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Animal model for dystrophic epidermolysis bullosa and acquired epidermolysis bullosa using genetically engineered mice of type VII collagen

Research Project

Project/Area Number 20390305
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionHirosaki University

Principal Investigator

SAWAMURA Daisuke  Hirosaki University, 大学院・医学研究科, 教授 (60196334)

Co-Investigator(Kenkyū-buntansha) NAKANO Hajime  弘前大学, 大学院・医学研究科, 准教授 (90281922)
MATSUZAKI Yasushi  弘前大学, 医学部附属病院, 講師 (50322946)
Co-Investigator(Renkei-kenkyūsha) SHIMIZU Hiroshi  北海道大学, 大学医学研究科, 教授 (00146672)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords表皮水疱症 / VII型ゴラーゲン / 基底膜 / 遺伝子治療 / マウスモデル / 自己免疫 / 皮膚 / 抗体 / VII型コラーゲン / 遺伝子 / 後天性表皮水疱症 / 動物モデル / 自己免疫性疾患 / ノックアウトマウス / トランスジェニックマウス
Research Abstract

Type VII collagen is a structural protein within basement membrane zone and its gene defect leads to dystrophic epidermolysis bullosa. Also generation of autoantibody against type Vii collagen causes acquired epidermolysis bullosa. Thus, type VII collagen is a major protein in the field of dermatology. The purposes of this study are to establish models of those type VII collagen related diseases and make great contributions for disclosing disease mechanisms and development of new effective treatments using genetically engineered mice. In this study we could generate model mouse of dystrophic epidermolysis which can survive for long time. However, we could not detect auto antibody against type VII collagen in the model mice for acquired epidermolysis. Furthermore, we performed mutation analysis of patients with epidermolysis bullosa.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (66 results)

All 2011 2010 2009 2008 Other

All Journal Article (63 results) (of which Peer Reviewed: 50 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Hair follicle stem cells provide a functional niche for melanocyte stem cells.2011

    • Author(s)
      Tanimura S, Tadokoro Y, Inomata K, Tanaka Y, Nishie W, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK
    • Journal Title

      Cell Stem Cell 8

      Pages: 177-187

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Raf kinase inhibitor protein expression correlates with differentiation but does not affect MAP kinase pathway activity in cutaneous squamous cell carcinoma2010

    • Author(s)
      Rokunohe D, Nakano H, Akasaka E, Kimura K, Takiyoshi N, Nakajima K, AIzu T, Kaneko T, Matsuzaki Y, Tsuchida S, Sawamura D.
    • Journal Title

      J Dermatol Sci 60

      Pages: 199-201

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation2010

    • Author(s)
      Takemoto H, Tamai K, Akasaka E, Rokunohe D, Takiyoshi N, Umegaki N, Nakajima K, Aizu T, Kaneko T, Nakano H, Sawamura D
    • Journal Title

      J Dermatol Sci 60

      Pages: 203-205

    • NAID

      10027841207

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] is an early sign of blast transformation that may mimic a common skin disease : sycosis-like eruptions in chronic myelomonocytic leukemia.2010

    • Author(s)
      Takeuchi S, Akasaka E, Rokunohe D, Kayo SJ, Matsuzaki Y, Ooshima H, Nakano H, Sawamura D. Leukemia cutis
    • Journal Title

      J Dermatol 37

      Pages: 916-918

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of autoantibody-initiated tissue damage by using recombinant fab antibody fragments against pathogenic autoantigen.2010

    • Author(s)
      Wang G, Ujiie H, Shibaki A, Nishie W, Tateishi Y, Kikuchi K, Li Q, McMillan JR, Morioka H, Sawamura D, Nakamura H, Shimizu H
    • Journal Title

      Am J Pathol 176

      Pages: 914-925

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex.2010

    • Author(s)
      Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Bruckner-Tuderman L, Shimizu H
    • Journal Title

      Hum Mutat 31

      Pages: 308-316

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Response of intractable skin ulcers in recessive dystrophic epidermolysis bullosa patients to an allogeneic cultured dermal substitute.2010

    • Author(s)
      Natsuga K, Sawamura D, Goto M, Homma E, Goto-Ohguchi Y, Aoyagi S, Akiyama M, Kuroyanagi Y, Shimizu H
    • Journal Title

