Analysis of in vivo functions of LMIR3/4/5

• Project/Area Number: 20390279
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: KITAURA Jiro The University of Tokyo, 医科学研究所, 助教 (30282651)
• Co-Investigator(Kenkyū-buntansha): KITAMURA Toshio 東京大学, 医科学研究所, 教授 (20282527) ; NAKAO Kazuki 理化学研究所, 動物実験ユニット, ユニットリーダー (20217657)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: ノックアウトマウス / ペア型免疫レセプター / ミエロイド / 自己免疫 / 自然免疫 / アレルギー / 炎症 / ミエロイド系細胞

Research Abstract

In the present study, we have clarified the physiological functions of LMIR3/4/5. Co-engagement of FcεRI and LMIR3 impaired cytokine production in bone marrow-derived mast cells (BMMCs) induced by FcεRI crosslinking alone, demonstrating that LMIR3 is an inhibitory receptor. On the other hand, LMIR3 has a unique receptor to associate with FcRγ and thereby functions as an activating receptor in concert with TLR4 stimulation. We have identified T cell Ig mucin I (TIM1) by retrovirus-mediated expression cloning. Notably, LMIR5 deficiency suppressed TIM1-Fc-induced recruitment of neutrophils in the dorsal air pouch, and LMIR5 deficiency attenuated neutrophil accumulation in a model of ischemia/reperfusion injury in the kidneys in which TIM1 expression is up-regulated. In that model, LMIR5 deficiency resulted in ameliorated tubular necrosis and cast formation in the acute phase. Collectively, TIM1-LMIR5 interaction plays a physiological role in immune regulation by myeloid cells.

Research Products

• [Journal Article] Two types of C/EBP. mutations play distinct but collaborative roles in leukemogenesis : Lessonsfrom clinical data and BMT models. (2011)
  • Author(s): Kato, N., Kitaura, J., Doki, N., Komeno, Y., Watanabe-Okochi, N., Togami, K., Nakahara, F., Oki, T., Enomoto, Y., Fukuchi, Y., Nakajima, H., Harada, Y., Harada, H., Kitamura, T.
  • Journal Title: Blood. 117 Pages: 221-233
• [Journal Article] Two types of C/EBPα mutations play distinct but collabora tive roles in leukemogenesis : Lessons from clinical data and BMT models. (2011)
  • Author(s): Kato, N
  • Journal Title: Blood Volume: 117 Pages: 221-233
  • Peer Reviewed
• [Journal Article] Characterization of leukocyte mono-immunoglobulin-like recept or 7 (LMIR7)/CLM-3 as an activating receptor : its similarities to and differences from LMIR4/CLM-5. (2011)
  • Author(s): Enomoto, Y
  • Journal Title: J Biol Chem Volume: 285 Pages: 35274-35283
  • Peer Reviewed
• [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blastic crisis of chronic myelogenous leukemia. (2010)
  • Author(s): Nakahara, F., Sakata-Yanagimoto, M., Komeno, Y., Kato, N., Haraguchi, K., Kumano, K., Harada, Y., Harada, H., Kitaura, J., Ogawa, S., Kurokawa, M., Kitamura, T., Chiba, S.
  • Journal Title: Blood. 115 Pages: 2872-2881
• [Journal Article] Expression of ADAMTS4 in Ewing's sarcoma. (2010)
  • Author(s): Minobe, K., Ono, R., Matsumine, A., Shibata-Minoshima, F., Izawa, K., Oki, T., Kitaura, J., Iino, T., Takita, J., Iwamoto, S., Hori, H., Komada, Y., Uchida, A., Hayashi, Y., Kitamura, T., Nosaka, T.
  • Journal Title: Int J Oncol. 37 Pages: 569-581
• [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. (2010)
  • Author(s): Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T., Kitamura, T.
  • Journal Title: Leukemia. 24 Pages: 1018-1024
• [Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. (2010)
  • Author(s): Yamanishi, Y., Kitaura, J., Izawa, K., Kaitani, A., Komeno, Y., Nakamura, M., Yamazaki, S., Enomoto, Y., Oki, T., Akiba, H., Abe, T., Komori, T., Morikawa, Y., Kiyonari, H., Takai, T., Okumura, K., Kitamura, T.
