| Project/Area Number |
20390294
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Toyama |
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Principal Investigator |
MIYAWAKI Toshio University of Toyama, 大学院・医学薬学研究部(医学), 教授 (10143885)
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| Co-Investigator(Kenkyū-buntansha) |
KANEGANE Hirokzu 富山大学, 大学病院, 講師 (00293324)
ADACHI Yuhichi 富山大学, 大学病院, 講師 (80184191)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 制御性T細胞 / FOXP3遺伝子 / IPEX / フローサイトメトリー / 遺伝子解析 / IL-7受容体 / FOXP3 / CD4^+CD25^+T細胞 / アトピー性皮膚炎 / IL-7R(CD127) / CD4^+CD25^+CD127^<dim>T細胞 / フローサイトメトー / IL-7R (CD127) |
|---|
| Research Abstract |
This study was intended to elucidate the functional maturation process of human regulatory T (Treg) cells through the pathogenic examination of congenital deficiency of Treg cells (IPEX). We developed the simple and easy method by flow cytometry for detection of IPEX patients, resulting in identification of some new IPEX cases in Japan. Based on the analyses of IPEX patients, the IPEX case undergoing bone marrow transplantation, carriers, newborns and healthy adults, it could partially be clarified that FOXP3, the product of the gene responsible for IPEX, plays a crucial role in development and differentiation of Treg cells in humans.
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