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Analysis of in vivo functions of LMIR3/4/5

Research Project

Project/Area Number 20390279
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe University of Tokyo

Principal Investigator

KITAURA Jiro  The University of Tokyo, 医科学研究所, 助教 (30282651)

Co-Investigator(Kenkyū-buntansha) KITAMURA Toshio  東京大学, 医科学研究所, 教授 (20282527)
NAKAO Kazuki  理化学研究所, 動物実験ユニット, ユニットリーダー (20217657)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsノックアウトマウス / ペア型免疫レセプター / ミエロイド / 自己免疫 / 自然免疫 / アレルギー / 炎症 / ミエロイド系細胞
Research Abstract

In the present study, we have clarified the physiological functions of LMIR3/4/5. Co-engagement of FcεRI and LMIR3 impaired cytokine production in bone marrow-derived mast cells (BMMCs) induced by FcεRI crosslinking alone, demonstrating that LMIR3 is an inhibitory receptor. On the other hand, LMIR3 has a unique receptor to associate with FcRγ and thereby functions as an activating receptor in concert with TLR4 stimulation. We have identified T cell Ig mucin I (TIM1) by retrovirus-mediated expression cloning. Notably, LMIR5 deficiency suppressed TIM1-Fc-induced recruitment of neutrophils in the dorsal air pouch, and LMIR5 deficiency attenuated neutrophil accumulation in a model of ischemia/reperfusion injury in the kidneys in which TIM1 expression is up-regulated. In that model, LMIR5 deficiency resulted in ameliorated tubular necrosis and cast formation in the acute phase. Collectively, TIM1-LMIR5 interaction plays a physiological role in immune regulation by myeloid cells.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (80 results)

All 2011 2010 2009 2008

All Journal Article (31 results) (of which Peer Reviewed: 15 results) Presentation (45 results) Book (4 results)

  • [Journal Article] Two types of C/EBP. mutations play distinct but collaborative roles in leukemogenesis : Lessonsfrom clinical data and BMT models.2011

    • Author(s)
      Kato, N., Kitaura, J., Doki, N., Komeno, Y., Watanabe-Okochi, N., Togami, K., Nakahara, F., Oki, T., Enomoto, Y., Fukuchi, Y., Nakajima, H., Harada, Y., Harada, H., Kitamura, T.
    • Journal Title

      Blood. 117

      Pages: 221-233

    • Related Report
      2010 Final Research Report
  • [Journal Article] Two types of C/EBPα mutations play distinct but collabora tive roles in leukemogenesis : Lessons from clinical data and BMT models.2011

    • Author(s)
      Kato, N
    • Journal Title

      Blood

      Volume: 117 Pages: 221-233

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of leukocyte mono-immunoglobulin-like recept or 7 (LMIR7)/CLM-3 as an activating receptor : its similarities to and differences from LMIR4/CLM-5.2011

    • Author(s)
      Enomoto, Y
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 35274-35283

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blastic crisis of chronic myelogenous leukemia.2010

    • Author(s)
      Nakahara, F., Sakata-Yanagimoto, M., Komeno, Y., Kato, N., Haraguchi, K., Kumano, K., Harada, Y., Harada, H., Kitaura, J., Ogawa, S., Kurokawa, M., Kitamura, T., Chiba, S.
    • Journal Title

      Blood. 115

      Pages: 2872-2881

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression of ADAMTS4 in Ewing's sarcoma.2010

    • Author(s)
      Minobe, K., Ono, R., Matsumine, A., Shibata-Minoshima, F., Izawa, K., Oki, T., Kitaura, J., Iino, T., Takita, J., Iwamoto, S., Hori, H., Komada, Y., Uchida, A., Hayashi, Y., Kitamura, T., Nosaka, T.
    • Journal Title

      Int J Oncol. 37

      Pages: 569-581

    • Related Report
      2010 Final Research Report
  • [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010

    • Author(s)
      Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T., Kitamura, T.
    • Journal Title

      Leukemia. 24

      Pages: 1018-1024

    • Related Report
      2010 Final Research Report
  • [Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.2010

