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Effects of early postnatal stress on the development of 5-HT/GABA co-localized neuron in the raphe nuclei

Research Project

Project/Area Number 20390309
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHokkaido University

Principal Investigator

YOSHIOKA Mitsuhiro  北海道大学, 大学院・医学研究科, 教授 (40182729)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Taku  北海道大学, 大学院・医学研究科, 助教 (80325563)
IZUMI Takeshi  北海道大学, 大学院・医学研究科, 助教 (60312360)
YOSHIDA Takayuki  北海道大学, 大学院・医学研究科, 助教 (60374229)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords精神薬理学 / セロトニン / GABA / 縫線核 / 情動 / ストレス / 発達 / 海馬 / 内側前頭前野 / RT-PCR
Research Abstract

We characterized 5-HTergic neurons that also contained GAD67 compared to neurons containing only 5-HT through electrophysiological, molecular biological and neuroanatomical methods. We confirmed tryptophan hydroxylase 2 (TPH2) mRNA and GAD67 mRNA co-expression in the DRN via in situ hybridization and single-cell RT-PCR methods. We also demonstrated that GABA is not released into the synaptic cleft of these neurons. In the electrophysiological experiment, we found that the action potential amplitude, membrane resistance and firing frequency of both TPH2 and GAD67 mRNA-positive neurons were all significantly lower than in neurons that were positive for TPH2 mRNA only. An early postnatal stress disturbed the development of TPH2 and GAD67 mRNA-positive neurons.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (64 results)

All 2011 2010 2009 2008 Other

All Journal Article (24 results) (of which Peer Reviewed: 20 results) Presentation (35 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type 2 receptor2010

    • Author(s)
      Ohmura Y, Izumi T, Yamaguchi T, Tsutsui-Kimura I, Yoshida T, Yoshioka M.
    • Journal Title

      Neuropsychopharmacology

      Volume: 35(6) Pages: 1271-8

    • NAID

      120002548777

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex2010

    • Author(s)
      Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 209(4) Pages: 351-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats2010

    • Author(s)
      Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.
    • Journal Title

      Eur J Pharmacol

      Volume: 641(2-3) Pages: 148-53

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory throughthe corticotropin-releasing factor type 2 receptor2010

    • Author(s)
      Ohmura Y, Izumi T, Yamaguchi T, Tsutsui-Kimura I, Yoshida T, Yoshioka M
    • Journal Title

      Neuropsychopharmacology

      Volume: 35 Pages: 1271-278

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors2010

    • Author(s)
      Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T
    • Journal Title

      Psychopharmacoloey (Ber1)

      Volume: 209 Pages: 351-359

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats2010

    • Author(s)
      Isutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M
    • Journal Title

      Eur J Pharmacol

      Volume: 641 Pages: 148-153

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corticotropin releasing factor enhances attentional function as assessed by the five-choice serial reaction time task in rats2009

    • Author(s)
      Ohmura Y, Yamaguchi T, Futami Y, Togashi H, Izumi T, Matsumoto M, Yoshida T, Yoshioka M.
    • Journal Title

      Behav Brain Res

      Volume: 198(2) Pages: 429-33

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early postnatal stress affects 5-HT(1A) receptor function in the medial prefrontal cortex in adult rats2009

    • Author(s)
      Togashi H, Yamaguchi T, Yoshida T, Watanabe M, Yoshioka M.
    • Journal Title

      Eur J Pharmacol

      Volume: 615(1-3) Pages: 76-82

    • NAID

      120001452160

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trial of context-dependent fear memory in juvenile rat stress models : Simultaneous electrophysiological and behavioral analysis2009

    • Author(s)
      Koseki H, Matsumoto M, Togashi H, Miura Y, Fukushima K, Yoshioka M.
    • Journal Title

      Synapse

      Volume: 63(9) Pages: 805-13

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of serotonin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the three-choice serial reaction time task : a simple and valid model of impulsive action using rats2009

    • Author(s)
      Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.
    • Journal Title

      Behav Pharmacol

      Volume: 20(5-6) Pages: 474-83

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early postnatal stress and neural circuit underlying emotional regulation.2009

    • Author(s)
      Machiko Matsumoto
    • Journal Title

      International Review of Neurobiology 85

      Pages: 95-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trial of context-dependent fear memory in juvenile rat stress models : Simultaneous electrophysiological and behavioral analysis2009

