Genetic analysis of cancer stems cells in the carcinogenesis and the intractability of treatment of cancer.

• Project/Area Number: 20390360
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: INOUE Hiroshi Kyushu University, 生体防御医学研究所・腫瘍外科, 学術研究者(共同研究員) (90203249)
• Co-Investigator(Kenkyū-buntansha): MORI Masaki (70190999) ; MIMORI Koshi 九州大学, 生体防御医学研究所, 准教授 (50322748) ; ISHII Hideshi 九州大学, 生体防御医学研究所, 学術研究員 (10280736) ; 田中 文明 九州大学, 大学病院, 助教 (30332836)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 遺伝子多型 / 疫学関連因子 / 交互作用 / p53制御分子 / 癌幹細胞 / CD13 / 活性酸素 / CD133 / CD44 / 転移再発 / 治療抵抗性 / 多様性 / 消化器癌 / マイクロアレイ / LMD / EMT / 癌間質

Research Abstract

Background : Colorectal cancer (CRC) oncogenesis is considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Patients and Methods : A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at eleven known single nucleotide polymorphisms (SNPs) and performed GWAS study. TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Then, we performed microarray analysis of genes from cancer cells extracted from 110 primary tumors by laser microdissection. Results : Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (OR=1.16(1.06-1.27), p=0.0015). Non-insulin-dependent diabetes mellitus, a higher body mass index (BMI) at age 20 and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and diabetes had a 1.66 fold higher risk ratio than the cohort of major allele patients without diabetes. Meta-analysis of gene profiles (MetaGP) provide a clew to explain the risk for CRC in major allele at rs6983267 with diabetes mellitus. Conclusion : We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G-allele at the 8q24 rs6983267 SNP, however, a major T-allele SNP could more clearly reveal a correlation with CRC specifically when diabetes mellitus is present. In addition, PICT1 gene, located on 19q13 (CRC oncogenic SNP), a p53 regulating gene, is associated with the progression of CRC and determined prognosis of CRC cases definitely.

Research Products

• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. (2011)
  • Author(s): Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.
  • Journal Title: Clin Cancer Res.
• [Journal Article] Kinesin 18A expression clinical relevance to colorectal cancer progression. (2011)
  • Author(s): Nagahara M, Nishida N, Iwatsuki M, Ishimaru S, Mimori K, Tanaka F, Nakagawa T, Sato T, Sugihara K, Hoon DS, Mori M.
  • Journal Title: Int J Cancer.
• [Journal Article] Clinical Significance of Circulating Tumor Cells, Including Cancer Stem-Like Cells, in Peripheral Blood for Recurrence and Prognosis in Patients With Dukes' Stage B and C Colorectal Cancer (2011)
  • Author(s): Iinuma, H., Watanabe, T., Mimori, K., et al.
  • Journal Title: J Clin Oncol Volume: (CDR)
  • Peer Reviewed
• [Journal Article] Identification of HLA-A^*0201/-A^*2402-restricted CTL epitope-peptides derived from a novel cancer/testis antigen, MCAK, and induction of a specific antitumor immune response (2011)
  • Author(s): Kawamoto, M., Tanaka, F., Mimori, K., et al.
  • Journal Title: Oncol Rep Volume: 25 Pages: 469-76
  • Peer Reviewed
• [Journal Article] STC2 : a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma (2011)
  • Author(s): Kita, Y., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 18 Pages: 261-72
  • Peer Reviewed
• [Journal Article] The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events (2011)
  • Author(s): Maeda, T., Oyama, J., Higuchi, Y., Koyanagi, M., Sasaki, M., Arima, T., Mimori, K., et al.
  • Journal Title: Aging Male Volume: 14 Pages: 21-6
  • Peer Reviewed
• [Journal Article] The physical ability of Japanese female elderly with cerebrovascular disease correlates with the telomere length and subtelomeric methylation status in their peripheral blood leukocytes (2011)
  • Author(s): Maeda, T., Oyama, J., Higuchi, Y., Nishiyama, Y., Kudo, Y., Yamori, T., Nakazono, T., Arima, T., Mimori, K., et al.
  • Journal Title: Gerontology Volume: 57 Pages: 137-43
  • Peer Reviewed
• [Journal Article] Kinesin 18A expression clinical relevance to colorectal cancer progression (2011)
  • Author(s): Nagahara, M., Nishida, N., Iwatsuki, M., Ishimaru, S., Mimori, K., et al.
  • Journal Title: Int J Cancer Volume: (in press)
  • Peer Reviewed
• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab (2011)
  • Author(s): Nishida, N., Mimori, K., et al.
