Targeting therapy against cancer stem cells

• Project/Area Number: 20390341
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: KUBO Hajime Kyoto University, 医学研究科, 講師 (50362520)
• Co-Investigator(Kenkyū-buntansha): OBMA Kazutaka 京都大学, 医学研究科, 助手 (50322649)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: がん幹細胞 / 転移 / 分子標的治療 / 癌幹細胞 / 大腸癌 / 分子標的 / 創薬

Research Abstract

We have proven the presence of cancer stem cells in the human samples, leading to the establishment of screening methods in vitro targeting cancer stem cells. In addition, we observed the new finding that non-cancer stem cells convert to cancer stem cells. The pathway could be the novel target.

Research Products

• [Journal Article] Transcriptional Factor Prox1 Plays an Essential Role in the Antiproliferative Action of Interferon-γ in Esophageal Cancer Cells. (2011)
  • Author(s): Akagami M, Kawada K, Kubo H, Kawada M, Takahashi M, Kaganoi J, Kato S, Itami A, Shimada Y, Watanabe G, Sakai Y.
  • Journal Title: Ann Surg Oncol. 31 [Epub ahead of print]
• [Journal Article] The importance of precompression time for secure stapling with a linear stapler. (2010)
  • Author(s): Nakayama S, Hasegawa S, Nagayama S, Kato S, Hida K, Tanaka E, Itami A, Kubo H, Sakai Y.
  • Journal Title: Surg Endosc. 24 [Epub ahead of print]
• [Journal Article] Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis. (2009)
  • Author(s): Matsusue R, Kubo H, Hisamori S, Okoshi K, Takagi H, Hida K, Nakano K, Itami A, Kawada K, Nagayama S, Sakai Y.
  • Journal Title: Ann Surg Oncol.2009 Sep 16(9)
• [Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors. (2008)
  • Author(s): Nagayama S, Yamada E, Kohno Y, Aoyama T, Fukukawa C, Kubo H, Watanabe G, Katagiri T, Nakamura Y, Sakai Y, Toguchida J.
  • Journal Title: Cancer Sci.2009 100(3) Pages: 402-412
• [Journal Article] All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production. (2008)
  • Author(s): Hisamori S, Tabata C, Kadokawa Y, Okoshi K, Tabata R, Mori A, Nagayama S Watanabe G, Kubo H, Sakai Y.
  • Journal Title: Liver Int. 2008 28(9) Pages: 1217-1225
• [Journal Article] All-trans-retinoic acid attenuates radiation-induced intestinal fibrosis in mice. (2008)
  • Author(s): Okoshi K, Kubo H, Nagayama S, Tabata C, Kadokawa Y, Hisamori S, Yonenaga Y, Fujimoto A, Mori A, Onodera H, Watanabe G, Sakai Y.
  • Journal Title: J Surg Res. 2008 150(1) Pages: 53-59
• [Journal Article] All-trans-retinoic acid attenuates radiation-induced intestinal fibrosis in mice. (2008)
  • Author(s): Kae Okoshi, Hajime Kubo, et al.
  • Journal Title: J Surg Res. 150 Pages: 53-59
  • Peer Reviewed
• [Journal Article] All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine (2008)
  • Author(s): Shigeo Hisamori, Hajime Kubo, et al.
  • Journal Title: Liver Int. 28 Pages: 1217-1225
  • Peer Reviewed