Development of disease specific novel therapeutic strategy of pediatric solid tumors based on the molecular pathogenesis
| Project/Area Number |
20390292
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKITA Junko The University of Tokyo, 医学部附属病院, 講師 (00359621)
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| Co-Investigator(Kenkyū-buntansha) |
NANYA Yasuhito 東京大学, 医学部附属病院, 助教 (60451811)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 小児悪性腫瘍 / 神経芽腫 / Ewing肉腫 / 横紋筋肉腫 / ALK遺伝子 / SNPアレイ / IDH1遺伝子 / IDH2遺伝子 / 小児固形腫瘍 / SNPアレイ解析 / ミスセンス変異 / キロシンキナーゼ |
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| Research Abstract |
To explore molecular pathogenesis and identify therapeutic gene targets of pediatric solid tumors, we performed genome-wide copy number analysis of 419 pediatric solid tumors using SNP-genotype microarrays. High-grade amplifications of 2p23 involving ALK locus were identified in several neuroblastoma cases. Of note, oncogenic mutations of ALK were also found in approximately 6% of fresh tumors and 30% of cell lines. Thus, our findings implicate that ALK is one of the gene targets of neuroblastoma and have potential as tractable targets for this intractable disease.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Japan Marrow Donation Program (JMDP). Exploration of the genetic basis of GVHD by genetic association studies.2009
Author(s)
Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato M, Nannya Y, Akatsuka Y, Satake M, Takita J, 他7名
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Journal Title
Biol Blood Marrow Transplant. 15(1 Suppl)
Pages: 39-41
Related Report
Peer Reviewed
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[Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.2009
Author(s)
Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, 他16名
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Journal Title
Nature. 460
Pages: 904-908
Related Report
Peer Reviewed
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[Presentation] ALK gene aberrations in pediatric solid tumors.2010
Author(s)
Takita J, Nishimura R, Sanada M, Ohki K, Kato M, ChenY, Kanegane H, Okita H, Fujimoto J, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S
Organizer
The 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association
Place of Presentation
Taipei, Taiwan
Related Report
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[Presentation] Effects of selective ALK inhibitors to neuroblastoma2010
Author(s)
Takita J, Okubo J, Nishimura R, Oki K, Uchisaka N, Chen Y, Sanada M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S
Organizer
Advances in Neuroblastoma Research
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] 小児固形腫瘍におけるALK遺伝子の関与2010
Author(s)
滝田順子, 西村力, 大木健太郎, 樋渡光輝, 大久保淳, 内坂直樹, 真田昌, 大喜多肇, 藤本純一郎, 金兼弘和, 五十嵐隆, 林泰秀, 小川誠司
Organizer
第69回日本癌学会学術総会
Place of Presentation
大阪
Related Report
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[Presentation] 小児固形腫瘍におけるALK遺伝子の増幅と変異2009
Author(s)
滝田順子, 大木健太郎, 西村力, 加藤元博, 陳玉彦, 真田昌, 金兼弘和, 大喜多肇, 藤本純一郎, 菊地陽, 五十嵐隆, 林康秀, 小川誠司
Organizer
第68回日本癌学会学術総会
Place of Presentation
横浜
Related Report
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[Presentation] 小児固形腫瘍におけるALK遺伝子の解析2009
Author(s)
滝田順子, 西村力, 大木健太郎, 陳玉彦, 加藤元博, 真田昌, 金兼弘和, 大喜多肇, 藤本純一郎, 菊地陽, 五十嵐隆, 林康秀, 小川誠司
Organizer
第32回日本分子生物学会年会
Place of Presentation
横浜
Related Report
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