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Biologic significance of candidate genes in genomic alteration regions of lymphoidmalignancies

Research Project

Project/Area Number 20390277
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

SETO Masao  Aichi Cancer Center Research Institute, 遺伝子医療研究部, 部長 (80154665)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
KeywordsアレイCGH / 細胞増殖 / 細胞分化 / アポトーシス / 悪性リンパ腫 / 不死化細胞 / 発現ライブラリー / 造腫瘍能 / がん化 / MALTリンパ腫 / マントル細胞リンパ腫 / DLBCL / TNFAIP3 / A20 / NF-κB / CD40 / 6q23 / NF-kappaB / MALT1 / BCL10 / API2-MALT1
Research Abstract

Ocular adnexal marginal zone B cell lymphoma (Ocular MALT lymphoma) has been shown to possess characteristic 6q23.3 loss and the candidate gene was found to be TNFAIP3/A20 by our group. The loss was also found in about 31% of mantle cell lymphoma and 50% of ABC type diffuse large B-cell lymphoma. The knock-down experiment revealed that the loss of the gene leads to activation of NF-kappaB. When the gene was knock-down in EB virus immortalized B-cell, the colony formation ability was increased, suggesting that the loss contribute B-cell lymphomagenesis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (58 results)

All 2011 2010 2009 2008 Other

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (27 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Nodal Relapse After Helicobacter pylori Eradication in a Patient With Primary Localized Gastric Mucosa-Associated Lymphoid Tissue Lymphoma.2011

    • Author(s)
      Kato, H.
    • Journal Title

      Am J Gastroenterol

      Volume: 106 Pages: 549-551

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous type adult T-cell leukemia/lymphoma is a characteristic subtype and includes erythema/papule and nodule/tumor subgroups.2010

    • Author(s)
      Miyata, T
    • Journal Title

      Int J Cancer

      Volume: 126 Pages: 1521-1528

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micro RNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3 zeta.2010

    • Author(s)
      Tsukamoto, Y
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 2339-2349

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of genome profiles in malignant lymphoma2010

    • Author(s)
      Seto, M
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 573-578

    • NAID

      10026588848

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization.2010

    • Author(s)
      Uchida, M.
    • Journal Title

      Journal of Pathology

      Volume: 221 Pages: 96-105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact and predisposing factors of delayed-onset neutropenia after autologous hematopoietic stem-cell transplantation for B-cell non-Hodgkin lymphoma : association with an incremental risk of infectious events.2010

    • Author(s)
      Kato, H.
    • Journal Title

      Ann Oncol.

      Volume: 21 Pages: 1699-1705

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-4/CD40L Co-Stimulation Induces Long-Term Proliferation for CD10-Positive Germinal Center B Cell-Like Diffuse Large B-Cell Lymphoma.2010

    • Author(s)
      Kato, H.
    • Journal Title

      The Open Leukemia Journal

      Volume: 3 Pages: 60-68

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enteropathy-associated T-cell lymphoma-a clinicopathologic and array comparative genomic hybridization study.2010

    • Author(s)
      Ko, YH.
    • Journal Title

      Hum Pathol.

      Volume: 41 Pages: 1231-1237

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International Peripheral T -Cell Lymphoma Project. : Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma.2010

    • Author(s)
      Iqbal, J.
    • Journal Title

      Blood

      Volume: 115 Pages: 1026-1036

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma.2010

    • Author(s)
      Sung, CO.
    • Journal Title

      Blood

      Volume: 117 Pages: 1291-1300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous type adult T-cell leukemia/lymphoma is a characteristic subtype and includes erythema/papule and nodule/tumor subgroups.2010

    • Author(s)
      Miyata,T
    • Journal Title

      Int J Cancer 126

      Pages: 1521-1528

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta.2010

    • Author(s)
      Tsukamoto,Y
    • Journal Title

      Cancer Res. 70

      Pages: 2339-2349

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of genome profiles in malignant lymphoma.2010

    • Author(s)
      Seto,M
    • Journal Title

      Cancer Science (in press)

    • NAID

      10026588848

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization.2010

    • Author(s)
      Uchida,M.
    • Journal Title

      Journal of Pathology (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Array CGH analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type ATLL.2009

    • Author(s)
      Nakagawa,M.
    • Journal Title

      Clin Cancer Res. 15

      Pages: 30-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis.2009

    • Author(s)
      Takeuchi,I.
    • Journal Title

      Haematologica 94

      Pages: 61-69

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma.2009

    • Author(s)
      Lee,S-Y.
    • Journal Title

      Cancer Science 100

      Pages: 920-926

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas.2009

    • Author(s)
      Honma,K
    • Journal Title

      Blood 114

      Pages: 2467-2475

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Array CGH analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type ATLL2009

    • Author(s)
      Nakagawa, M.
    • Journal Title

      Clin Cancer Res. 15

      Pages: 30-38

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis2009

    • Author(s)
      Takeuchi, I.
    • Journal Title

      Haematologica 94

      Pages: 61-69

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma2009

    • Author(s)
      Lee, S-Y.
    • Journal Title

      Cancer Science (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in cular. Adnexal marginal zone B cell lymphoma2008

    • Author(s)
      Honma, K.
    • Journal Title

      Genes Chrom. Cancer 47

      Pages: 1-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features and prognosis of gastric MALT lymphoma with special reference to responsiveness to H. pylori eradication and API2-MALT1 status2008

    • Author(s)
      Nakamura, T.
    • Journal Title

      Am J Gastroenterol 103

      Pages: 62-70

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation2008

    • Author(s)
      Karube, K
    • Journal Title

      Mod Pathol. 21

      Pages: 973-978

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer2008

    • Author(s)
      Tsukamoto, Y.
    • Journal Title

      J Pathol. 216

      Pages: 471-482

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide microRNA expression profiling in renal cell carcinoma : significant downregulation of miR-141 and miR-200c2008

    • Author(s)
      Nakada, C.
    • Journal Title

      J Pathol. 216

      Pages: 418-427

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clonal evolution of adult T -cell leukemia/lymphoma takes place in lymph node.

