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Molecular targeting imaging of angiogenesis using hepatocyte growth as a probe in ischemia and tumor models.

Research Project

Project/Area Number 20390328
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

NISHIMURA Tsunehiko  Kyoto Prefectural University of Medicine, 医学研究科, 教授 (70237733)

Co-Investigator(Kenkyū-buntansha) YAMAGAMI Takuji  京都府立医科大学, 医学研究科, 講師 (10257537)
OKUYAMA Chio  京都府立医科大学, 医学研究科, 講師 (40347464)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Keywords分子イメージング / 肝細胞増殖因子(HGF) / 血管新生 / 虚血 / 腫瘍 / 虚血性心疾患 / 腫瘍性疾患 / HGF / 虚血性疾患
Research Abstract

[Purpose]c-Met, the specific receptor for hepatocyte growth factor (HGF), has been attracting interest as an important target for the development of treatments for tumors and ischemic diseases. Since imaging c-Met at the cell surface may provide useful information for diagnosing the degree of malignancy and deciding on treatment policy in tumors, and in deciding on sites for effective administration of therapeutic agents in ischemic diseases, our aim in this study was to develop a molecular imaging agent that targeted c-Met.
The basic structure of the probe consists of the 73-amino-acid polypeptide (HGF [11-83]) sequence of the α-chain N-terminal of HGF, which contains the heparin binding site, and we used ^<125>I-labeled and ^<123>I-labeled polypeptides to evaluate the probe.
Retention of heparin-binding activity and c-Met-binding activity by the labeled probes was confirmed in vitro by using the heparin-column method and c-Met-expressing cancer cells. High accumulation of the labeled probes was observed in the xenograft model implanted with c-Met-expressing cancer cells, and accumulation was observed in the infarct boundary region, where c-Met expression is said to be increased, in the myocardial ischemia model.
Because this probe enables non-invasive imaging of c-Met expression in tumors and ischemic diseases, it seems that it will be useful for clinical diagnosis and monitoring treatment, and that it will be able to contribute to promoting the development of drugs and methods of treatment that target c-Met.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (33 results)

All 2010 2009 2008

All Journal Article (29 results) (of which Peer Reviewed: 9 results) Presentation (2 results) Book (2 results)

  • [Journal Article] Venous thromboembolism after removal of retrievable inferior vena cava filters.2010

    • Author(s)
      T.Yamagami, O.Tanaka, R.Yoshimatsu, H.Miura, T.Nishimura
    • Journal Title

      Cardiovasc Intervent Radiol 33

      Pages: 74-79

    • Related Report
      2010 Final Research Report
  • [Journal Article] Implantation of port-catheter system for hepatic arterial infusion chemotherapy with catheter tip fixation in a patient with celiac arterial obstruction.2010

    • Author(s)
      T.Yamagami, R.Yoshimatsu, T.Tanaka, K.Tsuji, H.Miura, O.Tanaka, T.Nishimura.
    • Journal Title

      J Vasc Interv Radiol 21

      Pages: 409-411

    • Related Report
      2010 Final Research Report
  • [Journal Article] Unusual fatty metamorphosis observed in diffuse liver metastases of stage 4S neuroblastoma.2010

    • Author(s)
      J.Tazoe, C.Okuyama, T.Iehara, H.Hosoi, T.Nishimura
    • Journal Title

      Pediatr Radiol 40

      Pages: 777-780

    • Related Report
      2010 Final Research Report
  • [Journal Article] J-ACCESS Investigators. Prognostic value of post-ischemic stunning as assessed by gated myocardial perfusion single-photon emission computed tomography : a subanalysis of the J-ACCESS study.2010

    • Author(s)
      Y.Usui, T.Chikamori, K.Nakajima, S.Hida, A.Yamashina, T.Nishimura
    • Journal Title

      Circ J 74

      Pages: 1591-1599

    • Related Report
      2010 Final Research Report
  • [Journal Article] Endovascular thrombolysis using monteplase for non-chronic deep venous thrombosis.2010

    • Author(s)
      T.Yamagami, R.Yoshimatsu, O.Tanaka, H.Miura, T.Nishimura
    • Journal Title

      Cardiovasc Intervent Radiol 33

      Pages: 1223-1229

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prognostic value of gated myocardial perfusion imaging for asymptomatic patients with type-2 diabetes : The J-ACCESS 2 investigation.2010

    • Author(s)
      Y.Yamasaki, K.Nakajima, H.Kusuoka, T.Izumi, A.Kashiwagi, R.Kawamori, K.Shimamoto, N.Yamada, T.Nishimura
    • Journal Title

