The mechanism and function of astrocytes in ischemic spinal cord injury in rabbit

Research Project

Project/Area Number	20390362
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	Hokkaido University
Principal Investigator	WAKASA Satoru Hokkaido University, 北海道大学病院, 助教 (10374365)
Co-Investigator(Kenkyū-buntansha)	SHIIYA Norihiko 北海道大学, 北海道大学病院, 講師 (00250449)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	脊髄虚血再潅流障害 / 活性化グリア細胞 / 遅延性脊髄障害 / 細胞膜リン脂質 / 質量顕微鏡 / 脊髄虚血再灌流障害 / アポトーシス
Research Abstract	Spinal cord injury is one of the disastrous complications after surgical repair of thoracoabdominal aortic aneurysm and remains to be eliminated. We investigated the role of astrocytes in the spinal cord injury after transient spinal cord ischemia to elucidate whether the astrocyte would be a target for prevention of spinal cord injury. In the rabbit model, we demonstrated the significant inverse correlation between the activity of astrocytes and number of intact motor neurons. Furthermore, a concentration of arachidonic adid significantly correlated with the activity of astrocytes.