Molecular imaging for dynamic analysis of cancer pathological states : Toward clinical molecular imaging
| Project/Area Number |
20390320
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KUGE Yuji Hokkaido University, アイソトープ総合センター, 教授 (70321958)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAKI Nagara 北海道大学, 大学院・医学研究科, 教授 (30171888)
SEKI KohーIchi 北海道大学, アイソトープ総合センター, 教授 (60094835)
OHKURA Kazue 北海道医療大学, 薬学部, 教授 (60094827)
ZHAO Songji 北海道大学, 大学院・医学研究科, 准教授 (80374239)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 放射線 / 癌 / 生体分子 / 臨床 / 分子イメージング |
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| Research Abstract |
In the present study, we utilized molecular imaging technology that visualized tumor proliferation and hypoxia, and demonstrated the usefulness in the analyses of tumor pathological states and response to molecular-targeted/radiation therapies, in animal models and clinical settings. We also demonstrated, in animal models, potentials and safety profiles of our novel candidate compound for angiogenesis imaging. The present results could provide important evidences to develop novel diagnosis and treatment strategy taking advantages of molecular imaging technology that visualizes alteration in tumor pathological states at molecular/cellular levels.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article]2010
Author(s)
Kuge Y, et al.
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Journal Title
Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In : Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N, kuge Y, eds.)(Springer(Springer Science+Business Media), Heidelberger Kuge Y et al.)
Related Report
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[Journal Article]2010
Author(s)
Magota K, et al.
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Journal Title
Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small Animal Imaging. In : Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N, Kuge Y, eds.)(Springer(Springer Science+Business Media), Heidelberger)
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