Alteration of delta-bilirubin concentration during biliary drainage and its relationships with plasma half-life of albumin and functional hepatocyte mass in patients with obstructive jaundice

• Project/Area Number: 20390352
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Juntendo University
• Principal Investigator: IMAMURA Hiroshi Juntendo University, 医学(系)研究科, 准教授 (00283268)
• Co-Investigator(Kenkyū-buntansha): AOKI Taku 東京大学, 医学部, 講師 (30302722) ; MOMOSE Toshimitu 東京大学, 医学部, 准教授 (20219992) ; 石崎 陽一 順天堂大学, 医学部, 准教授 (20260490)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 閉塞性黄疸 / 減黄 / デルタビリルビン / アンチピリンテスト / アミノピリンテスト / プレアルブミン / ヘパプラスチンテスト / 胆管炎 / アンチピリンクリアランス / アミノピリンクリアランス

Research Abstract

Plasma half-lives of delta and non-delta bilirubin fractions in patients with obstructive jaundice undergoing biliary drainages were 13.6 day and 2.4 day, respectively. Antipyrine and aminopyrine plasma clearances, which are indicators of liver microsomal function, were deteriorated by the obstructive jaundice but recovered rapidly after the biliary drainage. Other parameters of liver function showed wide range of alterations, i.e., from unaffected to moderate degree of deterioration, by the jaundice and also showed wide ranges of chronological changes during drainage. The half-lives of delta and non-delta bilirubin fractions showed close correlations with antipyrine and aminopyrine plasma clearances before the drainage and similar relationships were found with values of these clearances after the drainage. The episode of cholangitis during the drainage period and the absence of entero-hepatic circulation of the bile prolonged the half-lives of bilirubin fractions.

