| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
Evidence has accumulated indicating that obesity is associated with a state of chronic, low-grade inflammation, suggesting that inflammation may be a potential mechanism, whereby obesity leads to the metabolic syndrome. We have demonstrated that the crosstalk between adipocytes and macrophages may aggravate obesity-induced adipose tissue inflammation. In this study, we provided evidence on the novel molecular mechanisms underlying the inflammatory changes in hypertrophied adipocytes and adipose tissue macrophages, which may lead to novel therapeutic strategies to prevent or treat the metabolic syndrome.
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