  • Journal Title: J Exp Med. 207 Pages: 1501-1511
• [Journal Article] Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor : its similarities to and differences from LMIR4/CLM-5. (2010)
  • Author(s): Enomoto, Y., Yamanishi, Y., Izawa, K., Kaitani, A., Takamatsu, R., Kajikawa, M., Takai, T., Kitamura, T., Kitaura, J.
  • Journal Title: J Bio Chem. 285 Pages: 35274-35283
• [Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reuerfusion injury. (2010)
  • Author(s): Yamanishi, Y
  • Journal Title: J Exp Med. Volume: 207 Pages: 1501-1511
  • Peer Reviewed
• [Journal Article] Expression of ADAMTS4 in Ewing's sarcoma. (2010)
  • Author(s): Minobe, K
  • Journal Title: Int J Oncol. Volume: 37 Pages: 569-581
  • Peer Reviewed
• [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a moos e BMT model. (2010)
  • Author(s): Komeno, Y
  • Journal Title: Leukemia Volume: 24 Pages: 1018-1024
  • Peer Reviewed
• [Journal Article] Hesl immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogeneou leukemia. (2010)
  • Author(s): Nakahara, F
  • Journal Title: Blood (in press)
  • Peer Reviewed
• [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. (2010)
  • Author(s): Komeno, Y
  • Journal Title: Leukemia (in press)
  • Peer Reviewed
• [Journal Article] Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia. (2009)
  • Author(s): Miyazaki, K., Yamasaki, N., Oda, H., Kuwata, T., Kanno, Y., Miyazaki, M., Komeno, Y., Kitaura, J., Honda, Z., Warming, S., Jenkins, N.A., Copeland, N.G., Kitamura, T., Nakamura, T., Honda, H.
  • Journal Title: Blood. 113 Pages: 4702-4710
• [Journal Article] Molecular bases of myelodysplastic syndromes: lessons from animal models. (2009)
  • Author(s): Komeno, Y., Kitaura, J., Kitamura, T.
  • Journal Title: J Cell Physiol. 219 Pages: 529-534
• [Journal Article] Possible involvement of RasGRP4 in leukemogenesis. (2009)
  • Author(s): Watanabe-Okochi, N., Oki, T., Komeno, Y., Kato, N., Yuji, K., Ono, R., Harada, Y., Harada, H., Hayashi, Y., Nakajima, H., Nosaka, T., Kitaura, J., Kitamura, T.
  • Journal Title: Int J Hematol. 89 Pages: 470-481
  • NAID: 10025161257
• [Journal Article] An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1 : LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. (2009)
  • Author(s): Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Kaitani, A., Sugiuchi, M., Takahashi, M., Maehara, A., Enomoto, Y., Oki, T., Takai, T., Kitamura, T.
  • Journal Title: J Immunol. 183 Pages: 925-936
• [Journal Article] Evidence that integrin τIIbυ3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. (2009)
  • Author(s): Oki, T., Eto, K., Izawa, K., Yamanishi, Y., Inagaki, N., Frampton, J., Kitamura, T., Kitaura, J.
  • Journal Title: J Bio Chem. 284 Pages: 31463-31472
• [Journal Article] Molecular bases of myelodysplastic syndromes : Lessons from animal models. (2009)
  • Author(s): Komeno, Y
  • Journal Title: J Cell.Physiol. 219 Pages: 529-534
  • Peer Reviewed
• [Journal Article] A Rac GTPase activating protein MgcRacGAP is an NLS-containing nuclear chaperone in the activation of STAT transcription factors. (2009)
  • Author(s): Kawashima, T
  • Journal Title: Mol Cell Biol. 29 Pages: 1796-1813
  • Peer Reviewed
• [Journal Article] Activating and inhibitory signals from an inhibitory receptor LMIR3/CLM-1 : LMIR3 augments LPS response through association with FcRg in mast cells. (2009)
  • Author(s): Izawa, K
  • Journal Title: J.Immunol. 183 Pages: 925-936
  • Peer Reviewed
• [Journal Article] A Rac GTPase activating protein MgcRacGAP is constitutively phosphorylated on serine 387 in the v-Src-transformed NIH3T3 cells. (2009)
  • Author(s): Doki, N
  • Journal Title: Cancer Science 100 Pages: 1675-1679
  • Peer Reviewed
• [Journal Article] Mixed-lineage-leukemia(MLL)fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. (2009)
  • Author(s): Ono, R
  • Journal Title: Leukemia 23 Pages: 2197-209
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 沖俊彦
  • Journal Title: 細胞工学(株式会社学研メディカル秀潤社) Pages: 209-214
• [Journal Article] (2009)
  • Author(s): 北村俊雄
  • Journal Title: 臨床血液(社団法人日本血液学会) Pages: 174-181
• [Journal Article] (2009)
  • Author(s): 加藤菜穂子
  • Journal Title: 日本臨床(株式会社日本臨牀社) Pages: 1875-1879
• [Journal Article] Molecular bases of myelodysplastic syndromes: lessons from animal models. (2009)
  • Author(s): Komeno Y
  • Journal Title: J Cell Physiol 219 Pages: 529-534
  • Peer Reviewed
• [Journal Article] Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype. (2008)
  • Author(s): Kashiwakura, J., Xiao, W., Kitaura, J., Kawakami, Y., Maeda-Yamamoto, M., Pfeiffer, J.R., Wilson, B.S., Blank, U., Kawakami, T.
