| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Research Abstract |
Rheumatoid arthritis (RA) is a chronic inflammatory disease, involving multiple joints. In addition to the biologics, novel therapies should be established. We identified a novel RA-related protein of annexin 7 by proteomics, evidenced arthritogenecity of annexin7 and its role as a therapeutic target suing transgenic mice. Further, we evidenced annexin 7 contributed to arthritis through IL-8. Our study would be useful to establish a new therapy for RA.
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