| Project/Area Number |
20390352
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
IMAMURA Hiroshi Juntendo University, 医学(系)研究科, 准教授 (00283268)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Taku 東京大学, 医学部, 講師 (30302722)
MOMOSE Toshimitu 東京大学, 医学部, 准教授 (20219992)
石崎 陽一 順天堂大学, 医学部, 准教授 (20260490)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 閉塞性黄疸 / 減黄 / デルタビリルビン / アンチピリンテスト / アミノピリンテスト / プレアルブミン / ヘパプラスチンテスト / 胆管炎 / アンチピリンクリアランス / アミノピリンクリアランス |
|---|
| Research Abstract |
Plasma half-lives of delta and non-delta bilirubin fractions in patients with obstructive jaundice undergoing biliary drainages were 13.6 day and 2.4 day, respectively. Antipyrine and aminopyrine plasma clearances, which are indicators of liver microsomal function, were deteriorated by the obstructive jaundice but recovered rapidly after the biliary drainage. Other parameters of liver function showed wide range of alterations, i.e., from unaffected to moderate degree of deterioration, by the jaundice and also showed wide ranges of chronological changes during drainage. The half-lives of delta and non-delta bilirubin fractions showed close correlations with antipyrine and aminopyrine plasma clearances before the drainage and similar relationships were found with values of these clearances after the drainage. The episode of cholangitis during the drainage period and the absence of entero-hepatic circulation of the bile prolonged the half-lives of bilirubin fractions.
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