Basic and clinical research on the significance of androgen as the basis for the onset background of lifestyle-related diseases

• Project/Area Number: 20390263
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kyushu University
• Principal Investigator: YANASE TOSHIHIKO Kyushu University, 医学部, 教授 (30239818)
• Co-Investigator(Kenkyū-buntansha): TANAKA Tomoko 福岡大学, 医学部, 助教 (10380528)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: アンドロゲン / 動脈硬化 / メタボリックシンドローム / 選択的アンドロゲン受容 / 体修飾剤 / DHT / アンドロゲン受容体 / LOX-1 / ApoE / 選択的アンドロゲン受容体修飾剤 / レプチン / STAT3 / 肥満

Research Abstract

As a mechanism for the anti-obesity effect of androgen, we clarified that androgen receptor (AR) can potentiate leptin-STAT3 signaling which is closely associated with energy expenditure. By extending this work, we identified a testosterone analogue, S42 as a new selective androgen receptor modulator (SARM) and found that S42 can dramatically reduce serum triglyceride level in male castrated SD rats. The significance of androgen in atherosclerosis is controversial. We revealed the anti- atherosclerotic effect of endogenous androgen in animal atherosclerotic model and clarified one mechanism related with the suppression of oxidized LDL receptor, LOX-1.

Research Products

• [Journal Article] Connexon-mediated cell adhesion drives microtissue self-assembly. (2011)
  • Author(s): Bao B, Jiang J, Yanase T, Nishi Y, Morgan JR.
  • Journal Title: FASEB J. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Peroxisome ProliferatorActivated Receptor-gamma Mediates Bisphenol A Inhibition of FSH-Stimulated IGF-1, Aromatase, and Estradiol in Human Granulosa Cells. (2010)
  • Author(s): Kwintkiewicz J, Nishi Y, Yanase T, Giudice LC
  • Journal Title: Environ Health Perspect. 18(3) Pages: 400-406
  • Peer Reviewed
• [Journal Article] Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development. (2010)
  • Author(s): Qiu Y, Yanase T, Hu H, Tanaka T, Nishi Y, Liu M, Sueishi K, Sawamura Nawata H
  • Journal Title: Endocrinology 151 Pages: 3307-16
  • Peer Reviewed
• [Journal Article] Serum gamma-glutamyltransferase, triglyceride and total cholesterol are possible prediabetic risk markers in young Japanese men. (2010)
  • Author(s): Akehi Y, Mitsuyoshi Y, Tatsumoto A, Yoshida R, Ohkubo K, Kudo T, Ashida K, Anzai K, Yamashita T, Kawashima H, Ono J, Yanase T
  • Journal Title: Endocrine J 57 Pages: 981-989
  • NAID: 130004443592
  • Peer Reviewed
• [Journal Article] Sex hormone and neuroendocrine aspects of the metabolic syndrome. (2010)
  • Author(s): Nawata H, Watanabe T, 柳瀬敏彦, Nomura M, Ashida K, Min L, Fan W
  • Journal Title: Prog Brain Res 182 Pages: 175-87
  • Peer Reviewed
• [Journal Article] 性ホルモンと糖尿病 (2010)
  • Author(s): 柳瀬敏彦、野見山崇
  • Journal Title: Diabetes Journal 38 Pages: 144-148
• [Journal Article] 特集:男性更年期障害の考え方と実地臨床各種ホルモンの加齢変動の意義 (2010)
  • Author(s): 柳瀬敏彦、明比祐子
  • Journal Title: 日本医師会雑誌 139(9) Pages: 1828-1829
• [Journal Article] 性ホルモン受容体とアデイポサイエンスアデイ (2010)
  • Author(s): 柳瀬敏彦、村瀬邦崇、田中智子
  • Journal Title: ポサイエンス 7 Pages: 113-117
• [Journal Article] 核内受容体と内分泌疾患UP DATE:アンドロゲン受容体とメタボリックシンドローム (2010)
  • Author(s): 柳瀬敏彦
  • Journal Title: ホルモン臨床 58 Pages: 93-98
• [Journal Article] III. 内分泌B. 臨床分野での進歩「4.アンチエイジングとホルモン」 (2010)
  • Author(s): 柳瀬敏彦、蘆田健二、明比祐子
  • Journal Title: Annual Review糖尿病・代謝・内分泌 Pages: 242-245
• [Journal Article] 特集・アンチエイジング医学の進歩アンチエイジグとしてのホルモン補充療法:GH, DHEA (2010)
  • Author(s): 柳瀬敏彦、村瀬邦崇
  • Journal Title: テストステロン臨床と研究 87 Pages: 515-520
• [Journal Article] 特集テストステロンと骨「アンドロゲンの骨への作用」 (2010)
  • Author(s): 蘆田健二、明比祐子、工藤忠睦、柳瀬敏彦
  • Journal Title: CLINICAL CALCIUM 20 Pages: 165-173
• [Journal Article] Peroxisome Proliferator Activated Receptor-gamma Mediates Bisphenol A Inhibition of FSH-Stimulated IGF-l, Aromatase, and Estradiol in Human Granulosa Cells. (2010)
  • Author(s): Kwintkiewicz J, Nishi Y, Yanase T, Giudice LC.
