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Mutations of CD38 in autism spectrum disorder and oxytocin treatment.

Research Project

Project/Area Number 20390311
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

MINABE Yoshio  Kanazawa University, 医学系, 教授 (60181947)

Co-Investigator(Kenkyū-buntansha) MUNESUE Toshio  金沢大学, 子どものこころの発達研究センター, 特任准教授 (50293353)
KIKUCHI Mitsuru  金沢大学, 医学系, 特任助教 (00377384)
NAKATANI Hideo  金沢大学, 附属病院, 助教 (10452103)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords自閉症 / オキシトシン / CD38 / 遺伝子研究 / 脳画像研究 / 全般性発達障害 / MEG / NIRS / 遺伝子 / 医療・福祉 / シグナル伝達 / 神経科学 / 臨床
Research Abstract

(1) We investigated the genetic variants of CD38 in subjects with autism spectrum disorder in association with symptomatology and Oxytocin plasma levels. (2) Single-blind, placebo-controlled study with 20 healthy male subjects demonstrated that oxytocin treatment results in considerable individual variability. There was no adverse event with this treatment. (3) In Japan, we followed up some patients whose family voluntary started to treat them with oxytocin nasal spray. Some patients who have some specific clinical feature showed the apparent improvement.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (57 results)

All 2011 2010 2009 2008 Other

All Journal Article (28 results) (of which Peer Reviewed: 18 results) Presentation (20 results) Book (4 results) Remarks (5 results)

  • [Journal Article] phenomenon in adolescents and adults with autism spectrum disorders : Case series.2011

    • Author(s)
      Tochimoto S, Kurata K, Munesue T'Time slip'
    • Journal Title

      Psychiatry Clin Neurosci.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced acetylchol inesterase activity in the fusiform gyrus in adults with autism spectrum disorders.2011

    • Author(s)
      Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwa In Y, Tsuchiya KJ, Matsumoto K, Take bayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T Irie T, Mori N.
    • Journal Title

      Arch Gen Psychiatry. 68(3)

      Pages: 306-313

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic responses to visual stimuli in cortex of adults and 3- to 4-year-old children.2011

    • Author(s)
      Remijn GB, Kikuchi M, Yoshimura Y, Shitamichi K, Ueno S, Nagao K, Munesue T, Kojima H, Minabe Y.
    • Journal Title

      Brain Res.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic responses to visual stimuli in cortex of adults and 3-to 4-year-old children2011

    • Author(s)
      Remijn, G.B., et al.
    • Journal Title

      Brain Research

      Volume: 1383 Pages: 242-251

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 躁うつ病治療薬2011

    • Author(s)
      棟居俊夫
    • Journal Title

      医薬ジャーナル増刊号「新薬展望」

      Volume: 47 Pages: 362-366

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Cd38 gene knockout juvenile mice : a model of oxytocin signal defects in autism.2011

    • Author(s)
      Higashida, et al.
    • Journal Title

      Biol.Pharm. Bull

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自閉症の原因遺伝子と治療:オキシトシンをめぐって2011

    • Author(s)
      東田陽博, 他
    • Journal Title

      日本小児心身医学会雑誌

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 自閉症スペクトラム障害におけるoxytocinの有効性2011

    • Author(s)
      棟居俊夫
    • Journal Title

      日本生物学的精神医学会誌

      Volume: (印刷中)

    • NAID

      120006555322

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Two genetic variants of CD38 in subjects with antism spectrum disorder and controls.2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
    • Journal Title

      Neurosci Res. 67(2)

      Pages: 181-91

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin signal and social behaviour : comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice.2010

    • Author(s)
      Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, Munesue T, Minabe Y, Kikuchi M, Ono Y, Korshunova N, Salmina AB.
    • Journal Title

      J Neuroendocrinol. 22(5)

      Pages: 373-379

    • NAID

      120002561624

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smaller insula and inferior frontal volumes in young adults with pervasive devel opmental disorders.2010

