Human bone marrow stromal cells transplantation to regenerate central nervous system ; The translational research with novel technologies.

• Project/Area Number: 20390377
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Hokkaido University
• Principal Investigator: SHICHINOHE Hideo Hokkaido University, 北海道大学・病院, 助教 (80374479)
• Co-Investigator(Kenkyū-buntansha): KURODA Satoshi 北海道大学, 北海道大学病院, 講師 (10301904) ; IWASAKI Yoshinobu 北海道大学, 大学院・医学研究科, 名誉教授 (00113522) ; HIDA Kazutoshi 北海道大学, 大学院・医学研究科, 准教授 (10238305) ; KOBAYASHI Hiroyuki 北海道大学, 北海道大学病院, 助教 (70374478) ; 矢野 俊介 北海道大学, 病院, 助教 (20374481)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 中枢神経再生医療 / 骨髄間質細胞 / 幹細胞移植 / 脳梗塞 / 脊髄損傷 / サイトカイン / バイオマテリアル / 光イメージング / PET

Research Abstract

This study was aimed to translate the regenerative medicine with human bone marrow stromal cells (BMSC) to the central nervous system disorders. The results were as follows; (1) the BMSC could be cultured with some bio-matrixes. (2) The addition of G-CSF (granulocyte-colony stimulating factor) to the culture medium could stimulate the cellular activity of the BMSC. On the other hand, the addition of human platelet lysate (PL) was useful for the animal serum-free cell culture. (3) The scaffold with fibrin matrix or Mebiol gelR was useful as a cell delivery system to the lesion. (4) The behavior of the transplanted BMSC could be monitored temporally and noninvasively using the optical imaging or MRI.

Research Products

• [Journal Article] Therapeutic Impact of Human Bone Marrow Stromal Cells (hBMSC) Expanded by Animal Serum-Free Medium for Cerebral Infarct in Rats (2011)
  • Author(s): Sugiyama T, Kuroda S, Takeda Y, Nishio M, Ito M, Shichinohe H, Koike T
  • Journal Title: Neurosurg (in press)
• [Journal Article] Near-infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain (2011)
  • Author(s): Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M, Iwasaki Y
  • Journal Title: Neurosurg (in press)
• [Journal Article] Autologous bone marrow stromal cell transplantation for central nervous system disorders-Recent progress and perspective for clinical application (2011)
  • Author(s): Kuroda S, Shichinohe H, Houkin K, Iwasaki Y
  • Journal Title: J Stem Cell Regen Med 7 Pages: 1-12
• [Journal Article] Near-infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain. (2011)
  • Author(s): Sugiyama T, Kuroda S, et al.
  • Journal Title: Neurosurgery Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Autologous bone marrow stromal cell transplantation for central nervou s system disorders-Recent progress and perspective for clinical application. (2011)
  • Author(s): Kuroda S, et al.
  • Journal Title: J Stem Cell Regen Med Volume: 7 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Therapeutic Impact of Human Bone Marrow Stromal Cells (hBMSC) Expanded by Animal Serum-Free Medium for Cerebral Infarct in Rats. (2011)
  • Author(s): Sugiyama T, Kuroda S, et al.