    • Author(s)
      Yamanishi, Y., Kitaura, J., Izawa, K., Kaitani, A., Komeno, Y., Nakamura, M., Yamazaki, S., Enomoto, Y., Oki, T., Akiba, H., Abe, T., Komori, T., Morikawa, Y., Kiyonari, H., Takai, T., Okumura, K., Kitamura, T.
    • Journal Title

      J Exp Med. 207

      Pages: 1501-1511

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor : its similarities to and differences from LMIR4/CLM-5.2010

    • Author(s)
      Enomoto, Y., Yamanishi, Y., Izawa, K., Kaitani, A., Takamatsu, R., Kajikawa, M., Takai, T., Kitamura, T., Kitaura, J.
    • Journal Title

      J Bio Chem. 285

      Pages: 35274-35283

    • Related Report
      2010 Final Research Report
  • [Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reuerfusion injury.2010

    • Author(s)
      Yamanishi, Y
    • Journal Title

      J Exp Med.

      Volume: 207 Pages: 1501-1511

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of ADAMTS4 in Ewing's sarcoma.2010

    • Author(s)
      Minobe, K
    • Journal Title

      Int J Oncol.

      Volume: 37 Pages: 569-581

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a moos e BMT model.2010

    • Author(s)
      Komeno, Y
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1018-1024

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hesl immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogeneou leukemia.2010

    • Author(s)
      Nakahara, F
    • Journal Title

      Blood (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010

    • Author(s)
      Komeno, Y
    • Journal Title

      Leukemia (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.2009

    • Author(s)
      Miyazaki, K., Yamasaki, N., Oda, H., Kuwata, T., Kanno, Y., Miyazaki, M., Komeno, Y., Kitaura, J., Honda, Z., Warming, S., Jenkins, N.A., Copeland, N.G., Kitamura, T., Nakamura, T., Honda, H.
    • Journal Title

      Blood. 113

      Pages: 4702-4710

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular bases of myelodysplastic syndromes: lessons from animal models.2009

    • Author(s)
      Komeno, Y., Kitaura, J., Kitamura, T.
    • Journal Title

      J Cell Physiol. 219

      Pages: 529-534

    • Related Report
      2010 Final Research Report
  • [Journal Article] Possible involvement of RasGRP4 in leukemogenesis.2009

    • Author(s)
      Watanabe-Okochi, N., Oki, T., Komeno, Y., Kato, N., Yuji, K., Ono, R., Harada, Y., Harada, H., Hayashi, Y., Nakajima, H., Nosaka, T., Kitaura, J., Kitamura, T.
    • Journal Title

      Int J Hematol. 89

      Pages: 470-481

    • NAID

      10025161257

    • Related Report
      2010 Final Research Report
  • [Journal Article] An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1 : LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells.2009

    • Author(s)
      Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Kaitani, A., Sugiuchi, M., Takahashi, M., Maehara, A., Enomoto, Y., Oki, T., Takai, T., Kitamura, T.
    • Journal Title

      J Immunol. 183

      Pages: 925-936

    • Related Report
      2010 Final Research Report
  • [Journal Article] Evidence that integrin τIIbυ3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation.2009

    • Author(s)
      Oki, T., Eto, K., Izawa, K., Yamanishi, Y., Inagaki, N., Frampton, J., Kitamura, T., Kitaura, J.
    • Journal Title

      J Bio Chem. 284

      Pages: 31463-31472

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular bases of myelodysplastic syndromes : Lessons from animal models.2009

    • Author(s)
      Komeno, Y
    • Journal Title

      J Cell.Physiol. 219

      Pages: 529-534

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Rac GTPase activating protein MgcRacGAP is an NLS-containing nuclear chaperone in the activation of STAT transcription factors.2009

    • Author(s)
      Kawashima, T
    • Journal Title

      Mol Cell Biol. 29

      Pages: 1796-1813

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activating and inhibitory signals from an inhibitory receptor LMIR3/CLM-1 : LMIR3 augments LPS response through association with FcRg in mast cells.2009

    • Author(s)
      Izawa, K
    • Journal Title

      J.Immunol. 183

      Pages: 925-936

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Rac GTPase activating protein MgcRacGAP is constitutively phosphorylated on serine 387 in the v-Src-transformed NIH3T3 cells.2009

    • Author(s)
      Doki, N
    • Journal Title

      Cancer Science 100

      Pages: 1675-1679

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mixed-lineage-leukemia(MLL)fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation.2009

