Novel Tumor Seeking PET Imaging focused on Epigenetic Regulation by Histone Deacetylases
Project/Area Number |
20390335
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | University of Miyazaki (2010) Research Institute, Shiga Medical Center (2008-2009) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HIGASHI Tatsuya 滋賀県立成人病センター, 研究所, 総括研究員 (50324629)
KAGAWA Shinya 滋賀県立成人病センター, 研究所, 主任研究員 (10393191)
KAWAI Keiichi 金沢大学, 大学院・医学研究科, 教授 (30204663)
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Co-Investigator(Renkei-kenkyūsha) |
ONOE Hirotata 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, チームリーダー (80214196)
MIZUMA Hiroshi 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 研究員 (00382200)
NAGAMACHI Shigeki 宮崎大学, 医学部, 准教授 (40180517)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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Keywords | ヒストン脱アセチル化酵素 / PET画像診断 / 癌 / 分子標的 / 放射線医薬品 / 造影剤 / 国際情報交換 / アメリカ |
Research Abstract |
Epigenetic modifications mediated by histone deacetylases(HDACs) play important roles in the mechanisms of different neurologic diseases and HDAC inhibitors(HDACIs) have shown promise in therapy. However, pharmacodynamic profiles of many HDACIs in the tumor remain largely unknown due to the lack of validated methods for noninvasive imaging of HDACs expression-activity. In this study, we have developed a novel PET imaging [^18F] FAHA.
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Report
(5 results)
Research Products
(63 results)
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[Journal Article] Pharmacokinetics, metabolism, biodistribution, radiation dosimetry, and toxicology of (18) F-fluoroacetate((18) F-FACE) in non-human primates2012
Author(s)
Nishii R, Tong W, Wendt R 3rd, Soghomonyan S, Mukhopadhyay U, Balatoni J, Mawlawi O, Bidaut L, Tinkey P, Borne A, Alauddin M, Gonzalez-Lepera C, Yang B, Gelovani JG
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Journal Title
Mol Imaging Biol
Volume: 14
Pages: 213-224
Related Report
Peer Reviewed
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[Journal Article] Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-acetate PET2012
Author(s)
Kobayashi M, Mori T, Kiyono Y, Tsujikawa T, Maruyama R, Higaki Y, Shikano N, Nishii R, Kawai K, Kudo T, Okazawa H
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Journal Title
Nucl Med Commun
Volume: 33
Pages: 130-138
Related Report
Peer Reviewed
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[Journal Article] Putative transport mechanism and intracellular fate of trans-1-amino-3-^18F-fluorocyclobutanecarboxylic acid in human prostate cancer2012
Author(s)
Okudaira H, Shikano N, Nishii R, Miyagi T, Yoshimoto M, Kobayashi M, Ohe K, Nakanishi T, Tamai I, Namiki M, Kawai K
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Journal Title
J Nucl Med
Volume: 52
Pages: 822-829
Related Report
Peer Reviewed
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[Journal Article] Comparison of the transcellular transport of FDG and D-glucose by the kidney epithelial cell line2011
Author(s)
Kobayashi M, Shikano N, Nishii R, Kiyono Y, Araki H, Nishi K, Oh M, Okudaira H, Ogura M, Yoshimoto M, Okazawa H, Fujibayashi Y, Kawai K
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Journal Title
LLC-PK1 Nucl Med Commun
Volume: 31
Pages: 141-146
Related Report
Peer Reviewed
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[Journal Article] Pharmacokinetics, Metabolism, Biodistribution, Radiation Dosimetry, and Toxicology of (18)F-Fluoroacetate ((18)F-FACE) in Non-human Primates.2011
Author(s)
Nishii R, Tong W, Wendt R 3rd, Soghomonyan S, Mukhopadhyay U, Balatoni J, Mawlawi O, Bidaut L, Tinkey P, Borne A, Alauddin M, Gonzalez-Lepera C, Yang B, Gelovani JG.
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Journal Title
Mol Imaging Biol.(Epub ahead of print) in press
Related Report
Peer Reviewed
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[Journal Article] HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance.2011
Author(s)
Schwartz DL, Bankson J, Bidaut L, He Y, Williams R, Lemos R, Thitai AK, Oh J, Volgin A, Soghomonyan S, Yeh HH, Nishii R, Mukhopadhay U, Alauddin M, Mushkudiani I, Kuno N, Krishnan S, Bornman W, Lai SY, Powis G, Hazle J, Gelovani J.
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Journal Title
Mol Cancer Res.
