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Demonstration of serotonin hypothesis for autism by PET, and the identification and analysis of function on gene related to the control of serotonin synthesis

Research Project

Project/Area Number 20390312
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

NAKAMURA Kazuhiko  Hamamatsu University School of Medicine, 医学部, 准教授 (80263911)

Co-Investigator(Kenkyū-buntansha) NAKEI Noriyoshi  浜松医科大学, 子どものこころの発達研究センター, 教授 (80206937)
OUCHI Yasuomi  浜松医科大学, 分子イメージング先端研究センター, 教授 (40436978)
TSUZII Masatsugu  中京大学, 現代社会学部, 教授 (20257546)
MATSUZAKI Hideo  浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00334970)
KATAYAMA Taichi  大阪大学, 連合小児発達学研究科, 教授 (80333459)
IWATA Keiko  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (30415088)
IWATA Yasuhide  浜松医科大学, 医学部附属病院, 講師 (10285025)
TSUCHIYA Kenzi  浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (20362189)
SUDA Shirou  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (40432207)
SUZUKI Katsuaki  浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00285040)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords児童・思春期精神医学 / 神経科学 / 脳・神経 / 自閉症 / PET / 遺伝子 / 死後脳 / 画像
Research Abstract

We showed the associations of factors related to the serotoninergic system with autism, in a trio association study. We further showed the significant difference of these factors' mRNA expression between the autistic and control groups in the postmortem brain. Thus, we suggest a possible role of these factors in the pathogenesis of autism. PET study indicated the gross abnormalities in the serotoninergic and cholinergic systems. A deficit in cholinergic innervations of the fusiform gyrus may be related to not only current but also childhood impairment of social functioning.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (68 results)

All 2011 2010 2009 2008 Other

All Journal Article (33 results) (of which Peer Reviewed: 19 results) Presentation (28 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011

    • Author(s)
      Suzuki K, Genichi G, Ouchi Y, Nakamura K, Tsuiii M, Futatsubashi M, Iwata Y, Tsuchiya K, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
    • Journal Title

      Arch Gen Psychiatry. 68

      Pages: 306-313

    • Related Report
      2010 Final Research Report
  • [Journal Article] *corresponding author Replication study of Japanese cohorts supports the role of STXJA in autism susceptibility2011

    • Author(s)
      Nakamura K*, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada, Tsuiii M, Tsuchiva JK, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 35

      Pages: 454-458

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011

    • Author(s)
      Suzuki K
    • Journal Title

      Arch Gen Psychiatry

      Volume: 68 Pages: 306-313

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility2011

    • Author(s)
      Nakamura K
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry.

      Volume: 35 Pages: 454-458

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism.2010

    • Author(s)
      Kajizuka M, Miyachi T, Matsuzaki H, Iwata K Shinmura C, Suzuki K, Suda S, Tsuchiva KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 154-158

    • Related Report
      2010 Final Research Report
  • [Journal Article] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism.2010

    • Author(s)
      Suzuki K, Nishimura K, Sugihara G, Nakamura K, Tsuchiva KJ, Matsumoto K, Takebayashi K, Isoda H, Sakahara H, Sugiyama T, Tsujii M, Takei N, Mori N.
    • Journal Title

      Int J Neuropsychopharmacol. 13

      Pages: 529-534

    • NAID

      120005305395

    • Related Report
      2010 Final Research Report
  • [Journal Article] Brain serotonin and dopamine transporter bindings in adults with high-functioning autism.2010

    • Author(s)
      Nakamura K, Sekine Y, Ouchi Y, Tsujii M, Yoshikawa E, Futatsubashi M, Tsuchiva KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Suda S, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Arch Gen Psychiatry. 67

      Pages: 59-68

    • Related Report
      2010 Final Research Report
  • [Journal Article] Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects.2010

    • Author(s)
      Maekawa M, Iwayama Y, Arai R, Nakamura K, Ohnishi T, Toyota T, Tsujii M, Okazaki Y, Osumi N, Owada Y, Mori N, Yoshikawa T.
    • Journal Title

      J Hum Genet. 55

      Pages: 127-130

    • NAID

      10030733813

    • Related Report
      2010 Final Research Report
  • [Journal Article] *corresponding author Decreased serum levels of adiponectin in subjects with autism.2010

    • Author(s)
      Fujita-Shimizu A, Suzuki K, Nakamura K*, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiva KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 455-458

    • Related Report
      2010 Final Research Report
  • [Journal Article] # These authors contributed equally to this work Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T#, Yokoyama S#, Nakamura K#, Anitha A#, Yamada K#, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Nods M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
    • Journal Title

      Neurosci Res. 67(2)

      Pages: 181-191

    • Related Report
      2010 Final Research Report
  • [Journal Article] *corresponding author Further evidence for the role of MET in autism susceptibility.2010

    • Author(s)
      Thanseem I, Nakamura K*, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiva KJ, Anitha A, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, Suds S, Kawai M, Sugihara G, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N.
    • Journal Title

      Neurosci Res. 68

      Pages: 137-141

    • Related Report
      2010 Final Research Report
  • [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are in creased in male children with autism2010

    • Author(s)
      Kajizuka M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34 Pages: 154-158

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism.2010

    • Author(s)
      Suzuki K
    • Journal Title

      Int J Neuropsychopharmacol.