  • Journal Title: Neurosurgery Volume: (In Press)
  • Peer Reviewed
• [Journal Article] ヒト骨髄間質細胞の安全で効率的な培養法-骨髄間質細胞移植による中枢神経再生の臨床応用に向けて- (2011)
  • Author(s): 伊東雅基、黒田敏, ら
  • Journal Title: 再生医療 Volume: 9 Pages: 72-79
  • Peer Reviewed
• [Journal Article] 脳梗塞再生医療の展望 (2011)
  • Author(s): 黒田敏, ら
  • Journal Title: Medical Practice Volume: 28巻4号 Pages: 681-684
• [Journal Article] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats (2010)
  • Author(s): Shichinohe H, Kuroda S, Sugiyama T, Ito M, Kawabori M
  • Journal Title: Dement Geriatr Cogn Disord 30 Pages: 293-301
• [Journal Article] Noninvasive transplantation of bone marrow stromal cells for ischemic stroke : preliminary study with a thermoreversible gelation polymer hydrogel (2010)
  • Author(s): Osanai T, Kuroda S, Yasuda H, Chiba Y, Maruichi K, Hokari M, Sugiyama T, Shichinohe H, Iwasaki Y
  • Journal Title: Neurosurg 66 Pages: 1140-7
• [Journal Article] Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury. (2010)
  • Author(s): Chiba Y, Kuroda S, Shichinohe H, Hokari M, Osanai T, Maruichi K, Yano S, Hida K, Iwasaki Y
  • Journal Title: Neuropathol 30 Pages: 241-50
  • NAID: 10029320824
• [Journal Article] Bone marrow stromal cells and bone marrow-derived mononuclear cells : which are suitable as cell source of transplantation for mice infarct brain? (2010)
  • Author(s): Shichinohe H, Kuroda S, Maruichi K, Osanai T, Sugiyama T, Chiba Y, Yamaguchi A, Iwasaki Y
  • Journal Title: Neuropathol 30 Pages: 113-22
  • NAID: 10029320219
• [Journal Article] Effect of biodegradable fibrin scaffold on survival, migration, and differentiation of transplanted bone marrow stromal cells after cortical injury in rats (2010)
  • Author(s): Yasuda H, Kuroda S, Shichinohe H, Kamei S, Kawamura R, Iwasaki Y
  • Journal Title: J Neurosurg. 112 Pages: 336-44
• [Journal Article] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats. (2010)
  • Author(s): Shichinohe H, et al.
  • Journal Title: Dement Geriatr Cogn Disord. Volume: 30(4) Pages: 293-301
  • Peer Reviewed
• [Journal Article] 脳梗塞をターゲットとした再生医療における最適な細胞移植法 (2010)
  • Author(s): 川堀真人、黒田敏, ら
  • Journal Title: 再生医療 Volume: 9 Pages: 477-486
  • NAID: 120006488412
  • Peer Reviewed
• [Journal Article] 脳卒中に対する骨髄間質細胞移植研究の現状と課題 (2010)
  • Author(s): 黒田敏, ら
  • Journal Title: 脳卒中 Volume: 32 Pages: 532-537
  • NAID: 10027895546
• [Journal Article] Biodegradable fibrin scaffold enhances survival, migration, and differentiation of transplanted bone marrow… (2010)
  • Author(s): Yasuda H, et al.
  • Journal Title: J Neurosurg 112 Pages: 336-344
  • Peer Reviewed
• [Journal Article] Non-invasive transplantation of bone marrow stromal cells using a thermoreversible gelation polymer(TGP)hydrogel… (2010)
  • Author(s): Osanai T, et al.
  • Journal Title: Neurosurgery (in press)
  • Peer Reviewed
• [Journal Article] 中枢神経再生におけるバイオイメージング (2010)
  • Author(s): 杉山拓, ら
  • Journal Title: 再生医療 (in press)
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in a rat spinal cord injury model (2009)
  • Author(s): Chiba Y, Kuroda S, Maruichi K, Osanai T, Hokari M, Yano S, Shichinohe H, Hida K, Iwasaki Y
  • Journal Title: Neurosurg 64 Pages: 991-9
• [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation for mice cerebral infarct (2009)
  • Author(s): Hokari M, Kuroda S, Chiba Y, Maruichi K, Iwasaki Y
  • Journal Title: Cytokine 46 Pages: 260-6
• [Journal Article] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats (2009)
  • Author(s): Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
  • Journal Title: Neuropathol 29 Pages: 422-32
  • NAID: 10028191635
• [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into injured spinal cord : A novel material for CNS tissue engineering (2009)
  • Author(s): Itosaka H, Kuroda S, Shichinohe H, Yasuda H, Yano S, Kamei S, Kawamura R, Hida K, Iwasaki Y
  • Journal Title: Neuropathol 29 Pages: 248-57
  • NAID: 10026609224
• [Journal Article] Graded model of diffuse axonal injury for studying head injury-induced cognitive dysfunction in rats (2009)
  • Author(s): Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
  • Journal Title: Neuropathol 29 Pages: 132-9
  • NAID: 10026608745
• [Journal Article] Graded model of diffuse axonal injury for studying head Injury-induced cognitive dysfunction in rats. (2009)
  • Author(s): Maruichi K, et al.