      Diabetic Care 33

      Pages: 2320-2326

    • Related Report
      2010 Final Research Report
  • [Journal Article] Endovascular thrombolysis using monteplase for non-chronic deep venous thrombosis2010

    • Author(s)
      Yamagami T, Yoshimatsu R, Tanaka O, Miura H, Nishimura T
    • Journal Title

      Cardiocasc Intervent Radiol

      Volume: 33 Pages: 1223-1229

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implantation of port-catheter system for hepatic arterial infusion chemotherapy with catheter tip fixation in a patient with celiac arterial obstruction2010

    • Author(s)
      Yamagami T, Yoshimatsu R, Tanaka T, Nishimura T, et al
    • Journal Title

      J Vasc Interv Radiol

      Volume: 21 Pages: 409-411

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of post-ischemic stunning as assessed by gated myocardial perfusion single-photon emission computed tomography : a subanalysis of the J-ACCESS study2010

    • Author(s)
      Usui Y, Chikamori T, Nishimura T, et al
    • Journal Title

      Circ J

      Volume: 74 Pages: 1591-1599

    • NAID

      10026565615

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of new-onset refractory congestive heart failure using stress/rest gated perfusion SPECT imaging in patients with known or suspected coronary artery disease : Sub-analysis of the J-ACCESS.2009

    • Author(s)
      T.Nakata, A.Hashimoto, T.Wakabayashi, H.Kusuoka, T.Nishimura
    • Journal Title

      J Am Coll Cardiol Cardiovasc Imaging 2

      Pages: 1393-1400

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cardiovascular events in Japanese asymptomatic patients with type 2 diabetes: a 1-year interim report of a J-ACCESS 2 investigation using myocardial perfusion imaging.2009

    • Author(s)
      K.Nakajima, Y.Yamasaki, H.Kusuoka, T.Izumi, A.Kashiwagi, R.Kawamori, K.Shimamoto, N.Yamada, T.Nishimura.
    • Journal Title

      Eur J Nucl Med Mol Imaging 36

      Pages: 2049-2057

    • NAID

      120001828368

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prognostic risk stratification of myocardial ischaemia evaluated by gated myocardial perfusion SPECT in patients with chronic kidney disease.2009

    • Author(s)
      T.Hatta, S.Nishimura, T.Nishimura
    • Journal Title

      Eur J Nucl Med Mol Imaging 36

      Pages: 1835-1841

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prognostic significance of stress myocardial gated SPECT among Japanese patients referred for coronary angiography: A study of data from the J-ACCESS database.2009

    • Author(s)
      M.Momose, K.Nakajima, T.Nishimura
    • Journal Title

      Eur J Nucl Med Mol Imaging 36

      Pages: 1329-1337

    • Related Report
      2010 Final Research Report
  • [Journal Article] Dysfunction of a port-catheter system percutaneously implanted for hepatic arterial infusion chemotherapy due to a fibrin sheath.2009

    • Author(s)
      T.Yamagami, T.Matsumoto, R.Yoshimatsu, T.Nishimura
    • Journal Title

      Clin J Gastroenterol 2

      Pages: 47-50

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intense FDG accumulation in idiopathic tumoral calcinosis2009

    • Author(s)
      C.Okuyama, T.Kubota, S.Matsushima, Y.Ushijima, T.Nishimura
    • Journal Title

      Clin Nucl Med 34

      Pages: 230-232

    • Related Report
      2010 Final Research Report
  • [Journal Article] Tc-99mMIBI scintigraphy in evaluating the effect of hepatocyte growth factor gene therapy for peripheral arteriosclerosis obliterans.2009

    • Author(s)
      T.Yamagami, K.Kanda, C.Okuyama, T.Nishimura
    • Journal Title

      Ann Nucl Med 23

      Pages: 205-208

    • NAID

      10025135860

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intramural metastasis of esophageal carcinoma to the reconstructed gastric tube detected by FDG PET/CT.2009

    • Author(s)
      K.Nishida, C.Okuyama, T.Kubota, S.Matsushima, M.Oda, K.Akazawa, T.Nishimura
    • Journal Title

      Clin Nucl Med 34

      Pages: 523-525

    • Related Report
      2010 Final Research Report
  • [Journal Article] FDG avid patchy bone marrow misinterpreted as melanoma metastases to bone in a case of aplastic anemia.2009

    • Author(s)
      C.Okuyama, T.Kubota, Y.Ushijima, S.Matsushima, T.Nishimura
    • Journal Title

      Clin Nucl Med 34

      Pages: 927-930

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prediction of new-onset refractory congestive heart failure using stress/rest gated perfusion SPECT imaging in patients with known or suspected coronary artery disease : Sub-analysis of the J-ACCESS.2009

