| Project/Area Number |
20390310
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Gunma University |
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Principal Investigator |
FUKUDA Masato Gunma University, 大学院・医学系研究科, 准教授 (20221533)
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| Co-Investigator(Kenkyū-buntansha) |
MIKUNI Masahiko 群馬大学, 大学院・医学系研究科, 教授 (00125353)
UEHARA Toru 群馬大学, 健康支援総合センター, 准教授 (60303145)
KAMEYAMA Masaki 群馬大学, 大学院・医学系研究科, 助教 (00455982)
YUUKI Naoya 群馬大学, 大学院・医学系研究科, 助教 (20420193)
TAKAHASHI Keisuke 群馬大学, 医学部, 助教 (20455984)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 統合失調症 / 気分障害 / 意欲 / 近赤外線スペクトロスコピィ |
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| Research Abstract |
Brain substrates of motivational symptoms in psychiatric disorders were investigated using magnetic resonance imaging (MRI), near-infrared spectroscopy (NIRS), and magnetoencephalography (MEG). Prefrontal cortex volume and function correlated 1) with subjective sleepiness and fatigue, parental bonding in infancy, and cooperative personality in healthy subjects, 2) with global assessment of functioning (GAF), DNA polymorphism of sigma-1 receptor and catecholamine-O-methyl transferase (COMT) in schizophrenia, 3) with clinical symptoms in eating disorders, and 4) with mismatch negativity latency in bipolar disorder. These results suggest prefrontal cortex as brain substrates of motivational symptoms in psychiatric disorders.
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