      Volume: 13 Pages: 529-534

    • NAID

      120005305395

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain serotonin and dopamine transporter bindings in adults with high-functioning autism.2010

    • Author(s)
      Nakamura K
    • Journal Title

      Arch Gen Psychiatry.

      Volume: 67 Pages: 59-68

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects.2010

    • Author(s)
      Maekawa M
    • Journal Title

      J Hum Genet.

      Volume: 55 Pages: 127-130

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased serum levels of adiponectin in subjects with autism.2010

    • Author(s)
      Fujita-Shimizu A
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry.

      Volume: 34 Pages: 455-458

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T
    • Journal Title

      Neurosci Res.

      Volume: 67 Pages: 181-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence for the role of MET in autism susceptibility.2010

    • Author(s)
      Thanseem I
    • Journal Title

      Neurosci Res.

      Volume: 68 Pages: 137-141

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls2010

    • Author(s)
      Munesue T
    • Journal Title

      NEUROCHEMICAL RESEARCH 67巻

      Pages: 181-191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased serum levels of adiponectin in subjects with autism2010

    • Author(s)
      Fujita-Shimizu A
    • Journal Title

      PROGRESS IN NEURO-PSYCHOPHARMACOLO GY & BIOLOGICAL PSYCHIATRY 34巻

      Pages: 455-458

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects2010

    • Author(s)
      Maekawa M
    • Journal Title

      JOURNAL OF HUMAN GENETICS 55巻

      Pages: 127-130

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain serotonin and dopamine transporter bindings in adults with high-functioning autism2010

    • Author(s)
      Nakamura K
    • Journal Title

      ARCHIVES OF GENERAL PSYCHIATRY 67巻

      Pages: 59-68

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient.2009

    • Author(s)
      Maekawa M, Iwayama Y, Nakamura K, Sato M, Toyota T, Ohnishi T, Yamada K, Miyachi T, Tsujii M, Hattori E, Maekawa N, Osumi N, Mori N, Yoshikawa T.
    • Journal Title

      Neurosci Lett. 462(3)

      Pages: 267-271

    • Related Report
      2010 Final Research Report
  • [Journal Article] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism2009

    • Author(s)
      Suzuki K
    • Journal Title

      INTERNATIONAL JOURNAL OF NEUROPSYCHOP HARMACOLOGY 13巻

      Pages: 529-534

    • NAID

      120005305395

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism2009

    • Author(s)
      Kajizuka M
    • Journal Title

      PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 34巻

      Pages: 154-158

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient2009

    • Author(s)
      Maekawa M
    • Journal Title

      NEUROSCIENCE LETTERS 462巻

      Pages: 267-271

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] *corresponding author Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.2008

    • Author(s)
      Anitha A, Nakamura K*, Yamada K, Suda S, Thanseem I, Tsuiji M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiva K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N Yoshikawa T, Mori N.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B

      Pages: 1019-1027

    • Related Report
      2010 Final Research Report
  • [Journal Article] Paternal aye at birth and high-functioning autistic-spectrum disorder in offspring.2008

    • Author(s)
      Tsuchiva KJ, Matsumoto K, Miyachi T, Tsujii M, Nakamura K, Takagai S, Kawai M, Yagi A, Iwaki K, Suda S Sugihara G, Iwata Y, Matsuzaki H, Sekine Y, Suzuki K, Sugiyama T, Mori N, Takei N.
    • Journal Title

      Br J Psychiatry. 193

      Pages: 316-321

    • Related Report
      2010 Final Research Report
  • [Journal Article] *corresponding author Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism.2008

    • Author(s)
      Nakamura Kr*, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota T, Suda S Takei N, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya KJ, Sugihara G, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
    • Journal Title

      Int J Neuropsychopharmacol. 11

      Pages: 1073-1084

    • Related Report
      2010 Final Research Report
  • [Journal Article] Serum levels of P-selectin in men with high-functioning autism.2008

    • Author(s)
      Iwata Y, Tsuchiva KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Br J Psychiatry. 193

      Pages: 338-339

    • Related Report
      2010 Final Research Report
  • [Journal Article] Serum levels of P-selectin in men with high-functioning autism2008