  • Journal Title: Clin Cancer Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] FOXC2 is a Novel Prognostic Factor in Human Esophageal Squamous Cell Carcinoma (2011)
  • Author(s): Nishida, N., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 18 Pages: 535-42
  • Peer Reviewed
• [Journal Article] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients (2011)
  • Author(s): Nishida, N., Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 38 Pages: 955-62
  • Peer Reviewed
• [Journal Article] Significance of Lgr5(+ve) Cancer Stem Cells in the Colon and Rectum (2011)
  • Author(s): Takahashi, H., Ishii, H., Nishida, N., Takemasa, I., Mizushima, T., Ikeda, M., Yokobori, T., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 18 Pages: 1166-74
  • Peer Reviewed
• [Journal Article] Hypoxia-inducible Adrenomedullin in Colorectal Cancer (2011)
  • Author(s): Uemura, M., Yamamoto, H., Takemasa, I., Mimori, K., et al.
  • Journal Title: Anticancer Res Volume: 31 Pages: 507-14
  • Peer Reviewed
• [Journal Article] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients. (2010)
  • Author(s): Ota D, Mimori K, Yokobori T, Iwatsuki M, Kataoka A, Masuda N, Ishii H, Ohno S, Mori M.
  • Journal Title: Int J Oncol 38 Volume: 38(4) Issue: 4 Pages: 955-962
  • DOI: 10.3892/ijo.2011.926
  • Peer Reviewed
• [Journal Article] Serum Matrix-Metalloproteinase-1 is a Bona Fide Prognostic Marker for Colorectal Cancer. (2010)
  • Author(s): Mimori K, Tahara K, Iinuma H, Iwatsuki M, Yokobori T, Ishii H, Anai H, Kitano S, Mori M
  • Journal Title: Ann Surg Oncol
• [Journal Article] FHIT Suppresses Inflammatory Carcinogenic Activity by Inducing Apoptosis in Esophageal Epithelial Cells. (2010)
  • Author(s): Mimori K, Yokobori T, Iwatsuki M, Sudo T, Tanaka F, Shibata K, Ishii H, Mori M
  • Journal Title: J Nucleic Acid Invest
• [Journal Article] Clinical Significance of Stanniocalcin 2 as a Prognostic Marker in Gastric Cancer. (2010)
  • Author(s): Yokobori T, Mimori K, Ishii H, Iwatsuki M, Tanaka F, Kamohara Y, Ieta K, Kita Y, Doki Y, Kuwano H, Mori M
  • Journal Title: Ann Surg Oncol
• [Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. (2010)
  • Author(s): Tanaka F, Yamamoto K, Suzuki S, Inoue H, Tsurumaru M, Kajiyama Y, Kato H, Igaki H, Furuta K, Fujita H, Tanaka T, Tanaka Y, Kawashima Y, Natsugoe S, Setoyama T, Tokudome S, Mimori K, Haraguchi N, Ishii H, Mori M
  • Journal Title: Gut
• [Journal Article] FANCD2 mRNA overexpression is a bona fide indicator of lymph node metastasis in human colorectal cancer. (2010)
  • Author(s): Ozawa H, Iwatsuki M, Mimori K, Sato T, Johansson F, Toh H, Watanabe M, Mori M
  • Journal Title: Ann Surg Oncol 17 Pages: 2341-2348
• [Journal Article] FOXC2 is a Novel Prognostic Factor in Human Esophageal Squamous Cell Carcinoma. (2010)
  • Author(s): Nishida N, Mimori K, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M
  • Journal Title: Ann Surg Oncol
• [Journal Article] Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients. (2010)
  • Author(s): Nagahara M, Mimori K, Kataoka A, Ishii H, Tanaka F, Nakagawa T, Sato T, Ono S, Sugihara K, Mori M
  • Journal Title: Clin Cancer Res 16 Pages: 4625-4635
• [Journal Article] Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer. (2010)
  • Author(s): Motoyama K, Inoue H, Mimori K, Tanaka F, Kojima K, Uetake H, Sugihara K, Mori M
  • Journal Title: Int J Oncol 36 Pages: 1089-1095
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells. (2010)
  • Author(s): Miyoshi N, Ishii H, Nagai K, Hoshino H, Mimori K, Tanaka F, Nagano H, Sekimoto M, Doki Y, Mori M
  • Journal Title: Proc Natl Acad Sci USA 107 Pages: 40-45
• [Journal Article] STC2 : A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma. (2010)
  • Author(s): Kita Y, Mimori K, Iwatsuki M, Yokobori T, Ieta K, Tanaka F, Ishii H, Okumura H, Natsugoe S, Mori M
  • Journal Title: Ann Surg Oncol
• [Journal Article] Epithelial-mesenchymal transition in cancer development and its clinical significance. (2010)
  • Author(s): Iwatsuki M, Mimori K, Yokobori T, Ishii H, Beppu T, Nakamori S, Baba H, Mori M
  • Journal Title: Cancer Sci 101 Pages: 293-299
  • NAID: 10026587181
• [Journal Article] Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. (2010)