Volume: 9
Pages: 259-270
Related Report
Peer Reviewed
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[Journal Article] Predictive value of Tc-99m galactosyl human serum albumin liver SPECT on the assessment of functional recovery after partial hepatectomy : a comparison with CT volumetry.2010
Author(s)
Wakamatsu H, Nagamachi S, Kiyohara S, Fujita S, Kamimura K, Futami S, Nishii R, Nagano M, Kondou K, Kai M, Chijiiwa K, Tamura S.
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Journal Title
Ann Nucl Med.
Volume: 24
Pages: 729-734
NAID
Related Report
Peer Reviewed
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[Journal Article] Comparison of the transcellular transport of FDG and D-glucose by the kidney epithelial cell line, LLC-PK1.2010
Author(s)
Kobayashi M, Shikano N, Nishii R, Kiyono Y, Araki H, Nishi K, Oh M, Okudaira H, Ogura M, Yoshimoto M, Okazawa H, Fujibayashi Y, Kawai K.
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Journal Title
Nucl Med Commun. 31
Pages: 141-146
Related Report
Peer Reviewed
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[Journal Article] Erratum to : FDG PET as a prognostic predictor in the early post-therapeutic evaluation for unresectable hepatocellular carcinoma.2010
Author(s)
Higashi T, Hatano E, Ikai I, Nishii R, Nakamoto Y, Ishizu K, Suga T, Kawashima H, Togashi K, Seo S, Kitamura K, Takada Y, Uemoto S.
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Journal Title
Eur J Nucl Med Mol Imaging. 37
Pages: 468-482
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Peer Reviewed
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[Journal Article] The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects.2009
Author(s)
Schwartz DL, Powis G, Thitai-Kumar A, He Y, Bankson J, Williams R, Lemos R, Oh J, Volgin A, Soghomonyan S, Nishii R, Alauddin M, Mukhopadhay U, Peng Z, Bornmann W, Gelovani J.
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Journal Title
Mol Cancer Ther. 50
Pages: 947-958
Related Report
Peer Reviewed
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[Journal Article] Role of gastric distention with additional water in differentiating locally advanced gastric carcinomas from physiological uptake in the stomach on 18F-fluoro-2-deoxy-D-glucose PET.2009
Author(s)
Kamimura K, Nagamachi S, Wakamatsu H, Fujita S, Nishii R, Umemura Y, Ogita M, Komada N, Sakurai T, Inoue T, Fujimoto T, Nakajo M.
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Journal Title
Nucl Med Commun. 30
Pages: 431-439
Related Report
Peer Reviewed
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[Journal Article] Usefulness of a deep-inspiration breath-hold 18F-FDG PET/CT technique in diagnosing liver, bile duct, and pancreas tumors.2009
Author(s)
Nagamachi S, Wakamatsu H, Kiyohara S, Fujita S, Futami S, Arita H, Nishii R, Tamura S, Kawai K.
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Journal Title
Nucl Med Commun. 30
Pages: 326-332
Related Report
Peer Reviewed
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[Presentation] Cell Uptake Study of [^18F] Fluoroacetate in Human-Derived Hepatocellular Carcinomas2011
Author(s)
Kenji Takemoto, Ryuichi Nishii, Etsuro Hatano, Shinya Kagawa, Tatsuya Higashi, Kan Toriguchi, Kazutaka Tanabe, KojiroTaura, Hiroshi Mizuma, Hirotaka Onoe, Shigeki Nagamachi, Shozo Tamura
Organizer
2011 World Molecular Imaging Congress
Place of Presentation
Sandiego, USA
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[Presentation] Preclinical assessment of [^18F]-FAHA PET imaging as a novel biomarker for HDAC activity2010
Author(s)
R. Nishii, H. Yeh, U. Mukhopadhyay, S. Soghomonyan, J. Balatoni, O. Mawlawi, M. M. Alauddin, T. Hisgashi, W. Tong, and J. G. Gelovani
Organizer
The 57th SNM Annual Meeting
Place of Presentation
Salt Lake City, USA
Related Report
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[Presentation] Amino Acid Transport Imaging Using PET in Clinical Application-[11C]MeAIB PET Imaging As A Marker of System A Amino Acid Transport-2009
Author(s)
Nishii R., Higashi R., Kagawa S., Kishibe Y., Takahashi M., Uehara Y., Kobayashi M., Nagamachi S., Arano Y., Kawai K.
Organizer
Symposium, Asian Federation for Pharmaceutical Sciences 2009
Place of Presentation
福岡
Related Report
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