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Molecular analysis of lung adenocarcinomas that do not have mutations in the EGFR pathway and development of therapeutic strategies against them

Research Project

Project/Area Number 20390376
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

MITSUDOMI Tetsuya  Aichi Cancer Center Research Institute, 分子腫瘍学部, 研究員 (70209807)

Co-Investigator(Kenkyū-buntansha) YATABE Yasushi  愛知県がんセンター研究所, 分子腫瘍学部, 研究員 (90280809)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords呼吸器外科学 / 分子標的治療 / 個別化医療 / 肺癌 / EGFR経路 / HER2 / 腺癌 / 個別化治療 / 分子分類
Research Abstract

EGFR tyrosine kinase inhibitor confers often dramatic response in lung cancer harboring EGFR mutation. However, virtually all the tumors acquire resistance. For large fraction of lung cancer, a efficacious therapeutic target is not known. In this study, we confirmed the HER2 mutation or MET amplification could be the therapeutic target although their incidences were low. Furthermore, we found a reciprocal relationship between T790M secondary mutation of the EGFR gene and MET amplification in acquire resistance.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (73 results)

All 2011 2010 2009 2008 Other

All Journal Article (42 results) (of which Peer Reviewed: 10 results) Presentation (30 results) Book (1 results)

  • [Journal Article] Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers.2011

    • Author(s)
      Tomizawa K, Mitsudomi T., et al(10番目/10人)
    • Journal Title

      Lung Cancer Epub

    • Related Report
      2010 Final Research Report
  • [Journal Article] Analysis of ERBB4 mutations and expression in Japanese patients with lung cancer.2010

    • Author(s)
      Tomizawa K, Yatabe Y, Mitsudomi T., et al (6番目/6人)
    • Journal Title

      J Thorac Oncol 5

      Pages: 1859-1861

    • Related Report
      2010 Final Research Report
  • [Journal Article] Biological and clinical significance of KRAS mutations in lung cancer : an oncogenic driver that contrasts with EGFR mutation.2010

    • Author(s)
      Suda K, Tomizawa K, Mitsudomi T., et al
    • Journal Title

      Cancer Metastasis Rev 29

      Pages: 49-60

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reciprocal and Complementary Role of MET Amplification and EGFR T790M Mutation in Acquired Resistance to Kinase Inhibitors in Lung Cancer2010

    • Author(s)
      Suda K, Y, Yatabe Y, Mitsudomi T., et al (9番目/9人)
    • Journal Title

      Clin Cancer Res 16

      Pages: 5489-5498

    • Related Report
      2010 Final Research Report
  • [Journal Article] Epidermal growth factor receptor in relation to tumor development : EGFR gene and cancer.2010

    • Author(s)
      Mitsudomi T, Yatabe Y.
    • Journal Title

      FEBS J 277

      Pages: 301-308

    • Related Report
      2010 Final Research Report
  • [Journal Article] Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJT0G3405) : an open label, randomised phase 3 trial.2010

    • Author(s)
      Mitsudomi T, Morita S, Yatabe Y, et al (1番目/21人)
    • Journal Title

      Lancet Oncol 11

      Pages: 121-128

    • Related Report
      2010 Final Research Report
  • [Journal Article] Advances in target therapy for lung cancer.2010

    • Author(s)
      光冨徹哉
    • Journal Title

      Jpn J Clin Oncol 40

      Pages: 101-106

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of gefitinib on the survival of patients with recurrence of lung adenocarcinoma after surgery : a retrospective case-matching cohort study.2010

    • Author(s)
      Katayama T, Yatabe Y, Mitsudomi T., et al (6番目/6人)
    • Journal Title

      Surg Oncol 19

      Pages: 144-149

    • Related Report
      2010 Final Research Report
  • [Journal Article] EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.2010

    • Author(s)
      Choi YL, Mitsudomi T, et al (13番目/15人)
    • Journal Title

      N Engl J Med 363

      Pages: 1734-1739

    • Related Report
      2010 Final Research Report
  • [Journal Article] Analysis of ERBB4 mutations and expression in Japanese patients with lung cancer2010

    • Author(s)
      Tomizawa K., et al.
    • Journal Title

      J.Thorac.Oncol.

