| Co-Investigator(Kenkyū-buntansha) |
TOI Masakazu 京都大学, 医学研究科, 教授 (10207516)
TSUJIMOTO Gozoh 京都大学, 薬学研究科, 教授 (80172013)
SATO Fumikai 京都大学, 薬学研究科, 准教授 (20467426)
UENO Takayuki 京都大学, 医学研究科, 助教 (40452362)
TSUCHIYA Soken 京都大学, 薬学研究科, 助教 (80423002)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Research Abstract |
In this project, we performed microRNA profiling for future application to breast cancer diagnosis and therapy. First, we identified miR-26a/30b as microRNAs involved in molecular mechanisms of trastuzumab therapy for HER2-positive breast cancer. Mir-26a/30b inhibited cell growth of breast cancer cells by targeting CCNE2. Secondary, we demonstrated that epigenetical regulation of miR200b cluster is associated with epithelial-mesenchymal transition of breast cancer cells. The miR200b cluster members inhibit cell motility by targeting fibronectin.
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