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Molecular mechanisms of closure of the ductus arteriosus

Research Project

Project/Area Number 20390300
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionWaseda University

Principal Investigator

MINAMISAWA Susumu  Waseda University, 理工学術院, 教授 (40257332)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Keywords発達小児科学 / 小児循環器学 / 骨格筋・平滑筋 / 未熟児・新生児医学 / 血管病態学 / 分子生理学 / 生理活性物質 / 未熟児医学 / 新生児医学 / 発違小児科学
Research Abstract

The ductus arteriosus (DA), a fetal arterial connection between the main pulmonary artery and the descending aorta, normally closes immediately after birth. The DA is a normal and essential fetal structure. However, it becomes abnormal if it remains patent after birth. In addition to functional closure of the DA (vasoconstriction), anatomical closure of the DA is essential for the final DA closure. The present study identified that the DA-specific downstream signals via PGE2-EP4 stimulation induced vascular remodeling of the DA to promote anatomical closure. Furthermore, we found that other factors such as calcium influx via T-type calcium channels and growth hormone play a role in vascular remodeling in the DA. Clarifying the molecular mechanism of DA closure will lead to develop a novel therapeutic strategy for patent DA.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (106 results)

All 2011 2010 2009 2008 Other

All Journal Article (27 results) (of which Peer Reviewed: 20 results) Presentation (78 results) Remarks (1 results)

  • [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus2011

    • Author(s)
      Jin MH, Yokoyama U, Sato Y, Shioda A, Jiao Q, Ishikawa Y, Minamisawa S (correspondence)
    • Journal Title

      J Physiol Sci. 61(3)

      Pages: 167-79

    • Related Report
      2010 Final Research Report
  • [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Yokoyama U, Minamisawa S (correspondence), Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y.
    • Journal Title

      Circ Res 106(12)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of vascular tone and remodeling of the ductus arteriosus.2010

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y
    • Journal Title

      J Smooth Muscle Res. 46(2)

      Pages: 77-87

    • NAID

      10030687229

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 出生に関わる循環アダプテーション(3)動脈管の分子生物学2010

    • Author(s)
      横山詩子、南沢享、中澤誠
    • Journal Title

      Fetal & Neonatal Medicine 2(2)

      Pages: 12-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Yokoyama U, Minamisawa S, et al.
    • Journal Title

      Circ Res

      Volume: 106 Pages: 1882-92

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of vascular tone and remodeling of the ductus arteriosus.2010

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y.
    • Journal Title

      J Smooth Muscle Res.

      Volume: 46 Pages: 77-87

    • NAID

      10030687229

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 出生に関わる循環アダプテーション(3)動脈管の分子生物学2010

    • Author(s)
      横山詩子、南沢享、中澤誠
    • Journal Title

      Fetal & Neonatal Medicine

      Volume: 2 Pages: 12-15

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Caveolin gene transfer improves glucose metabolism in diabetic mice.2010

    • Author(s)
      Otsu K, Minamisawa S, et al.
    • Journal Title

      Am J physiol Cell Physiol.

      Volume: 298

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.2010

    • Author(s)
      Wakui H, Tamura K, Minamisawa S, et al.
    • Journal Title

      Am J physiol Renal Physiol.

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac-Specific Activation of Angiotensin II Type 1 Receptor-Associated Protein Completely Suppresses Cardiac Hypertrophy in Chronic Angiotensin II-Infused Mice.2010

    • Author(s)
      Wakui H, Tamura K, Minamisawa S, et al.
    • Journal Title

      Hypertension

      Volume: 55 Pages: 1157-64

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation.2009

    • Author(s)
      Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S (correspondence).
    • Journal Title

      J Biol Chem. 284(36)

      Pages: 24025-34

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation2009

    • Author(s)
      Akaike T, et. al.
    • Journal Title

      J Biol Chem. 284(45)

      Pages: 31431-31440

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes2009

    • Author(s)
      Masumiya H, et. al.
    • Journal Title

      Channels 3

      Pages: 6-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sarcalumenin is essential for maintaining cardiac function during endurance exercise training2009

    • Author(s)
      Jiao Q, et. al.
    • Journal Title

      Am J Physiol Heart Circ Physiol 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activator of G protein signaling 8(AGS8)is required for hypoxia-induced apoptosis of cardiomyocytes : Role of gbetagamma and connexin43(CX43)2009

