Investigation of the genes associated with bone mineral density by high-density SNP chip analysis in a large cohort study
| Project/Area Number |
20390264
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHNAKA Keizo 九州大学, 大学院・医学研究院, 講師 (30325518)
YAMAMOTO Ken 九州大学, 生体防御医学研究所, 准教授 (60274528)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 骨密度 / 遺伝子多型 / 骨粗鬆症 / コホート / 内科 / ゲノム / 老化 / 遺伝子 / 全ゲノム相関解析 |
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| Research Abstract |
To explore candidate g:enes associated with bone mineral density(BMD) of Japanese women, we performed a genome-wide association study(GWAS) in a large community-based cohort. The study subjects were postmenopausal women without taking any drugs, having any diseases or gynecological history. The GWAS and the following analyses uncovered several candidate genes to be associated with BMD in Japanese women.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Blood pressure and hypertension are associated with 7 loci in the Japanese population2010
Author(s)
Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N.
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Journal Title
Circulation
Volume: 121(21)
Pages: 2302-2309
Related Report
Peer Reviewed
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