  • Journal Title: Neuropathology 29 Pages: 132-139
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal injury in rats (2009)
  • Author(s): Maruichi K, et al.
  • Journal Title: Neuropathology(E-pub) 29 Pages: 422-432
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat… (2009)
  • Author(s): Chiba Y, et al.
  • Journal Title: Neurosurgery 64 Pages: 991-1000
  • Peer Reviewed
• [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation… (2009)
  • Author(s): Hokari M, et al.
  • Journal Title: Cytokine 46 Pages: 260-266
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cell & bone marrow mononuclear cells-Which are suitable as cell source of transplantation… (2009)
  • Author(s): Shichinohe H, et al.
  • Journal Title: Neuropathology(E-pub)
  • Peer Reviewed
• [Journal Article] Synergistic effects of bone marrow stromal cells and a Rhokinase(ROCK)inhibitor, Fasudil on axon… (2009)
  • Author(s): Chiba Y, et al.
  • Journal Title: Neuropathology(E-pub)
  • Peer Reviewed
• [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into… (2009)
  • Author(s): Itosaka H, et al.
  • Journal Title: Neuropathology 29 Pages: 248-257
  • Peer Reviewed
• [Journal Article] Effect of biodegradable fibrin scaffold on survival, migration, and differentiation of transplanted bone marrow stromal cells after cortical injury in rats (2009)
  • Author(s): Yasuda H, Kuroda S, Shichinohe H, et.al.
  • Journal Title: Journal of Neurosurgery Mar 6
  • Peer Reviewed
• [Journal Article] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats (2009)
  • Author(s): Maruichi K, Kuroda S, Chiba Y, et.al.
  • Journal Title: Neuropathology Jan 9(Epub ahead of print)
  • NAID: 10028191635
  • Peer Reviewed
• [Journal Article] Graded model of diffuse axonal injury for studying headinjury-induced cognitive dysfunction in rats (2009)
  • Author(s): Maruichi K, Kuroda S, Chiba Y, et.al.
  • Journal Title: Neuropathology. 29(2) Pages: 132-9
  • NAID: 10026608745
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells promote neurite extension in organotypic spinal cord slice : significance for cell transplantation therapy (2008)
  • Author(s): Shichinohe H, Kuroda S, Tsuji S, Yamaguchi S, Yano S, Lee JB, Kobayashi H, Kikuchi S, Hida K, Iwasaki Y
  • Journal Title: Neurorehabil Neural Repair 22 Pages: 447-57
• [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into injured spinal cord : A novel material for CNS tissue engineering (2008)
  • Author(s): Itosaka H, Kuroda S, Shichinohe H, et.al.
  • Journal Title: Neuropathology Oct 20(Epub ahead of print)
  • NAID: 10026609224
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cells promote neurite extension in organotypic spinal cord slice : significance for cell transplantation therapy (2008)
  • Author(s): Shichinohe H, Kuroda S, Tsuji S, et.al.
  • Journal Title: Neurorehabilitation and Neural Repair. 22(5) Pages: 447-57
  • Peer Reviewed
• [Presentation] Platelet lysateを用いたヒト骨髄間質細胞培養-安全な中枢神経再生の臨床応用を目指して (2011)
  • Author(s): 七戸秀夫、黒田敏, ら
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] 臨床用MRIを用いた鉄製剤で標識された骨髄間質細胞のファントム内検出 (2011)
  • Author(s): 七戸秀夫、黒田敏, ら
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] 骨髄間質細胞移植による脳卒中予防効果-発症前SHR-SPにおけるneuro-vascular unitの保護および脳損傷の軽減 (2011)
  • Author(s): 伊東雅基、黒田敏, ら
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] ラット脳凍結損傷モデルに対する骨髄間質細胞の経動脈的移植-生体蛍光イメージング法による評価 (2011)
  • Author(s): 長内俊也、黒田敏, ら
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] 脳梗塞ラットモデルに対するBMSC移植の投与経路に関しての検討 (2011)
  • Author(s): 川堀真人、黒田敏, ら
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] Transplanted Bone Marrow Stromal Cells Protect Neurovascular Units and Ameliorate Brain Damage in Stroke-Prone Spontaneously Hypertensive Rats (SHR-SP) (2011)
  • Author(s): Ito M, Kuroda S, et al.