  • Journal Title: Environ Health Perspect Volume: 18(3) Pages: 400-406
  • Peer Reviewed
• [Journal Article] Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development. (2010)
  • Author(s): Qiu Y, Yanase T, Hu H, Tanaka T, Nishi Y, Liu M, Sueishi K, Sawamura T, Nawata H.
  • Journal Title: Endocrinology Volume: 151 Pages: 3307-3316
  • Peer Reviewed
• [Journal Article] Granulosa cell tumor with activated mTOR9HIF-1alpha-VEGF pathway (2010)
  • Author(s): Miyazawa M, Yasuda M, Fujita M, Hirabayashi K, Hirasawa T, Kajiwara H, Muramatsu T, Miyazaki S, Harasawa M, Matsui N, Ogane N, Murakami M, Mikami M, Yanase T, Osamura RY.
  • Journal Title: J Obstet Gynaecol Res Volume: 36(2) Pages: 448-453
  • Peer Reviewed
• [Journal Article] Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells. (2010)
  • Author(s): Zhang Y, Huang Q, Cheng JC, Nishi Y, Yanase T, Huang HF, Leung PC.
  • Journal Title: Reprod Biol Endocrinol Volume: 14 Pages: 61-71
  • Peer Reviewed
• [Journal Article] Serum gamma-glutamyltransferase, triglyceride and total cholesterol are possible prediabetic risk markers in young Japanese men. (2010)
  • Author(s): Akehi Y, Mitsuyoshi Y, Tatsumoto A, Yoshida R, Ohkubo K, Kudo T, Ashida K, Anzai K, Yamashita T, Kawashima H, Ono J, Yanase T.
  • Journal Title: Endocrine J Volume: 57(11) Pages: 981-989
  • NAID: 130004443592
  • Peer Reviewed
• [Journal Article] Sex hormone and neuroendocrine aspects of the metabolic syndrome. (2010)
  • Author(s): Nawata H, Watanabe T, Yanase T, Nomura M, Ashida K, Min L, Fan W.
  • Journal Title: Prog Brain Res Volume: 182 Pages: 175-187
  • Peer Reviewed
• [Journal Article] 特集・アンチエイジング医学の進歩:アンチエイジングとしてのホルモン補充療法:GH, DHEA, テストステロン (2010)
  • Author(s): 柳瀬敏彦、村瀬邦崇
  • Journal Title: 臨床と研究 Volume: 87 Pages: 515-520
• [Journal Article] A novel synthetic androgen receptor ligand, S42, works as a selective androgen receptor modulator and possesses metabolic effects with little impact on the prostate. (2009)
  • Author(s): Min L, Yanase T, Tanaka T, Fan W, Nomura M, Kawate H, Okabe T, Takayanagi R, Nawata H
  • Journal Title: Endocrinology 150 Pages: 5606-16
  • Peer Reviewed
• [Journal Article] Impact of metabolic syndrome on the progression of Intima-Media Thickening in Japanese--a follow-up study. (2009)
  • Author(s): Matoba Y, Inoguchi T, Suzuki S, Nasu S, Hashimoto T, Yanase Nawata H, Takayanagi R.