      Acta Derm Venereol 90

      Pages: 165-169

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen2010

    • Author(s)
      Ujiie H, Shibaki A, Nishie W, Sawamura D, Wang G, Tateishi Y, Li Q, Moriuchi R, Qiao H, Nakamura H, Akiyama M, Shimizu H
    • Journal Title

      J Immunol 184

      Pages: 2166-2174

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disseminated lupus vulgaris diagnosed more than 63 years after onset due to early misdiagnosis as a port-wine stain2010

    • Author(s)
      Takeuchi S, Nakano H, Daiki R, Akasaka E, Nishizawa A, Matsuzaki Y, Sawamura D
    • Journal Title

      Clin Exp Dermatol 35

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overview of epidermolysis bullosa.2010

    • Author(s)
      Sawamura D, Nakano H, Matsuzaki Y.
    • Journal Title

      J Dermatol 37

      Pages: 214-219

    • NAID

      10027066027

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Linear immunoglobulin A bullous dermatosis possibly induced by mefenamic acid.2010

    • Author(s)
      Jiin K, Nakano H, Akasaka E, Rokunohe D, Minakawa S, Ishii N, Hashimoto T, Sawamura D
    • Journal Title

      J Dermatol 37

      Pages: 269-271

    • NAID

      10027066309

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice2010

    • Author(s)
      Fujita Y, Abe R, Inokuma D, Sasaki M, Hoshina D, Natsuga K, Nishie W, McMillan JR, Nakamura H, Shimizu T, Akiyama M, Sawamura D, Shimizu H
    • Journal Title

      Proc Natl Acad Sci USA. 107

      Pages: 14345-14350

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice.2010

    • Author(s)
      Fujita Y
    • Journal Title

      Proc Natl Acad Sci

      Volume: 107 Pages: 14345-14350

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linear immunog lobulin A bullous dermatosis possibly induced by mefenamic acid.2010

    • Author(s)
      Jin K
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 269-271

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overview of epidermolysis bullosa.2010

    • Author(s)
      Sawamura D
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 214-219

    • NAID

      10027066027

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disseminated lupus vulgaris diagnosed more than 63 years after onset due to early misdiagnosis as a port-wine stain.2010

    • Author(s)
      Takeuchi s
    • Journal Title

      Clin Exp Dermatol

      Volume: 35

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anovel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen.2010

    • Author(s)
      Ujiie H
    • Journal Title

      J Immunol

      Volume: 184 Pages: 2166-2174

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response of intractable skin ulcers in recessive dystrophic epidermolysis bullosa patients to an allogeneic cultured dermalsubstitute2010

    • Author(s)
      Natsuga K
    • Journal Title

      Acta Derm Venereol

      Volume: 90 Pages: 165-169

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex.2010

    • Author(s)
      Natsuga K
    • Journal Title

      Hum Mutat

      Volume: 31 Pages: 308-316

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of autoantibody-initiated tissue damage by using recombinant fab antibody fragments against pathogenic autoantigen.2010

    • Author(s)
      Wang G
    • Journal Title

      Am J Pathol

      Volume: 176 Pages: 914-925

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leukemia cutis is an early sign of blast transformation that may mimic a common skin disease : sycosis-like eruptions in chronic Myelomonocytic leukemia.2010

    • Author(s)
      Takeuchi s
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 916-918

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation between the expression levels of the POU transcription factors Skn-la and Skn-1n and keratinocyte differentiation.2010

    • Author(s)
      Takemoto H
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 203-205

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Raf kinase inhibitor protein expression correlates with differentiation but does not affect MAP kinase pathway activityin cuta neous squamous cell carcinoma.2010

    • Author(s)
      Rokunohe D
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 199-201

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hair follicle stem cells provide a functional niche for melanocyte stem cells.2010

    • Author(s)
      Tanimura S
    • Journal Title

      Cell Stem Cell

      Volume: 8 Pages: 177-187

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response of intractable skin ulcers in recessive dystrophic epidermolysis bullosa patients to an allogeneic cultured dermal substitute.2010