    • Author(s)
      Sato M, et. al.
    • Journal Title

      J Biol Chem 284

      Pages: 31431-31440

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 心臓の中のカルシウム:旧友の新な役目2009

    • Author(s)
      南沢享
    • Journal Title

      日本小児循環器学会雑誌 25

      Pages: 22-29

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration.2008

    • Author(s)
      Yokoyama U, induced closure(correspondence), Quan H, Akaike T, Jin M, Otsu K, Ulucan C, Wang X, Baljinnyam E, Takaoka M, Sata M, Ishikawa Y.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 295(4)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PGE2-activated Epac promotes neointimal cushion formation of the rat ductus arteriosus by a process distinct from that of PKA.2008

    • Author(s)
      Yokoyama U, Minamisawa S (correspondence), Quan H, Akaike T, Suzuki S, Jin M, Jiao Q, Watanabe M, Otsu K, Iwasaki S, Nishimaki S, Sato M, Ishikawa Y.
    • Journal Title

      J Biol Chem. 1283(42)

      Pages: 28702-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+handIing of the sarcoplasmic reticulum.2008

    • Author(s)
      Shimura M, Minamisawa S, et. al.
    • Journal Title

      Cardiovasc Res 77(2)

      Pages: 362-370

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient neonataI diabetes mellitus in extremely preterm infant.2008

    • Author(s)
      Nishimaki s, Yukawa T, et. al.
    • Journal Title

      Arch Dis Child Fetal Neonatal Ed. 93(3)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyaluronan oonstitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.2008

    • Author(s)
      Misra S, Obeid LM, et. al.
    • Journal Title

      J Biol Chem. 283(21)

      Pages: 14335-14344

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type 5 adenylyl cyclase plays a major role in stabiIizing heart rate in response to microgravity induced by parabolic flight.2008

    • Author(s)
      Okumura S, Tsunematsu T, et. al.
    • Journal Title

      J AppI Physiol. 105(1)

      Pages: 173-179

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood flow velocities in the anterior cerebral artery and basilar artery in asphyxiated infants.2008

    • Author(s)
      Nishimaki S, Iwasaki S, Minamisawa S, et. al.
    • Journal Title

      J Ultrasound Med. 27(6)

      Pages: 955-960

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration.2008

    • Author(s)
      Yokoyama U, Minamisawa S., et. al.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 295(4)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PGE2-activated Epac promotes neointimal cushion formation of the rat ductus arteriosus by a process distinct from that of PKA.2008

    • Author(s)
      Yokoyama U, Minamisawa S., et. al.
    • Journal Title

      J Biol Chem. 1283(42)

      Pages: 28702-28709

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心筋症の分子生物学2008

    • Author(s)
      赤池徹, 南沢享
    • Journal Title

      小児科 49(6)

      Pages: 795-801

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Mitsugumin 53-mediated maintenance of K+currents in cardiac myocytes.2008

    • Author(s)
      Masumiya H, Asaumi Y, Nishi M, Minamisawa S, et. al.
    • Journal Title

      Channels 3(1)

      Pages: 6-11

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Successful Isolation of Vascular Endothelial Cells from the Rat Ductus Arteriosus.2011

    • Author(s)
      Liu N, Yokota T, Maekawa S, Yokoyama U, Kato T, Minamisawa S.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Thromnoxane A2 Receptor Stimulation Specifically Causes Closure of the Rat Ductus Arteriosus.2011

    • Author(s)
      Aida T, Yokota T, Yokoyama U, Minamisawa S
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epacl promotes vascular remodeling upon vascular injury in vivo.2011

    • Author(s)
      Kato Y, Yokoyama U, Minamisawa S, ishikawa Y, et.al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serum depletion and three-dimensional multilayer composition induce elastic fiber formation and a contractile phenotype of rat vascular smooth muscle cells.2011

    • Author(s)
      Ishiwata R, Yokoyama U, Minamisapa S, et.al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation of vascular remodeling of the ductus arteriosus.2011

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] A comprehensive approach to understand the formation of the cardiovascular network (Over view)2011

    • Author(s)
      Minamisawa S
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama, Japan(招待講演)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] A comprehensive approach to understand the formation of the cardiovascular network (Overview).2011