    • Author(s)
      Iwata Y
    • Journal Title

      Br J Psychiatry 193

      Pages: 338-339

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism2008

    • Author(s)
      Nakamura K
    • Journal Title

      Int J Neuropsychopharmacology 11

      Pages: 1073-1084

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism2008

    • Author(s)
      Anitha A
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 147B

      Pages: 1019-1027

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] In vivo alterations in cerebral serotonin and dopamine systems in autism2010

    • Author(s)
      Ouch Y, Nakamura K Yoshikawa E, Futatsubashi M, Kikuchi M, Suzuki K, Tsuiii M, Mori N
    • Organizer
      International Conference on Brain Function and Development
    • Related Report
      2010 Final Research Report
  • [Presentation] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism.2010

    • Author(s)
      Suzuki K, Ouchi Y, Nakamura K, Tsuiii M, Mori N
    • Organizer
      International Conference on Brain Function and Development
    • Related Report
      2010 Final Research Report
  • [Presentation] Dyslipidemia in male patients with high-functioning autism.2010

    • Author(s)
      Matsuzaki H, Iwata K, Suda S, Tsuchiva KJ, Suzuki K, Nakamura K, Tsuiii M, Takei N, Mori N
    • Organizer
      9th Annual International Meeting For Autism Research
    • Related Report
      2010 Final Research Report
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism.2010

    • Author(s)
      Nakamura K, Ouchi Y, Tsujii M, Tsuchiva KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Suda S, Sugiyama T, Takei N.
    • Organizer
      Mori N 9th Annual International Meeting For Autism Research
    • Related Report
      2010 Final Research Report
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism.2010

    • Author(s)
      Nakamura K, Ouchi Y, Tsuiii M, Tsuchiva KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Suda S, Sugiyama T, Takei N, Mori N
    • Organizer
      40th annual meeting of the Society for Neuroscience
    • Related Report
      2010 Final Research Report
  • [Presentation] In vivo alterations in cerebral serotonin and dopamine systems in autism2010

    • Author(s)
      Ouch Y
    • Organizer
      International Conference on Brain Function and Development
    • Place of Presentation
      Fukui (Japan)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism.2010

    • Author(s)
      Suzuki K
    • Organizer
      International Conference on Brain Function and Development
    • Place of Presentation
      Fukui (Japan)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dyslipidemia in male patients with high-functioning autism.2010

    • Author(s)
      Matsuzaki H
    • Organizer
      9^<th> Annual International Meeting For Autism Research
    • Place of Presentation
      Philadelphia (USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism.2010

    • Author(s)
      Nakamura K
    • Organizer
      9^<th> Annual International Meeting For Autism Research
    • Place of Presentation
      Philadelphia (USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism.2010

    • Author(s)
      Nakamura K
    • Organizer
      40th annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dyslipidemia in male patients with high-functioning autism2009

    • Author(s)
      Matsuzaki H
    • Organizer
      The 39^<th> annual meeting of the Society for Neuroscience
    • Place of Presentation
      Mc Cormick Place Cnvention Center
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Serotonin related gene expression changes in subjects with autism : a postmortem brainstudy2009

    • Author(s)
      須田史郎
    • Organizer
      The 39^<th> annual meeting of the Society for Neuroscience
    • Place of Presentation
      McCormick Place Cnven-tion Center
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自閉症者血清中の血管内皮増殖因子および血小板由来増殖因子濃度の変化2009

    • Author(s)
      梶塚正誠
    • Organizer
      第50回日本児童青年精神医学学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 広汎性発達障害者における血清アディポネクチン濃度の低下2009

    • Author(s)
      藤田梓
    • Organizer
      第50回日本児童青年精神医学学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自閉症におけるセロトニン系因子の遺伝子解析と発現解析2009

    • Author(s)
      亀野陽亮
    • Organizer
      第36回日本脳科学会
    • Place of Presentation
      金沢大学医学部記念館
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] MET and Autism Susceptibility : A Replication Study2009

    • Author(s)
      Thanseem I
    • Organizer
      第36回日本脳科学会
    • Place of Presentation
      金沢大学医学部記念館
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic and Expression Analyses of Serotonergic Factors in Autism2009

    • Author(s)
      Nakamura K
    • Organizer
      8^<th> Annual International Meeting For Autism Research
    • Place of Presentation
      Hilton Chicago
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自閉症におけるセロトニン系因子の遺伝子解析と発現解析2009

    • Author(s)
      亀野陽亮
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自閉症死後脳を用いたセロトニン神経関連遺伝子の発現解析2009

    • Author(s)
      須田史郎
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic and Expression Analyses of Serotonergic Factors in Autism.2009