  • Journal Title: Diabetes Res Clin Pract. 86
  • Peer Reviewed
• [Journal Article] Modification of androgen receptor function by IGF-1 signaling implications in the mechanism of refractory prostate carcinoma. (2009)
  • Author(s): Yanase T, Fan W.
  • Journal Title: Vitam Horm 80 Pages: 649-66
  • Peer Reviewed
• [Journal Article] Late-onset hypogonadism (LOH) and androgens : validity of the measurement of free testosterone levels in the diagnostic criteria in Japan. (2009)
  • Author(s): Iwamoto T, Yanase T, Horie H, Namiki M, Okuyama A.
  • Journal Title: Int J Urol. 16 Pages: 168-74
  • NAID: 10025196305
  • Peer Reviewed
• [Journal Article] アンドロゲン-アンドロゲンレセプターとメタボリックシーム (2009)
  • Author(s): 柳瀬敏彦
  • Journal Title: Annual Review糖尿病・代謝・内分泌 Pages: 141-146
• [Journal Article] アンドロゲンの見直されつある生理作用 (2009)
  • Author(s): 柳瀬敏彦
  • Journal Title: アドロゲンの抗メタボ作用実験医学 27 Pages: 2276-2280
• [Journal Article] symposium 第5回メタボリックシンドローム研究会proceeding「アンドロゲ受容体とメタボリックシンドローム」 (2009)
  • Author(s): 柳瀬敏彦
  • Journal Title: Therapeutic Research 30 Pages: 942-947
• [Journal Article] アンドロゲンの医学: DHEA(-S)+テストステン (2009)
  • Author(s): 柳瀬敏彦
  • Journal Title: 日本抗加齢医学会雑誌 5 Pages: 42-46
• [Journal Article] 「新しい臨床検査」DHEA(-S) (2009)
  • Author(s): 柳瀬敏彦
  • Journal Title: アンドロステンジオン、テストステロン診断と治療 97(特大号) Pages: 1892-1895
• [Journal Article] わかってきた男性ホルモンの作用 (2009)
  • Author(s): 蘆田健二、竹之下博正、明比祐子、柳瀬敏彦
  • Journal Title: 治療 91 Pages: 2185-2191
• [Journal Article] A novel synthetic androgen receptor ligand, S42, works as a selective androgen receptor modulator and possesses metabolic effects with little impact on the prostate (2009)
  • Author(s): Min L, Yanase T, Tanaka T, Fan W, Nomura M, Kawate H, Okabe T, Takayanagi R, Nawata H
  • Journal Title: Endocrinology 150 Pages: 5606-5616
  • Peer Reviewed
• [Journal Article] Impact of metabolic syndrome on the progression of Intima-Media Thickening in Japanese--a follow-up study (2009)
  • Author(s): Matoba Y, Inoguchi T, Suzuki S, Nasu S, Hashimoto T, Yanase T, Nawata H, Takayanagi R
  • Journal Title: Diabetes Res Clin Pract 86
  • Peer Reviewed
• [Journal Article] 6-Deoxy-6-[131I]iodo-L-ascorbic acid for the in vivo study of ascorbate : autoradiography, biodistribution in normal and hypolipidemic rats, and in tumor-bearing nude mice (2009)
  • Author(s): Kim J, Yamamoto F, Gondo S, Yanase T, Mukai T, Maeda M
  • Journal Title: Biol Pharm Bull 32 Pages: 1906-1911
  • NAID: 130000116966
  • Peer Reviewed
• [Journal Article] TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary (2009)
  • Author(s): Jaaskelainen M, Kyronlahti A, Anttonen M, Nishi Y, Yanase T, Secchiero P, Zauli G, Tapanainen JS, Heikinheimo M, Vaskivuo TE.
  • Journal Title: Differentiation 77 Pages: 369-376
  • Peer Reviewed
• [Journal Article] Modification of androgen receptor function by IGF-1 signaling implications in the mechanism of refractory prostate carcinoma (2009)
  • Author(s): Yanase T, Fan W.
