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Molecular imaging for dynamic analysis of cancer pathological states : Toward clinical molecular imaging

Research Project

Project/Area Number 20390320
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

KUGE Yuji  Hokkaido University, アイソトープ総合センター, 教授 (70321958)

Co-Investigator(Kenkyū-buntansha) TAMAKI Nagara  北海道大学, 大学院・医学研究科, 教授 (30171888)
SEKI KohーIchi  北海道大学, アイソトープ総合センター, 教授 (60094835)
OHKURA Kazue  北海道医療大学, 薬学部, 教授 (60094827)
ZHAO Songji  北海道大学, 大学院・医学研究科, 准教授 (80374239)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords放射線 / 癌 / 生体分子 / 臨床 / 分子イメージング
Research Abstract

In the present study, we utilized molecular imaging technology that visualized tumor proliferation and hypoxia, and demonstrated the usefulness in the analyses of tumor pathological states and response to molecular-targeted/radiation therapies, in animal models and clinical settings. We also demonstrated, in animal models, potentials and safety profiles of our novel candidate compound for angiogenesis imaging. The present results could provide important evidences to develop novel diagnosis and treatment strategy taking advantages of molecular imaging technology that visualizes alteration in tumor pathological states at molecular/cellular levels.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (51 results)

All 2011 2010 2009 2008 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (36 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions2011

    • Author(s)
      S.Okamoto, et al.
    • Journal Title

      lAnn Nucl Med

      Volume: 25 Pages: 213-220

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Performance characterization of the Inveon preclinical small-animal PET /SPECT/CT system for multimodality imaging2011

    • Author(s)
      K.Magota, et aL
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 38 Pages: 742-752

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.2010

    • Author(s)
      Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K
    • Journal Title

      Nucl Med Biol. 37

      Pages: 427-432

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging2010

    • Author(s)
      H.Akizawa, et al.
    • Journal Title

      Nucl Med Biol.

      Volume: 37 Pages: 427-432

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      Kuge Y, et al.
    • Journal Title

      Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy. In : Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N, kuge Y, eds.)(Springer(Springer Science+Business Media), Heidelberger Kuge Y et al.)

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      Magota K, et al.
    • Journal Title

      Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small Animal Imaging. In : Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N, Kuge Y, eds.)(Springer(Springer Science+Business Media), Heidelberger)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Molecular Imaging of Apoptosis with Radio-Labeled Annexin A5 Focused on the Evaluation of Tumor Response to Chemotherapy.2009

    • Author(s)
      Kuge Y, Zhao S, Takei T, Tamaki N.
    • Journal Title

      Anti-Cancer Agents in Medicinal Chemistry. 9

      Pages: 1003-1011

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of a radioiodinated Lumiracoxib derivative for the imaging of cyclooxygenase-2 expression.2009

    • Author(s)
      Kuge Y, et al.
    • Journal Title

      Nucl Med Biol. 36(8)

      Pages: 869-76

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Imaging of Apoptosis with Radio-Labeled Annexin A5 Focused on the Evaluation of Tumor Response to Chemotherapy2009

    • Author(s)
      Kuge Y, et al.
    • Journal Title

      Anti-Cancer Agents in Medicinal Chemistry 9

      Pages: 1003-1011

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a radioiodinated thymidine phosphorylase inhibitor and its preliminary evaluation as a potential SPECT tracer for angiogenic enzyme expiession2008

    • Author(s)
      Takahashi M, et.al.
    • Journal Title

      J Labelled Compounds and Radiopharmaceuticals 51(11)

      Pages: 384-387

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions.

    • Author(s)
      Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima K, Kuge Y, Tamaki N
    • Journal Title

      Ann Nucl Med. (印刷中)

    • NAID

      10028999449

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging.

    • Author(s)
      Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N
    • Journal Title

      Eur J Nucl Med Mol Imaging. (印刷中)

    • NAID

      120003918916

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] A novel radiolabeled probe for molecular imaging of thymidine phosphorylase : Suppressed accumulation into tumor cells by target gene knockdown.2010

    • Author(s)
      Li H, Zhao S, Jin Y, Nishijima K, Akizawa H, Ohkura K, Seki K, Tamaki N, Kuge Y
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Biologic aspects of intratumoral [^<18>F]FMISO distribution in a rodent model of glioma.2010

    • Author(s)
      Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno K, Hanzawa H, Sakamoto T, Tamaki N, Kuge Y
    • Organizer
      57th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City.
    • Related Report
      2010 Final Research Report
  • [Presentation] Hyoxia imaging with ^<18>F-fluoromisonidazole (FMISO) for differentiating tumors from granulomas : A comparison with FDG in experimental rat models using small animal PET.2010