    • Author(s)
      Nakata T, Hashimoto A, Nishimura T, et al.
    • Journal Title

      J Am Coll Cardiol Cardiovasc Imaging 2

      Pages: 1393-1400

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiovascular events in Japanese asymptomatic patients with type 2 diabetes : a 1-year interim report of a J-ACCESS 2 investigation using myocardial perfusion imaging.2009

    • Author(s)
      Nakajima K, Yamasaki Y, Nishimura T, et al.
    • Journal Title

      Eur J Nucl Med Mol Imaging 36

      Pages: 2049-2057

    • NAID

      120001828368

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intense FDG accumulation in idiopathic tumoral calcinosis2009

    • Author(s)
      Okuyama C, Kubota T, Nihsimura T, et al.
    • Journal Title

      Clin Nucl Med 34

      Pages: 230-232

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic study of risk stratification among Japanese patients with ischemic heart disease using gated myocardial perfusion SPECT : J-ACCESS study.2008

    • Author(s)
      T.Nishimura, K.Nakajima, H.Kusuoka, A.Yamashina, S.Nishimura
    • Journal Title

      Eur J Nucl Med Mol Imaging 35

      Pages: 319-328

    • Related Report
      2010 Final Research Report
  • [Journal Article] J-ACCESS Investigators. Prognostic value of normal stress myocardial perfusion imaging in Japanese population.2008

    • Author(s)
      S.Matsuo, K.Nakajima, M.Horie, I.Nakae, T.Nishimura.
    • Journal Title

      Circ J 72

      Pages: 611-617

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prophylactic implantation of inferior vena cava filter during endovascular therapies for deep venous thrombosis of the lower extremity : is it necessary2008

    • Author(s)
      T.Yamagami, R.Yoshimatsu, T.Matsumoto, T.Nishimura
    • Journal Title

      Acta Radiol 49

      Pages: 391-397

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prognostic table for predicting major cardiac events based on J-ACCESS investigation.2008

    • Author(s)
      K.Nakajima, T.Nishimura
    • Journal Title

      Ann Nucl Med 22

      Pages: 891-897

    • NAID

      10025134899

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prognostic study of cardiac events in Japanese high risk hemodialysis patients using I-BMIPP-SPECT : B-SAFE study design.2008

    • Author(s)
      N.Hasebe, M.Moroi, M.Nishimura, K.Hara, H.Hase, A.Hashimoto, S.Kumita, K.Haze, M.Momose, Y.Nagai, T.Sugimoto, E.Kusano, T.Akiba, T.Nakata, T.Nishimura, N.Tamaki, K.Kikuchi
    • Journal Title

      Ther Apher Dial 12

      Pages: 526-530

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prognostic study of risk stratification among Japanese patients with ischemic heart disease using gated myocardial perfusion SPECT : J-ACCESS study.2008

    • Author(s)
      Nishimura T, Nakajima K, et al.
    • Journal Title

      Eur J Nucl Med Mol Imaging 35

      Pages: 319-328

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidental acute infarcts identified on diffusion-weighted images : A university hospital-based study.2008

    • Author(s)
      Yamada K, Nishimura T, et al.
    • Journal Title

      ATNR Am J Neuroradiol 29

      Pages: 937-940

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Value of Micronester coils in port-catheter implantation for continuous hepatic arterial infusion chemotherapy with fixed catheter tip method.2008

    • Author(s)
      Yamagami T, Nishimura T, et al.
    • Journal Title

      Eur Radiol 18

      Pages: 152-157

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Japanese multi-center prognostic study in patients with type-2 diabetesusing gated myocardial perfusion SPECT : An interim report of J-ACCESS II study.2009

    • Author(s)
      Nakajima K, Nishimura T, et al
    • Organizer
      Annual Meeting of the Society of Nuclear Medicine 2009.
    • Place of Presentation
      Toronto
    • Year and Date
      2009-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] これからの心臓核医学2008

    • Author(s)
      西村恒彦
    • Organizer
      第48回日本核医学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Book] 癌治療における放射線診療の役割 癌治療における放射線診療の展開-放射線治療・IVR・RI内用療法-(西村恒彦、山崎秀哉、山上卓士、奥山智緒 編)(京都)2008

    • Author(s)
      西村恒彦
    • Publisher
      金芳堂
    • Related Report
      2010 Final Research Report
  • [Book] 癌治療における放射線診療の展開-放射線治療・IVR・RI内用療法-2008

    • Author(s)
      西村恒彦
    • Total Pages
      141
    • Publisher
      金芳堂
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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