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Identification of molecular targets for lung adenocarcinoma treatment through proteome analysis of phospholyrated kinases

Research Project

Project/Area Number 20390363
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTohoku University

Principal Investigator

SAKURADA Akira  Tohoku University, 病院, 助教 (60360872)

Co-Investigator(Kenkyū-buntansha) ENDO Chiaki  東北大学, 病院, 講師 (80333813)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords肺癌 / EGFR遺伝子 / キナーゼ / プロテオーム / リン酸化 / GRLF1
Research Abstract

Phospholyration of protein is important in signal transduction. We screened phospholyrated proteins in lung adenocarcinoma cell by using mass spectrometry to identify molecular targets for lung cancer treatment. Some proteins, including GFRF1/p190 A RhoGAP, were strongly controlled by EGFR protein. Functional analysis revealed that GFRF1/p190 A RhoGAP protein controls lung cancer cell proliferation through regulating MEK/ERK pathway. This protein could be a candidate of molecular treatment of lung adenocarcinoma.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (28 results)

All 2011 2010 2009 2008 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer.2011

    • Author(s)
      Tsao MS, Sakurada A, Ding K, Aviel-Ronen S, Ludkovski O, Liu N, Le Maitre A, Gandara D, Johnson DH, Rigas JR, Seymour L, Shepherd FA.
    • Journal Title

      J Thorac Oncol

      Volume: 6 Pages: 139-147

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer.2010

    • Author(s)
      Tsao MS, Sakurada A, et al.
    • Journal Title

      J Thorac Oncol 6巻

      Pages: 139-147

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resection of apical lung carcinoma involving the vertebral artery.2010

    • Author(s)
      Watanabe T, Okada Y, Sakurada A, Sado T, Matsuda Y, Shimizu H, Fukuhara T, Kondo T
    • Journal Title

      Ann Thorac Surg

      Volume: 90 Pages: 302-303

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of preoperative gefitinib in clinical stage I non-small-cell lung cancer.2009

    • Author(s)
      Lara-Guerra H, Sakurada A, et al.
    • Journal Title

      J Clin Oncol 27巻

      Pages: 6229-6236

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Results of long-term follow-up of photodynamic therapy for roentgenographically occult bronchogenic squamous cell carcinoma.2009

    • Author(s)
      Endo C, Sakurada A, et al.
    • Journal Title

      Chest 136巻

      Pages: 369-357

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung2009

    • Author(s)
      Endo C, Sakurada A, et al.
    • Journal Title

      Acta Cytol 53巻

      Pages: 36-40

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictive biomarkers for EGFR therapy2009

    • Author(s)
      Sakurada A, Tsao MS
    • Journal Title

      Idrugs 12巻

      Pages: 34-38

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of preoperative gefitinib in clinical stage I non-small-cell lung cancer.2009

    • Author(s)
      Lara-Guerra H, Waddell TK, Salvarrey MA, Joshua AM, Chung CT, Paul N, Boerner S, Sakurada A, Ludkovski O, Ma C, Squire J, Liu G, Shepherd FA, Tsao MS, Leighl NB
    • Journal Title

      J Clin Oncol 27

      Pages: 6229-6236

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Results of long-term follow-up of photodynamic therapy for roentgenographically occult bronchogenic squamous cell carcinoma.2009

    • Author(s)
      Endo C, Miyamoto A, Sakurada A, Aikawa H, Sagawa M, Sato M, Saito Y, Kondo T
    • Journal Title

      Chest 136

      Pages: 369-375

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung2009

    • Author(s)
      Endo C, Honda M, Sakurada A, Sato M, Saito Y, Kondo T
    • Journal Title

      Acta Cytol 53

      Pages: 36-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive biomarkers for EGFR therapy2009