    • Author(s)
      Ono, R
    • Journal Title

      Leukemia 23

      Pages: 2197-209

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      沖俊彦
    • Journal Title

      細胞工学(株式会社学研メディカル秀潤社)

      Pages: 209-214

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      北村俊雄
    • Journal Title

      臨床血液(社団法人日本血液学会)

      Pages: 174-181

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      加藤菜穂子
    • Journal Title

      日本臨床(株式会社日本臨牀社)

      Pages: 1875-1879

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Molecular bases of myelodysplastic syndromes: lessons from animal models.2009

    • Author(s)
      Komeno Y
    • Journal Title

      J Cell Physiol 219

      Pages: 529-534

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype.2008

    • Author(s)
      Kashiwakura, J., Xiao, W., Kitaura, J., Kawakami, Y., Maeda-Yamamoto, M., Pfeiffer, J.R., Wilson, B.S., Blank, U., Kawakami, T.
    • Journal Title

      J Leukoc Biol. 84

      Pages: 357-367

    • Related Report
      2010 Final Research Report
  • [Journal Article] AML1 mutations induced MDS and MDS/AML in a mouse BMT model.2008

    • Author(s)
      Watanabe-Okochi, N., Kitaura, J., Ono, R., Harada, H., Harada, Y., Komeno, Y., Nakajima, H., Nosaka, T., Inaba, T., Kitamura, T.
    • Journal Title

      Blood. 111

      Pages: 4297-4308

    • Related Report
      2010 Final Research Report
  • [Journal Article] AML1 mutations induced MDS and MDS/AML in a mouse BMT model2008

    • Author(s)
      Watanabe-Okochi N
    • Journal Title

      Blood 111

      Pages: 4297-4308

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 between mouse and human.2008

    • Author(s)
      Yamanishi Y
    • Journal Title

      Blood 111

      Pages: 688-698

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Leukocyte mono-Ig like receptor (LMIR)/CD300とマスト細胞2010

    • Author(s)
      北浦次郎
    • Organizer
      第60回日本アレルギー学会秋期学述大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Leukocyte mono-Ig like receptor (LMIR)/CD300と炎症・アレルギー2010

    • Author(s)
      北浦次郎
    • Organizer
      小児アレルギー同好会
    • Place of Presentation
      東京(口演)
    • Year and Date
      2010-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Leukocyte mono-Ig like receptor(LMIR)/CD300と炎症・アレルギー2010

    • Author(s)
      北浦次郎
    • Organizer
      第72回小児アレルギー同好会
    • Place of Presentation
      ホテルグランドパレス
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hes1による造血前駆細胞の不死化と、慢性骨髄性白血病の急性転化誘導2010

    • Author(s)
      中原史雄
    • Organizer
      第6回麟麟塾
    • Place of Presentation
      コクヨホール
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Leukocyte mono-Ig like receptor (LMIR)/CD300とマスト細胞2010

    • Author(s)
      北浦次郎
    • Organizer
      日本アレルギー学会シンポジウム
    • Place of Presentation
      東京(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Comparative analysis of leukocyte mono-Ig-like receptor 7 (LMIR7)/CLM-3 with LMIR4/CLM-5 as an activating receptor: lessons from association with FcRgamma2010

    • Author(s)
      榎本豊、北浦次郎、山西吉典、伊沢久未、高井俊行、北村俊雄
    • Organizer
      国際免疫学会議
    • Place of Presentation
      神戸(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury2010

    • Author(s)
      山西吉典、北浦次郎、伊沢久未、北村俊雄
    • Organizer
      国際免疫学会議
    • Place of Presentation
      神戸(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] A FUNCTIONAL ANALYSIS OF microRNA ABERRANTLY EXPRESSED IN LEUKEMIC CELLS.2010

    • Author(s)
      榎本豊、北浦次郎、園木孝志、中熊秀喜、北村俊雄
    • Organizer
      日本遺伝子治療学会学術集会ポスター
    • Place of Presentation
      宇都宮
    • Related Report
      2010 Final Research Report
  • [Presentation] A FUNCTIONAL ANALYSIS OF microRNA ABERRANTLY EXPRESSED IN LEUKEMIC CELLS.2010