  • Journal Title: Vitam Horm. 80 Pages: 649-666
  • Peer Reviewed
• [Journal Article] Late-onset hypogonadism(LOH)and androgens : validity of the measurement of free testosterone levels in the diagnostic criteria in Japan (2009)
  • Author(s): Iwamoto T, Yanase T, Horie H, Namiki M, Okuyama A
  • Journal Title: Int J Urol. 16 Pages: 168-174
  • NAID: 10025196305
  • Peer Reviewed
• [Journal Article] Characterizaton of human growth differntiation factor-9 signaling in ovarian granulose cells. (2008)
  • Author(s): Mottershead D.G, Pulkko M, Muggalla P, Pastemach A, Tolone M, Myllymaa S, Korchynskyi O, Nishi Y, Yanase T, Lun S, Juengel J, Laitinen M, Rivos O.
  • Journal Title: Mol Cell Endocrinol 283 Pages: 58-67
  • Peer Reviewed
• [Journal Article] Optimal cut-points of waist circumference for the clinical diagnosis of metabolic syndrome in the Japanese population. (2008)
  • Author(s): Matoba T, Inoguchi T, Nasu S, Suzuki S, Yanase Nawata H, Takayanagi R.
  • Journal Title: Diabetes Care 31 Pages: 590-592
  • Peer Reviewed
• [Journal Article] Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression. (2008)
  • Author(s): Shirohzu H, Okabe T, Gondo S, Tanaka T, Ohe K, Morinaga H, Kawate H, Nomura M, Takayanagi R, Nawata H, Yanase T
  • Journal Title: Biochem Biophys Res Commun 369 Pages: 862-867
  • Peer Reviewed
• [Journal Article] Working committee on clinical practice guidelines for late-onset hypogonadism ; Japanese Urological Association/Society for Study of Aging Male. Clinical practice manual for late-onset hypogonadism syndrome. (2008)
  • Author(s): Namiki M, Akaza H, Shimazui T, Ito N, Iwamoto T, Baba K, Kumano H, Koh E, TsujimuraA, Matsumiya K, Horie S, Maruyama O, Marumo K, Yanase T, Kumamoto Y.
  • Journal Title: Int J Urol 15 Pages: 377-388
  • Peer Reviewed
• [Journal Article] Androgens and metabolic syndrome : lessons from androgen receptor knock out (ARKO) mice. (2008)
  • Author(s): Yanase T, Fan W , Kyoya K , Liu M, Takayanagi R, Kato S, Nawata H.
  • Journal Title: J Steoid Biochem Molec Biol 109 Pages: 254-257
  • Peer Reviewed
• [Journal Article] High prevalence of peripheral arterial disease diagnosed by low ankle-brachial index in Japanese patients with diabetes : the Kyushu Prevention Study for Atherosclerosis. (2008)
  • Author(s): Maeda Y, Inoguchi T, Tsubouchi H,Sawada F, Sasaki S, Fujii M, Saito R, Yanase T, Shimabukuro Nawata H, Takayanagi R.
  • Journal Title: Diabetes Res Clin Pract 82 Pages: 378-82
  • Peer Reviewed
• [Journal Article] Functional potentiation of leptin-signal transducer and activator of transcription 3 signaling by the androgen receptor. (2008)
  • Author(s): Fan W, Yanase T, Nishi Y, Chiba S, Okabe T, Nomura M, Yoshimatsu H, Kato Takayanagi R, Nawata H.