    • Author(s)
      Kosaka H, Omori M, Munesue T, Ishitobi M, Matsumura Y, Takahashi T, Narito K, Murata T, Saito DN, Uchiyama H, Morita T, Kikuchi M, Mizukami K, Okazawa H, Sadato N, Wada Y.
    • Journal Title

      Neuroimage. 50(4)

      Pages: 1357-1363

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 青年期双極性障害と白閉症スペクトラム障害との併存2010

    • Author(s)
      棟居俊夫
    • Journal Title

      そしてその薬物療法,臨床精神薬理 13巻

      Pages: 910-919

    • Related Report
      2010 Final Research Report
  • [Journal Article] Nurovascular coupling in the human somatosensory cortex : a single trial study.2010

    • Author(s)
      Kikuchi M, Shitamichi K, Ueno S, Yoshimura Y, Remijn BG, Nagao K, Munesue T, Iiyama K, Tsubokawa T, Haruta Y, Inoue Y, Watanabe K, Hashimoto T, Higashida H, Minabe Y
    • Journal Title

      Neuro Report 21

      Pages: 1106-1110

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurovascular coupling in the human somatosensory cortex : a single trial study.2010

    • Author(s)
      Kikuchi, M., et al.
    • Journal Title

      NeuroReport

      Volume: 21 Pages: 1106-1110

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin signal and social behaviour : comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice.2010

    • Author(s)
      Higashida, H., et al.
    • Journal Title

      J Neuroendocrinol

      Volume: 22 Pages: 373-379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue, T., et al.
    • Journal Title

      Neurosci Res

      Volume: 67 Pages: 181-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attentional engagement to sound : cortical hemodynamics assessed with near-infrared snectrosconv.2010

    • Author(s)
      Remijn, G.B., et al.
    • Journal Title

      Proceedings of the Acoustical Society of Japan

      Volume: 146 Pages: 807-809

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Differential amygdale response to lower face in patients with autistic spectrum disorders : an fMRI study2010

    • Author(s)
      Ishitobi M, et al.
    • Journal Title

      Res.Autism Spectr. Disord

      Volume: 5 Pages: 910-919

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 青年期双極性障害と自閉症スペクトラム障害との併存、そしてその薬物療法2010

    • Author(s)
      棟居俊夫
    • Journal Title

      臨床精神薬理

      Volume: 13 Pages: 921-926

    • Related Report
      2010 Annual Research Report
  • [Journal Article] オキシトシンとバゾプッレシン:社会性認知行動と信頼の神経化学的基盤2010

    • Author(s)
      東田陽博, 他
    • Journal Title

      子どものこころと脳の発達

      Volume: 1 Pages: 80-89

    • Related Report
      2010 Annual Research Report
  • [Journal Article] オキシトシンと発達障害2010

    • Author(s)
      東田陽博, 他
    • Journal Title

      脳21

      Volume: 13 Pages: 211-214

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 青年期の双極II型障害:診断上の注意点2010

    • Author(s)
      棟居俊夫
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 21 Pages: 195-198

    • NAID

      10029784939

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Oxytocin signal and social behavior : comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice2010

    • Author(s)
      Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, Munesue T, Minabe Y, Kikuchi M, Ono Y, Korshunova N, Salmina AB
    • Journal Title

      Journal of Neuroendocrinology Epub ahead of print

    • NAID

      120002561624

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart rate variability in drug-naive patients with panic disorder and major depressive disorder.2009

    • Author(s)
      Kikuchi M, Hanaoka A, Kidani T, Remijn GB, Minabe Y, Munesue T, Koshino Y.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 33(8)

      Pages: 1474-1478

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related variation in EEG complexity to photic stimulation : a multiscale entropy a nalysis.2009

    • Author(s)
      Takahashi T, Cho RY, Murata T, Mizuno T, Kikuchi M, Mizukami K, Kosaka H, Takahashi K, Wada Y.
    • Journal Title

      Clin Neurophysiol. 120

      Pages: 476-483

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自閉症の脳イメージング2009

    • Author(s)
      中村和彦、菊知充
    • Journal Title

      精神科 14巻

      Pages: 112-120

    • Related Report
      2010 Final Research Report
  • [Journal Article] Heart rate variability in drug-naive patients with panic disorder and major depressive disorder2009

