The schizophrenia study about systems of dopamine, glutamate, and GABA by imaging mass spectrometry

• Project/Area Number: 20390315
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Fukushima Medical University
• Principal Investigator: NIWA Shin-ichi Fukushima Medical University, 医学部, 教授 (30110703)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 統合失調症 / 死後脳 / 質量顕微鏡 / ドパミン / グルタミン酸 / GABA / プロテオーム解析 / トバミン

Research Abstract

There are limits to brain research on psychiatric disorders using animals. In the present study, we analyzed postmortem brain samples of schizophrenia patients obtained from the Postmortem Brain Bank of Fukushima using a cutting-edge technology called mass microscopy. While dopamine, glutamic acid, and GABA are thought to play key roles in the etiology of schizophrenia, and neural networks are considered to form the basis of neurotransmission, in the present study, we succeeded in visualizing the 2-dimensional distribution of neuronal membrane components that are important for elucidating neural networks in the postmortem brains of schizophrenia patients.

Research Products

• [Journal Article] Abnormal phospholipids distribution in the prefrontal cortex from a patient with schizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometr (2011)
  • Author(s): 松本純弥、杉浦悠毅、由木大、早坂孝弘、井上菜穂子、財満信弘、國井泰人、和田明、楊巧会、西浦継介、赤津裕康、堀映、橋詰良夫、山本孝之、池本桂子、瀬藤光利、丹羽真一
  • Journal Title: Analytical and Bioanalytical Chemistry 400(7)(Epub 2011 Apr 2) Pages: 1933-1943
  • Peer Reviewed
• [Journal Article] Abnormal phospholipids distribution in the prefrontal cortex from a patient with schizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry. (2011)
  • Author(s): 松本純弥
  • Journal Title: Analytical and Bioanalytlcal Chemistry Volume: (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 死後脳を用いて脂質プロフィール解析を実施した統合失調症の一例 (2011)
  • Author(s): 松本純弥, 國井泰人, 和田明, 楊巧会, 西浦継介, 池本桂子, 杉浦悠毅, 井上菜穂子, 早坂孝弘, 財満信弘, 瀬藤光利, 丹羽真一
  • Organizer: 第22回福島県精神医学会
  • Place of Presentation: 福島県福島市
  • Year and Date: 2011-02-20
• [Presentation] 質量顕微鏡法による統合失調症死後脳解析 (2010)
  • Author(s): 松本純弥, 國井泰人, 和田明, 楊巧会, 西浦継介, 池本桂子, 杉浦悠毅, 井上菜穂子, 早坂孝弘, 財満信弘, 瀬藤光利, 丹羽真一
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 福岡県北九州市小倉
  • Year and Date: 2010-10-09
• [Remarks]
  • URL: http://www.fmu-bb.jp/index.htm
• [Remarks]
  • URL: http://www.fmu-bb.jp/index.htm