| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Research Abstract |
As a mechanism for the anti-obesity effect of androgen, we clarified that androgen receptor (AR) can potentiate leptin-STAT3 signaling which is closely associated with energy expenditure. By extending this work, we identified a testosterone analogue, S42 as a new selective androgen receptor modulator (SARM) and found that S42 can dramatically reduce serum triglyceride level in male castrated SD rats. The significance of androgen in atherosclerosis is controversial. We revealed the anti- atherosclerotic effect of endogenous androgen in animal atherosclerotic model and clarified one mechanism related with the suppression of oxidized LDL receptor, LOX-1.
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