    • Author(s)
      南沢享
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Final Research Report
  • [Presentation] Successful isolation of vascular endothelial cells from the rat ductus arteriosus.2011

    • Author(s)
      Liu N, et al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Final Research Report
  • [Presentation] Thromnoxane A2 receptor stimulation specifically causes closure of the rat ductus arteriosus.2011

    • Author(s)
      Aida T, et al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Final Research Report
  • [Presentation] Epac1 promotes vascular remodeling upon vascular injury in vivo.2011

    • Author(s)
      Kato Y, et al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Final Research Report
  • [Presentation] Serum depletion and three-dimensional multilayer composition induce elastic fiber formation and a contractile phenotype of rat vascular smooth muscle cells.2011

    • Author(s)
      Ishiwata R, et al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of vascular remodeling of the ductus arteriosus.2011

    • Author(s)
      Yokoyama U, et al.
    • Organizer
      The 88th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Final Research Report
  • [Presentation] Thromboxane A2 Receptor Stimulation Induces Closure of the Rat Ductus Arteriosus.2011

    • Author(s)
      Yokota T, et al.
    • Organizer
      The 5th Global COE International Symposium on 'Practical Chemical Wisdom'
    • Place of Presentation
      Waseda University, Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly.2010

    • Author(s)
      Shioda A, Yokoyama U, Minamisawa S, Ishikawa Y, et al.
    • Organizer
      The 33th Annual Meeting of the Molecular Biological Society of Japan
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly.2010

    • Author(s)
      Yokoyama U, Minamisawa S, Ishikawa Y., et.al.
    • Organizer
      The 84th Scientific Session, American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y.
    • Organizer
      The 16th International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Role of Thromboxane A2 Receptor in the Rat Ductus Arteriosus as a Vasoconstrictor.2010

    • Author(s)
      Yokota T, Ozawa M, Yokoyama U, Minamisawa S.
    • Organizer
      The 16th International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロスタグランジンEの新たな作用-動脈管リモデリングへの多面的関与2010

    • Author(s)
      南沢享
    • Organizer
      第8回京都心血管代謝セミナー
    • Place of Presentation
      京都、杉浦ホール
    • Year and Date
      2010-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] プロスタグランジンEの新たな作用-動脈管リモデリングへの多面的関与2010

    • Author(s)
      南沢享
    • Organizer
      第8回京都心血管代謝セミナー
    • Place of Presentation
      京都、杉浦ホール(招待講演)
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oxygenation promotes migration of smooth muscle cell in the rat ductus arteriosus.2010

    • Author(s)
      南沢享, et al.
    • Organizer
      Developmental Vascular Biology Workshop IV
    • Place of Presentation
      at the Asilomar Conference Grounds, Pacific Grove, Monterey, California.
    • Related Report
      2010 Final Research Report
  • [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      南沢享, et al.
    • Organizer
      The 16th International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles
    • Related Report
      2010 Final Research Report
  • [Presentation] A Role of Thromboxane A2 receptor in the rat ductus arteriosus as a vasoconstrictor.2010

    • Author(s)
      Yokota T, et al.
    • Organizer
      The 16th International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles
    • Related Report
      2010 Final Research Report
  • [Presentation] Prostaglandin EP4 signaling negatively regulates vascular elastic fiber assembly.2010

    • Author(s)
      Yokoyama U, et al.
    • Organizer
      The 84th Scientific Session, American Heart Association (AHA)
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット動脈管内膜肥厚におけるアデニル酸シクラーゼアイソフォームの役割の検討2010

    • Author(s)
      岩崎志穂、他
    • Organizer
      第46回日本周産新生児医学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly.2010

    • Author(s)
      Shioda A, et al.
    • Organizer
      The 33th Annual Meeting of the Molecular Biological Society of Japan
    • Place of Presentation
      Kobe
    • Related Report
      2010 Final Research Report
  • [Presentation] Oxygenation from hypoxia to normoxia promotes smooth muscle cell migration in the rat ductus arteriosus.2009

    • Author(s)
      南沢享, et al.
    • Organizer
      The 26th Annual Meeting of the Japanese Section.
    • Place of Presentation
      Sapporo, Hokkaido University.
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Oxygenation from hypoxia to normoxia promotes smooth muscle cell migration in the rat ductus arteriosus2009