    • Author(s)
      Hiroyo Koseki
    • Journal Title

      Synapse 5

      Pages: 805-813

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early postnatal stress affects 5-HT(1A)receptor function in the medial prefrontal cortex in adult rats.2009

    • Author(s)
      Hirokazu Matsuzaki
    • Journal Title

      Eur J Pharmacol. 1

      Pages: 76-82

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 社会不安障害(SAD)の生物学的基盤2009

    • Author(s)
      泉剛
    • Journal Title

      医薬ジャーナル 45

      Pages: 2094-2097

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 社会不安障害の脳機能と薬物療法2009

    • Author(s)
      泉剛
    • Journal Title

      臨床精神薬理 12

      Pages: 193-1937

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The effects of serotonin and/or noradrenaline reuptake inhibitors on impulsive-like action assessed by the three-choice serial reaction time task : a simple and valid model of impulsive action using rats.2009

    • Author(s)
      Iku Tsutsui-Kimura
    • Journal Title

      Behav Pharmacol. 20

      Pages: 474-83

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Roles of Corticotropin Releasing Factor(CRF)in Responses to Emotional Stress : Is CRF Release a Cause or Result of Fear/Anxiety?2009

    • Author(s)
      Yu Ohmura
    • Journal Title

      CNS Neurol Disord Drug Targets. 8

      Pages: 459-69

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 5-選択反応時間課題(5-choice serial reaction time task)/3-選択反応時間課題(3-choice serial reaction time task)による注意機能・衝動性の評価2009

    • Author(s)
      大村優
    • Journal Title

      日本薬理学雑誌 134

      Pages: 137-141

    • Related Report
      2009 Annual Research Report
  • [Journal Article] セロトニン系の発達と進化2009

    • Author(s)
      吉岡充弘
    • Journal Title

      小児科 50

      Pages: 2111-16

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats2009

    • Author(s)
      Satoshi Deyama
    • Journal Title

      Behavioural Brain Research 197

      Pages: 279-283

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corticotropin releasing factor enhances attentional function as assessed by the five-choice serial reaction time task in rats.2009

    • Author(s)
      Yu Ohmura
    • Journal Title

      Behavioural Brain Research 198

      Pages: 429-433

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible relationship between the stress-induced synaptic response and metaplasticity in the hippocampal CA1 field of freely moving rats2009

    • Author(s)
      Riki Hirata
    • Journal Title

      Synapse 63

      Pages: 549-556

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of stress-induced suppression of long-term potentiation in the hippocampal CA1 field of freely moving rats2008

    • Author(s)
      Riki Hirata
    • Journal Title

      Brain Research 1226

      Pages: 27-32

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the B-adrenoceptor?protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats2008

    • Author(s)
      Satoshi Deyama
    • Journal Title

      Journal of Neuroscience 28

      Pages: 7728-7736

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 内側前頭前野腹側部α4β2ニコチン性アセチルコリン受容体の衝動的行動における役割2011

    • Author(s)
      木村生, 大村優, 泉剛, 山口拓, 吉田隆行, 吉岡充弘
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-03-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 縫線核5-HT/GAD67共発現ニューロンの細胞学的特性2010

    • Author(s)
      鹿内浩樹,吉田隆行,今野幸太郎,泉剛,山口拓,吉岡充弘
    • Organizer
      第24回北海道薬物作用談話会
    • Place of Presentation
      北海道大学学術交流会館
    • Year and Date
      2010-07-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 3-選択反応時間課題を用いた衝動性関連疾患治療薬の探索2010

    • Author(s)
      木村生
    • Organizer
      第83回日本薬理学年会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット脳虚血後の異常行動に対する人工酸素運搬体の改善効果2010

    • Author(s)
      濱舘直史
    • Organizer
      第83回日本薬理学年会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 幼若期ストレス負荷は恐怖条件付けにおける海馬5-HT1A受容体機能を減弱させる2010

    • Author(s)
      松崎広和
    • Organizer
      第83回日本薬理学年会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 扁桃体基底外側核における内因性カンナビノイドを介する逆行性シグナル伝達機構2010

