| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
To explore molecular pathogenesis and identify therapeutic gene targets of pediatric solid tumors, we performed genome-wide copy number analysis of 419 pediatric solid tumors using SNP-genotype microarrays. High-grade amplifications of 2p23 involving ALK locus were identified in several neuroblastoma cases. Of note, oncogenic mutations of ALK were also found in approximately 6% of fresh tumors and 30% of cell lines. Thus, our findings implicate that ALK is one of the gene targets of neuroblastoma and have potential as tractable targets for this intractable disease.
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