    • Author(s)
      Kikuchi M, Hanaoka A, Kidani T, Remijn GB, Minabe Y, Munesue T., Koshino Y
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 33

      Pages: 1474-1478

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of bipolar disorder comorbidity in adolescents and young adults with high-functioning autism spectrum disorder : a preliminary study of 44 outpatients.2008

    • Author(s)
      Munesue T, Ono Y, Match K, Shimoda K, Nakatani H, Kikuchi M
    • Journal Title

      J Affect Disord. 111(2-3)

      Pages: 170-175

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Advantages and pitfalls of segmentation methods using texture, anatomical features, and VBM on brain MR images.2010

    • Author(s)
      Hayashi, N Sanada, S Miyati T, Suzuki M, Kikuchi M, Matsui O, Minabe Y, Yamamoto T, Minehiro K, Sakuta K, Takanaga M, Kawashima H
    • Organizer
      Radiological Society of North America 2010 96th Scientific Assembly and Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2010-11-30
    • Related Report
      2010 Final Research Report
  • [Presentation] バンビプラン-広汎性発達障害の早期診断にむけて-2010

    • Author(s)
      三辺義雄
    • Organizer
      第一回金沢大学子どものこころサミット
    • Place of Presentation
      金沢大学病院「宝ホール」金沢市(石川県)
    • Year and Date
      2010-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] バンビプラン-広汎性発達障害の早期診断にむけて-2010

    • Author(s)
      三辺義雄
    • Organizer
      第一金沢大学子どものこころサミット
    • Place of Presentation
      金沢大学病院「宝ホール」金沢市(石川県)
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子どもに優しい脳発達研究プロジェクト:バンビプラン2010

    • Author(s)
      菊知充、渡邊克巳、鈴木道雄、春田康博、井上芳浩、三邉義雄
    • Organizer
      第19回海馬と高次脳機能学会
    • Place of Presentation
      金沢市(石川県)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 子どもに優しい脳発達研究プロジェクト:バンビプラン2010

    • Author(s)
      菊知充
    • Organizer
      第19回海馬と高次脳機能学会
    • Place of Presentation
      湯涌創作の森金沢市(石川県)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Auditory evoked response of speech stimuli in 3- to 4-year-old children : a magnetoencephalography study.2010

    • Author(s)
      Yoshimura Y.Kikuchi M., Shitamichi, K., Ueno, S., Nagao, K.Minabe Y.
    • Organizer
      International Congress of Clinical Neurophysiology (ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Correlations between the development of cognitive functions and spontaneous MEG responses of healthy 3- to 4-year-old infants.2010

    • Author(s)
      Nagao, K.Kikuchi M., oshimura Y.Shitamichi, K., Ueno, S.Minabe Y.
    • Organizer
      International Congress of Clinical Neurophysiology (ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] NIRS-measurements of cortical hemodynamic activity in adults and preschool infants in response to static and motion stimuli.2010

    • Author(s)
      Remi jn, G.B., Kikuchi M., Yoshimura, Y., Shitamichi, K., Ueno, S.,Nagao, K., Kojima, H., Minabe Y.
    • Organizer
      International Congress of Clinical Neurophysiology (TCCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] NIRS-measurements of cortical hemodynamic activity in adults and preschool infants in response to static and motion stimuli.2010

    • Author(s)
      Remijn, G.B., et al.
    • Organizer
      International Congress of Clinical Neurophysiology (ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bambi Plan : project with NIRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children.2010

    • Author(s)
      三辺義雄
    • Organizer
      2010Kanazawa-Chonbuk Symposium Speakers.
    • Place of Presentation
      Symposium in Chonbuk University (Chonbuk, Korea)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Bambi Plan : project with NIRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children.2010

    • Author(s)
      三辺義雄
    • Organizer
      2010Kanazawa-Chonbuk Symposium Speakers
    • Place of Presentation
      Symposium in Chonbuk University (Chonbuk, Korea)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bambi plan : Project with NIRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children.2010