    • Author(s)
      南沢享, et. al.
    • Organizer
      The 26th Annual Meeting of the Japanese Section
    • Place of Presentation
      北海道
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管閉鎖を制御する因子の同定と新治療法開発2009

    • Author(s)
      南沢享、他
    • Organizer
      第1回成果報告シンポジウム「早稲田大学が目指す新しい医・理・工学融合研究の展開」
    • Place of Presentation
      東京TWIns
    • Year and Date
      2009-08-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Adenylyl cyclase type 2 and 6 differentially promote vascular tone and remodeling in the ductus arteriosus.2009

    • Author(s)
      Katayama A, et al.
    • Organizer
      36th International Congress of Physiological Sciences.
    • Place of Presentation
      Kyoto.
    • Year and Date
      2009-07-31
    • Related Report
      2010 Final Research Report
  • [Presentation] ADENYLYL CYCLASE TYPE 2 AND 6 DIFFERENTIALLY PROMOTE VASCULAR TONE AND REMODELING IN THE DUCTUS ARTERIOSUS2009

    • Author(s)
      片山綾子, et. al.
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygen Promoters Calcium-dependent Smooth Muscle Cell Migration in the Rat Ductus Arteriosus.2009

    • Author(s)
      Ozawa M, et al.
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences.
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      2009-07-27
    • Related Report
      2010 Final Research Report
  • [Presentation] T-type calcium channels regulate smooth muscle cell migration, neointimal formation, and oxygen-induced closure in rat ductus arteriosus.2009

    • Author(s)
      Yokota T, et al.
    • Organizer
      The 1st international Symposium on Biomedical Science and Engineering Waseda University High-Tech Research Center.
    • Place of Presentation
      TWIns, Tokyo
    • Year and Date
      2009-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 動脈管閉鎖の分子機序:プロスタグランジンの予期せぬ役割(ワークショップ:1W15心臓大血管形成における器官形成メカニズムの普遍性と独自性)2009

    • Author(s)
      南沢享、横山詩子
    • Organizer
      第32 回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Oxygenation promotes smooth muscle cell migration in the rat ductus arteriosus.2009

    • Author(s)
      南沢享, et al.
    • Organizer
      BCVS Conference-Molecular Mechanisms of Cardiovascular Diseases.
    • Place of Presentation
      Lake Las Vegas, Nevada.
    • Related Report
      2010 Final Research Report
  • [Presentation] Adenylyl cyclase type6, but not type2 and 5, selectively promotes cAMP-dependent vascular remodeling in rat ductus arteriosus.2009

    • Author(s)
      Yokoyama U, et al.
    • Organizer
      The 73rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Osaka
    • Related Report
      2010 Final Research Report
  • [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維(エラスチン)形成の制御2009

    • Author(s)
      塩田亜樹、他
    • Organizer
      心臓血管発生研究会
    • Place of Presentation
      福島
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 胎生後期ラット動脈管におけるTRPMチャネルの発現2009

    • Author(s)
      青木理加、他
    • Organizer
      心臓血管発生研究会
    • Place of Presentation
      福島
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット動脈管組織におけるTRPMチャネルの発現~発達段階での大動脈組織との比較検討2009

    • Author(s)
      青木理加、他
    • Organizer
      第13回Molecular Cardiovascular Conference.
    • Place of Presentation
      北海道
    • Related Report
      2010 Final Research Report
  • [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御2009

    • Author(s)
      横山詩子、他
    • Organizer
      第13回Molecular Cardiovascular Conference.
    • Place of Presentation
      北海道
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット動脈管における6型アデニル酸シクラーゼの内膜肥厚形成作用2009

    • Author(s)
      片山綾子、他
    • Organizer
      第13回Molecular Cardiovascular Conference.
    • Place of Presentation
      北海道
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット動脈管において酸素化は平滑筋細胞遊走を促進する2009

    • Author(s)
      小澤基、他
    • Organizer
      第13回Molecular Cardiovascular Conference.
    • Place of Presentation
      北海道
    • Related Report
      2010 Final Research Report
  • [Presentation] 動脈管閉鎖の分子機序:プロスタグランジンの予期せぬ役割2009

    • Author(s)
      南沢享, 横山詩子
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygenation Promotes Smooth Muscle Cell Migration in the Rat Ductus Arteriosus2009

