Neuroimaging studies to investigate brain mechanisms of cognitive emotional interaction and the effects of abnormal interactions on psychiatric disorders

• Project/Area Number: 20390313
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: YAMAWAKI Shigeto Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (40230601)
• Co-Investigator(Kenkyū-buntansha): OKAMOTO Yasumasa 広島大学, 大学院・医歯薬学総合研究科, 講師 (70314763) ; YAMASHITA Hidehisa 広島大学, 病院, 講師 (50294591) ; OKADA Go 広島大学, 大学院・医歯薬学総合研究科, 特任助教 (10457286) ; MANTANI Tomoyuki 広島大学, 病院, 講師 (70325174)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 情動制御 / 認知機能 / うつ病 / 摂食障害 / 扁桃体 / 前頭前野 / 前帯状回 / MEG / 安静時fMRI / パーソナリティー特性 / 扁挑体 / 認知行動療法 / 前帶状回 / 心理的痛み / 自己関連ずけ / 身体イメージ / 情動・認知制御 / 情動予期 / 報酬予期 / 自己関連処理 / メタ分析

Research Abstract

We conducted neuroimaging studies to investigate specific patterns of cognitive-emotional interaction and the underlying neurocircuitry in healthy controls and stress-related psychiatric disorders like depression and eating-disorders. The findings of our studies using various cognitive-emotional tasks and functional magnetic resonance imaging suggest that prefrontal and anterior cingulate cortex cognitively modulate emotional responses mediated by amygdala, and functional changes of these regions are present in stress-related psychiatric disorders.