      Volume: 5 Pages: 1859-1861

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal and complementary role of MET amplification and EGFR T790 M mutation in acquired resistance to kinase inhibitors in lung cancer2010

    • Author(s)
      Suda K., et al.
    • Journal Title

      Clin.Cancer Res.

      Volume: 16 Pages: 5489-5498

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of EGFR mutation analysis in non-small cell lung cancer.2009

    • Author(s)
      Yamamoto H, Toyooka S, Mitsudomi T.
    • Journal Title

      Lung Cancer 63

      Pages: 315-321

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery : impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort.2009

    • Author(s)
      Varella-Garcia M, Mitsudomi T, et al (2番目/11人)
    • Journal Title

      J Thorac Oncol 4

      Pages: 318-325

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR T790M mutation : a double role in lung cancer cell survival?2009

    • Author(s)
      Suda K, Onozato R, Yatabe Y, Mitsudomi T.
    • Journal Title

      J Thorac Oncol 4

      Pages: 1-4

    • Related Report
      2010 Final Research Report
  • [Journal Article] Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers.2009

    • Author(s)
      Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, Mitsudomi T.
    • Journal Title

      J Thorac Oncol 4

      Pages: 5-11

    • Related Report
      2010 Final Research Report
  • [Journal Article] Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations.2009

    • Author(s)
      Morita S, Mitsudomi T, et al (15番目/17人)
    • Journal Title

      Clin Cancer Res 15

      Pages: 4493-4498

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma.2009

    • Author(s)
      Kosaka T, Yatabe Y, Onozato R, Kuwano H, Mitsudomi T
    • Journal Title

      J Thorac Oncol 4

      Pages: 22-29

    • Related Report
      2010 Final Research Report
  • [Journal Article] Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small-cell lung cancer for gefitinib treatment.2009

    • Author(s)
      Jida M, Mitsudomi T, Yatabe Y, et al (3番目/17人)
    • Journal Title

      Cancer Sci 100

      Pages: 1931-1934

    • NAID

      10027195949

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR受容体遺伝子変異を有する肺癌2009

    • Author(s)
      須田健一, 小野里良一, 高坂貴行, 光冨徹哉
    • Journal Title

      別冊日本臨床 10

      Pages: 5-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR作用薬EGFR-TKIreversibleについて2009

    • Author(s)
      清水淳市, 光冨徹哉
    • Journal Title

      Mebio Oncology 6

      Pages: 12-22

    • Related Report
      2010 Final Research Report
  • [Journal Article] ME1の増幅、変異、多型2009

    • Author(s)
      小野里良一, 須田健一, 高坂貴行, 光冨徹哉
    • Journal Title

      がん分子標的治療 7

      Pages: 117-123

    • Related Report
      2010 Final Research Report
  • [Journal Article] 肺癌-EGFR標的治療のバイオマーカーとしてのEGFRとKRAS遺伝子2009

    • Author(s)
      光冨徹哉
    • Journal Title

      カレントテラピー 27

      Pages: 1112-1117

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFRに対する小分子阻害剤2009

    • Author(s)
      光冨徹哉
    • Journal Title

      癌と化学療法 36

      Pages: 1058-1062

    • Related Report
      2010 Final Research Report
  • [Journal Article] Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations.2009

    • Author(s)
      Morita S, et al.
    • Journal Title

      Clin Cancer Res 15

      Pages: 4493-4498

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of erlotinib for brain and leptomeningeal metastases in-patients with lunadenocarcinoma who showed initial good response to gefitinib.2009

