pages: 94-98
  • NAID: 10029891696
  • Peer Reviewed
• [Journal Article] Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice. (2011)
  • Author(s): Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E.
  • Journal Title: Biochem Biophys Res Commun. 404(1) Pages: 339-344
  • Peer Reviewed
• [Journal Article] Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects. (2010)
  • Author(s): Kondo T, Sasaki K, Adachi H, Nakayama Y, Hatemura M, Matsuyama R, Tsuruzoe K, Furukawa N, Motoshima H, Morino (Koga) S, Yamashita Y, Miyamura N, Kai H, Araki E
  • Journal Title: Obesity Research and Clinical Practice 4
  • NAID: 120003184552
  • Peer Reviewed
• [Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice. (2010)
  • Author(s): Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
  • Journal Title: Am J Physiol Endocrinol Metab 29(5)
  • Peer Reviewed
• [Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice (2010)
  • Author(s): Hironori Adachi, Tatsuya Kondo, Eiichi Araki, et al.
  • Journal Title: American Journal of Physiology.Endocrinology and Metabolism. Volume: 29(5)
  • Peer Reviewed
• [Journal Article] Heat Shock Treatment with Mild Electrical Stimulation Safely Reduced Inflammatory Markers in Healthy Male Subjects (2010)
  • Author(s): Kondo, T., Sasaki, K., Adachi, H., Nakayama, Y., Hatemura, M., Matsuyama, R., Tsuruzoe, K., Furukawa, N., Motoshima, H., Morino, S., Yamashita, Y., Miyamura, N., Kai, H., Araki, E.
  • Journal Title: Obesity Research and Clinical Practice Vol.4 Issue 2
  • NAID: 120003184552
  • Peer Reviewed
• [Journal Article] A novel combination of mild electrical stimulation and hyperthermia : general concepts and applications. (2009)
  • Author(s): Kai H, Suico MA, Morino S, Kondo T, Oba M, Noguchi M, Shuto T, Araki E
  • Journal Title: Int J Hyperthermia 25 Pages: 655-660
  • Peer Reviewed
• [Journal Article] A novel combination of mild electrical stimulation and hyperthermia : general concepts and applications (2009)
  • Author(s): Kai H, Suico MA, Morino S, Kondo T, Oba M, Noguchi M, Shuto T, Araki E.
  • Journal Title: Int J Hyperthermia 25(8) Pages: 655-660
  • Peer Reviewed
• [Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis. (2009)
  • Author(s): Adachi H
  • Journal Title: Biochem Biophys Res Commun. 379(4) Pages: 806-811
  • Peer Reviewed
• [Journal Article] Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation. (2008)
  • Author(s): Morino S, Suico MA, Kondo T, Sekimoto E, Yano S, Matsuda T, Matsuno T, Shuto T, Araki E, Kai H
  • Journal Title: J Pharmacol Sci 108 Pages: 222-226
  • NAID: 10024385095
  • Peer Reviewed
• [Journal Article] Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling. (2008)
  • Author(s): Morino S, Kondo T, Sasaki K, Adachi H, Suico MA, Sekimoto E, Matsuda T, Shuto T, Araki E, Kai H
  • Journal Title: PLoS ONE 3 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling. (2008)
  • Author(s): Morino S
  • Journal Title: PLoS ONE. 3(12)
  • Peer Reviewed
• [Journal Article] Mild electrical stimulation increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation. (2008)
  • Author(s): Morino S
  • Journal Title: Journal of Pharmacological Science. 108(2) Pages: 222-226
  • Peer Reviewed
• [Presentation] 原発性アルドステロン症自験44例における耐糖能異常の頻度と特徴 (2011)
  • Author(s): 後藤理英子、河島淳司、近藤龍也、水流添覚、下田誠也、宮村信博、荒木栄一
  • Organizer: 第20回臨床内分泌代謝Update
  • Place of Presentation: 札幌・札幌コンベンションセンター
  • Year and Date: 2011-01-28
• [Presentation] Activation of Heat Shock Response Reduces Visceral Adiposity and Improves Metabolic Profiles in Male Subjects with Metabolic Syndrome (2010)
  • Author(s): 近藤龍也, 荒木栄一, et al.
  • Organizer: 3^<rd> Insulin Resistance in Metabolic Disease Forum
  • Place of Presentation: ホテル日航福岡
  • Year and Date: 2010-11-21
• [Presentation] Activation of Heat Shock Response Reduces Visceral Adiposity and lmproves Metabolic Profiles in Male Subjects with Metabolic Syndrome (2010)
  • Author(s): Tatsuya Kondo, Rina Matsuyama, Katsutoshi Miyagawa, Rieko Goto, Hirofumi Kai, Eiichi Araki.
