Intra venous injection of Oncolytic virus against liver metastasis
| Project/Area Number |
20390354
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
NAKAO Akimasa Nagoya University, 医学系研究科, 教授 (70167542)
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| Co-Investigator(Kenkyū-buntansha) |
KASUYA Hideki 名古屋大学, 大学院・医学系研究科, 准教授 (00402636)
TAKEDA Shin 名古屋大学, 大学院・医学系研究科, 講師 (20314015)
SUGIMOTO Hiroyuki 名古屋大学, 医学部附属病院, 助教 (20437007)
NOMOTO Shuji 名古屋大学, 医学部附属病院, 助教 (40300967)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 癌 / ウイルス / 転移性肝癌 / 腫瘍溶解性ウイルス / HF10 |
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| Research Abstract |
we encapsulated the oncolytic virus in liposomal emulsion body Anti-HSV antibodies attenuated the infectiousness and cytotoxicity of hrR3, whereas hrR3/liposome complexes were not attenuated by these anti-HSV antibodies. Although the survival rate of non-immunized mice treated with hrR3 alone was similar to that of mice treated with the hrR3/liposome complexes, the survival rates of immunized mice treated with hrR3 alone were significantly reduced compared to mice treated with the hrR3/liposome complexes.
This systemic intravascular delivery of hrR3/liposome complexes in the presence of pre-existing neutralizing antibodies is effective to treat multiple liver metastases.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer2011
Author(s)
Nakao A, Kasuya H, Sahin TT, Nomura N, Kanzaki A, Misawa M, Shirota T, Yamada S, Fujii T, Sugimoto H, Shikano T, Nomoto S, Takeda S, Kodera Y, Nishiyama Y
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Journal Title
Cancer Gen Ther Vol.18, No.3
Pages: 167-175
Related Report
Peer Reviewed
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[Journal Article] High therapeutic potential for systemic delivery of a liposome-conjugated herpes simplex virus2010
Author(s)
Shikano T, Kasuya H, Sahin TT, Nomura N, Kanzaki A, Misawa M, Nishikawa Y, Shirota T, Yamada S, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Takeda S, Nakao A
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Journal Title
Curr Cancer Drug Targets Vol.11, No.1
Pages: 111-122
Related Report
Peer Reviewed
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[Journal Article] Considerations for intravascular administration of oncolytic herpes virus for the treatment of multiple liver metastases2009
Author(s)
Nomura N, Kasuya H, Watanabe I, Shikano T, Shirota T, Misawa M, Sugimoto H, Kanazumi N, Nomoto S, Takeda S, Nakao A
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Journal Title
Cancer Chemother Pharmacol Vol.63, No.2
Pages: 321-330
Related Report
Peer Reviewed
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