    • Author(s)
      南沢享, et. al.
    • Organizer
      BCVS Conference-Molecular Mechanisms of Cardiovascular Diseases
    • Place of Presentation
      Lake Las Vegas, Nevada, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adenylyl cyclase type6, but not type2 and 5, selectively promotes cAMP-dependent vascular remodeling in rat ductus arteriosus2009

    • Author(s)
      横山詩子, 南沢享, et. al.
    • Organizer
      The 73rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット動脈管組織におけるTRPMチャネルの発現~発達段階での大動脈組織との比較検討2009

    • Author(s)
      青木理加, 他
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御2009

    • Author(s)
      横山詩子, 他
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット動脈管における6型アデニル酸シクラーゼの内膜肥厚形成作用2009

    • Author(s)
      片山綾子, 他
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心房特異的発現を制御するサルコリピン-Creノックインマウス2009

    • Author(s)
      横田知大, 他
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット動脈管において酸素化は平滑筋細胞遊走を促進する2009

    • Author(s)
      小澤基, 他
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygen Promoters Calcium-dependent Smooth Muscle Cell Migration in the Rat Ductus Arteriosus2009

    • Author(s)
      小澤基, et. al.
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygenation Promotes Calcium-dependent Smooth Muscle Cell Migration in the Rat Ductus Arteriosus2009

    • Author(s)
      赤池徹, 他
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] Adenylyl Cyclase Type 6, but not Type 2 and 5, Selectively Promotes cAMP-dependent Vascular Remodeling in Rat Ductus Arteriosus2009

    • Author(s)
      横山詩子, 他
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular mechanisms of anatomical closure of ductus arteriosus.2008

    • Author(s)
      南沢享
    • Organizer
      Buddhist Tzu Chi General Hospital
    • Place of Presentation
      Taipei
    • Year and Date
      2008-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular mechanisms of neointimal thickening : A new role of prostaglandins2008

    • Author(s)
      南沢享
    • Organizer
      Institute of Biomedical Science in Academia Sinica
    • Place of Presentation
      Taipei
    • Year and Date
      2008-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Animal model of ductus arteriosus : A new role of prostaglandin E. 2008Pediatric Research Workshop2008

    • Author(s)
      南沢享
    • Organizer
      What Animal Model Can Do in Pediatric Research
    • Place of Presentation
      Taiwan Pediatric Association. Taipei
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Animal model of ductus arteriosus : A new role of prostaglandin E.2008

    • Author(s)
      Minamisawa S
    • Organizer
      (招待講演)2008Pediatric Research Workshop 「what Animal Model Can Do in Pediatric Research」 by Taiwan Pediatric Association.
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] プロスタグランジンによる血管内膜肥厚:A new role for an old friend.2008

    • Author(s)
      南沢享
    • Organizer
      岩手医科大学先端医療研究センター公開シンポジウム「バイオイメージングと分子生物学による脳・血管解明-健康増進に向けた最先端研究」
    • Place of Presentation
      盛岡・岩手県医師会館
    • Year and Date
      2008-07-19
    • Related Report
      2010 Final Research Report
  • [Presentation] プロスタグランジンによる血管内膜肥厚 : A new role for an old friend.2008

    • Author(s)
      南沢 享
    • Organizer
      岩手医科大学先端医療研究センター公開シンポジウム「バイオイメージングと分子生物学による脳・血管解明-健康増進に向けた最先端研究」
    • Place of Presentation
      盛岡・岩手県医師会館
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 構造変化から見た動脈管閉鎖機構2008

    • Author(s)
      南沢享
    • Organizer
      第7回心臓血管発生研究会
    • Place of Presentation
      磐梯熱海温泉ホテル華の湯
    • Year and Date
      2008-07-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 構造変化から見た動脈管閉鎖機構.2008

    • Author(s)
      南沢 享
    • Organizer
      第7回心臓血管発生研究会
    • Place of Presentation
      福島県磐梯熱海市
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Calcium in the heart : An old friend for new roles.2008

    • Author(s)
      南沢 享
    • Organizer
      (教育講演)第44回日本小児循環器学会学術集会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] EPAC promotes pathophysiological neointima formation in rodent artery.2008

    • Author(s)
      Sinica, et al.
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-04-08
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Prostaglandin E-cAMP signals promote neointimal cushion formation in the ductus arteriosus.2008