  • Organizer: 3^<rd> Insulin Resistance in Metabolic Disease Forum
  • Place of Presentation: Fukuoka, Hotel Nikko
  • Year and Date: 2010-11-21
• [Presentation] 熱ショック応答経路(HSR)活性化によるメタボリックシンドローム治療成績 (2010)
  • Author(s): 近藤龍也、松山利奈、後藤理英子、宮川克俊、河島淳司、本島寛之、西川武志、荒木栄一
  • Organizer: 第48回日本糖尿病学会九州地方会
  • Place of Presentation: 別府・ビーコンプラザ
  • Year and Date: 2010-10-30
• [Presentation] 熱ショック応答経路(HSR)活性化によるメタボリックシンドローム治療成績 (2010)
  • Author(s): 近藤龍也、荒木栄一, ほか
  • Organizer: 第48回 日本糖尿病学会九州地方会
  • Place of Presentation: 別府ビーコンプラザ
  • Year and Date: 2010-10-29
• [Presentation] 熱ショック応答経路(HSR)活性化による生活習慣病治療 (2010)
  • Author(s): 近藤龍也、荒木栄一, ほか
  • Organizer: 第60回日本体質医学会総会
  • Place of Presentation: 熊本パレア
  • Year and Date: 2010-10-16
• [Presentation] 熱ショック応答経路(HSR)活性化による生活習慣病治療 (2010)
  • Author(s): 近藤龍也、松山利奈、古賀沙緒里、後藤理英子、宮川克俊、河島淳司、本島寛之、西川武志、甲斐広文、荒木栄一
  • Organizer: 第60回日本体質医学会総会
  • Place of Presentation: 熊本・パレア
  • Year and Date: 2010-10-16
• [Presentation] Induction of HSP72, a Potential Novel Therapeutic Approach For Metabolic Syndrome and Type 2 Diabetes (2010)
  • Author(s): Tatsuya Kondo, Eiichi Araki, et al.
  • Organizer: 3^<rd> Baker IDI diabetes summit
  • Place of Presentation: Melbourne, Australia, Baker IDI
  • Year and Date: 2010-10-13
• [Presentation] Induction of HSP72, a Potential Novel Therapeutic Approach For Metabolic Syndrome and Type 2 Diabetes (2010)
  • Author(s): 近藤龍也, 荒木栄一, et al.
  • Organizer: 3^<rd> Baker IDI diabetes summit
  • Place of Presentation: メルボルン、オーストラリア
  • Year and Date: 2010-10-07
• [Presentation] タボリックシンドロームに対する熱ショック応答経路(HSR)活性化療法の臨床応用 (2010)
  • Author(s): 近藤龍也、松山利奈、後藤理英子、宮川克俊、河島淳司、本島寛之、西川武志、荒木栄一
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 群馬・前橋テルサ
  • Year and Date: 2010-10-02
• [Presentation] メタボリックシンドロームに対する熱ショック応答経路(HSR)活性化療法の臨床応用 (2010)
  • Author(s): 近藤龍也、荒木栄一, ほか
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 前橋テルサ
  • Year and Date: 2010-10-01
• [Presentation] Induction of HSP72, a Potential Novel Therapeutic Approach For Metabolic Syndrome and Type 2 Diabetes (2010)
  • Author(s): Tatsuya Kondo, Eiichi Araki, et al.
  • Organizer: 46^<th> EASD Annual Meeting
  • Place of Presentation: Stockholm.Sweden Stockholmsmassen
  • Year and Date: 2010-09-21
• [Presentation] Induction of HSP72, a Potential Novel Therapeutic Approach For Metabolic Syndrome and Type 2 Diabetes (2010)
  • Author(s): 近藤龍也, 荒木栄一, et al.
