Biologic significance of candidate genes in genomic alteration regions of lymphoidmalignancies
| Project/Area Number |
20390277
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
SETO Masao Aichi Cancer Center Research Institute, 遺伝子医療研究部, 部長 (80154665)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | アレイCGH / 細胞増殖 / 細胞分化 / アポトーシス / 悪性リンパ腫 / 不死化細胞 / 発現ライブラリー / 造腫瘍能 / がん化 / MALTリンパ腫 / マントル細胞リンパ腫 / DLBCL / TNFAIP3 / A20 / NF-κB / CD40 / 6q23 / NF-kappaB / MALT1 / BCL10 / API2-MALT1 |
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| Research Abstract |
Ocular adnexal marginal zone B cell lymphoma (Ocular MALT lymphoma) has been shown to possess characteristic 6q23.3 loss and the candidate gene was found to be TNFAIP3/A20 by our group. The loss was also found in about 31% of mantle cell lymphoma and 50% of ABC type diffuse large B-cell lymphoma. The knock-down experiment revealed that the loss of the gene leads to activation of NF-kappaB. When the gene was knock-down in EB virus immortalized B-cell, the colony formation ability was increased, suggesting that the loss contribute B-cell lymphomagenesis.
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Report
(4 results)
Research Products
(58 results)