    • Author(s)
      Sawamura D
    • Journal Title

      Acta Derm Venereol. 90

      Pages: 165-169

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen.2010

    • Author(s)
      Ujiie H, Sawamura D
    • Journal Title

      J Immunol. 184

      Pages: 2166-2184

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex.2010

    • Author(s)
      Natsuga K, Sawamura D
    • Journal Title

      Hum Mutat. 31

      Pages: 308-316

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The compound heterozygote for new/recurrent COL7A1 mutations in a Japanese patient with bullous dermolysis of the newborn.2009

    • Author(s)
      Hashikawa K, Hamada T, Ishii N, Fukuda S, Kuroki R, Nakama T, Yasumoto S, Tamai K, Nakano H, Sawamura D, Hashimoto T
    • Journal Title

      J Dermatol Sci 56

      Pages: 66-68

    • NAID

      10029372278

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel humanized neonatal autoimmune blistering skin disease model induced by maternally transferred antibodies.2009

    • Author(s)
      Nishie W, Sawamura D, Natsuga K, Shinkuma S, Goto M, Shibaki A, Ujiie H, Olasz E, Yancey KB, Shimizu H
    • Journal Title

      J Immunol 183

      Pages: 4088-4093

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Keratinocyte-/fibroblast-targeted rescue of Col7a1-disrupted mice and generation of an exact dystrophic epidermolysis bullosa model using a human COL7A1 mutation.2009

    • Author(s)
      Ito K, Sawamura D, Goto M, Nakamura H, Nishie W, Sakai K, Natsuga K, Shinkuma S, Shibaki A, Uitto J, Denton CP, Nakajima O, Akiyama M, Shimizu H
    • Journal Title

      Am J Pathol, 175

      Pages: 2508-2517

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cowden syndrome : a novel mutation and overlooked glycogenic acanthosis in gingiva.2009

    • Author(s)
      Nishizawa A, Satoh T, Watanabe R, Takayama K, Nakano H, Sawamura D, Yokozeki H
    • Journal Title

      Br J Dermatol 160

      Pages: 1116-1118

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Birt-Hogg-Dube syndrome with clear-cell and oncocytic renal tumour and trichoblastoma associated with a novel FLCN mutation.2009

    • Author(s)
      Imada K, Dainichi T, Yokomizo A, Tsunoda T, Song YH, Nagasaki A, Sawamura D, Nishie W, Shimizu H, Fukagawa S, Urabe K, Furue M, Hashimoto T, Naito S
    • Journal Title

      Br J Dermatol 160

      Pages: 1350-1353

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel and recurrent nonsense mutation of the SLC39A4 gene in Japanese patients with acrodermatitis enteropathica.2009

    • Author(s)
      Nakano H, Nakamura Y, Kawamura T, Shibagaki N, Matsue H, Aizu T, Rokunohe D, Akasaka E, Kimura K, Nishizawa A, Umegaki N, Mitsuhashi Y, Shimada S, Sawamura D
    • Journal Title

      Br J Dermatol. 161

      Pages: 184-186

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Japanese family with dominant pretibial dystrophic epidermolysis bullosa : Identification of a new glycine substitution in the triple-helical collagenous domain of type VII collagen.2009

    • Author(s)
      Hamada T, Fukuda S, Ishii N, Abe T, Nagata K, Koro O, Hatano Y, Nakano H, Sawamura D, Hashimoto T
    • Journal Title

      J Dermatol Sci 54

      Pages: 212-214

    • NAID

      10025333973

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A severe and refractory case of anti-p200 pemphigoid resulting in multiple skin ulcers and scar formation.2009

    • Author(s)
      Goto-Ohguchi Y, Nishie W, Akiyama M, Tateishi Y, Aoyagi S, Tsuji-Abe Y, Sawamura D, Ishii N, Hashimoto T, Shimizu H
    • Journal Title

      Dermatology 218

      Pages: 265-271

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Haber's syndrome may be a clinical entity different from Dowling-Degos disease.2009

    • Author(s)
      Nishizawa A, Nakano H, Satoh T, Takayama K, Sawamura D, Yokozeki H
    • Journal Title

      Br J Dermatol 160

      Pages: 215-217

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chromosome 22q11.2 deletion syndrome associated with severe eczema.2009

    • Author(s)
      Minakawa S, Nakano H, Takeda H, Mizukami H, Yagihashi S, Satou T, Sawamura D
    • Journal Title