Research Products

• [Journal Article] Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state (2011)
  • Author(s): Kunisato Yoshihiko, Okamoto Yasumasa, Okada Go, Aoyama Shiori, Nishiyama Yoshiko, Onoda Keiichi, Yamawaki Shigeto
  • Journal Title: Neuroscience Letters 49 Pages: 109-113
  • Peer Reviewed
• [Journal Article] Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change : a resting state functional magnetic resonance imaging study (2011)
  • Author(s): Kunisato Yoshihiko, Okamoto Yasumasa, Okada Go, Aoyama Shiori, Demoto Yoshihiko, Munakata Ayumi, Nomura Michio, Onoda Keiichi, Yamawaki Shigeto
  • Journal Title: Neuroscience Research 69 Pages: 129-134
  • NAID: 10028190643
  • Peer Reviewed
• [Journal Article] Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change : a resting state functional magnetic resonance imaging study. (2011)
  • Author(s): Yoshihiko Kunisato
  • Journal Title: Neuroscience Research Volume: 69 Pages: 129-134
  • Peer Reviewed
• [Journal Article] Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state. (2011)
  • Author(s): Yoshihiko Kunisato
  • Journal Title: Neuroscience Letters Volume: 492 Pages: 109-113
  • Peer Reviewed
• [Journal Article] Brain activation during the perception of distorted body images in eating disorders (2010)
  • Author(s): Miyake Yoshie, Okamoto Yasumasa, Onoda Keiichi, Kurosaki Mitsuhaya, Shirao Naoko, Okamoto Yuri, Yamawaki Shigeto
  • Journal Title: Psychiatry Research 30 Pages: 183-192
  • Peer Reviewed
• [Journal Article] Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism (2010)
  • Author(s): Onoda Keiichi, Okamoto Yasumasa, Nakashima Kenichiro, Nittono Hiroshi, Yoshimura Shinpei, Yamawaki Shigeto, Yamaguchi Shuhei, Ura Mitsuhiro
  • Journal Title: Social Cognitive and Affective Neuroscience 5 Pages: 385-391
  • Peer Reviewed
• [Journal Article] Neural processing of negative word stimuli concerning body image in patients with eating disorders : an fMRI study (2010)
  • Author(s): Miyake Yoshie, Okamoto Yasumasa, Onoda Keiichi, Shirao Naoko, Okamoto Yuri, Otagaki Yoko, Yamawaki Shigeto
  • Journal Title: Neuroimage 50 Pages: 1333-1339
  • Peer Reviewed
• [Journal Article] Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala : an fMRI study (2010)
  • Author(s): Yoshino Atsuo, Okamoto Yasumasa, Onoda Keiichi, Yoshimura Shinpei, Kunisato Yoshihiko, Demoto Yoshihiko, Okada Go, Yamawaki Shigeto
  • Journal Title: Neuroimage 50 Pages: 1194-1201
  • Peer Reviewed
• [Journal Article] Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity (2010)
  • Author(s): Yoshimura Shinpei, Okamoto Yasumasa, Onoda Keiichi, Matsunaga Miki, Ueda Kazutaka, Suzuki Shinichi, Yamawaki Shigeto
  • Journal Title: Journal of Affect Disorder 122 Pages: 76-85
  • Peer Reviewed
• [Journal Article] Neural processing of negative word stimuli concerning body image in patients with eating disorders : an fMRI study. (2010)
  • Author(s): Yoshie Miyake
  • Journal Title: Neuroimage Volume: 50 Pages: 1333-1339
  • Peer Reviewed
• [Journal Article] Rostral anterior cingulated cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity (2010)
  • Author(s): Yoshimura, S.
  • Journal Title: Journal of Affective Disorders 122 Pages: 76-85
  • Peer Reviewed
• [Journal Article] Brain activation during the perception of distorted body images in eating disorders (2010)
  • Author(s): 三宅典恵
  • Journal Title: Psychiatry Research 181 Pages: 183-192
  • Peer Reviewed
• [Journal Article] Sadness enhances the experience of pain via neural activation in the anterior cingulated cortex and amygdala (2010)
  • Author(s): Yoshino, A.
  • Journal Title: Neuroimage 50 Pages: 1194-1201
  • Peer Reviewed
• [Journal Article] Does low self-esteem enhance social pain? : The relationship between trait self esteem and anterior cingulate cortex activation induced by ostracism (2010)
  • Author(s): Onoda, K.
  • Journal Title: Social Cognitive and Affective Neuroscience (in press)
  • Peer Reviewed
• [Journal Article] やせの病態生理 摂食障害の高次脳機能 身体イメージの認知基盤 (2009)
  • Author(s): 三宅典恵, 岡本泰昌, 山脇成人
  • Journal Title: Pharma Medica 27 Pages: 25-28
  • Peer Reviewed
• [Journal Article] 共感的態度は"こころの痛み"を緩和する 精神療法の神経科学的基盤に関する-考察 (2009)
  • Author(s): 岡本泰昌, 小野田慶一, 吉野敦雄, 岡田剛, 山脇成人
  • Journal Title: 62 Pages: 437-438
  • Peer Reviewed
• [Journal Article] Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala (2009)
  • Author(s): Yoshimura Shinpei, Ueda Kazutaka, Suzuki Shinichi, Onoda Keiichi, Okamoto Yasumasa, Yamawaki Shigeto
  • Journal Title: Brain and Cognition 69 Pages: 218-225
  • Peer Reviewed
• [Journal Article] やせの病態生理 摂食障害の高次脳機能 身体イメージの認知基盤 (2009)
  • Author(s): 三宅典恵