    • Author(s)
      Zhao S, Kuge Y, Zhao Y, Yi M, Hatano T, Suzuki K, Magota K, Nishijima K, Kohanawa M, Tamaki N
    • Organizer
      57th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City.
    • Related Report
      2010 Final Research Report
  • [Presentation] FLT PET can early predict antiproliferative response to anti-EGFR moleculartargeting therapy (cetuximab) in human lung cancer xenograft.2010

    • Author(s)
      Zhao S, Takeuchi S, Kuge Y, Zhao Y, Hatano T, Li H, Nishijima K, Kinoshita I, Dosaka-Akita H, Tamaki N
    • Organizer
      57th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City.
    • Related Report
      2010 Final Research Report
  • [Presentation] Hyoxia imaging with ^<18>F-fluoromisonidazole (FMISO) for differentiating tumors from granulomas : A comparison with FDG in experimental rat models using small animal PET2010

    • Author(s)
      S.Zhao, et al.
    • Organizer
      57th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, Utah (America)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biologic aspects of intratumoral [18F]FMISO distribution in a rodent model of glioma2010

    • Author(s)
      T.Hatano, et al.
    • Organizer
      57th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, Utah (America)
    • Related Report
      2010 Annual Research Report
  • [Presentation] FLT PET can early predict antiproliferative response to anti-EGFR molecular-targeting therapy (cetuximab) in human lung cancer xenograft2010

    • Author(s)
      S.Zhao, et al.
    • Organizer
      57th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, Utah (America)
    • Related Report
      2010 Annual Research Report
  • [Presentation] High performance of an integrated PET/SPECT/CT system for small-animal imaging2010

    • Author(s)
      K.Magota, et al.
    • Organizer
      57th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, Utah (America)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of intratumoral ^<18>F-FDG distribution using small animal PET : Comparison with autoradiography2010

    • Author(s)
      S.Zhao, et al.
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan.(国立京都国際会館)
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel radiolabeled probe for molecular imaging of thymidine phosphorylase : Suppressed accumulation into tumor cells by target gene knockdown2010

    • Author(s)
      H.Li, et al.
    • Organizer
      2010 world Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan.(国立京都国際会館)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト癌移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:^<18>F-FLT-PETを用いた早期治療効果評価2010

    • Author(s)
      趙松吉, 他
    • Organizer
      第5回日本分子イメージング学会学術集会
    • Place of Presentation
      滋賀県大津(ピアザ淡海滋賀県民交流センター)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分子イメージング装置を用いた研究とその成果~動物用PETを中心に~2010

    • Author(s)
      久下裕司, 他
    • Organizer
      日本動物技術者協会 第44回全国総会
    • Place of Presentation
      旭川(旭川市民会館) 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肉芽腫・腫瘍における^<18>F-FMISO-PETの有用性:小動物用PETを用いた基礎的検討2010

    • Author(s)
      趙松吉, 他
    • Organizer
      第50回日本核医学会総会
    • Place of Presentation
      さいたま(大宮ソニックシティ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床用半導体PET装置により描出される腫瘍内FDG分布のオートラジオグラフィーによる検証2010

    • Author(s)
      竹内渉, 他
    • Organizer
      第50回日本核医学会総会
    • Place of Presentation
      さいたま(大宮ソニックシティ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] チミジンホスホリラーゼを標的とする新規腫瘍イメージング剤の開発:siRNA導入による腫瘍細胞への集積低下2010

    • Author(s)
      李花, 他
    • Organizer
      第50回日本核医学会総会
    • Place of Presentation
      さいたま(大宮ソニックシティ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低酸素イメージング剤[^<18>F] FAZAの製剤学的検討2010

    • Author(s)
      阿保憲史, 他
    • Organizer
      第50回日本核医学会総会
    • Place of Presentation
      さいたま(大宮ソニックシティ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動物用PETを用いた分子イメージング研究-「腫瘍の診断と治療効果評価-2010

    • Author(s)
      久下裕司, 他
    • Organizer
      日本放射線安全管理学会 第9回学術大会
    • Place of Presentation
      東広島(広島大学) 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] [11C]phosgeneを用いるoxoimidazolidinylmethyluracilの合成とがんイメージングプローブへの応用。2010

    • Author(s)
      関興一, 他
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪(近畿大学本部キャンパス)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放射性がん血管新生イメージングプローブの創製2010

    • Author(s)
      大倉一枝, 他
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪(近畿大学本部キャンパス)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prediction of early antiproliferative response to anti-VEGF monoclonal antibody molecular-targeting therapy (bevacizumab) in human tumor xenograft using FLT.2009

    • Author(s)
      Zhao S, Kuge Y, Zhao Y, Takeuchi S, Jin Y, Hatano T, Kinoshita I, Dosaka-Akita H, Tamaki N
    • Organizer
      56th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Tronto.
    • Related Report
      2010 Final Research Report
  • [Presentation] Prediction of early antiproliferative response to anti-VEGF monoclonal antibody molecular-targeting therapy(bevacizumab)in human tumor xenograft using FLT.2009