    • Author(s)
      南沢享
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Prostaglandin E2 in the Ductus Arteriosus : A New Role for an Old Friend.2008

    • Author(s)
      南沢享
    • Organizer
      CNSI-ASMeW Joint Symposium on Nano-scale Research into Biosenors, Biomaterials, and Nanotoxicology.
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      2008-03-06
    • Related Report
      2010 Final Research Report
  • [Presentation] c-AMP dependent intimal cushion formation of the rat ductus arteriosus.2008

    • Author(s)
      南沢享
    • Organizer
      The 4th Joint Scientific Symposium University of Bonn and Waseda University.
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-02-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of regulatory factors and innovation of novel therapeutic strategy for neointimal thickening of arteries.2008

    • Author(s)
      南沢享, et al.
    • Organizer
      ASMeW International Symposium. "Realizing High Quality of Life and Extension of Health Life Expectancy" Waseda International Conference Center
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] Blockade of T-type calcium channels attenuates smooth muscle cell migration, neointimal formation, and oxygen-induced vascular contraction in rat ductus arteriosus.2008

    • Author(s)
      Akaike T, et al.
    • Organizer
      China-Korea-Japan Pediatric Heart Forum 2008
    • Place of Presentation
      Fukushima
    • Related Report
      2010 Final Research Report
  • [Presentation] Blockade of T-type calcium channels attenuates smooth muscle cell migration, neointimal formation, and oxygen-induced vascular contraction in rat ductus arteriosus. Pediatric Academic Societies and The 4th Congress of Asian Society for2008

    • Author(s)
      Akaike T, et al.
    • Organizer
      Pediatric Research Joint Meeting.
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] PGE2-activated EPAC promotes neointimal cushion formation of the rat ductus arteriosus in a distinct way of PKA.2008

    • Author(s)
      Akaike T, et al.
    • Organizer
      Pediatric Academic Societies and The 4th 42. Congress of Asian Society for Pediatric Research Joint Meeting.
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット動脈管における酸素濃度の上昇と平滑筋細胞遊走能の関連の検討2008

    • Author(s)
      赤池徹, 他
    • Organizer
      第111回日本小児科学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] T-type calcium channels regulate smooth muscle cell migration, neointimal formation, and oxygen-induced vascular contraction in rat ductus arteriosus.2008

    • Author(s)
      Akaike T, et al.
    • Organizer
      Experimantal Biology 2008
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Rising oxygen tension promoted smooth muscle cell migration in the rat ductus arteriosus.2008

    • Author(s)
      赤池徹, 他
    • Organizer
      第72回日本循環器学会総会
    • Place of Presentation
      福岡(ポスター発表)
    • Related Report
      2010 Final Research Report
  • [Presentation]2008

    • Author(s)
      赤池徹, 他
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京(ポスター発表)
    • Related Report
      2010 Final Research Report
  • [Presentation] Blockade of T-type calcium channels attenuates smooth muscle cell migration. neointimal formation, and oxygen-induced vascular contraction in rat ductus arteriosus.2008

    • Author(s)
      Akaike T., et al.
    • Organizer
      China-Korea-Japan Pediatrio Heart Forum 2008
    • Place of Presentation
      Fukushima, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sarcalumenin plays a critical role in age-dependent reduction in cardiac function and SERCA2a activity2008

    • Author(s)
      Jiao 0, et. al.
    • Organizer
      Experimental Biology 2008.
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] T-type calcium channels regulate smooth museIe cell migration, neointimai formation, and oxygen-induced vascular contraction in rat ductus arteriosus.2008

    • Author(s)
      Akaike T., et al.
    • Organizer
      Experimantal Biology 2008
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] PGE2-aotivated EPAC promotes neointimal cushion formation of the rat ductus arteriosus in a distinct way of PKA.2008

    • Author(s)
      Akaike T., et al.
    • Organizer
      Pediatric Academic Societies and The 4th Congress of Asian Society for Pediatric Research Joint Meeting.
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラツト動脈管における酸素濃度の上昇と平滑筋細胞遊走能の関連の検討.2008

    • Author(s)
      赤池徹, 他
    • Organizer
      第111回日本小児科学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://web.mac.com/sminamisawa/set/Welcome.h

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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