  • Author(s): Iwatsuki M, Mimori K, Sato T, Toh H, Yokobori T, Tanaka F, Ishikawa K, Baba H, Mori M
  • Journal Title: Int J Oncol 36 Pages: 569-575
• [Journal Article] The Clinical Significance of Vimentin-Expressing Gastric Cancer Cells in Bone Marrow. (2010)
  • Author(s): Iwatsuki M, Mimori K, Fukagawa T, Ishii H, Yokobori T, Sasako M, Baba H, Mori M
  • Journal Title: Ann Surg Oncol
• [Journal Article] Clinical Significance of Human Kallikrein7 Gene Expression in Colorectal Cancer. (2010)
  • Author(s): Inoue Y, Yokobori T, Yokoe T, Toiyama Y, Miki C, Mimori K, Mori M, Kusunoki M
  • Journal Title: Ann Surg Oncol
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells. (2010)
  • Author(s): Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF, Doki Y, Mori M
  • Journal Title: J Clin Invest 120 Pages: 3326-39
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells. (2010)
  • Author(s): Haraguchi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: J Clin Invest Volume: (CDR)
  • Peer Reviewed
• [Journal Article] Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors (2010)
  • Author(s): Hirose, H., Ishii, H., Mimor, K., et al.
  • Journal Title: Oncol Rep Volume: 23 Pages: 35-43
  • Peer Reviewed
• [Journal Article] Clinical Significance of Human Kallikrein7 Gene Expression in Colorectal Cancer. (2010)
  • Author(s): Inoue, Y., Yokobori, T., Yokoe, T., Toiyama, Y., Miki, C., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CDR)
  • Peer Reviewed
• [Journal Article] The Clinical Significance of Vimentin-Expressing Gastric Cancer Cells in Bone Marrow (2010)
  • Author(s): Iwatsuki, M., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CDR)
  • Peer Reviewed
• [Journal Article] Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance (2010)
  • Author(s): Iwatsuki, M., Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 569-75
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition in cancer development and its clinical significance (2010)
  • Author(s): Iwatsuki, M., Mimori, K., et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 293-9
  • NAID: 10026587181
  • Peer Reviewed
• [Journal Article] STC2 : A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma (2010)
  • Author(s): Kita, Y., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 4-4
  • Peer Reviewed
• [Journal Article] Expression of C4.4A at the invasive front is a novel prognostic marker for disease recurrence of colorectal cancer (2010)
  • Author(s): Konishi, K., Yamamoto, H., Mimori, K., et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 2269-77
  • NAID: 10027832873
  • Peer Reviewed
• [Journal Article] FHIT Suppresses Inflammatory Carcinogenic Activity by Inducing Apoptosis in Esophageal Epithelial Cells (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: J Nucleic Acid Invest Volume: 101 Pages: 2269-77
  • Peer Reviewed
• [Journal Article] Serum Matrix-Metalloproteinase-1 is a Bona Fide Prognostic Marker for Colorectal Cancer (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CDR)
  • Peer Reviewed
• [Journal Article] Abnormal Expression of PFDN4 in Colorectal Cancer : A Novel Marker for Prognosis (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CDR)
  • Peer Reviewed
• [Journal Article] TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 563-8
  • Peer Reviewed
• [Journal Article] SCRN1 is a novel marker for prognosis in colorectal cancer (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K, et al.
  • Journal Title: J Surg Oncol Volume: 101 Pages: 156-9
  • Peer Reviewed
• [Journal Article] TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 17 Pages: 967-72
  • Peer Reviewed
• [Journal Article] ATP11A is a novel predictive marker for metachronous metastasis of colorctal cancer (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Oncol Rep Volume: 23 Pages: 505-10
  • Peer Reviewed
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107 Pages: 40-5
  • Peer Reviewed
• [Journal Article] Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 1089-95
  • Peer Reviewed
• [Journal Article] Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients (2010)
  • Author(s): Nagahara, M., Mimori, K, et al.
