| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
Adult growth hormone deficiency (AGHD) is characterized by visceral obesity, abnormal lipid profile, and liver dysfunction. In this study, we clarified that in AGHD, the prevalence of NAFLD/NASH was substantially increased. We also demonstrated that GH exerts its effect mainly via IGF-I and IGF-I ameliorates mitochondrial dysfunction, oxidative stress, and abnormal activation of stellate cells, which leads to fibrosis in the liver. These results indicate that GH and IGF-I play an important role in liver and are closely related with the pathogenesis of NASH.
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