Research Products

• [Journal Article] AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC. (2010)
  • Author(s): Yamamoto K, Imamura H, Matsuyama Y, Kume Y, Ikeda H, Norman GL, Shums Z, Aoki T, Hasegawa K, Beck Y, Sugawara Y, Kokudo N.
  • Journal Title: J Gastroenterol 45 Pages: 1272-82
  • NAID: 10027700270
• [Journal Article] Isolated sling suspension during resection of the Spiegel lobe of the liver : a safe alternative technique for difficult cases. (2010)
  • Author(s): Shindoh J, Imamura H, Kokudo N.
  • Journal Title: J Hepatobiliary Pancreat Sci 17 Pages: 359-364
  • NAID: 10027422965
• [Journal Article] Cohort study of the survival benefit of resection for recurrent hepatic and/or pulmonary metastases after primary hepatectomy for colorectal metastases. (2010)
  • Author(s): Mise Y, Imamura H, Hashimoto T, Seyama Y, Aoki T, Hasegawa K, Beck Y, Sugawara Y, Makuuchi M, Nakajima J, Kokudo N.
  • Journal Title: Ann Surg 251 Pages: 902-909
• [Journal Article] Evaluation of donor vasculobiliary anatomic variations in liver graft procurements. (2010)
  • Author(s): Kishi Y, Imamura H, Sugawara Y, Sano K, Kaneko J, Kokudo N, Makuuchi M.
  • Journal Title: Surgery 147 Pages: 30-39
• [Journal Article] Value of prophylactic abdominal drainage in 1269 consecutive cases of elective liver resection. (2010)
  • Author(s): Kyoden Y, Imamura H, Sano K, Beck Y, Sugawara Y, Kokudo N, Makuuchi M.
  • Journal Title: J Hepatobilliary Pancreat Sci 17 Pages: 186-192
  • NAID: 10027662826
• [Journal Article] Significance of alpha-fetoprotein and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma undergoing hepatectomy. (2009)
  • Author(s): Yamamoto K, Imamura H, Matsuyama Y, Hasegawa K, Beck Y, Sugawara Y, Makuuchi M, Kokudo N.
  • Journal Title: Ann Surg Oncol 16 Pages: 2795-2804
• [Journal Article] Inclusion of tumor markers improves the correlation of the Milan criteria with vascular invasion and tumor cell differentiation in patients with hepatocellular carcinoma undergoing liver resection. (2008)
  • Author(s): Hasegawa K, Imamura H, Ijichi M, Matsuyama Y, Sano K, Sugawara Y, Kokudo N, Makuuchi M.
  • Journal Title: J Gastorointest Surg 12 Pages: 858-866
• [Presentation] Significance of serum alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) levels to identify treatment failure and contraindication for hepatectomy in patients with hepatocellular carcinoma (HCC). (2010)
  • Author(s): Yamamoto K, Imamura H, Aoki T, Beck Y, Hasegawa K, Sugawara Y, Makuuchi M, Kokudo N.
  • Organizer: The 61th Annual Meeting of the American Association for the Study of Liver Diseases.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2010-11-02
• [Presentation] Intermittent clamping is more effective than ischemic preconditioning and its effect is more marked with shorter cycle of intermittent clamping in a rat model of ischemia/reperfusion injury. (2010)
  • Author(s): Imamura H, Seyama Y, Inagaki Y, Tang W, Kokudo N, Makuuchi M.
  • Organizer: The 61th Annual Meeting of the American Association for the Study of Liver Diseases.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2010-10-31
• [Presentation] Prognostic significance of alpha-fetoprptein(AFP)anddes-Y-carboxy prothrombin in patients with hepatocellular cacinoma(HCC)undergoing hepatectomy. (2009)
  • Author(s): Yamamoto K, Imamura H, Matsuyama Y, Tanaka M, Takahashi M, Ishizawa T,Hasegawa K, Aoki T, Beck Y, Sugawara Y, Makuuchi M ,Kokudo N.
  • Organizer: The 60th Annual meeting of the American Association for the study of liver diseases.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2009-11-03
• [Presentation] A prospective study of measurements of four tumor markers in patients with hepatocelluler carcinoma (HCC). (2009)
  • Author(s): Yamamoto K, Imamura H, Matsuyama Y, Ikeda H, Norman.L.G, Shums Z, Aoki T, Hasegawa K, Beck Y, Sugawara Y, Kokudo N.
  • Organizer: The 60th Annual meeting of the American Association for the study of liver diseases.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2009-11-03
• [Presentation] Clinical significance of production quantity of alpha-fetoprotein (AFP) and des-gammma-carboxy prothrombin (DCP) in patients with hepatocellular carcinoma (HCC). (2009)
  • Author(s): Yamamoto K, Imamura H, Aoki T, Hasegawa K, Beck Y, Sugawara Y, Makuuchi M, Kokudo N.
  • Organizer: The 44th Annual meeting of the European Association for the study of liver.
  • Place of Presentation: Copenhagen, Denmark.
  • Year and Date: 2009-04-25
• [Presentation] 肝切除および肝移植症例における標準肝容積の再検討 (2009)
  • Author(s): 今村宏, 青木琢, 橋本拓哉, 菅原寧彦, 長谷川潔, 石崎陽一, 別宮好文, 國土典宏, 川崎誠治
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-03
• [Presentation] Re-evaluation of standard liver volume (SLV) in patients undergoing living donor liver transplantation (LDLT) and liver resection. (2009)
  • Author(s): Imamura H, Aoki T, Hashimoto T, Sugawara Y, Hasegawa K, Beck Y, Kokodo N, Makuuchi M.
  • Organizer: American Hepato Pancreato Biliary Association 2009 Annual meeting.
  • Place of Presentation: Miami Beach, USA
  • Year and Date: 2009-03-14
• [Presentation] Comparison of result of hepatic and lung resection to recurrences after first hepatectomy to liver metastases of colorectal origin. (2009)
  • Author(s): Mise Y, Imamura H, Hashimoto T, Seyama Y, Aoki T, Hasegawa K, Beck Y, Sugawara Y, Makuuchi M, Nakajima J, Kokudo N.
  • Organizer: American Hepato Pancreato Biliary Association 2009 Annual meeting.
  • Place of Presentation: Miami Beach, USA.
  • Year and Date: 2009-03-13
• [Book] Recurrent colorectal cancer : Repeated liver resections(Lipska L, Visokai editors)(Recurrent colorectal cancer-the complex treatment from the surgical point of view) (2009)
  • Author(s): Imamura H, Hashimoto T, Kokudo N, Makuuchi M.
  • Publisher: GRADA Publishing(Prague, Czech)
• [Book] Sequential TACE and PVE for HCC Venous Embolization of the Liver : Radiological and Surgical Practice(Madoff DC, Makuuchi M, Nagino M, Vauthey JN editors)
  • Author(s): Imamura H, Seyama Y, Kokudo N, Makuuchi M.
  • Publisher: Springer.(in press)