| Project/Area Number |
20390367
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
DATE Hiroshi Kyoto University, 医学研究科, 教授 (60252962)
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| Co-Investigator(Kenkyū-buntansha) |
KOIKE Kaoru 京都大学, 大学院・医学研究科, 教授 (10267164)
BANDO Toru 京都大学, 大学院・医学研究科, 准教授 (20293954)
TSUYOSHI Shoji 京都大学, 大学院・医学研究科, 助教 (80402840)
CHEN Fengshi 京都大学, 大学院・医学研究科, 助教 (00452334)
FUJINAGA Takuji 京都大学, 大学院・医学研究科, 助教 (00444456)
OKAMOTO Toshihiro 京都大学, 大学院・医学研究科, COEリサーチアシスタント (90467465)
SANO Yoshifumi 岡山大学, 医学部歯学部附属病院, 講師 (60322228)
OTO Takahiro 岡山大学, 医学部歯学部附属病院, 助教 (40452578)
YAMANE Masaomi 岡山大学, 医学部歯学部附属病院, 助教 (20432643)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 心停止ドナー / 肺移植 / Ex-vivo evaluation / 温虚血 / 再灌流 / ex-vivo evaluation |
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| Research Abstract |
The purpose of this study was to establish a clinically applicable method for lung transplantation utilizing non-heart-beating donors under the collaboration between Kyoto University and Okayama University groups. Using a large animal ex-vivo perfusion (EVLP) model, both groups performed the experimental studies. At Kyoto University, we demonstrated the usefulness of ET-Kyoto solution as perfusion solution of EVLP and the effect of EVLP in repairing edematous lung graft. At Okayama University, the effect of removing cytokines (TNF α and IL-8) by absorbable membrane was investigated. We suggested that factors other than these cytokines might play a rule for the graft injury during EVLP.
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