    • Author(s)
      Katayama T, et al.
    • Journal Title

      J Thorac Oncol 4 : 1415-9, 2009 4

      Pages: 1415-1419

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EGFR T790M mutation : a double role in lung cancer cell survival?2009

    • Author(s)
      Suda K, et al
    • Journal Title

      J Thorac Oncol 4

      Pages: 1-4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EGFR and HER2 genomic gain in recurrent non-small cell lung cancer surgery : impact on outcome to treatment with gefitinib and association EGFR and KRAS mutations in a Japanese cohort2009

    • Author(s)
      Varella-Garcia M, Mitsudomi T, Yatabe Y, et al.
    • Journal Title

      J Thorac Oncol 4

      Pages: 318-325

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers2009

    • Author(s)
      Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, Mitsudomi T.
    • Journal Title

      J Thorac Oncol 4

      Pages: 5-11

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma2009

    • Author(s)
      Kosaka T, Yatabe Y, Onozato R, Kuwano H, Mitsudomi T.
    • Journal Title

      J Thorac Oncol 4

      Pages: 22-29

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer.2008

    • Author(s)
      Yatabe Y, Takahashi T, Mitsudomi T
    • Journal Title

      Cancer Res 68

      Pages: 2106-2111

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.2008

    • Author(s)
      Yano S, Mitsudomi T, Yatabe Y, et al (12番目/15人)
    • Journal Title

      Cancer Res 68

      Pages: 9479-9487

    • Related Report
      2010 Final Research Report
  • [Journal Article] Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma.2008

    • Author(s)
      Toyooka S, Yatabe Y, Mitsudomi T, et al (14番目/15人)
    • Journal Title

      Cancer Sci 99

      Pages: 303-308

    • NAID

      10024002340

    • Related Report
      2010 Final Research Report
  • [Journal Article] Epidermal growth factor receptor mutations in small cell lung cancer.2008

    • Author(s)
      Tatematsu A, Mitsudomi T, Yatabe Y. et al (8番目/9人)
    • Journal Title

      Clin Cancer Res 14

      Pages: 6092-6096

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR阻害剤耐性のメカニズム2008

    • Author(s)
      高坂貴行, 小野里良一, 光冨徹哉
    • Journal Title

      Annual Review呼吸器2008.東京:中外医学社

      Pages: 44-51

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR遺伝子変異とEGFR-TKI阻害剤の感受性2008

    • Author(s)
      遠藤秀紀, 光冨徹哉
    • Journal Title

      呼吸器科 13

      Pages: 246-250

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR-TKI(ゲフィチニブ,エルロチニブ)の基礎-効果,副作用規定因子-2008

    • Author(s)
      片山達也, 高坂貴行, 小野里良一, 光冨徹哉
    • Journal Title

      最新医学 63

      Pages: 14-21

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFRチロシンキナーゼ阻害薬の現状2008

    • Author(s)
      清水淳市, 光冨徹哉
    • Journal Title

      医学のあゆみ 224

      Pages: 45-50

    • Related Report
      2010 Final Research Report
  • [Journal Article] 癌治療の分子標的としてのHGF-MET系2008

    • Author(s)
      光冨徹哉, 小野里良一, 須田健一
    • Journal Title

      RL宝函 29

      Pages: 30-37

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR-TKIの臨床効果とバイオマーカー2008

    • Author(s)
      光冨徹哉
    • Journal Title

      日本臨床 66

      Pages: 583-587

    • Related Report
      2010 Final Research Report
  • [Journal Article] EGFR変異の生物学2008

    • Author(s)
      光冨徹哉
    • Journal Title

      MOOK肺がんの臨床 2008

      Pages: 77-85

    • Related Report
      2010 Final Research Report
  • [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer2008

    • Author(s)
      Yatabe Y, Takahashi T, Mitsudomi T.
    • Journal Title

      Cancer research 68

      Pages: 2106-2111

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor receptor mutations in small cell lung cancer2008