  • Organizer: 国際脳卒中会議2011
  • Place of Presentation: ロサンゼルス(USA)
  • Year and Date: 2011-02-10
• [Presentation] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats. (2011)
  • Author(s): Shichinohe H, Kuroda S, et al.
  • Organizer: 国際脳卒中会識2011
  • Place of Presentation: ロサンゼルス(USA)
  • Year and Date: 2011-02-10
• [Presentation] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats (2011)
  • Author(s): Shichinohe H
  • Organizer: 国際脳卒中会議
  • Place of Presentation: ロサンゼルス
  • Year and Date: 2011-02-09
• [Presentation] 脳神経外科疾患に対する骨髄間質細胞移植研究の現状と課題 (2010)
  • Author(s): 黒田敏, ら
  • Organizer: 第69回日本脳神経外科学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-27
• [Presentation] Direct or Intravenous Delivery of Bone Marrow Stromal Cells-Which is Better Route for Ischemic Stroke (2010)
  • Author(s): Kawabori M, Kuroda S, et al.
  • Organizer: 第60回米国神経外科コングレス
  • Place of Presentation: サンフランシスコ(USA)
  • Year and Date: 2010-10-16
• [Presentation] Serial Magnetic Resonance Tracking of Human Bone Marrow Stromal CellsTransplanted into Infarct Brain of Rats-Validity of Cell Expansion in Animal Serum-Free Medium (2010)
  • Author(s): Ito M, Kuroda S, et al.
  • Organizer: 第60回米国神経外科コングレス
  • Place of Presentation: サンフランシスコ(USA)
  • Year and Date: 2010-10-16
• [Presentation] Optimal delivery route of bone marrow stromal cells for rat infarct brain-Astudy using non-invasive optical imaging (2010)
  • Author(s): Kawabori M, Kuroda S, et al.
  • Organizer: 第5回日印再生医療研究会
  • Place of Presentation: チェンナイ、インド
  • Year and Date: 2010-10-09
• [Presentation] Transplantation of autologous bone marrow stromal cells (BMSC) for CNS disorders-Strategy and tactics for clinical application (2010)
  • Author(s): Kuroda S, et al.
  • Organizer: 第5回日印再生医療研究会
  • Place of Presentation: チェンナイ、インド(招待講演)
  • Year and Date: 2010-10-09
• [Presentation] Transplantation of autologous bone marrow stromal cells (BMSC) for CNS disorders-Strategy and tactics for clinical application (2010)
  • Author(s): 黒田敏
  • Organizer: 第5回日印再生医療研究会
  • Place of Presentation: チェンナイ、インド
  • Year and Date: 2010-09-25
• [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題 (2010)
  • Author(s): 黒田敏
  • Organizer: 第35回日本脳卒中学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-15
• [Presentation] Animal serum-free mediumで培養したヒト骨髄間質細胞の脳梗塞治療における有用性-in vivo study (2010)
  • Author(s): 杉山拓、黒田敏, ら
  • Organizer: 第35回日本脳卒中学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-15
• [Presentation] もやもや病の発症におけるendothelial progenitor cells(EPC)の役割;病理学的検討 (2010)
  • Author(s): 杉山拓、黒田敏, ら
  • Organizer: 第35回日本脳卒中学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-15
• [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題 (2010)
  • Author(s): 黒田敏, ら
  • Organizer: 第35回日本脳卒中学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-15
• [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略 (2010)
  • Author(s): 黒田敏
  • Organizer: 第10回脳血管疾患治療研究会
  • Place of Presentation: 東京都、如水会館
  • Year and Date: 2010-02-27
• [Presentation] Bone marrow stromal cells and bone marrow-derived mononuclear cells : which are suitable as cell source of transplantation for mice infarct brain? (2010)
  • Author(s): Shichinohe H
  • Organizer: 国際脳卒中会議2010
  • Place of Presentation: サンアントニオ
  • Year and Date: 2010-02-25
• [Presentation] 慢性脳循環不全・骨髄間質細胞移植モデルにおける記憶学習障害の改善 (2010)
  • Author(s): 七戸秀夫, ら
  • Organizer: 第9回再生医療学会
  • Place of Presentation: 広島市、広島国際会議場
• [Presentation] ラット脳梗塞モデルへの骨髄間質細胞の最適な移植経路 (2010)
  • Author(s): 川堀真人, ら
  • Organizer: 第9回再生医療学会
