| Project/Area Number |
20390361
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMAGUCHI Kouji Kyushu University, 大学院・医学研究院, 共同研究員 (50191226)
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| Co-Investigator(Kenkyū-buntansha) |
KATANO Mitsuo 九州大学, 大学院・医学研究院, 教授 (10145203)
NAKAMURA Masafumi 九州大学, 大学病院, 講師 (30372741)
MORISAKI Takashi 九州大学, 大学院・医学研究院, 共同研究員 (90291517)
ONISHI Hideya 九州大学, 大学院・医学研究院, 准教授 (30553276)
SATOH Norihiro 九州大学, 大学院・医学研究院, 助教 (20423527)
KOJIMA Masayuki 九州大学, 大学病院, 助教 (90380394)
KUBO Makoto 九州大学, 大学病院, 助教 (60403961)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Keywords | 大腸癌 / 膵癌 / gamma secretase (GS)複合体 / GS 阻害剤 / Taxane / アポトーシス / 分子標的治療 / 細胞周期 / ガンマセクレターゼ複合体 / Presenilin-1 / Presenilin-2 / Nicastrin / 細胞増殖 / g-secretase / Notch / G2 / M集積 / γ-secretase / 特異的 / 薬剤耐性 |
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| Research Abstract |
We showed for the first time that gamma secretase (GS) complexes regulate the response of colon and pancreatic cancer cells to taxanes through GS-dependent and GS-independent mechanisms. GS-dependent pathway is independent of Notch signaling. Interestingly, it was strongly indicated that GS complexes regulate the cell cycle progression of these cells in a GS-independent manner. Data suggest that GS complexes could be a new therapeutic target for overcoming resistance to taxanes in these cancers.
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