  • Journal Title: Endocrinology 149 Pages: 6028-36
  • Peer Reviewed
• [Journal Article] Adipose tissue-derived and bone marrow-derived mesenchymal cells develop into different lineage of steroidogenic cells by forced expression of steroidogenic factor 1. (2008)
  • Author(s): Gondo S, Okabe T, Tanaka T, Morinaga H, Nomura M, Takayanagi R, Nawata H, Yanase T
  • Journal Title: Endocrinology 149 Pages: 4717-25
  • Peer Reviewed
• [Journal Article] 増刊新時代の糖尿病学(1) (2008)
  • Author(s): 柳瀬敏彦
  • Journal Title: DHEA-S,アンドロゲン日本臨床 66(増刊号) Pages: 281-284
• [Journal Article] 名和田新特集老年病の進歩と糖代謝老化に伴う内分泌機能変化 (2008)
  • Author(s): 柳瀬敏彦
  • Journal Title: 糖尿病 51 Pages: 299-301
• [Journal Article] 特集核内受容体と疾患アンドロゲン受容体と疾患 (2008)
  • Author(s): 柳瀬敏彦、岡部泰二郎
  • Journal Title: ゲノム医学 8 Pages: 27-30
• [Journal Article] 心血管疾患と核内受容体性ホルモン受容体と代謝系異常 (2008)
  • Author(s): 柳瀬敏彦
  • Journal Title: 分子心血管病 6 Pages: 278-283
• [Journal Article] 特集:大きく変わる肥満症のとらえ方-摂食とエネルギー消費のバランス機構性ステロイドと肥満 (2008)
  • Author(s): 柳瀬敏彦
  • Journal Title: 最新医学 63 Pages: 2085-2092
• [Journal Article] Optimal cut-points of waist circumference for the clinical diagnosis of metabolic syndrome in the Japanese population. (2008)
  • Author(s): Matoba Y, Inoguchi T, Nasu S, Suzuki S, Yanase T, Nawata H, Takayanagi R
  • Journal Title: Diabetes Care 31 Pages: 590-592
  • Peer Reviewed
• [Journal Article] Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specifie expression. (2008)
  • Author(s): Shirohzu H, Okabe T, Gondo S, Tanaka T, Ohe K, Morinaga H, Kawate H, Nomura M, Takayanagi R, Nawata H, Yanase T
  • Journal Title: Biochem Biophys Res Commun 369 Pages: 862-867
  • Peer Reviewed
• [Journal Article] Working committee on clinical practice guidelines for late-onsethypogonadism ; Japanese Urological Association/Japanese Society for study of Aging Male. Clinical practice manual for late-onsethypogonadism syndrome. (2008)
  • Author(s): Namiki M, Akaza H, Shimazui T, Ito N, Iwamoto T, Baba K, Kumano H, Koh E, Tsujimura A, Matsumiya K, Horie s, Maruyama 0, Marumo K, Yanase T, Kumamoto Y
  • Journal Title: Int J Urol 15 Pages: 377-388
  • Peer Reviewed
• [Journal Article] Androgens and metabolic syndrome : lessons from androgen receptor knock out (ARKO)mice. (2008)
  • Author(s): Yanase T, Fan W, Kyoya K, Liu M, Takayanagi R, Kato S, Nawata H
  • Journal Title: J steroid Biochem Mol Biol. 109 Pages: 254-257
  • Peer Reviewed
• [Journal Article] Adipose tissue-derived and bone marrow-derived mesenchymal cells develop into different lineage of steroidogenic cells by forced expression of steroidogenic factor 1. (2008)
  • Author(s): Gondo S, Okabe T, Tanaka T, Morinaga H, Nomura M, Takayanagi R, Nawata H. Yanase T
  • Journal Title: Endocrinology 149 Pages: 4717-4725
  • Peer Reviewed
• [Journal Article] Functional potentiation of leptin-STAT3 signaling by the androgen receptor. (2008)
  • Author(s): Fan W, Yanase T, Nishi Y, Chiba S, Okabe T, Nomura M, Yoshimatsu H, Kato S, Takayanagi R, Nawata H
  • Journal Title: Endocrinology 149 Pages: 6028-6036
  • Peer Reviewed
• [Journal Article] High prevalence of peripheral arterial disease diagnosed by low ankle-brachial index in Japanese patients with diabetes : The Kyushu Prevention study for Atherosclerosis. (2008)
  • Author(s): Maeda Y, Inoguchi T. Tsubouchi H, Sawada F, Sasaki S, Fujii M, Saito R, Yanase T, Shimabukuro M, Nawata H, Takayanagi R
  • Journal Title: Diabetes Res Clin Pract 82 Pages: 378-382
  • Peer Reviewed
• [Presentation] サテライトシンポジウム「SERMとSARM」selective androgen receptor modulator (2010)
  • Author(s): 柳瀬敏彦
  • Organizer: 第15回日本生殖内分泌学会
  • Place of Presentation: 豊中市
  • Year and Date: 2010-11-20