    • Author(s)
      Nakamura K, Miyachi T, Ayyappan A, Tsujii M, Suda S, Thanseem I, Tsuchiva K, Matsuzaki H,Yamada K, Iwayama Y, Toyota T, Hattori E, Sugiyama T, Takei N, Yoshikawa T, Mori N
    • Organizer
      8th Annual International Meeting For Autism Research
    • Related Report
      2010 Final Research Report
  • [Presentation] Serotonin related gene expression changes in subjects with autism : a postmortem brain study.2009

    • Author(s)
      Suda S, Ieata K, Anitha A, Thanseem I, Matsuzaki H, Kameno Y, Nakamura K, Mori N, Takei N
    • Organizer
      39th annual meeting of the Society for Neuroscience
    • Related Report
      2010 Final Research Report
  • [Presentation] Dyslipidemia in male patients with high-functioning autism.2009

    • Author(s)
      Matsuzaki H, Iwata K, Suda S, Tsuchiva KJ, Matsumoto K, Miyachi T, Suzuki K, Nakamura K, Tsuiii M, Takei N, Mori N
    • Organizer
      39th annual meeting of the Society for Neuroscience
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic studies to elucidate the molecular mechanism of serotonergic dysfunction in autism.2008

    • Author(s)
      Anitha A, Nakamura K
    • Organizer
      XVIthe World Congree on Psychiatric Genetics
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic analyses of serotonergic factors in autism2008

    • Author(s)
      Nakamura K, Matsuzaki H, Tsujii M, Ayyappan A, Yamada K, Suda S, Iwayama Y, Miyachi T, Tsuchiva K, Sugiyama T, Takei N, Yoshikawa T, Mori N
    • Organizer
      7th Annual International Meeting For Autism Research
    • Related Report
      2010 Final Research Report
  • [Presentation] Serotonin transporter and serotonin related gene expression in autism.2008

    • Author(s)
      Suda S, Iwata K, Anitha A, Thanseem I, Nakamura K, Matsuzaki H Iwata Y, Yamamoto S, Suzuki K, Takei N, Koizumi K, Mori N
    • Organizer
      38th annual meeting of the Society for Neuroscience
    • Related Report
      2010 Final Research Report
  • [Presentation] Wide-spread decreases of serum growth factors levels in male with high-functioning autism2008

    • Author(s)
      Matsuzaki H, Iwata Y, Tsuchiva JK, Sugihara G, Suda S, Suzuki K, Nakamura K, Tsuiii M, Takei N, Hashimoto K, Mori N
    • Organizer
      38th annual meeting of the Society for Neuroscience, Washington
    • Related Report
      2010 Final Research Report
  • [Presentation] Brain serotonin and dopamine transporter densities in autism.2008

    • Author(s)
      Nakamura K
    • Organizer
      COE International Symposium 2008 on Development, Learning, Memory and Autism
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic analyses of serotonergic factors in autism2008

    • Author(s)
      Nakamura K
    • Organizer
      7^<th> Annual International Meeting For Autism Research
    • Place of Presentation
      London
    • Related Report
      2008 Annual Research Report
  • [Book] 子どもの発達と行動(身体と脳の検査・心に関する身体と脳の検査の現状)(最新の画像検査、飯田順三編集)(脳とこころのプライマリケア4)2010

    • Author(s)
      中村和彦
    • Publisher
      シナジー
    • Related Report
      2010 Final Research Report
  • [Book] 一般精神科医のための子どもの心の診療テキスト(II,小児に心の問題が生じる原因1.遺伝、厚生労働省雇用均等・児童家庭局編集)2008

    • Author(s)
      中村和彦
    • Publisher
      日本精神神経学会
    • Related Report
      2010 Final Research Report
  • [Book] 子どもの精神医学(子どもの精神医学における薬物治療について)(森則夫監修)(中村和彦編集)2008

    • Author(s)
      中村和彦
    • Publisher
      金芳堂
    • Related Report
      2010 Final Research Report
  • [Book] 子どもの精神医学(広汎性発達障害と注意欠陥/多動性障害)(森則夫監修)(中村和彦編集)2008

    • Author(s)
      中村和彦
    • Publisher
      金芳堂
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 高機能自閉症の発症危険度を判定する方法およびマーカー2010

    • Inventor(s)
      森則夫、中村和彦、鈴木勝昭、土屋賢治、岩口圭子、松崎秀夫
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学
    • Filing Date
      2010-10-14
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 高機能自閉症の発症危険度を判定する方法およびマーカー2009

    • Inventor(s)
      森則夫、中村和彦、鈴木勝昭、土屋賢治、岩田圭子、松崎秀夫
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学
    • Industrial Property Number
      2009-236976
    • Filing Date
      2009-10-14
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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