  • Journal Title: J Leukoc Biol. 84 Pages: 357-367
• [Journal Article] AML1 mutations induced MDS and MDS/AML in a mouse BMT model. (2008)
  • Author(s): Watanabe-Okochi, N., Kitaura, J., Ono, R., Harada, H., Harada, Y., Komeno, Y., Nakajima, H., Nosaka, T., Inaba, T., Kitamura, T.
  • Journal Title: Blood. 111 Pages: 4297-4308
• [Journal Article] AML1 mutations induced MDS and MDS/AML in a mouse BMT model (2008)
  • Author(s): Watanabe-Okochi N
  • Journal Title: Blood 111 Pages: 4297-4308
  • Peer Reviewed
• [Journal Article] Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 between mouse and human. (2008)
  • Author(s): Yamanishi Y
  • Journal Title: Blood 111 Pages: 688-698
  • Peer Reviewed
• [Presentation] Leukocyte mono-Ig like receptor (LMIR)/CD300とマスト細胞 (2010)
  • Author(s): 北浦次郎
  • Organizer: 第60回日本アレルギー学会秋期学述大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-11-26
• [Presentation] Leukocyte mono-Ig like receptor (LMIR)/CD300と炎症・アレルギー (2010)
  • Author(s): 北浦次郎
  • Organizer: 小児アレルギー同好会
  • Place of Presentation: 東京(口演)
  • Year and Date: 2010-10-02
• [Presentation] Leukocyte mono-Ig like receptor(LMIR)/CD300と炎症・アレルギー (2010)
  • Author(s): 北浦次郎
  • Organizer: 第72回小児アレルギー同好会
  • Place of Presentation: ホテルグランドパレス
  • Year and Date: 2010-10-02
• [Presentation] Hes1による造血前駆細胞の不死化と、慢性骨髄性白血病の急性転化誘導 (2010)
  • Author(s): 中原史雄
  • Organizer: 第6回麟麟塾
  • Place of Presentation: コクヨホール
  • Year and Date: 2010-06-05
• [Presentation] Leukocyte mono-Ig like receptor (LMIR)/CD300とマスト細胞 (2010)
  • Author(s): 北浦次郎
  • Organizer: 日本アレルギー学会シンポジウム
  • Place of Presentation: 東京(口演)
• [Presentation] Comparative analysis of leukocyte mono-Ig-like receptor 7 (LMIR7)/CLM-3 with LMIR4/CLM-5 as an activating receptor: lessons from association with FcRgamma (2010)
  • Author(s): 榎本豊、北浦次郎、山西吉典、伊沢久未、高井俊行、北村俊雄
  • Organizer: 国際免疫学会議
  • Place of Presentation: 神戸(口演)
• [Presentation] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury (2010)
  • Author(s): 山西吉典、北浦次郎、伊沢久未、北村俊雄
  • Organizer: 国際免疫学会議
  • Place of Presentation: 神戸(口演)
• [Presentation] A FUNCTIONAL ANALYSIS OF microRNA ABERRANTLY EXPRESSED IN LEUKEMIC CELLS. (2010)
  • Author(s): 榎本豊、北浦次郎、園木孝志、中熊秀喜、北村俊雄
  • Organizer: 日本遺伝子治療学会学術集会ポスター
  • Place of Presentation: 宇都宮
• [Presentation] A FUNCTIONAL ANALYSIS OF microRNA ABERRANTLY EXPRESSED IN LEUKEMIC CELLS. (2010)
  • Author(s): 榎本豊
  • Organizer: 第16回日本遺伝子治療学会学術集会
  • Place of Presentation: 栃木県総合文化センター
• [Presentation] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury (2010)
  • Author(s): Yamanishi, Y
  • Organizer: 第14回国際免疫会議
  • Place of Presentation: 神戸ポートピアホテル、神戸国際展示場
• [Presentation] Comparative analysis of leukocyte mono-Ig-like receptor 7 (LMIR7)/CLM-3 with mouseLMIR4/CLM-5 as an activating receptor : lessons from association with FcRγ (2010)
  • Author(s): Enomoto, Y
  • Organizer: 第14回国際免疫会議
  • Place of Presentation: 神戸ポートピアホテル、神戸国際展示場
• [Presentation] MiR125 induces hematological malignancies in vivo (2010)
  • Author(s): 榎本豊
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] TSC-22 is upregulated by activation of Ras/MAPK and suppresses cellular proliferation. (2010)
  • Author(s): Nakamura, M
  • Organizer: 2010 International Student Forum.