  • Journal Title: Clin Cancer Res Volume: 16 Pages: 4625-35
  • Peer Reviewed
• [Journal Article] FOXC2 is a Novel Prognostic Factor in Human Esophageal Squamous Cell Carcinoma (2010)
  • Author(s): Nishida, N., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CDR)
  • Peer Reviewed
• [Journal Article] FANCD2 mRNA overexpression is a bona fide indicator of lymph node metastasis in human colorectal cancer (2010)
  • Author(s): Ozawa, H., Iwatsuki, M., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 17 Pages: 2341-8
  • Peer Reviewed
• [Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles (2010)
  • Author(s): Tanaka, F., Yamamoto, K., Suzuki, S., Inoue, H., Tsurumaru, M., Kajiyama, Y., Kato, H., Igaki, H., Furuta, K., Fujita, H., Tanaka, T., Tanaka, Y., Kawashima, Y., Natsugoe, S., Setoyama, T., Tokudome, S., Mimori, K., et al.
  • Journal Title: Gut Volume: (CDR)
  • Peer Reviewed
• [Journal Article] Clinical significance of ASB9 in human colorectal cancer (2010)
  • Author(s): Tokuoka, M., Miyoshi, N, Hitora, T., Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 37 Pages: 1105-11
  • Peer Reviewed
• [Journal Article] Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer : in vivo identification from hypoxic tumor cells (2010)
  • Author(s): Uemura, M., Yamamoto, H., Takemasa, I., Mimori, K., et al.
  • Journal Title: Clin Cancer Res Volume: 16 Pages: 4636-46
  • Peer Reviewed
• [Journal Article] Clinical Significance of Stanniocalcin 2 as a Prognostic Marker in Gastric Cancer (2010)
  • Author(s): Yokobori, T., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CDR)
  • Peer Reviewed
• [Journal Article] The Clinical Significance of Vimentin-Expressing Gastric Cancer Cells in Bone Marrow (2010)
  • Author(s): Iwatsuki M, Mimori K., et al.
  • Journal Title: Ann Surg Oncol (掲載決定)
  • Peer Reviewed
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells (2010)
  • Author(s): Miyosi N., Mimori K., et al.
  • Journal Title: Proc Natl Acad Sci.(USA) 107 Pages: 40-5
  • Peer Reviewed
• [Journal Article] p53-Altered FBXW7 Expression Determines Poor Prognosis in Gastric Cancer Cases. (2009)
  • Author(s): Yokobori T, Mimori K, Iwatsuki M, Ishii H, Onoyama I, Fukagawa T, Kuwano H, Nakayama KI, Mori M
  • Journal Title: Cancer Res
• [Journal Article] Comprehensive analysis of the clinical significance of inducing pluripotent stemness-related gene expression in colorectal cancer cells. (2009)
  • Author(s): Saiki Y, Ishimaru S, Mimori K, Takatsuno Y, Nagahara M, Ishii H, Yamada K, Mori M
  • Journal Title: Ann Surg Oncol 16 Pages: 2638-2644
• [Journal Article] Over- and under-expressed microRNAs in human colorectal cancer. (2009)
  • Author(s): Motoyama K, Inoue H, Takatsuno Y, Tanaka F, Mimori K, Uetake H, Sugihara K, Mori M
  • Journal Title: Int J Oncol 34 Pages: 1069-1075
• [Journal Article] Preoperative u-PAR Gene Expression in Bone Marrow Indicates the Potential Power of Recurrence in Breast Cancer Cases. (2009)
  • Author(s): Mimori K, Kataoka A, Yamaguchi H, Masuda N, Kosaka Y, Ishii H, Ohno S, Mori M
  • Journal Title: Ann Surg Oncol
• [Journal Article] Important matters to identify robust markers for metastasis and recurrence in solid cancer. (2009)
  • Author(s): Mimori K, Iwatsuki M, Yokobori T, Mori M
  • Journal Title: Ann Surg Oncol 16 Pages: 1070-1071
• [Journal Article] Clinical significance of LAMB3 and COL7A1 mRNA in esophageal squamous cell carcinoma. (2009)
  • Author(s): Kita Y, Mimori K, Tanaka F, Matsumoto T, Haraguchi N, Ishikawa K, Matsuzaki S, Fukuyoshi Y, Inoue H, Natsugoe S, Aikou T, Mori M
  • Journal Title: Eur J Surg Oncol 35 Pages: 52-58
• [Journal Article] Expression of uPAR mRNA in peripheral blood is a favourite marker for metastasis in gastric cancer cases. (2009)
  • Author(s): Kita Y, Fukagawa T, Mimori K, Kosaka Y, Ishikawa K, Aikou T, Natsugoe S, Sasako M, Mori M
  • Journal Title: Br J Cancer 100 Pages: 153-159
• [Journal Article] Epithelial-mesenchymal transition in cancer development and its clinical significance. (2009)
  • Author(s): Iwatsuki M, Mimori K, Yokobori T, Ishii H, Beppu T, Nakamori S, Baba H, Mori M
  • Journal Title: Cancer Sci
  • NAID: 10026587181
• [Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : Clinical significance. (2009)
  • Author(s): Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M
  • Journal Title: Int J Cancer
• [Journal Article] Bone marrow and peripheral blood expression of ID1 in human gastric carcinoma patients is a bona fide indicator of lymph node and peritoneal metastasis. (2009)
  • Author(s): Iwatsuki M, Fukagawa T, Mimori K, Nakanishi H, Ito S, Ishii H, Yokobori T, Sasako M, Baba H, Mori M
  • Journal Title: Br J Cancer 100 Pages: 1937-42
• [Journal Article] Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer. (2009)
  • Author(s): Ieta K, Tanaka F, Yokobori T, Kita Y, Haraguchi N, Mimori K, Kato H, Asao T, Inoue H, Kuwano H, Mori M
  • Journal Title: Int J Cancer
• [Journal Article] p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases (2009)
  • Author(s): Yokobori T., Mimori K., et al.