    • Author(s)
      Tatematsu A, Shimizu J, Murakami Y, et al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 6092-6096

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] What is the next option for acquired resistance to EGFR-TKIs?2010

    • Author(s)
      Mitsudomi T
    • Organizer
      4th Asia Pacific Lung Cancer Conference
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Reciprocal and Complementary Relationship between Epidermal Growth Factor Receptor T790M Mutation and MET Amplification in Acquired Resistance to Kinase Inhibitors in Lung Adenocarcinoma2010

    • Author(s)
      須田健一, ら
    • Organizer
      4th Asia Pacific Lung Cancer Conference
    • Place of Presentation
      COEX Convention Center(韓国)
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Therapeutic strategies basedon biological markers...EGFR mutations and beyond2010

    • Author(s)
      Mitsudomi T
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-04
    • Related Report
      2010 Final Research Report
  • [Presentation] How did EGFR mutation testing become routine in Japan?2010

    • Author(s)
      Mitsudomi T
    • Organizer
      AstraZeneca sponsored satellite symposium, 35th ESMO congress
    • Place of Presentation
      MIlan, Italy
    • Year and Date
      2010-10-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinicopathological characteristics of lung cancers with HER2 mutation2010

    • Author(s)
      富沢健二, ら
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] EML4-ALK : Clinical data2010

    • Author(s)
      Mitsudomi T
    • Organizer
      4th Asian Pacific Perspectives in Lung Cancer
    • Place of Presentation
      Hong Kong
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Targeted theray of lung cancer-EGFR mutations and beyond2010

    • Author(s)
      Mitsudomi T
    • Organizer
      The 15th Taiwan Joint Cancer Conference
    • Place of Presentation
      Taipei
    • Year and Date
      2010-05-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Predicitive and prognostic markers in the treatment of NSCLC2010

    • Author(s)
      Mitsudomi T
    • Organizer
      The 8th Asia Pacific Oncology Summit
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-03-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinicopathologic features of eraly stage lung cancer with EML4-ALK tranlocation2010

    • Author(s)
      Mitsudomi T, Suda K, Tomozawa K, Yatabe Y
    • Organizer
      American Society of Clinical Oncology annual meeting
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] Asian evolution in advanced NSCLC treatment2009

    • Author(s)
      Mitsudomi T
    • Organizer
      Update in lung and liver cancer 2009
    • Place of Presentation
      Chiangmai, Thailand
    • Year and Date
      2009-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] individualized treatment of lung cancer2009

    • Author(s)
      Mitsudomi T
    • Organizer
      14th Congress of the APSR and 3d Joint Congress of the APSR/ACCP
    • Place of Presentation
      Seoul
    • Year and Date
      2009-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Biology of Lung Adenocarcinoma2009

    • Author(s)
      Mitsudomi T
    • Organizer
      14th Congress of the APSR and 3d Joint Congress of the APSR/ACCP
    • Place of Presentation
      Seoul
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Biology of Lung Adenocarcinoma2009

    • Author(s)
      Mitsudomi T
    • Organizer
      14th Congress of the APSR and 3d Joint Congress of the APSR/ACCP.
    • Place of Presentation
      Seoul COEX
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Personalized therapy of lung cancer…EGFR mutations and beyond2009

    • Author(s)
      Mitsudomi T
    • Organizer
      The 19th Hiroshima Cancer Seminar-The 3rd three universities' consortium International Symposium
    • Place of Presentation
      Hiroshima
    • Year and Date
      2009-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Personalized therapy of lung cancer...EGFR mutations and beyond2009

    • Author(s)
      Mitsudomi T
    • Organizer
      The 19th Hiroshima Cancer Seminar, The 3rd three universities' consortium International Symposium.
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺腺がんのシグナル依存と分子標的治療2009

    • Author(s)
      光冨徹哉
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人非小細胞肺癌外科切除例におけるSLC34A2-ROS融合遺伝子の解析2009