• [Presentation] サテライトシンポジウム「SERMとSARM」「selective androgen receptor modulator) (2010)
  • Author(s): 柳瀬敏彦
  • Organizer: 第15回日本生殖内分泌学会
  • Place of Presentation: 豊中市
  • Year and Date: 2010-11-20
• [Presentation] 教育講演アンドロゲンとメタボリックシンドローム (2010)
  • Author(s): 柳瀬敏彦
  • Organizer: 平成10回日本内分泌学会北陸支部学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2010-11-06
• [Presentation] シンポジウム3「性ホルモンと骨代謝」アンドロゲンと骨代謝 (2010)
  • Author(s): 柳瀬敏彦
  • Organizer: 第28回日本骨代謝学会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] Official Satellite Symposium 13 New aspects of steroid : stem cells, biosynthesis and versatile actions. Steroidogenic cells regenerated from mesenchymal stem cells. International Cogress of Endocrinology (2010)
  • Author(s): Tanaka T, Yanase T
  • Organizer: 第14回国際内分泌学会
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-30
• [Presentation] Official Satellite Symposium 13 New aspects of steroid : stem cells, biosynthesis and versatile actions. A novel syntheic androgen receptor ligand, S42 works as a selective androgen receptor modulator and possesses metabolic effects with little impact on the prostate. International Cogress of Endocrinology (2010)
  • Author(s): Liu M, Yanase T
  • Organizer: 第14回国際内分泌学会
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-30
• [Presentation] Symposium " Androgen" A new selective androgen receptor modulator which possesses metabolic effects with little impact on the prostate. (2010)
  • Author(s): 柳瀬敏彦
  • Organizer: 14^<th> International Cogress of Endocrinology(第14回国際内分泌学会)
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-29
• [Presentation] A new selective androgen receptor modulator which posseses metabolic effects (2010)
  • Author(s): Yanase T.
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)symposium 8-9 Androgen
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-29
• [Presentation] Management of congenital adrenal hyperplasia in adults (2010)
  • Author(s): Yanase T.
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)Meet the professor
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-29
• [Presentation] Session III A selective androgen receptor modulator which possesses metabolic effects with little impact on the prostate. (2009)
  • Author(s): 柳瀬敏彦
  • Organizer: 6^<th> Bone Biology Forum
  • Place of Presentation: Mishima (Invitation)
  • Year and Date: 2009-08-21
• [Presentation] シンポジウムI[ステロイドホルモンからみたメタボリックシンロームの成因と治療の展望]アドゲンとメタボリックシンドローム (2008)
  • Author(s): 柳瀬敏彦、范呉強、西芳寛、加藤茂明、名和田新、高柳涼一
  • Organizer: 第16回日本ステロイドホルモン学会
  • Place of Presentation: シンポジウム(福井市)
  • Year and Date: 2008-11-22
• [Presentation] シンポジウムI : ステロイドホルモンからみたメタボリックシンドロームの成因と治療の展望「アンドロゲンとメタボリックシンドローム」 (2008)
  • Author(s): 柳瀬 敏彦
  • Organizer: 第16回日本ステロイドホルモン学会
  • Place of Presentation: 福井市
  • Year and Date: 2008-11-22
• [Presentation] Symposium Androgen receptor regulated transcription "Androgen receptor tranascription" (2008)
  • Author(s): 柳瀬敏彦
  • Organizer: 13^<th> INternational Congress of Endocrinology (第13回国際内分泌学会)
  • Place of Presentation: リオデジャネイロ(ブラジル)
  • Year and Date: 2008-11-12
• [Presentation] アンドロゲン:生活習慣病研究からアンドロゲン産細胞再生まで (2008)
  • Author(s): 柳瀬敏彦
  • Organizer: 第27回日本アンドロジー学会
  • Place of Presentation: 大阪(特別講演)
  • Year and Date: 2008-07-04
• [Presentation] アンドロゲン : 生活習慣病研究からアンドロゲン産生細胞再生まで (特別講演) (2008)
  • Author(s): 柳瀬敏彦
  • Organizer: 第27回日本アンドロジー学会
  • Place of Presentation: 京都市
  • Year and Date: 2008-07-04
• [Presentation] Symposium: Androgen Receptor regulated transcription "Androgen receptor transcription (2008)
  • Author(s): Yanase T
  • Organizer: 13^<th> Internatinal Congress of Endocrinology (第13回国際内分泌学会)
  • Place of Presentation: リオデジャネイロ(ブラジル)