  • Journal Title: Cancer Res 69 Pages: 3788-94
  • Peer Reviewed
• [Journal Article] Preoperative u-PAR gene expression in bone marrow indicates the potential power of recurrence in breast cancer cases (2009)
  • Author(s): Mimori K., et al
  • Journal Title: Ann Surg Oncol 16 Pages: 2035-41
  • Peer Reviewed
• [Journal Article] Important matters to identify robust markers for metastasis and recurrence in solid cancer. (2009)
  • Author(s): Mimori K., et al.
  • Journal Title: Ann Surg Oncol 16 Pages: 1070-1
  • Peer Reviewed
• [Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : clinical significance. (2009)
  • Author(s): Iwatsuki M., Mimori K., et al.
  • Journal Title: Int J Cancer 126 Pages: 1828-37
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition in cancer development and its clinical significance (2009)
  • Author(s): Iwatsuki M, Mimori K., et al.
  • Journal Title: Cancer Sci 101 Pages: 293-9
  • NAID: 10026587181
  • Peer Reviewed
• [Journal Article] Bone marrow and peripheral blood expression of ID1 in human gastric carcinoma patients is a bona fide indicator of lymph node and peritoneal metastasis (2009)
  • Author(s): Iwatsuki M, Mimori K., et al.
  • Journal Title: Br J Cancer 100 Pages: 1937-42
  • Peer Reviewed
• [Journal Article] Over-and under-expressed microRNAs in human colorectal cancer. (2009)
  • Author(s): Motoyama, K. Inoue, H., 他
  • Journal Title: Int J Oncol 34 Pages: 1069-75
  • Peer Reviewed
• [Journal Article] Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells. (2008)
  • Author(s): Yoshinaga K, Yamashita K, Mimori K, Tanaka F, Inoue H, Mori M
  • Journal Title: Ann Surg Oncol 15 Pages: 96-103
• [Journal Article] Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line. (2008)
  • Author(s): Yoshinaga K, Mimori K, Inoue H, Kamohara Y, Yamashita K, Tanaka F, Mori M
  • Journal Title: Int J Oncol 33 Pages: 453-459
• [Journal Article] Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis. (2008)
  • Author(s): Yokoe T, Tanaka F, Mimori K, Inoue H, Ohmachi T, Kusunoki M, Mori M
  • Journal Title: Cancer Res 68 Pages: 1074-1082
• [Journal Article] Clinical significance of low expression of Prostasin mRNA in human gastric cancer. (2008)
  • Author(s): Sakashita K, Mimori K, Tanaka F, Tahara K, Inoue H, Sawada T, Ohira M, Hirakawa K, Mori M
  • Journal Title: J Surg Oncol 98 Pages: 559-564
• [Journal Article] Clinical significance of loss of Fhl1 expression in human gastric cancer. (2008)
  • Author(s): Sakashita K, Mimori K, Tanaka F, Kamohara Y, Inoue H, Sawada T, Hirakawa K, Mori M
  • Journal Title: Ann Surg Oncol 15 Pages: 2293-2300
• [Journal Article] Prognostic relevance of Tensin4 expression in human gastric cancer. (2008)
  • Author(s): Sakashita K, Mimori K, Tanaka F, Kamohara Y, Inoue H, Sawada T, Hirakawa K, Mori M
  • Journal Title: Ann Surg Oncol 15 Pages: 2606-2613
• [Journal Article] Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. (2008)
  • Author(s): Ohta M, Mimori K, Fukuyoshi Y, Kita Y, Motoyama K, Yamashita K, Ishii H, Inoue H, Mori M
  • Journal Title: Br J Cancer 98 Pages: 410-417
• [Journal Article] PDGF-BB is a novel prognostic factor in colorectal cancer. (2008)
  • Author(s): Nakamura Y, Tanaka F, Yoshikawa Y, Mimori K, Inoue H, Yanaga K, Mori M
  • Journal Title: Ann Surg Oncol 15 Pages: 2129-2136
