| Project/Area Number |
20390323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TSUBOI Koji University of Tsukuba, 大学院・人間総合科学研究科, 教授 (90188615)
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| Co-Investigator(Kenkyū-buntansha) |
ANZAI Kazunori 日本薬科大学, 薬品物理化学分野, 教授 (70128643)
TAKANO Shingo 筑波大学, 大学院・人間総合科学研究科, 准教授 (50292553)
SAKAE Takeji 筑波大学, 大学院・人間総合科学研究科, 教授 (60162278)
MORITAKE Takashi 筑波大学, 大学院・人間総合科学研究科, 講師 (50450432)
YASUOKA Kiyoshi 筑波大学, 大学院・人間総合科学研究科, 講師 (50200499)
TERUMUNA Toshiyuki 筑波大学, 大学院・人間総合科学研究科, 助手 (40361349)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 陽子線 / 脳腫瘍 / ラジカル / RBE / がん幹細胞 / 粒子線治療 / 癌幹細胞 |
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| Research Abstract |
In order to optimize the effects of proton beams radiotherapy for brain tumors, some uncertainties in the biological effects of proton beams were resolved in this study. First, characteristics of proton beams in DNA base damage and strand breaks were clarified compared to those of x-rays. Second, RBE values of proton beams to x-rays were measured in different endpoints. In addition, cancer-stemness in isolated radioresistant clones of brain tumor cells was demonstrated, indicating that population of cancer-stem like cells were enriched in survivors after irradiation.
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