| Project/Area Number |
20390284
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
MIYAKE Sachiko National Center of Neurology and Psychiatry, 神経研究所免疫研究部, 室長 (50266045)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Daiju 独)国立精神・神経医療研究センター, 神経研究所免疫研究部, 研究員 (60462793)
|
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIKAWA Daiju 独)国立精神・神経医療研究センター, 神経研究所免疫研究部, 研究員 (60462793)
|
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | NKT細胞 / MR1 / 関節炎 / 免疫調節性細胞 / 腸内細菌叢 |
|---|
| Research Abstract |
MHC-related molecule-1 (MR1)-restricted T cells are restricted by a nonpolymorphic MHC class 1b molecule, MR1, and express an invariant TCRα chain. MR1-restricted T cells are selected in the thymus in an MR1-dependent manner, but, interestingly, MR1-restricted T cells require B cells as well as commensal flora for their peripheral expansion. We demonstrated that MR1-restricted T cells contribute to the arthritis severity of CIA and CAIA, mostly by augmenting joint inflammation in the effector phase of arthritis. Furthermore, we showed that the frequency of MR1-restricted T cells in peripheral blood is reduced in patients with rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis.
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