| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Research Abstract |
We have previously proven that the interspecies incompatibility of CD47 results in phagocytosis of xenogeneic cells by macrophages in vitro. In this study, we demonstrated that interspecies incompatibility of CD47 contributed to the in vitro responses of xenoreactive CD4^+ T cell through the indirect pathway, but not the direct pathway. We also demonstrated that genetic induction of recipient species CD47 on xenograft cells could prevent macrophage-mediated rejection using an in vivo model.
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