Application of microRNA profilling to breast cancer diagnosis and therapy
| Project/Area Number |
20390342
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
SHIMIZU Kazuharu Kyoto University, 薬学研究科, 教授 (50456836)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOI Masakazu 京都大学, 医学研究科, 教授 (10207516)
TSUJIMOTO Gozoh 京都大学, 薬学研究科, 教授 (80172013)
SATO Fumikai 京都大学, 薬学研究科, 准教授 (20467426)
UENO Takayuki 京都大学, 医学研究科, 助教 (40452362)
TSUCHIYA Soken 京都大学, 薬学研究科, 助教 (80423002)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
|
|---|
| Keywords | 乳癌 / マイクロRNA / マイクロアレイ / 乳がん / microRNA |
|---|
| Research Abstract |
In this project, we performed microRNA profiling for future application to breast cancer diagnosis and therapy. First, we identified miR-26a/30b as microRNAs involved in molecular mechanisms of trastuzumab therapy for HER2-positive breast cancer. Mir-26a/30b inhibited cell growth of breast cancer cells by targeting CCNE2. Secondary, we demonstrated that epigenetical regulation of miR200b cluster is associated with epithelial-mesenchymal transition of breast cancer cells. The miR200b cluster members inhibit cell motility by targeting fibronectin.
|
Report
(4 results)
Research Products
(31 results)