• [Journal Article] Clinical significance of BMP7 in human colorectal cancer. (2008)
  • Author(s): Motoyama K, Tanaka F, Kosaka Y, Mimori K, Uetake H, Inoue H, Sugihara K, Mori M
  • Journal Title: Ann Surg Oncol 15 Pages: 1530-1537
• [Journal Article] Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment. (2008)
  • Author(s): Mimori K, Ishii H, Inoue H, Barnard GF, Mori M
  • Journal Title: J Gastroenterol Hepatol 23 Suppl 2
• [Journal Article] Hematogenous metastasis in gastric cancer requires isolated tumor cells and expression of vascular endothelial growth factor receptor-1. (2008)
  • Author(s): Mimori K, Fukagawa T, Kosaka Y, Kita Y, Ishikawa K, Etoh T, Iinuma H, Sasako M, Mori M
  • Journal Title: Clin Cancer Res 14 Pages: 2609-2016
• [Journal Article] A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases. (2008)
  • Author(s): Mimori K, Fukagawa T, Kosaka Y, Ishikawa K, Iwatsuki M, Yokobori T, Hirasaki S, Takatsuno Y, Sakashita H, Ishii H, Sasako M, Mori M
  • Journal Title: Ann Surg Oncol 15 Pages: 2934-2942
• [Journal Article] The search for cancer stem cells in hepatocellular carcinoma. (2008)
  • Author(s): Kamohara Y, Haraguchi N, Mimori K, Tanaka F, Inoue H, Mori M, Kanematsu T
  • Journal Title: Surgery 144 Pages: 119-124
• [Journal Article] Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes. (2008)
  • Author(s): Ishii H, Mimori K, Ishikawa K, Okumura H, Pichiorri F, Druck T, Inoue H, Vecchione A, Saito T, Mori M, Huebner K
  • Journal Title: Cancer Res 68 Pages: 3662-3670
• [Journal Article] Cancer stem cells and chemoradiation resistance. (2008)
  • Author(s): Ishii H, Iwatsuki M, Ieta K, Ohta D, Haraguchi N, Mimori K, Mori M
  • Journal Title: Cancer Sci 99 Pages: 1871-1877
  • NAID: 10024011398
• [Journal Article] CD133+CD44+ population efficiently enriches colon cancer initiating cells. (2008)
  • Author(s): Haraguchi N, Ohkuma M, Sakashita H, Matsuzaki S, Tanaka F, Mimori K, Kamohara Y, Inoue H, Mori M
  • Journal Title: Ann Surg Oncol 15 Pages: 2927-2933
• [Journal Article] Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis (2008)
  • Author(s): Yokoe, T. Inoue, H., 他
  • Journal Title: Cancer Res 68 Pages: 1074-82
  • Peer Reviewed
• [Journal Article] Clinical significance of the reduced expression of G protein gamm a 7 (GNG7)in oesophageal cancer (2008)
  • Author(s): Ohta, M. Inoue, H., 他
  • Journal Title: Br J Cancer 98 Pages: 410-7
  • Peer Reviewed
• [Journal Article] Activin a causes cancer cell aggressiveness in esophageal squam ous cell carcinoma cells (2008)
  • Author(s): Yoshinaga, K. Inoue, H., 他
  • Journal Title: Ann Surg Oncol 15 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Clinical significance of miR-146a in gastric cancer cases.
  • Author(s): Kogo R, Mimori K, Tanaka F, Komune S, Mori M.
  • Journal Title: Clin Cancer Res in press
• [Journal Article] Reprogramming of mouse and human cells to pluripotency using mature microRNAs.
  • Author(s): Miyoshi N, Ishii H, Nagano H, Haraguchi, Dewi DL, Kano Y Nishikawa S, Tanemura T, Mimori K, Tanaka F, Saito T, Nishimura J, Takemasa I, Mizusima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M.
  • Journal Title: Cell Stem Cell in press
• [Journal Article] Regulation of the MDM2-p53 Pathway and Tumor Growth by PICT1/GLTSCR2 via Nucleolar RPL11.