    • Author(s)
      三辺義雄
    • Organizer
      第37回日本脳科学会
    • Place of Presentation
      天津医科大学 国際会議センター(中国)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Bambi plan : Project with MRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children.2010

    • Author(s)
      三辺義雄
    • Organizer
      第37回日本脳科学会
    • Place of Presentation
      天津医科大学国際会議センター(中国)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] オキシトシン放出を制御するCD38と自閉症との関係:Syntocinonの個人使用を含めて.2010

    • Author(s)
      棟居俊夫、東田陽博
    • Organizer
      第3回発達障害の病態と治療研究ネットワーク
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-09
    • Related Report
      2010 Final Research Report
  • [Presentation] オキシトシン放出を制御するCD38と自閉症との関係:Syntocinonの個人使用を含めて2010

    • Author(s)
      棟居俊夫、東田陽博
    • Organizer
      第3回発達障害の病態と治療研究ネットワーク
    • Place of Presentation
      リーガロイヤルホテル小倉北九州市(福岡県)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抑うつ状態を呈する思春期の若者たちの診断および治療の留意点2010

    • Author(s)
      棟居俊夫
    • Organizer
      第7回日本うつ病学会ワークショップ「思春期の気分障害」
    • Place of Presentation
      石川県立音楽堂金沢市(石川県)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] A study on the relation between factor indices of WISC-III and symptoms ofASD children evaluated by PARS2010

    • Author(s)
      Nagao, K., Munesue, T
    • Organizer
      19^<th> World Congress of the International Association for Child and Adolescent Psychiatry and Allied Professions
    • Place of Presentation
      中国国際コンベンションセンター・北京(中国)
    • Year and Date
      2010-06-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] バンビプランの紹介-広汎性発達障害の診断・治療・経過観察総合システムの開発-2009

    • Author(s)
      菊知充
    • Organizer
      第17回北陸精神神経学会
    • Place of Presentation
      金沢都ホテル(石川県)
    • Year and Date
      2009-06-21
    • Related Report
      2010 Final Research Report
  • [Presentation] バンビプラン、広汎性発達障害の早期診断システム開発のための調査2009

    • Author(s)
      三辺義雄
    • Organizer
      第36回日本脳科学会
    • Place of Presentation
      金沢大学医学部記念館 (石川県)
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジウム『子どものこころの脳科学-大阪大学・浜松医科大学・金沢大学連合大学院発足を記念して-』: バンビプランの紹介2009

    • Author(s)
      菊知充、三邉義雄
    • Organizer
      第36回日本脳科学会
    • Place of Presentation
      金沢大学医学部記念館(石川県)
    • Year and Date
      2009-06-12
    • Related Report
      2010 Final Research Report
  • [Book] 双極性障害:齊藤万比古総編集、松本英夫、飯田順三責任編集:子どもの心の診療シリーズ4:子どもの不安障害と抑うつ2011

    • Author(s)
      棟居俊夫
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Book] 双極性障害:齊藤万比古総編集、松本英夫、飯田順三責任編集:子どもの心の診療シリーズ4:子どもの不安障害と抑うつ2010

    • Author(s)
      棟居俊夫
    • Publisher
      中山書店
    • Related Report
      2010 Final Research Report
  • [Book] 子どもの発達と行動:双極性障害(脳とこころのプライマリ・ケア)2010

    • Author(s)
      棟居俊夫
    • Publisher
      シナジー出版
    • Related Report
      2010 Final Research Report
  • [Book] 脳とこころのプライマリ・ケア第4巻:子どもの発達と行動:双極性障害2010

    • Author(s)
      棟居俊夫
    • Publisher
      シナジー出版
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://kokorosummit.w3.kanazawa-u.ac.jp/program.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://bambiplan.w3.kanazawa-u.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://kokorosummit.w3.kanazawa-u.ac.jp/program.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://kodomokokoro.w3.kanazawa-u.ac.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://kodomokokoro.w3.kanazawa-u.ac.jp/index.htm

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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