    • Author(s)
      Umino, A
    • Journal Title

      Blood

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Array comparative genomic hybridization revealed polyclonality in acute type adult T-cell leukemia/lymphoma and PTCL NOS2010

    • Author(s)
      Akira Umino
    • Organizer
      第52回米国血液学会総会
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] BCL2、c-MYC、CCND1は協調的に働き、正常B細胞の因子非依存性増殖をもたらす2010

    • Author(s)
      中川雅夫
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-4/CD40ligand共刺激はCD10陽性GCB-likeびまん性大細胞型Bリンパ腫細胞を長期増殖させる2010

    • Author(s)
      加藤春美
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Significant roles of TNFAIP3/A20 descoveried by array CGH in B cell Iymphoma.2010

    • Author(s)
      本間圭一郎
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ERG発現による白血病化2010

    • Author(s)
      都築忍
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎癌転移と9pゲノムコピー数異常の関係2010

    • Author(s)
      成松隆弘
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 粘膜下浸潤胃癌のアレイCGH2010

    • Author(s)
      黒田明子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] array-CGH法による口腔扁平上皮癌のゲノム異常解析2010

    • Author(s)
      吉岡俊一
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] BCL2、c-MYC、CCND1は協調的に働き、正常B細胞をトランスフォームさせる2010

    • Author(s)
      中川雅夫
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Significant Roles of A20 in Iymphomagenesis.2010

    • Author(s)
      本間圭一郎
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] アレイCGH法を用いて明らかになった急性型成人T細胞性白血病リンパ腫と末梢T細胞性リンパ腫の類似性2010

    • Author(s)
      海野啓
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] NK/T細胞性腫瘍のゲノムプロファイル2010

    • Author(s)
      加留部謙之輔
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌で発現低下するmiR-375はPDK1と14-3-3を標的として細胞生存を制御する2010

    • Author(s)
      塚本善之
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] アレイCGHにより明らかになった急性型ATLの多クローン性.2009

    • Author(s)
      海野啓
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性型成人T細胞性白血病/リンパ腫症例はリンパ腫型に特徴的な遺伝子発現プロファイルを用いると複数のグループに分類できる.2009

    • Author(s)
      中川雅夫
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] NK/T細胞性腫瘍の遺伝子発現プロファイル.()[ポスター(示説)]2009

    • Author(s)
      加留部謙之輔
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 悪性リンパ腫におけるTNFAIP3/A20.2009

    • Author(s)
      本間圭一郎
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性リンパ性白血病の前白血病期におけるTEL-AML1の役割.2009

    • Author(s)
      都築忍
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Distinct genome profiles of acute and lymphoma type ATLL : an indication for two subtypes in acute type ATLL.2009

    • Author(s)
      Masao Nakagawa
    • Organizer
      14th International Conference on Human Retrovirology
    • Place of Presentation
      ブラジル
    • Related Report
      2009 Annual Research Report
  • [Presentation] 悪性リンパ腫発症の分子機構2008

    • Author(s)
      瀬戸加大
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      (名古屋)[シンポジウム]
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 急性型成人T細胞性自血病/リンパ腫症例の一部はリンパ腫型と同一のゲノム異常領域を持つ2008

    • Author(s)
      中川雅夫
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      (名古屋)[ワークショップ]
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腎癌にむけるmiRNAの網羅的発現解析2008

    • Author(s)
      中田知里
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      (名古屋)[ポスター]
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] NK/T細胞性腫瘍の遺伝子発現プロファイル2008

    • Author(s)
      加留部謙之輔
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      (名古屋)[ワークショップ]
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] TEL-AML1自血病におけるTEL欠失の作用2008

    • Author(s)
      都築忍
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      (名古屋)[ポスター]
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] リンパ腫発生進展におけるA20の機能解析2008

    • Author(s)
      本間圭一郎
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      (名古屋)[ポスター]
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 胃癌におけるゲノムコピー数異常と遺伝子発現異常の統合解析2008

    • Author(s)
      塚本善之
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      (名古屋)[ポスター]
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] A Part of Acute-type ATLL Cases Has Genomic Imbalance in Common With Lymphoma-type ATLL2008

    • Author(s)
      Nakagawa, M.
    • Organizer
      第50回米国血液学会総会
    • Place of Presentation
      (米国)[ポスター(示説)]
    • Related Report
      2008 Annual Research Report
  • [Remarks] 研究開発支援総合ディレクトリ(Read)

    • URL

      http://read.jst.go.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks] 研究開発支援総合ディレクトリ(Read)

    • URL

      http://read.jst.go.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks] 研究開発支援総合ディレクトリ(Read)

    • URL

      http://read.jst.go.jp/

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] リンパ腫の病型および予後診断方法2008

    • Inventor(s)
      瀬戸加大, 田川博之, 吉田安子, 吉良茂樹
    • Industrial Property Rights Holder
      瀬戸加大, 田川博之, 吉田安子, 吉良茂樹
    • Filing Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
    • Overseas

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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