      Clin Exp Dermatol 34

      Pages: 410-411

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel p.M1T and recurrent p.G301S mutations in cathepsin C in a Japanese patient with Papillon-Lefevre syndrome : implications for understanding the genotype/phenotype relationship.2009

    • Author(s)
      Ochiai T, Nakano H, Rokunohe D, Akasaka E, Toyomaki Y, Mitsuhashi Y, Sawamura D
    • Journal Title

      J Dermatol Sci 53

      Pages: 73-75

    • NAID

      10025332173

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Squamous cell carcinoma arising from Darier's disease.2009

    • Author(s)
      Matsui K, Sawamura D
    • Journal Title

      Clin Exp Dermatol. 34

      Pages: 1015-1016

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of autoantibody-initiated tissue damage by using recombinantfab antibody fragments against pathogenic autoantigen.2009

    • Author(s)
      Wang G, Sawamura D
    • Journal Title

      Am J Pathol. 176

      Pages: 914-925

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Keratinocyte-/fibroblast-targeted rescue of Col7al-disrupted mice and generation of an exact dystrophic epidermolysis bullosa model using a human COL7A1 mutation.2009

    • Author(s)
      Ito K, Sawamura D
    • Journal Title

      Am J Pathol. 175

      Pages: 914-925

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scleroedema adultorum associated with sarcoidosis.2009

    • Author(s)
      Inokuma D, Sawamura D
    • Journal Title

      Clin Exp Dermatol. 34

      Pages: 428-429

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A linear basal cell carcinoma undergoing spontaneous regression.2009

    • Author(s)
      Takiyoshi N, Sawamura D
    • Journal Title

      Clin Exp Dermatol 34

      Pages: 411-413

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel humanized neonatal autoimmune blistering skin disease model induced by maternally transferred antibodies.2009

    • Author(s)
      Nishie W, Sawamura D
    • Journal Title

      J Immunol. 183

      Pages: 962-963

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An eclipse in the subungual space : a diagnostic sign for a subungual epidermal cyst?2009

    • Author(s)
      Takiyoshi N, Sawamura D
    • Journal Title

      Br J Dermatol. 161

      Pages: 962-963

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      澤村大輔
    • Journal Title

      からだの科学262(日本評論社)

      Pages: 47-50

    • Related Report
      2009 Annual Research Report
  • [Journal Article] A novel homozygous missense mutation in the fatty aldehyde dehydrogenase gene causes Sjogren-Larsson syndrome.2008

    • Author(s)
      Nakano H, Akasaka E, Rokunohe D, Yokoyama S, Toyomaki Y, Umegaki N, Mitsuhashi Y, Sawamura D
    • Journal Title

      J Dermatol Sci 52

      Pages: 136-138

    • NAID

      10024457607

    • Related Report
      2010 Final Research Report
  • [Journal Article] A de novo missense mutation in the keratin 13 gene in oral white sponge nevus2008

    • Author(s)
      Nishizawa A, Nakajima R, Nakano H, Sawamura D, Takayama K, Satoh T, Yokozeki H
    • Journal Title

      Br J Dermatol 159

      Pages: 974-975

    • Related Report
      2010 Final Research Report
  • [Journal Article] Vitamin D3 inhibits expression of pemphigus vulgaris antigen, desmoglein 3 : implication of partial mechanism in pharmacological effect of VD3 on skin diseases.2008

    • Author(s)
      Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, Kaneko T, Sawamura D
    • Journal Title

      Mol Med Rep 1

      Pages: 581-583

    • Related Report
      2010 Final Research Report
  • [Journal Article] Clinical and Genetic analysis of Fabry disease : report of 6 cases including 3 heterozygous females.2008

    • Author(s)
      Nagasaki A, Nishie W, Sato K, Oba I, Noguchi E, Akitsu H, Sawamura D, Shimizu H
    • Journal Title

      J Dermatol Sci 52

      Pages: 61-64

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genotype-phenotype correlation in non-Hallopeau-Siemens recessive dystrophic epidermolysis bullosa : The splice site mutation c.6216+5G>T in the COL7A1 gene results in aberrant and normal splicings.2008

    • Author(s)
      Hamada T, Fukuda S, Ishii N, Sakaguchi S, Ishikawa T, Abe T, Yasumoto S, Hashimoto T, Nakano H, Sawamura D
    • Journal Title