    • Author(s)
      Zhao S, et al.
    • Organizer
      56th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamic MET PET analysis has an additional value for differentiating tumors from granulomas : An experimental study using small animal PET.2009

    • Author(s)
      Zhao S, et al.
    • Organizer
      56th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] A radioiodinated lumiracoxib derivative : synthesis and in vitro/in vivo evaluation as a SPECT tracer for cyclooxygenase-2 expression2009

    • Author(s)
      Kuge Y, et al.
    • Organizer
      18th International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      Edmonton, Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evaluation of FMISO Uptake in Rat Tumor Tissue : Comparison with FDG Uptake2009

    • Author(s)
      Hatano T, et al.
    • Organizer
      2009 World Molecular Imaging Congress
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット腫瘍組織におけるFMISO集積の評価:FDG集積との比較2009

    • Author(s)
      波多野利行, 他
    • Organizer
      第4回日本分子イメージング学会学術集会
    • Place of Presentation
      東京(学術総合センター)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト癌細胞移植マウスにおける抗EGFR抗体(Cetuximab)による分子標的療法:FLTを用いた早期治療効果評価。2009

    • Author(s)
      竹内啓, 他
    • Organizer
      第49回日本核医学会総会
    • Place of Presentation
      旭川(旭川市民文化会館、旭川グランドホテル)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト癌細胞移植マウスにおける抗VEGF抗体(Bevacizumab)による分子標的療法;FLTを用いた早期治療効果評価。2009

    • Author(s)
      趙松吉, 他
    • Organizer
      第49回日本核医学会総会
    • Place of Presentation
      旭川(旭川市民文化会館、旭川グランドホテル)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肉芽腫・腫瘍の鑑別診断におけるdynamic C-MET-PETの有用性:小動物PETを用いた基礎的検討。2009

    • Author(s)
      趙松吉, 他
    • Organizer
      第49回日本核医学会総会
    • Place of Presentation
      旭川(旭川市民文化会館、旭川グランドホテル)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一体型の小動物用PET/SPECT/CT装置の性能評価。2009

    • Author(s)
      孫田惠一, 他
    • Organizer
      第49回日本核医学会総会
    • Place of Presentation
      旭川(旭川市民文化会館、旭川グランドホテル)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression Graduate School of Medicine.2008

    • Author(s)
      Seki K, Takahashi M, Zhao S, Nishijima K, Kuge Y, Tamaki N, Ohkura K
    • Organizer
      2008 World Molecular Imaging Congress
    • Place of Presentation
      Nice.
    • Related Report
      2010 Final Research Report
  • [Presentation] Dynamics of 18F-FDG Uptake in Experimental Granuloma and Tumor: Basic Studies in Rat Models Using Small Animal PET / CT System2008

    • Author(s)
      Zhao S, et.al.
    • Organizer
      2008 World Molecular Imaging Congress
    • Place of Presentation
      Nice, The Acropolis Convention Center
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression2008

    • Author(s)
      Seki K, et.al.
    • Organizer
      2008 World Molecular Imaging Congress
    • Place of Presentation
      Nice, The Acropolis Convention Center
    • Related Report
      2008 Annual Research Report
  • [Presentation] チミジンホスホリラーゼ標的イメージング剤の合成とその有用性に関する基礎的検討2008

    • Author(s)
      大倉一枝, 他
    • Organizer
      第48回日本核医学会総会
    • Place of Presentation
      千葉、幕張メッセ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rhodococcus肉芽腫とラットglioma腫瘍ラットモデルにおけるFDG集積の比較検討2008

    • Author(s)
      趙松吉, 他
    • Organizer
      第49回日本核医学会総会
    • Place of Presentation
      千葉、幕張メッセ
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多発性骨髄腫における全身methionine-PETの有用性 : FDG-PETとの比較2008

    • Author(s)
      鐘ヶ江香久子, 他
    • Organizer
      第48回日本核医学会総会
    • Place of Presentation
      千葉、幕張メッセ
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小動物用PET/SPECT/CT装置InveonのSPECT部の性能評価2008

    • Author(s)
      孫田恵一, 他
    • Organizer
      第48回日本核医学会総会
    • Place of Presentation
      千葉、幕張メッセ
    • Related Report
      2008 Annual Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development(Tamaki N, Kuge Y eds.)(Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy.)2010

    • Author(s)
      Kuge Y, Zhao S, Takei T, Tamaki N
    • Publisher
      Springer (Springer Science+Business Media), Heidelberger
    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.hokudai.ac.jp/radiois/kenkyu/kenkyu_toP.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.hokudai.ac.jp/radiois/

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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