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Effect of vitamin D supplementation on the clinical conditions in the institutionalized elderly subjects

Research Project

Project/Area Number 20390285
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Infectious disease medicine
Research InstitutionTohoku University

Principal Investigator

OHRUI Takashi  Tohoku University, 加齢医学研究所, 准教授 (90271923)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords感染症予防学 / 高齢者肺炎 / ビタミンD / 細胞性免疫 / 虚弱高齢者 / ビタミンD欠乏 / 肺炎 / 細胞性免疫能 / ツベルクリン反応 / 活性型ビタミンD / 25-OHビタミンD / 血中ビタミンD濃度 / 活性型ビタミンD製剤 / 高齢者 / 生命予後 / 活性型ビタミンD3
Research Abstract

Pneumonia is a common cause of death among older people despite the availability of potent new antimicrobials. Vitamin D (VD) deficiency is especially common in institutionalized elderly people probably due to limited sun-exposure, skin diseases and problems of dietary intake and is associated with hip fractures and higher mortality from life-threatening conditions such as cardiovascular diseases, cancer and diabetes mellitus. Recently, 1,25-dihydroxyvitamin D, a biologically active form of VD, was reported to be a potent immune modulator of the adaptive immune system and to stimulate the innate immune response upon infection. The aim of the first study was to examine whether VD deficiency correlates with depressed cellular immunity and increases susceptibility to respiratory tract infections among older residents of long-term care facilities. We measured serum concentrations of 1,25-dihydroxyvitamin D and albumin, performed a tuberculin skin test, an indicator of cellular immunity and assessed retrospectively the incidence of both febrile respiratory illnesses and pneumonia. In the first study we showed that a lower serum level of 1,25-dihydroxyvitamin D correlated with a depressed tuberculin response and an increased susceptibility to respiratory tract infections in the institutionalized elderly subjects. In the second study, we performed a prospective study to determine the effect of VD supplementation on the febrile respiratory illnesses in frail elderly people who often have low serum VD levels and are at high risk for pneumonia. As a result, we could find no significant effects in the VD supplementation in institutionalized frail elderly subjects.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Book (3 results)

  • [Journal Article] Low serum 1,25-dihydroxyvitamin D level and risk of respiratory infections in institutionalized older people.2010

    • Author(s)
      Asamura T, Ohrui T, Nakayama K, He M, Yamasaki M, Ebihara T, Ebihara S, Furukawa K, Arai H.
    • Journal Title

      Gerontology 56

      Pages: 542-543

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者肺炎・誤嚥性肺炎2010

    • Author(s)
      大類孝
    • Journal Title

      日本内科学雑誌

      Volume: 99 Pages: 2746-2751

    • NAID

      10027509111

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Low serum 1,25-dihydroxyvitamin D level and risk of respiratory infections in institutionalized older people.2010

    • Author(s)
      Asamura T, Ohrui T, et al.
    • Journal Title

      Gerontology Jan 12(Epub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized, single-blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patients.2009

    • Author(s)
      Sasaki T, Nakayama K, Yasuda H, Yoshida M, Asamura T, Ohrui T, Arai H, Araya J, Kuwano K, Yamaya M.
    • Journal Title

      J Am Geriatr Soc 57

      Pages: 1453-1457

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 誤嚥性肺炎予防の新戦略2009

    • Author(s)
      大類孝、海老原覚、海老原孝枝、浅村孝昭、宇根かおり、矢満田慎介、吉田元樹、山崎都、浅田成紀、高橋秀徳、荒井啓行
    • Journal Title

      呼吸 28

      Pages: 250-254

    • Related Report
      2010 Final Research Report
  • [Journal Article] Homicides of frail older persons by their caregivers in Japan2009

    • Author(s)
      He M, Ohrui T, Arai H.
    • Journal Title

      Journal of the American Geriatrics So ciety 57

      Pages: 173-174

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 誤嚥性肺炎予防の新戦略2009

    • Author(s)
      大類孝、海老原覚、海老原孝枝、他
    • Journal Title

      呼吸 28

      Pages: 250-254

    • Related Report
      2008 Annual Research Report
  • [Presentation] 高齢者肺炎の発症における活性型ビタミンDの役割に関する検討2009

    • Author(s)
      浅村孝昭、大類孝
    • Organizer
      第51回日本老年医学会学術集会一般演題
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 高齢者肺炎の発症における活性型ビタミンDの役割に関する検討2009

    • Author(s)
      浅村孝昭, 大類孝
    • Organizer
      第51回日本老年医学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高齢者肺炎の発症における活性型ビタミンDの役割に関する検討2009

    • Author(s)
      浅村孝昭、大類孝
    • Organizer
      第49回日本呼吸器学会学術講演会一般演題
    • Place of Presentation
      東京
    • Year and Date
      2009-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 高齢者肺炎の発症における活性型ビタミンDの役割に関する検討2009

    • Author(s)
      浅村孝昭, 大類孝
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高齢者認知機能の保護および肺炎予防の新戦略2009

    • Author(s)
      大類孝
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Book] 高齢者の肺炎(松本慶蔵総監修)2011

    • Author(s)
      大類孝
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] 高齢者の肺炎2011

    • Author(s)
      大類孝(松本慶蔵総監修)
    • Publisher
      ジャーナル社
    • Related Report
      2010 Annual Research Report
  • [Book] 老年医学テキスト(改定第3版)2008

    • Author(s)
      日本老年医学会
    • Publisher
      株式会社廣済堂
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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