  • Author(s): Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wangjia J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A.
  • Journal Title: Nat Med in press
• [Journal Article]
  • Author(s): Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Nozawa K, Ishihara Matsuda KN, Fukushima R, Okinaga K, Sasako M, Mori M.
  • Journal Title: J Clin Oncol(Reply to B Faltas et al.) in press
• [Journal Article] FBXO31 determines poor prognosis in esophageal squamous cell carcinoma.
  • Author(s): Kogo R, Mimori K, Tanaka F, Komune S, Mori M.
  • Journal Title: Int J Oncol in press
• [Journal Article] Absence of CD71 Transferrin Receptor Characterizes Human Gastric Adenosquamous Carcinoma Stem Cells.
  • Author(s): Ohkuma M, Haraguchi N, Ishii H, Mimori K, Tanaka F, Kim HM, et al.
  • Journal Title: Ann Surg Oncol in press
• [Journal Article] MicroRNA miR-125b is a prognostic marker in human colorectal cancer.
  • Author(s): Nishida N, Yokobori T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Kuwano H, Mori M.
  • Journal Title: Int J Oncol 38 Pages: 1437-1443
• [Journal Article] Identification of HLA-A*0201/-A*2402-restricted CTL epitope-peptides derived from a novel cancer/testis antigen, MCAK, and induction of a specific antitumune response.
  • Author(s): Kawamoto M, Tanaka F, Mimori K, Inoue H, Kamohara Y, Mori M.
  • Journal Title: Oncol Rep 25 Pages: 469-476
• [Journal Article] FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma.
  • Author(s): Nishida N, Mimori K, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.
  • Journal Title: Ann Surg Oncol 18 Pages: 535-542
• [Journal Article] STC2 : a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma.
  • Author(s): Kita Y, Mimori K, Iwatsuki M, Yokobori T, Ieta K, Tanaka F, Ishii H, Okumura H, Natsugoe S, Mori M.
  • Journal Title: Ann Surg Oncol 18 Pages: 261-272
• [Journal Article] Clinical Significance of Circulating Tumor Cells Including Cancer Stem-like Cells in Peripheral Blood for Recurrence and Prognosis in Colorectal Cancer Patients with Dukes stage B and C.
  • Author(s): Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Matsuda K, Fukushima R, Okinaga K, Sasako M, Mori M.
  • Journal Title: J Clin Oncol 29 Pages: 1547-1555
• [Journal Article] Reply : Preanalytical Interferences Compromise the Clinical Validity of Matrix Metalloproteinase 1 as Marker of Colorectal Cancer.
  • Author(s): Iwatsuki M, Mimori K, Tahara K, Baba H, Mori M.
  • Journal Title: Ann Surg Oncol.
• [Presentation] Single nucleotide Polymorphism of Fibronectin 1, Determining Tumor Shape and Malignant Behavior in Colorectal Cancer Cases. (2011)
  • Author(s): 三森功士, et al.
  • Organizer: 64th Society of Surgical Oncology (San Antonio)
  • Place of Presentation: Poster Presentation
• [Presentation] 大腸癌細胞のゲノムCGHクラスター解析および発現アレイpathway解析による5-FU適応症例の決定 (2010)
  • Author(s): 三森功士, 他8名
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-09
• [Presentation] Identification of target gene enhanced by Wnt/TCF binding to the predisposition SNP rs6983267 at chromosome 8q24 in colorectal cancer cases (2010)
  • Author(s): Mimori K., et al
  • Organizer: Society of Surgical Oncology, 2010
  • Place of Presentation: St.Loius
  • Year and Date: 2010-03-05
• [Presentation] 胃癌の進展転移を制御する宿主側細胞由来のmicroRNAの同定 (2010)
  • Author(s): 三森功士、岩槻政晃、深川剛生、石丸神矢、横堀武彦、笹子三津留、森正樹
  • Organizer: 第65回日本消化器外科学会
  • Place of Presentation: シンポジウム
• [Presentation] 10年後の消化器癌罹患率および致死率低減のための分子生物学的アプローチ (2010)
  • Author(s): 三森功士、横堀武彦、渡邊昌彦、工藤進英、楠正人、森谷宜皓、山田一隆、望月英隆、杉原健一、森正樹
  • Organizer: 第65回日本消化器外科学会(特別企画講演:「消化器外科領域におけるリサーチの重要性-具体的アプローチについて-」)
• [Presentation] 臨床病理学的診断を凌駕する、マイクロアレイを用いたDukes B大腸癌における転移予測因子の同定 (2010)
  • Author(s): 三森功士、横堀武彦、飯沼久恵、石井秀始、クラウスパンテル、森正樹
  • Organizer: 第69回日本癌学会
  • Place of Presentation: シンポジウム6
• [Presentation] The identification of novel microRNAs and target genes in bone marrow regulating gastric cancer progression. (2010)
  • Author(s): 三森功士、深川剛生, ムーラ・ファブリ, 岩槻政晃, 横堀武彦, 西田尚弘, 石井秀始, 笹子三津留, カルロ・クローチェ、森正樹
  • Organizer: 第69回日本癌学会
  • Place of Presentation: English Workshop
• [Presentation] Identification of target gene enhanced by Wnt/TCF binding to the predisposition SNP rs6983267 at chromosome 8q24 in colorectal cancer cases. (2010)
  • Author(s): 三森功士, et al.