  • Organizer: 46^<th> EASD Annual Meeting
  • Place of Presentation: ストックホルム、スウェーデン
  • Year and Date: 2010-09-20
• [Presentation] メタボリックシンドロームに対する熱ショック応答経路(HSR)活性化の臨床的有用性 (2010)
  • Author(s): 近藤龍也、松山利奈、後藤理英子、宮川克俊、本島寛之、西川武志、荒木栄一
  • Organizer: 第18回西日本肥満研究会
  • Place of Presentation: 福岡・九州大学医学部百年講堂
  • Year and Date: 2010-07-11
• [Presentation] メタボリックシンドロームに対する熱ショック応答経路(HSR)活性化の臨床的有用性 (2010)
  • Author(s): 近藤龍也、荒木栄一, ほか
  • Organizer: 第18回西日本肥満研究会
  • Place of Presentation: 九州大学医学部百年講堂
  • Year and Date: 2010-07-10
• [Presentation] Heat Treatment with Mild Electrical Stimulation Reduces Visceral Adiposity and Improves Insulin Resistance and Inflammatory Markers in Male Subjects with Metabolic Syndrome (2010)
  • Author(s): 近藤龍也, 荒木栄一, et al.
  • Organizer: 70^<th> American Diabetes Association Scien tific Sessions
  • Place of Presentation: オーランド、米国
  • Year and Date: 2010-06-25
• [Presentation] Heat Treatment with Mild Electrical Stimulation Reduces Visceral Adiposity and Improves Insulin Resistance and Inflammatory Markers in Male Subjects with Metabolic Syndrome (2010)
  • Author(s): Tatsuya Kondo, Eiichi Araki, et al.
  • Organizer: 70^<th> American Diabetes Association Scientific Sessions
  • Place of Presentation: Orlando, USA, Orange county convention center
  • Year and Date: 2010-06-25
• [Presentation] メタボリックシンドロームに対する温熱・電流同時印加療法(MET)の内臓脂肪減少・代謝改善・慢性炎症マーカー低下効果 (2010)
  • Author(s): 近藤龍也, 佐々木一成, 松山利奈, 水流添覚、古川昇、本島寛之、河島淳司、古賀沙緒里、甲斐広文、荒木栄一
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山・岡山コンベンションセンター
  • Year and Date: 2010-05-27
• [Presentation] メタボリックシンドロームに対する温熱・電流同時印加療法(MET)の内臓脂肪減少・代謝改善・慢性炎症マーカー低下効果 (2010)
  • Author(s): 近藤龍也、荒木栄一, ほか
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-05-23
• [Presentation] 糖代謝改善をもたらす分子シャペロンHsp72制御療法の臨床応用を目指して (2010)
  • Author(s): 近藤龍也、佐々木一成、松山利奈、古賀沙緒里、本島寛之、水流添覚、甲斐広文、荒木栄一
  • Organizer: 第107回日本内科学会総会・講演会
  • Place of Presentation: 東京・東京国際フォーラム
  • Year and Date: 2010-04-10
• [Presentation] 糖代謝改善をもたらす分子シャペロンHsp72制御療法の臨床応用を目指して (2010)
  • Author(s): 近藤龍也、荒木栄一, ほか
  • Organizer: 第107回日本内科学会総会・講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-09
• [Presentation] 細胞内ストレスを標的とした糖尿病治療 (2009)
  • Author(s): 荒木栄一, 近藤龍也, 他
  • Organizer: 第59回 日本体質医学会総会
  • Place of Presentation: 東京都 学士会館
  • Year and Date: 2009-07-26
• [Presentation] 温熱・電流同時印加療法(MET)の健常人における安全性と慢性炎症マーカー低下効果 (2008)
  • Author(s): 近藤龍也
  • Organizer: 第46回日本糖尿病学会九州地方会
  • Place of Presentation: 久留米市
  • Year and Date: 2008-10-10
• [Presentation] 分子シャペロンHsp72の物理的および薬理学的誘導による内臓脂肪減少・糖代謝改善効果 (2008)
  • Author(s): 近藤龍也
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-05-22
• [Book] Diabetes Frontier,細胞レベルにおけるストレス反応と糖尿病 (2010)
  • Author(s): 近藤龍也、古賀沙緒里、甲斐広文、荒木栄一
  • Publisher: メディカルレビュー社
• [Book] 「内蔵脂肪に対する温熱微弱電流併用療法の効果」Diabetes Frontier Vol.20 (2009)
  • Author(s): 近藤龍也, 森野沙緒里, 甲斐広文, 荒木栄一
  • Total Pages: 376
  • Publisher: メディカルレビュー社
• [Book] Diabetes Frontier第20巻6号肥満治療の最前線9. 内臓脂肪に対する温熱微弱電流併用療法の効果 (2009)
  • Author(s): 近藤龍也
  • Total Pages: 130
  • Publisher: メディカルレビュー社
• [Remarks] ホームページ等
  • URL: http://www2.kuh.kumamoto-u.ac.jp/met/