    • Author(s)
      榎本豊
    • Organizer
      第16回日本遺伝子治療学会学術集会
    • Place of Presentation
      栃木県総合文化センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] DEVELOPMENT OF NEW pMXs-BASED RETROVIRUS VECTORS EXPRESSING shRNA.2010

    • Author(s)
      榎本豊
    • Organizer
      第16回日本遺伝子治療学会学術集会
    • Place of Presentation
      栃木県総合文化センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury2010

    • Author(s)
      Yamanishi, Y
    • Organizer
      第14回国際免疫会議
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparative analysis of leukocyte mono-Ig-like receptor 7 (LMIR7)/CLM-3 with mouseLMIR4/CLM-5 as an activating receptor : lessons from association with FcRγ2010

    • Author(s)
      Enomoto, Y
    • Organizer
      第14回国際免疫会議
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] MiR125 induces hematological malignancies in vivo2010

    • Author(s)
      榎本豊
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] TSC-22 is upregulated by activation of Ras/MAPK and suppresses cellular proliferation.2010

    • Author(s)
      Nakamura, M
    • Organizer
      2010 International Student Forum.
    • Place of Presentation
      中国、北京
    • Related Report
      2010 Annual Research Report
  • [Presentation] TSC-22の発現はRas/MAPKの活性化により上昇する2010

    • Author(s)
      中村真樹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] Screnning of surface antigens on iPS cells with SST-REX2010

    • Author(s)
      沖俊彦
    • Organizer
      第8回幹細胞シンポジウム
    • Place of Presentation
      淡路夢舞台国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] LMIR5のリガンドとしてTIM1およびTIM4を同定した2009

    • Author(s)
      山西吉典、北浦次郎、伊沢久未、北村俊雄
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] LMIR3ノックアウトマウスの解析;LMIR3欠損はマウス腹膜炎モデルにおける致死率を改善する2009

    • Author(s)
      伊沢久未、北浦次郎、山西吉典、北村俊雄
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトLMIR/CD300ファミリー分子の解析:CD300CはFcRgammaと会合して活性化シグナルを伝達する2009

    • Author(s)
      高橋まり子、北浦次郎、山西吉典、伊沢久未、北村俊雄
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] LMIR8/CLM-6はpDCマーカーである2009

    • Author(s)
      貝谷綾子、北浦次郎、山西吉典、伊沢久未、北村俊雄
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] 活性化レセプターLMIR7とLMIR4の比較解析:FcRgammaとの会合から得られた知見2009

    • Author(s)
      榎本豊、北浦次郎、山西吉典、伊沢久未、北村俊雄
    • Organizer
      日本免疫学会、ポスター
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1:LMIR3 augments LPS response through association with FcRgamma in mast cells2009

    • Author(s)
      前原秋絵、北浦次郎、山西吉典、伊沢久未、北村俊雄
    • Organizer
      日本免疫学会、ポスター
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Learning from mouse BMT models for MDS and MPD2009

    • Author(s)
      Kitamura, T
    • Organizer
      MDS/MPN Meeting
    • Place of Presentation
      USA,ヒューストン
    • Related Report
      2009 Annual Research Report
  • [Presentation] Wnt modulators, SFRP-1 and SFRP-2 differentially regulate hematopoietic stem cells.2009

    • Author(s)
      中島秀明
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Constitutive phosphorylation of a RacGAP is involved in v-Src-induced transformation of NIH3T3 cells.2009

    • Author(s)
      土岐典子
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of C/EBPA mutations in AML, MDS by a mouse BMT model.2009

    • Author(s)
      加藤菜穂子
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hesl confers self-renewal capability on committed progenitors and induces CML BC-like disease.2009

    • Author(s)
      中原史雄
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Heslによる骨髄前駆細胞への自己複製能付与と、慢性骨髄性白血病における急性転化の誘導.2009

    • Author(s)
      中原史雄
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] MgcRacGAPの恒常的リン酸化はv-SrcによるNIH3T3細胞のtransformに関与する.2009

    • Author(s)
      土岐典子
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] LMIR5のリガンドとしてTIM1およびTIM4を同定した。2009

    • Author(s)
      山西吉典
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] LMIR3ノックアウトマウスの解析 ; LMIR3欠損はマウス腹膜炎モデルにおける致死率を改善する。2009