  • Place of Presentation: 中国、北京
• [Presentation] TSC-22の発現はRas/MAPKの活性化により上昇する (2010)
  • Author(s): 中村真樹
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] Screnning of surface antigens on iPS cells with SST-REX (2010)
  • Author(s): 沖俊彦
  • Organizer: 第8回幹細胞シンポジウム
  • Place of Presentation: 淡路夢舞台国際会議場
• [Presentation] LMIR5のリガンドとしてTIM1およびTIM4を同定した (2009)
  • Author(s): 山西吉典、北浦次郎、伊沢久未、北村俊雄
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪(口演)
• [Presentation] LMIR3ノックアウトマウスの解析;LMIR3欠損はマウス腹膜炎モデルにおける致死率を改善する (2009)
  • Author(s): 伊沢久未、北浦次郎、山西吉典、北村俊雄
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪(口演)
• [Presentation] ヒトLMIR/CD300ファミリー分子の解析:CD300CはFcRgammaと会合して活性化シグナルを伝達する (2009)
  • Author(s): 高橋まり子、北浦次郎、山西吉典、伊沢久未、北村俊雄
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪(口演)
• [Presentation] LMIR8/CLM-6はpDCマーカーである (2009)
  • Author(s): 貝谷綾子、北浦次郎、山西吉典、伊沢久未、北村俊雄
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪(口演)
• [Presentation] 活性化レセプターLMIR7とLMIR4の比較解析:FcRgammaとの会合から得られた知見 (2009)
  • Author(s): 榎本豊、北浦次郎、山西吉典、伊沢久未、北村俊雄
  • Organizer: 日本免疫学会、ポスター
  • Place of Presentation: 大阪
• [Presentation] An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1:LMIR3 augments LPS response through association with FcRgamma in mast cells (2009)
  • Author(s): 前原秋絵、北浦次郎、山西吉典、伊沢久未、北村俊雄
  • Organizer: 日本免疫学会、ポスター
  • Place of Presentation: 大阪
• [Presentation] Learning from mouse BMT models for MDS and MPD (2009)
  • Author(s): Kitamura, T
  • Organizer: MDS/MPN Meeting
  • Place of Presentation: USA,ヒューストン
• [Presentation] Wnt modulators, SFRP-1 and SFRP-2 differentially regulate hematopoietic stem cells. (2009)
  • Author(s): 中島秀明
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Constitutive phosphorylation of a RacGAP is involved in v-Src-induced transformation of NIH3T3 cells. (2009)
  • Author(s): 土岐典子
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Analysis of C/EBPA mutations in AML, MDS by a mouse BMT model. (2009)
  • Author(s): 加藤菜穂子
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Hesl confers self-renewal capability on committed progenitors and induces CML BC-like disease. (2009)
  • Author(s): 中原史雄
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Heslによる骨髄前駆細胞への自己複製能付与と、慢性骨髄性白血病における急性転化の誘導. (2009)
  • Author(s): 中原史雄
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] MgcRacGAPの恒常的リン酸化はv-SrcによるNIH3T3細胞のtransformに関与する. (2009)
  • Author(s): 土岐典子
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] LMIR5のリガンドとしてTIM1およびTIM4を同定した。 (2009)
  • Author(s): 山西吉典
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] LMIR3ノックアウトマウスの解析 ; LMIR3欠損はマウス腹膜炎モデルにおける致死率を改善する。 (2009)
  • Author(s): 伊沢久未