    • Author(s)
      Sakurada A, Tsao MS
    • Journal Title

      IDrugs 12

      Pages: 34-38

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma.2008

    • Author(s)
      Gu Z, Mitsui H, Sakurada A, et al.
    • Journal Title

      Biochem Biophys Res Commun 377巻

      Pages: 685-688

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21.2008

    • Author(s)
      Zhu CQ, Sakurada A, et al.
    • Journal Title

      J Clin Oncol 26巻

      Pages: 4268-4275

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148.2008

    • Author(s)
      Oza AM, Sakurada A, et al.
    • Journal Title

      J Clin Oncol 26巻

      Pages: 4319-4325

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue heterogeneity of EGFR mutation in lung adenocarcinoma.2008

    • Author(s)
      Sakurada A, Lara-Guerra H, et al.
    • Journal Title

      J Thorac Oncol 3巻

      Pages: 527-529

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma2008

    • Author(s)
      Yamanaka S, Gu Z, Sakurada A, et al.
    • Journal Title

      Pathology 75巻

      Pages: 2-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma2008

    • Author(s)
      Gu Z, Mitsui H, lnomata K, Honda M, Endo C, Sakurada A, Sato M, Okada Y, Kondo T, Horii A
    • Journal Title

      Biochem Biophys Res Commun 377

      Pages: 685-688

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR. 212008

    • Author(s)
      Zhu CQ, da Cunha Santos G, Ding K, Sakurada A, Cutz JC, Liu N, Zhang T, Marrano P, Whitehead M, Squire JA, Kamel-Reid S, Seymour L, Shepherd FA, Tsao MS
    • Journal Title

      J Clin Oncol 26

      Pages: 4268-4275

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of erlotinib in recurrent or metastatic endometrial cancer : NCIC IND-1482008

    • Author(s)
      Oza AM, Eisenhauer EA, Elit L, Cutz JC, Sakurada A, Tsao MS, Hoskins PJ, Biagi J, Ghatage P, Mazurka J, Provencher D, Dore N, Dancey J, Fyles A
    • Journal Title

      J Clin Oncol 26

      Pages: 4319-4325

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue heterogeneity of EGFR mutation in lung adenocarcinoma2008

    • Author(s)
      Sakurada A, Lara-Guerra H, Liu N, Shepherd FA, Tsao MS
    • Journal Title

      J Thorac Oncol 3

      Pages: 527-529

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma2008

    • Author(s)
      Yamanaka S, Gu Z, Sato M, Fujisaki R, Inomata K, Sakurada A, Inoue A, Nukiwa, T, Kondo T, Horii A
    • Journal Title

      Pathobiologyl 75

      Pages: 2-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺癌細胞におけるp190-A RhoGAPの役割について2010

    • Author(s)
      野津田泰嗣、桜田晃、遠藤千顕, ほか
    • Organizer
      日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺癌細胞におけるp190-A RhoGAPの役割について2010

    • Author(s)
      野津田泰嗣、桜旦晃、江場俊介、渡邉龍秋、渡辺有為、鈴木隆哉、大石久、前田寿美子、野田雅史、佐渡哲、星川康、遠藤千顕、岡田克典、近藤丘
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Surgical outcome of the patients with adenoidcystic carcinoma2010

    • Author(s)
      桜田晃, 遠藤千顕, et al.
    • Organizer
      World Conference for Bronchology 2010
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2010-06-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺腺癌におけるリン酸化チロシンを標的とした網羅的解析(シンポジウム)2010

    • Author(s)
      桜田晃、野津田泰嗣、遠藤千顕, ほか
    • Organizer
      日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺腺癌におけるリン酸化チロシンを標的とした網羅的解析(シンポジウム)2010

    • Author(s)
      桜田晃、野津田泰嗣、遠藤千顕、大石久、前田寿美子、小柳津毅、野田雅史、佐渡哲、星川康、岡田克典、近藤丘
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prognostic impact of visceral pleural involvement in patients with lung cancer2009

    • Author(s)
      桜田晃, 野津田泰嗣, 遠藤千顕, et al.
    • Organizer
      13^<th> World Congress on Lung Cancer
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-08-01
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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