| Project/Area Number |
20390335
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Miyazaki (2010)
Research Institute, Shiga Medical Center (2008-2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHI Tatsuya 滋賀県立成人病センター, 研究所, 総括研究員 (50324629)
KAGAWA Shinya 滋賀県立成人病センター, 研究所, 主任研究員 (10393191)
KAWAI Keiichi 金沢大学, 大学院・医学研究科, 教授 (30204663)
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| Co-Investigator(Renkei-kenkyūsha) |
ONOE Hirotata 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, チームリーダー (80214196)
MIZUMA Hiroshi 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 研究員 (00382200)
NAGAMACHI Shigeki 宮崎大学, 医学部, 准教授 (40180517)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | ヒストン脱アセチル化酵素 / PET画像診断 / 癌 / 分子標的 / 放射線医薬品 / 造影剤 / 国際情報交換 / アメリカ |
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| Research Abstract |
Epigenetic modifications mediated by histone deacetylases(HDACs) play important roles in the mechanisms of different neurologic diseases and HDAC inhibitors(HDACIs) have shown promise in therapy. However, pharmacodynamic profiles of many HDACIs in the tumor remain largely unknown due to the lack of validated methods for noninvasive imaging of HDACs expression-activity. In this study, we have developed a novel PET imaging [^18F] FAHA.
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