    • Author(s)
      吉田隆行
    • Organizer
      第83回日本薬理学年会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 正中縫線核から腹側海馬へのセロトニン神経投射がコルチコトロピン遊離因子タイプ2受容体を介して恐怖記憶の想起を制御する2010

    • Author(s)
      大村優
    • Organizer
      第83回日本薬理学年会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 両側扁桃体5-HT神経末破壊が不安関連行動に及ぼす効果2010

    • Author(s)
      泉剛
    • Organizer
      第83回日本薬理学年会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成熟ラットにおける正中縫線核5-HT神経およびGABA神経機能に及ぼす幼若期ストレスの影響2010

    • Author(s)
      今野幸太郎,松本真知子,泉剛,富樫廣子,吉田隆行,山口拓,長谷川宏幸,渡辺雅彦,吉岡充弘
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同年会
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2010 Final Research Report
  • [Presentation] パラボリックフライト(放物線飛行)によって誘導されるセロトニン関運遺伝子2009

    • Author(s)
      吉岡充弘
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      リジェール松山(松山市)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経活動による血流量上昇反応と長期増強現象の関連性2009

    • Author(s)
      濱舘直史
    • Organizer
      第39回日本神経精神薬理学会
    • Place of Presentation
      国立京都国際会議場(京都市)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 注意欠如・多動性障害モデルラットにおける多動性、注意機能障害および衝動的行動に対する選択的ノルアドレナリン再取り込み阻害薬atomoxetineの改善効果2009

    • Author(s)
      山口拓
    • Organizer
      第39回日本神経精神薬理学会
    • Place of Presentation
      国立京都国際会議場(京都市)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 条件付け恐怖で活性化される扁桃体基底外側核および間在核神経細胞の性質2009

    • Author(s)
      泉剛
    • Organizer
      第39回日本神経精神薬理学会
    • Place of Presentation
      国立京都国際会議場(京都市)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] The effects of milnacipran on impulsive-like action assessed by the 3-choice serial reaction time task : A simple and valid model of impulsive action using rats2009

    • Author(s)
      Iku Tsutsui-Kimura
    • Organizer
      第39回北米神経科学会年会
    • Place of Presentation
      McCormick Place convention center(Chicago, USA)
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Corticotropin releasing fator(CRF)in the median raphe nucleus evokes fear-related behavior via the activation of CRF type 2 receptor2009

    • Author(s)
      Yu Ohmura
    • Organizer
      第39回北米神経科学会年会
    • Place of Presentation
      McCormick Place convention center(Chicago, USA)
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Atypical antipsychotics ameliorate the impulsive behavior viaserotonin 5-HT_<2A> receptors in an ADHD model rat2009

    • Author(s)
      Taku Yamaguchi
    • Organizer
      第39回北米神経科学会年会
    • Place of Presentation
      McCormick Place convention center(Chicago, USA)
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association with the anxiolytic effects of diazepam and changes of synaptic efficacy in the hippocampal-MPFC pathway2009

    • Author(s)
      Hiroki Shikanai
    • Organizer
      35^<th> Congress on Science and Technology of Thailand
    • Place of Presentation
      The Tide Resort(チョンブリ、タイ)
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Juvenile Stress Induced Alteration of Development of the Serotonergic Nervous System in the Rat2009

    • Author(s)
      Mitsuhiro Yoshioka
    • Organizer
      35^<th> Congress on Science and Technology of Thailand
    • Place of Presentation
      The Tide Resort(チョンブリ、タイ)
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 扁桃体基底外側核における内因性カンナビノイドを介する逆行性シナプス伝達機構2009

    • Author(s)
      吉田隆行
    • Organizer
      第60回日本薬理学北部会
    • Place of Presentation
      富山国際会議場(富山市)
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of conditioned fear-induced c-Fos and phosphorylated CREB-positive cells in the basolateral amygdala2009

    • Author(s)
      Takeshi Izumi
    • Organizer
      22^<nd> ECNP Congress
    • Place of Presentation
      Istanbul Convention & Exhibition Centre(イスタンブール、トルコ)
    • Year and Date
      2009-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Early postnatal stress disturbs normal development of the serotonergic neurons in the raphe nuclei2009

    • Author(s)
      Mitsuhiro Yoshioka
    • Organizer
      9^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      Palais des Congres de Paris(パリ、フランス)
    • Year and Date
      2009-07-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] GABAergic neurons in the lateral habenula regulate anxiety-related behabior via the serotonergic raphe neurons2009