  • Journal Title: Pharma Medica 27 Pages: 25-28
  • Peer Reviewed
• [Journal Article] 共感的態度は"こころの痛み"を緩和する 精神療法の神経科学的基盤に関する一考察 (2009)
  • Author(s): 岡本泰昌
  • Journal Title: 広島医学 62 Pages: 437-438
  • Peer Reviewed
• [Journal Article] Self-referential processing of negative stimuli within the ventral anterior cingulate gyms and right amygdala. (2009)
  • Author(s): Yoshiinura, S.
  • Journal Title: Brain and Cognition 69 Pages: 218-225
  • Peer Reviewed
• [Journal Article] Anterior cingulate cortex modulates preparatory activation during certain anticipation of negative picture (2008)
  • Author(s): Onoda Keiichi, Okamoto Yasumasa, Toki Shigeru, Ueda Kazutaka, Shishida Kazuhiro, Kinoshita Akiko, Yoshimura Shinpei, Yamashita Hidehisa, Yamawaki Shigeto
  • Journal Title: Neuropsychologia 46 Pages: 102-110
  • Peer Reviewed
• [Journal Article] ストレス適応の神経生理学的基盤 (2008)
  • Author(s): 岡本泰昌, 小野田慶一, 三宅典恵, 吉村晋平, 吉野敦, 黒崎充勇, 世木田幹, 岡田剛, 山下英尚, 山脇成人
  • Journal Title: 日本薬理学雑誌 131 Pages: 5-10
  • NAID: 10024186338
  • Peer Reviewed
• [Journal Article] Anterior cingulated cortex modulates preparatory activation during certain anticipation of negative picture. (2008)
  • Author(s): Onoda, K.
  • Journal Title: Neuropsychologia 46 Pages: 102-110
  • Peer Reviewed
• [Journal Article] ストレス適応の神経生理学的基盤 (2008)
  • Author(s): 岡本 泰昌
  • Journal Title: 日本薬理学雑誌 131 Pages: 5-10
  • NAID: 10024186338
• [Presentation] 右上側頭回体積が集団認知行動療法への治療反応性を予測するVoxelbased morphometryを用いた検討 (2010)
  • Author(s): 国里愛彦
  • Organizer: 日本行動療法学会第36回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-12-05
• [Presentation] 不安に対する認知的再評価に関する心理生理学的検討 (2010)
  • Author(s): 吉村晋平
  • Organizer: 日本行動療法学会第36回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-12-05
• [Presentation] 右上側頭回体積が集団認知行動療法への治療反応性を予測する Voxel based morphometryを用いた検討 (2010)
  • Author(s): 国里愛彦
  • Organizer: 日本行動療法学会第36回大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-12-05
• [Presentation] 不安に対する認知的再評価に関する心理生理学的検討 (2010)
  • Author(s): 吉村晋平
  • Organizer: 日本行動療法学会第36回大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-12-05
• [Presentation] Mood dysregulation and stabilization : Perspectives from emotional cognitive neuroscience (2010)
  • Author(s): Yamawaki Shigeto
  • Organizer: Plenary Lecture, 2010 World Congress of the International College of Neuropsychopharmacology(CINP)
  • Place of Presentation: 中華人民共和国(香港)
  • Year and Date: 2010-06-09
• [Presentation] Mood dysregulation and stabilization : Perspectives from emotional cognitive neuroscience (2010)
  • Author(s): Shigeto Yamawaki
  • Organizer: Plenary Lecture, 2010 World Congress of the International College of Neuropsychopharmacology(CINP)
  • Place of Presentation: 中華人民共和国(香港)(招待講演)
  • Year and Date: 2010-06-09
• [Presentation] 情動処理と関連する脳機能と認知行動療法の影響について:うつ病患者を対象にしたfMRI研究 (2009)
  • Author(s): 吉村晋平
  • Organizer: 第6回日本うつ病学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-31
• [Presentation] 情報処理と関連する脳機能と認知行動療法の影響について-うつ病患者を対象にしたfMRI研究- (2009)
  • Author(s): 吉村晋平
  • Organizer: 第6回日本うつ病学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-07-31
• [Presentation] Emotional regulation of cortical activations evoked by pain perception-an MEG study (2008)
  • Author(s): Yoshino Atsuo
  • Organizer: The 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2008-11-16
• [Presentation] Emotional regulation of cortical activations evoked by pain perception-an MEG study. (2008)
  • Author(s): Yoshino, A.
  • Organizer: The 38^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-15
• [Presentation] ストレス制御に関する認知神経科学的研究 (2008)
  • Author(s): 小野田慶一
  • Organizer: 第24回ストレス学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-30
• [Presentation] ストレス制御に関する認知神経科学的研究 (2008)
  • Author(s): 小野田 慶一
  • Organizer: 第24回ストレス学会
  • Place of Presentation: 大阪府
  • Year and Date: 2008-10-30
• [Presentation] 認知行動療法は自己関連付けに関連して脳活動を改善する (2008)
  • Author(s): 吉村晋平
  • Organizer: 第5回日本うつ病学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-25
• [Presentation] 認知行動療法は自己関連付けに関連して脳活動を改善する (2008)
  • Author(s): 吉村 晋平
  • Organizer: 第5回日本うつ病学会
  • Place of Presentation: 福岡県
  • Year and Date: 2008-07-25
• [Presentation] Emotional support reduces social pain and anterior cingulate cortex activation during ostracism (2008)
  • Author(s): 小野田慶一
  • Organizer: The 29th International Congress of Psychology
  • Place of Presentation: Berlin, Germany.
  • Year and Date: 2008-07-20
• [Presentation] Emotional support reduces social pain and anterior cingulate cortex activation during ostracism. (2008)
  • Author(s): Onoda, K.
  • Organizer: The 29^<th> International Congress of Psychology
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-07-20