    • Author(s)
      伊沢久未
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトLMIR/CD300ファミリー分子の解析:CD300CはFcRgammaと会合して活性化シグナルを伝達する。2009

    • Author(s)
      高橋まり子
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] LMIR8/CLM-6はpDCマーカーである。2009

    • Author(s)
      貝谷綾子
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性化レセプターLMIR7とLMIR4の比較解析:FcRγとの会合から得られた知見。2009

    • Author(s)
      榎本豊
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1 : LMIR3 augments LPS response through association with FcRγ in mast cells.2009

    • Author(s)
      前原明絵
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 可溶性LMIR5はLPSによる炎症反応を増強する2008

    • Author(s)
      山西吉典
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 可溶性LMIR5はLPSによる炎症反応を増強する2008

    • Author(s)
      山西吉典、北浦次郎、伊沢久未、北村俊雄
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] 活性化レセプターLMIR7の機能解析2008

    • Author(s)
      榎本豊、北浦次郎、山西吉典、伊沢久未、沖俊彦、高井俊行、北村俊雄
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      京都(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] LMIR3はマスト細胞において細胞内領域ITIMを介した抑制化シグナルとITAMを有するFcRgammaとの会合を介した活性化シグナルを伝達する2008

    • Author(s)
      伊沢久未、北浦次郎、山西吉典、松岡孝幸、沖俊彦、高井俊行、北村俊雄
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      京都(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] 活性化レセプターのLMIR6は末梢血の樹状細胞に高発現する2008

    • Author(s)
      杉内正弘、北浦次郎、山西吉典、伊沢久未、沖俊彦、高井俊行、北村俊雄
    • Organizer
      日本免疫学会総会、ポスター
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 活性型レセプターLMIR5の機能解析:マウスおよびヒトLMIR5の相違2008

    • Author(s)
      山西吉典、北浦次郎、伊沢久未、沖俊彦、北村俊雄
    • Organizer
      麒麟塾
    • Place of Presentation
      東京(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of mouse LMIR5/CLM-7 as an activating receptor : differential regulation of LMIR5/CLM-7 in mouse versus human cells.2008

    • Author(s)
      山西吉典, 北浦次郎, 伊沢久未, 北村俊雄
    • Organizer
      The 15^<th> East Asia Joint Conference
    • Place of Presentation
      韓国ソウル(口演)
    • Related Report
      2010 Final Research Report
  • [Presentation] 活性型レセプターLMIR5の機能解析:マウスおよびヒトLMIR5の相違2008

    • Author(s)
      山西吉典
    • Organizer
      第4回麟麟塾
    • Place of Presentation
      品川
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.2008

    • Author(s)
      Yamanishi Y
    • Organizer
      The 15th East Asia Joint Conference
    • Place of Presentation
      Korea.
    • Related Report
      2008 Annual Research Report
  • [Presentation] LMIR3はマスト細胞において細胞内領域のITIMを介した抑制化シグナルとITAMを有するFcRgammaとの会合を介した活性化シグナルを伝達する2008

    • Author(s)
      伊沢久未
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Book] Leukocyte mono-Ig like receptor 3 (LMIR3)によるマスト細胞の活性化と抑制化542010

    • Author(s)
      伊沢久未、北浦次郎、北村俊雄
    • Publisher
      臨床免疫・アレルギー科
    • Related Report
      2010 Final Research Report
  • [Book] マスト細胞の活性化とLMIR3(「抑制型レセプターであるLMIR3はマスト細胞においてFcR.と会合し、リポポリサッカライドによる反応を増強する」)532010

    • Author(s)
      伊沢久未、北浦次郎、北村俊雄
    • Publisher
      臨床免疫\アレルギー科
    • Related Report
      2010 Final Research Report
  • [Book] 臨床免疫・アレルギー科2010

    • Author(s)
      伊沢久未
    • Publisher
      科学評論社
    • Related Report
      2010 Annual Research Report
  • [Book] 活性型レセプターLMIR5によるマスト細胞の機能制御-マウスおよびヒトLMIR5の相違522009

    • Author(s)
      山西吉典、北浦次郎、北村俊雄
    • Publisher
      臨床免疫・アレルギー科
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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