    • Author(s)
      Kohtaro Konno
    • Organizer
      9^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      Palais des Congres de Paris(パリ、フランス)
    • Year and Date
      2009-06-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 注意欠如・多動性障害モデルラット、幼若SHRSP/Ezo〜衝動性における行動薬理学的特性2009

    • Author(s)
      山口拓
    • Organizer
      第82回日本薬理学年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 3-choice serial reaction time task : 齧歯類における効率的な衝動性制御評価系の確立の試み2009

    • Author(s)
      筒井生
    • Organizer
      第82回日本薬理学年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 扁桃体基底外側核における内因性カンナビノイドシグナル伝達機構2009

    • Author(s)
      吉田隆行
    • Organizer
      第82回日本薬理学年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 正中縫線核におけるコルチコトロピン遊離因子(CRF)はCRF2受容体を介して恐怖関連行動を惹起する2009

    • Author(s)
      大村優
    • Organizer
      第82回日本薬理学年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Early postnatal stress disturbs normal development of the serotonergic neurons in the raphe nuclei2009

    • Author(s)
      M. Yoshioka
    • Organizer
      9th World Congress of Biological Psychiatry
    • Place of Presentation
      Paris
    • Related Report
      2010 Final Research Report
  • [Presentation] AD/HDモデルラット(SERSP)における皮質前頭前野機能2008

    • Author(s)
      鈴木直哉
    • Organizer
      第38回日本神経精神薬理学会
    • Place of Presentation
      品川プリンスホテル
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 幼若期ストレス負荷ラットの不安関連行動における性差と海馬シナプス応答2008

    • Author(s)
      重堂智加
    • Organizer
      第38回日本神経精神薬理学会
    • Place of Presentation
      品川プリンスホテル
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 幼若期ストレスによる成長後の社会的行動の欠如とGABA神経系の関与2008

    • Author(s)
      山口拓
    • Organizer
      第38回日本神経精神薬理学会
    • Place of Presentation
      品川プリンスホテル
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 疼痛関連不快情動反応における分界条床核内グルタミン酸神経情報伝達および一酸化窒素の役割2008

    • Author(s)
      近藤直人
    • Organizer
      第38回日本神経精神薬理学会
    • Place of Presentation
      品川プリンスホテル
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 海馬-前頭皮質神経伝達に及ぼす抗不安薬の影響2008

    • Author(s)
      鹿内浩樹
    • Organizer
      第59回日本薬理学会北部会
    • Place of Presentation
      仙台市情報・産業プラザ
    • Year and Date
      2008-09-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 幼若期ストレスによるSocial interaction行動障害2008

    • Author(s)
      山口拓
    • Organizer
      第59回日本薬理学会北部会
    • Place of Presentation
      仙台市情報・産業プラザ
    • Year and Date
      2008-09-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] AD/HDモデルの皮質前頭前野におけるDA神経機能-電気生理ならびに神経化学的評価-2008

    • Author(s)
      鈴木直哉
    • Organizer
      第59回日本薬理学会北部会
    • Place of Presentation
      仙台市情報・産業プラザ
    • Year and Date
      2008-09-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳虚血再灌流障害モデルラットの情動行動障害に対する人工酸素運搬体の効果2008

    • Author(s)
      濱舘直史
    • Organizer
      第82回日本薬理学年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-03-18
    • Related Report
      2008 Annual Research Report
  • [Book] 臨床精神薬理ハンドブック2009

    • Author(s)
      吉岡充弘(分担)
    • Total Pages
      428
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://hokudaineuropharmacol.com/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://hokudaineuropharmacol.com/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.hokudai.ac.jp/~pharm-1w/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許:重力変動ストレスの負荷方法、航空機、航空機の運転方法、セロトニン合成系遺伝子発現促進方法、セロトニン合成方法、中枢神経系刺激方法、および薬効測定方法2009

    • Inventor(s)
      落合俊昌, 吉岡充弘, 行徳淳一郎, 太田尚
    • Industrial Property Rights Holder
      三菱重工業株式会社
    • Industrial Property Number
      2009-253133
    • Filing Date
      2009-11-04
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2017-10-13  

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