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] ヒトLMIR/CD300ファミリー分子の解析:CD300CはFcRgammaと会合して活性化シグナルを伝達する。 (2009)
  • Author(s): 高橋まり子
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] LMIR8/CLM-6はpDCマーカーである。 (2009)
  • Author(s): 貝谷綾子
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] 活性化レセプターLMIR7とLMIR4の比較解析:FcRγとの会合から得られた知見。 (2009)
  • Author(s): 榎本豊
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1 : LMIR3 augments LPS response through association with FcRγ in mast cells. (2009)
  • Author(s): 前原明絵
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] 可溶性LMIR5はLPSによる炎症反応を増強する (2008)
  • Author(s): 山西吉典
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] 可溶性LMIR5はLPSによる炎症反応を増強する (2008)
  • Author(s): 山西吉典、北浦次郎、伊沢久未、北村俊雄
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都(口演)
• [Presentation] 活性化レセプターLMIR7の機能解析 (2008)
  • Author(s): 榎本豊、北浦次郎、山西吉典、伊沢久未、沖俊彦、高井俊行、北村俊雄
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(口演)
• [Presentation] LMIR3はマスト細胞において細胞内領域ITIMを介した抑制化シグナルとITAMを有するFcRgammaとの会合を介した活性化シグナルを伝達する (2008)
  • Author(s): 伊沢久未、北浦次郎、山西吉典、松岡孝幸、沖俊彦、高井俊行、北村俊雄
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都(口演)
• [Presentation] 活性化レセプターのLMIR6は末梢血の樹状細胞に高発現する (2008)
  • Author(s): 杉内正弘、北浦次郎、山西吉典、伊沢久未、沖俊彦、高井俊行、北村俊雄
  • Organizer: 日本免疫学会総会、ポスター
  • Place of Presentation: 京都
• [Presentation] 活性型レセプターLMIR5の機能解析:マウスおよびヒトLMIR5の相違 (2008)
  • Author(s): 山西吉典、北浦次郎、伊沢久未、沖俊彦、北村俊雄
  • Organizer: 麒麟塾
  • Place of Presentation: 東京(口演)
• [Presentation] Analysis of mouse LMIR5/CLM-7 as an activating receptor : differential regulation of LMIR5/CLM-7 in mouse versus human cells. (2008)
  • Author(s): 山西吉典, 北浦次郎, 伊沢久未, 北村俊雄
  • Organizer: The 15^<th> East Asia Joint Conference
  • Place of Presentation: 韓国ソウル(口演)
• [Presentation] 活性型レセプターLMIR5の機能解析:マウスおよびヒトLMIR5の相違 (2008)
  • Author(s): 山西吉典
  • Organizer: 第4回麟麟塾
  • Place of Presentation: 品川
• [Presentation] Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. (2008)
  • Author(s): Yamanishi Y
  • Organizer: The 15th East Asia Joint Conference
  • Place of Presentation: Korea.
• [Presentation] LMIR3はマスト細胞において細胞内領域のITIMを介した抑制化シグナルとITAMを有するFcRgammaとの会合を介した活性化シグナルを伝達する (2008)
  • Author(s): 伊沢久未
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
• [Book] Leukocyte mono-Ig like receptor 3 (LMIR3)によるマスト細胞の活性化と抑制化54 (2010)
  • Author(s): 伊沢久未、北浦次郎、北村俊雄
  • Publisher: 臨床免疫・アレルギー科
• [Book] マスト細胞の活性化とLMIR3(「抑制型レセプターであるLMIR3はマスト細胞においてFcR.と会合し、リポポリサッカライドによる反応を増強する」)53 (2010)
  • Author(s): 伊沢久未、北浦次郎、北村俊雄
  • Publisher: 臨床免疫\アレルギー科
• [Book] 臨床免疫・アレルギー科 (2010)
  • Author(s): 伊沢久未
  • Publisher: 科学評論社
• [Book] 活性型レセプターLMIR5によるマスト細胞の機能制御-マウスおよびヒトLMIR5の相違52 (2009)
  • Author(s): 山西吉典、北浦次郎、北村俊雄
  • Publisher: 臨床免疫・アレルギー科