| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
TRAIL induces cancer cell apoptosis, but pancreatic cancer cells hava a mechanism to strongly avoid apoptosis. In this study, we tried to develop a strategy to induce apoptotic cell death by modifying the mechanism to avoid apoptosis in pancreatic cancer cells so that TRAIL can induce pancreatic cancer cell death. The mechanism to avoid apoptosis in pancreatic cancer cell is, in other words, a survival signal. Pancreatic cancer tissue strongly expresses survivin, an inhibitor of apoptosis. We have successfully developed oncolytic virus that acts only in cells expressing survivin.
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