      J Dermatol Sci 50

      Pages: 147-150

    • NAID

      10024118958

    • Related Report
      2010 Final Research Report
  • [Journal Article] Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas.2008

    • Author(s)
      Kivisaari AK, Kallajoki M, Mirtti T, McGrath JA, Bauer JW, Weber F, Konigova R, Sawamura D, Sato-Matsumura KC, Shimizu H, Csikos M, Sinemus K, Beckert W, Kahari VM
    • Journal Title

      Br J Dermatol 158

      Pages: 778-1785

    • Related Report
      2010 Final Research Report
  • [Journal Article] Calcineurin/NFAT-dependent regulation of 230-kDa bullous pemphigoid antigen (BPAG1) gene expression in normal human epidermal keratinocytes.2008

    • Author(s)
      Aizu T, Tamai K, Nakano H, Rokunohe D, Toyomaki Y, Uitto J, Sawamura D
    • Journal Title

      J Dermatol Sci 51

      Pages: 45-51

    • NAID

      10024119446

    • Related Report
      2010 Final Research Report
  • [Journal Article] Papillon-Lefevre syndrome and malignant melanoma : a high incidence of melanoma development in Japanese palmoplanter keratoderma patients.2008

    • Author(s)
      Nakajima K, Nakano H, Takiyoshi N, Rokunohe D, Ikenaga S, Aizu T, Kaneko T, Mitsuhashi Y, Sawamura D
    • Journal Title

      Dermatol 217

      Pages: 58-62

    • Related Report
      2010 Final Research Report
  • [Journal Article] Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders.2008

    • Author(s)
      Sato-Jin K, Nishimura EK, Akasaka E, Huber W, Nakano H, Miller A, Du J, Wu M, Hanada K, Sawamura D, Fisher DE, Imokawa G
    • Journal Title

      FASEB J 22

      Pages: 1155-1168

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of Skn-1n, a splice variant that is induced by high calcium concentration and specifically expressed in normal human keratinocytes.2008

    • Author(s)
      Nakajima K, Tamai K, Yamazaki T, Toyomaki Y, Nakano H, Uitto J, Sawamura D.
    • Journal Title

      J Invest Dermatol 128

      Pages: 1336-1339

    • Related Report
      2010 Final Research Report
  • [Journal Article] Vitamin D3 inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis.2008

    • Author(s)
      Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, Kaneko T, Sawamura D
    • Journal Title

      J Dermatol Sci 50

      Pages: 155-158

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reduction in epidermal Langerhans cells in patients with necrolytic migratory erythema.2008

    • Author(s)
      Rokunohe D, Nakano H, Ikenaga S, Umegaki N, Kaneko T, Matsuhashi Y, Tando Y, Toyoki Y, Hakamada K, Kusumi T, Harada K, Sawamura D
    • Journal Title

      J Dermatol Sci 50

      Pages: 76-80

    • NAID

      10031136041

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genotype-phenotype correlation in non-Hallopeau-Siemens recessive dystrophic epidermolysis bullosa : the splice site mutation c.6216+5G > T in the COL7A1 gene results in aberrant and normal splicings2008

    • Author(s)
      Hamada T
    • Journal Title

      J Dermatol Sci 50

      Pages: 147-150

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin D(3) inhibits expression of bullous pemphigoid antigenl through post-transcriptional mechanism without new protein synthesis2008

    • Author(s)
      Yamamoto C
    • Journal Title

      J Dermatol Sci 50

      Pages: 155-158

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas2008

    • Author(s)
      Kivisaari AK
    • Journal Title

      Br J Dermatol 158

      Pages: 778-785

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcineurin/NFAT-dependent regulation of 230-kDa bullous pemphigoid antigen (BPAG1) gene expression in normal human epidermal keratinocytes2008

    • Author(s)
      Aizu T
    • Journal Title

      J Dermatol Sci 51

      Pages: 45-51

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of sentinel node biopsy in the management of squamous cell carcinoma arising from recessive dystrophic epidermolysis bullosa2008

    • Author(s)
      Rokunohe A
    • Journal Title

      J Dermatol 35

      Pages: 336-340

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Book] やさしい皮膚科学2009

    • Author(s)
      澤村大輔
    • Total Pages
      248
    • Publisher
      診断と治療社
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.med.hirosaki-u.ac.jp/~derma/index.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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