| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
In order to create new molecular therapy for gastrointestinal cancer, we have planed the regulation of gene transduction, translation and protein synthesis. Furthermore, we have tried inhibition of intracellular molecular transport for the same purpose. We found that new molecule which inhibit enzyme for genetic expression have good efficieny for gene therapy. And this molecule was revealed anti-tumor action. The regulation of molecular transportation between nuclear and cytoplasm have induced cell death. These new molecules are important seeds for translational research and extremely useful for new development of molecular therapy for gastrointestinal cancer.
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