    • Author(s)
      須田健一, ら
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Translational research on EGFR in lung cancer2009

    • Author(s)
      Mitsudomi T
    • Organizer
      11th Meeting of Chinese Lung Cancer
    • Place of Presentation
      天津
    • Year and Date
      2009-08-02
    • Related Report
      2010 Final Research Report
  • [Presentation] EGFR and KRAS mutations in lung adenocarcinoma : Two contrasting and mutually exclusive mechanisms for pathogenesis2009

    • Author(s)
      Mitsudomi T, Gazdar A, Yatabe T
    • Organizer
      13th World Conference of Lung Cancer
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-08-02
    • Related Report
      2010 Final Research Report
  • [Presentation] EGFR and KRAS mutations in lung adenocarcinoma : Two contrasting and mutuaexclusive mechanisms for pathogenesis2009

    • Author(s)
      Mitsudomi T, et al.
    • Organizer
      13th World Conference of Lung Cancer
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-08-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Targeted Therapy of Lung Cancer-Toward Personalized Treatment-2009

    • Author(s)
      Mitsudomi T
    • Organizer
      台湾臨床腫瘍学会Recent Advances in Target Therapy
    • Place of Presentation
      Taipei
    • Year and Date
      2009-02-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel therapeutic targets in lung cancer2009

    • Author(s)
      Mitsudomi T
    • Organizer
      Third Asian Pacific Conference Perspectives in Lung Cancer
    • Place of Presentation
      Bangkok
    • Related Report
      2010 Final Research Report
  • [Presentation] EGFR遺伝子変異を有する非小細胞肺癌術後再発患者におけるゲフィチニブ治療効果の臨床病理学的予測因子の解析2009

    • Author(s)
      須田健一, ら
    • Organizer
      第13回世界肺癌学会
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2009 Annual Research Report
  • [Presentation] EGFR遺伝子変異L858Rと Exon 19欠失変異のバリエーションの検討2008

    • Author(s)
      須田健一, 小野里良一, 高坂貴行, 谷田部恭, 光冨徹哉
    • Organizer
      第49回日本肺癌学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺癌におけるEGFRチロシンキナーゼ阻害剤の獲得耐性のメカニズムとその克服2008

    • Author(s)
      光冨徹哉, 谷田部恭
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 原発性肺癌切除例におけるMET遺伝子の活性化いついての検討2008

    • Author(s)
      小野里良一, 高坂貴行, 須田健一, 谷田部恭, 光冨徹哉
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] EGFR-targeted therapy of lung cancer2008

    • Author(s)
      Mitsudomi T
    • Organizer
      The 7th Kazusa Academia Respiratory Forum
    • Place of Presentation
      Kisarazu
    • Year and Date
      2008-09-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Personalized therapy of lung cancer using EGFR-TKI2008

    • Author(s)
      Mitsudomi T
    • Organizer
      The second Asian Pacific Conference-Perspectives in Lung Cancer-
    • Place of Presentation
      Sappporo
    • Year and Date
      2008-08-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Is adenocarcinoma of the lung one disease?2008

    • Author(s)
      Mitsudomi T
    • Organizer
      1st European Lung Cancer Conference
    • Place of Presentation
      Geneve
    • Year and Date
      2008-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] EGFR-TKi in the first treatment option for patients with lung cancer harboring EGFR mutation

    • Author(s)
      Mitsudomi T
    • Organizer
      AstraZeneca satellite symposium, 4th Asia Pacific Lung Cancer Conference
    • Related Report
      2010 Final Research Report
  • [Book] Lippincott Williams & Wilkins2010

    • Author(s)
      Hirsch FR, Mitsudomi T
    • Publisher
      Janne PA. Chapter 49, Anti-EGFR therapies : How to select patients. In : Pass H, Carbone DP, Johnson DH, Minna JD, Turrisi AT, Scagliotti GV, editors. Principles and Practice of Lung Cancer. 4th ed. Baltimore
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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