Basic Comparison of Biological Effects between Protons and Carbon-Ions

• Project/Area Number: 20390327
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: HISHIKAWA Yoshio Kobe University, 医学系研究科, 客員教授 (20122335)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Masao 神戸大学, 医学系研究科, 客員准教授 (50210018) ; SASAKI Ryohei 神戸大学, 医学部附属病院, 特命准教授 (30346267) ; DEMIZU Yusuke 神戸大学, 医学系研究科, 医学研究員 (50452496)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 癌 / 粒子線治療 / 陽子線 / 炭素線 / 生物学的効果 / 細胞老化 / 活性酸素種

Research Abstract

Particle therapy using protons or carbon-ions showed higher effectiveness than conventional X-ray therapy on basic research basis. A new finding was obtained that generation of reactive oxygen species (ROS), which plays an important role in biological effects of radiation, was not temporary but continuous after irradiation. It was also found that continuous suppression of ROS by N-acetylcysteine (NAC) lead to increased cell survival after irradiation. NAC could be used as a radioprotective agent in clinical settings.

Research Products

• [Presentation] Particle radiotherapy Using Protons or Carbon Ions for Adenoid Cystic Carcinoma of the Head and Neck (2010)
  • Author(s): Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, K.Morimoto, D.Miyawaki, R.Sasaki, Y.Hishikawa, M.Abe, M.Murakami
  • Organizer: 52nd Annual Meeting of American Society for Radiation Oncology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-02
• [Presentation] Particle radiotherapy Using Protons or Carbon Ions for Adenoid Cystic Carcinoma of the Head and Neck (2010)
  • Author(s): Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, K.Morimoto, D.Miyawaki, R.Sasaki, Y.Hishikawa, M.Abe, M.Murakami
  • Organizer: 52^<nd> Annual Meeting of American Society for Radiation Oncology
  • Place of Presentation: San Diego(USA)
  • Year and Date: 2010-11-02
• [Presentation] Proton radiotherapy for stage C prostate cancer (2010)
  • Author(s): M.Murakami, Y.Demizu, Y.Niwa, O.Fujii, K.Terashima, M.Mima, Y.Hishikawa
  • Organizer: 29th Annual Meeting of European Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-09-12
• [Presentation] Proton radiotherapy for stage C prostate cancer (2010)
  • Author(s): M.Murakami, Y.Demizu, Y.Niwa, O.Fujii, K.Terashima, M.Mima, Y.Hishikawa
  • Organizer: 29^<th> Annual Meeting of European Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Barcelona(Spain)
  • Year and Date: 2010-09-12
• [Presentation] Difference of cell biological effects in cancer cell lines irradiated by X-ray or particle beams (2009)
  • Author(s): T.Maeda, M.Murakami, Y.Demizu, Y.Hishikawa, M.Abe
  • Organizer: 440th Wilhelm und Else Heraeus Seminar
  • Place of Presentation: Frauenworth, Germany
  • Year and Date: 2009-09-15
• [Presentation] Difference of cell biological effects in cancer cell lines irradiated by X-ray or particle beams (2009)
  • Author(s): T.Maeda, M.Murakami, Y.Demizu, Y.Hishikawa, M.Abe
  • Organizer: 440^<th> Wilhelm und Else Heraeus Seminar
  • Place of Presentation: Frauenworth, Germany
  • Year and Date: 2009-09-15
• [Presentation] Revaluation for problem of chemical particle therapy in cell biological effect of proton, carbon-ion and X-ray at Hyogo Ion Beam Medical Center (2009)
  • Author(s): S.Nagayama, M.Murakami, Y.Demizu, Y.Hishikawa, M.Abe
  • Organizer: World Congress
  • Place of Presentation: Munich, Germany
  • Year and Date: 2009-09-12
• [Presentation] Revaluation for problem of chemical particle therapy in cell biological effect of proton, carbon-ion and X-ray at Hyogo Ion Beam Medical Center (2009)
  • Author(s): S.Nagayama, M.Murakami, Y.Demizu, Y.Hishikawa, M.Abe
  • Organizer: World Congress 2009
  • Place of Presentation: Munich, Germany
  • Year and Date: 2009-09-12