| Project/Area Number |
20390368
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
|
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| Research Institution | Osaka University |
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Principal Investigator |
OKUMURA Meinoshin Osaka University, 医学系研究科, 教授 (40252647)
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| Co-Investigator(Kenkyū-buntansha) |
MINAMI Masato 大阪大学, 医学部付属病院, 准教授 (10240847)
INOUE Masayosi 大阪大学, 医学系研究科, 講師 (10379232)
KADOTA Yosihisa 大阪大学, 医学系研究科, 助教 (50464243)
TAKEDA Kiyosi 大阪大学, 医学系研究科, 教授 (20309446)
UTUMI Tomoki 大阪大学, 医学系研究科, 助教 (40423165)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 肺移植 / 閉塞性際気管支炎 / 拒絶反応 / IL-6 / Th17 / IL-17 / Stat3 / シグナル伝達 / 慢性拒絶反応 / Treg / 免疫抑制 |
|---|
| Research Abstract |
A newly defined T cell subset called Th17 has been focused during these several years. Th17 is supposed to be induced by TGF β and IL-6 and to suppress regulatory T cells, which results in development of autoimmune diseases. We hypothesized that Th17 is involved in rejection of the graft after lung transplantation. Our experimental results using mouse model showed that Th17 is significantly induced in the local site of chronic rejection. Furthermore, bronchiolitis obliterans is suppressed by anti-IL6 antibody.
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