  • Organizer: 63^<rd> Society of Surgical Oncology (St.Louis)
  • Place of Presentation: Cancer Forum 1 (Oral Presentation)
• [Presentation] 大腸発癌において高いリスクを示す8q24多型における発癌機構の解明 (2009)
  • Author(s): 井上裕, ほか
  • Organizer: 日本がん転移学会
  • Place of Presentation: 旭川
  • Year and Date: 2009-09-15
• [Presentation] 大腸癌におけるEMTを制御し造腫瘍能と多分化能を有する遺伝子の臨床的意義と機能解析 (2009)
  • Author(s): 三森功士、横堀武彦、岩槻政晃、石丸神矢、秋吉清百合、永原誠、石井秀始、森正樹
  • Organizer: 第18回日本がん転移学会総会
  • Place of Presentation: シンポジウム
• [Presentation] 臨床応用にむけた消化器癌の真の転移・再発予測因子の同定について (2009)
  • Author(s): 三森功士、深川剛生、横堀武彦、岩槻政晃、飯沼久恵、田原光一郎、笹子三津留、森正樹
  • Organizer: 第64回日本消化器外科学会
  • Place of Presentation: パネルディスカッション
• [Presentation] Comprehensive Analysis of the Clinical Significance of Inducing Pluripotent Stemness-Related Gene Expression in Colorectal Cancer Cells. (2009)
  • Author(s): Mimori K, Saiki, Y, Mori M
  • Organizer: 62nd Society of Surgical Oncology (Phoenix)
  • Place of Presentation: Poster Presentation
• [Presentation] EMT Induction by a gene Determines Poorer Prognosis in CRC Cases. (2009)
  • Author(s): Mimori K, Yokobori T, Ishii H, Iwatsuki M, Eguchi H, Klaus Pantel, Mori M
  • Organizer: 7th ISMRC (Athens)
  • Place of Presentation: Symposium
• [Presentation] 胃癌転移成立における癌側因子(ITCの存在)と宿主側因子との共存の臨床的意義 (2008)
  • Author(s): 三森功士、深川剛生、小坂愉賢、石川健二、横堀武彦、岩槻政明、笹子三津留、森正樹
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: ワークショップ
• [Presentation] 癌の浸潤・転移機構の包括的解明 (2008)
  • Author(s): 三森功士、深川剛生、井上裕、石川健二、原口直紹、田中文明、蒲原行雄、片岡明美、衛藤剛、山本聖一郎、石井秀始、大野真司、笹子三津留、森正樹
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: シンポジウム
• [Presentation] Clinical significance of u-PAR gene expression in peripheral blood and bone marrow in breast cancer cases. (2008)
  • Author(s): 三森功士, 片岡明美, 西田尚弘, 横堀武彦, 岩槻政晃, 森正樹
  • Organizer: 61th Society of Surgical Oncology (Chicago)
  • Place of Presentation: Poster Presentation
• [Presentation] 癌の浸潤・転移機構の包括的解明-難治性癌の克服への戦い- (2008)
  • Author(s): 井上 裕
  • Organizer: 日本外科学会
  • Place of Presentation: 長崎
• [Presentation] Carcinogenic Rs6983267 at 8q24 SNP regulate MYC transcription, one of iPS genes, which also determines the progression of colorectal cancer cases
  • Author(s): 三森功士, et al.
  • Organizer: 第111回日本外科学会
  • Place of Presentation: 国際シンポジウム
• [Remarks]
  • URL: http://www.mib-beppu.kyushu-u.ac.jp/MIB_res/Surgery/
• [Patent(Industrial Property Rights)] 固形がんの再発および予後因子、およびその臨床利用
  • Inventor(s): 森正樹, 三森功士
  • Industrial Property Rights Holder: 森正樹