  • Place of Presentation: 広島市、広島国際会議場
• [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルへの移植 (2010)
  • Author(s): 伊東雅基, ら
  • Organizer: 第9回再生医療学会
  • Place of Presentation: 広島市、広島国際会議場
• [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルにおける治療効果の検討 (2010)
  • Author(s): 杉山拓, ら
  • Organizer: 第9回再生医療学会
  • Place of Presentation: 広島市、広島国際会議場
• [Presentation] Bone marrow stromal cell transplantation for chronic cerebral ischemia (2010)
  • Author(s): Shichinohe H, et al
  • Organizer: International Stroke Conference 2010
  • Place of Presentation: San Antonio(USA), Convention Center
• [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略 (2009)
  • Author(s): 黒田敏
  • Organizer: 第9回ブレインアタックカンファレンス研究会
  • Place of Presentation: 福岡市、西鉄グランドホテル
  • Year and Date: 2009-10-30
• [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略 (2009)
  • Author(s): 黒田敏
  • Organizer: 第12回浜松脳神経障害とフリーラジカル研究会
  • Place of Presentation: 浜松市、オークラアクトシティホテル浜松
  • Year and Date: 2009-07-08
• [Presentation] 長波長蛍光物質で標識した骨髄間質細胞(BMSC)の頭蓋内光イメージング (2009)
  • Author(s): 杉山拓
  • Organizer: 第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
  • Place of Presentation: 松江市
  • Year and Date: 2009-03-22
• [Presentation] マウス脳梗塞-骨髄間質細胞移植モデルにおける、SDF-1/CXCR4系の遊走・生着への関与 (2009)
  • Author(s): 七戸秀夫
  • Organizer: 第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
  • Place of Presentation: 松江市
  • Year and Date: 2009-03-22
• [Presentation] GM1アナログMCC-257はBMSCからのneurotrophin分泌を促進する (2009)
  • Author(s): 小林徹
  • Organizer: 第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
  • Place of Presentation: 松江市
  • Year and Date: 2009-03-22
• [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について (2009)
  • Author(s): 長内俊也
  • Organizer: 第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
  • Place of Presentation: 松江市
  • Year and Date: 2009-03-22
• [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題 (2009)
  • Author(s): 黒田敏
  • Organizer: 第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
  • Place of Presentation: 松江市
  • Year and Date: 2009-03-21
• [Presentation] マウス脳梗塞-骨髄間質細胞移植モデルにおける、SDF-1/CXCR4系の遊走・生着への関与 (2009)
  • Author(s): 七戸秀夫
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-03-06
• [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について (2009)
  • Author(s): 長内俊也
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-03-06
• [Presentation] 塩酸ファスジルは脊髄損傷に対する骨髄間質細胞の移植効果を増強するか (2009)
  • Author(s): 千葉泰弘
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-03-06
• [Presentation] 骨髄間質細胞の移植はびまん性軸索損傷による高次脳機能障害を改善する11C-FMZ PET/CTを用いた検討 (2009)
  • Author(s): 丸一勝彦
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-03-06
• [Presentation] 長波長蛍光物質で標識した骨髄間質細胞(BMSC)の頭蓋内光イメージング (2009)
  • Author(s): 杉山拓
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-03-06
• [Presentation] Bone marrow stromal cell transplantation for cerebral stroke-lab to bedside (2008)
  • Author(s): Shichinohe H
  • Organizer: 第35回北米神経科学大会
  • Place of Presentation: ワシントンDC
  • Year and Date: 2008-11-19
• [Presentation] Bone marrow stromal cell transplantation for cerebral stroke-lab to bedside (2008)
  • Author(s): Hideo Shichinohe
  • Organizer: Neuroscience 2008
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-19
• [Presentation] 自己骨髄細胞による損傷脊髄の再生-分かってきたことと解明すべきこと (2008)
  • Author(s): 黒田敏
  • Organizer: 第43回日本脊髄障害医学会
  • Place of Presentation: 札幌市
  • Year and Date: 2008-11-06
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development (2010)
  • Author(s): Tamaki N, Kuge Y, et al.
  • Total Pages: 303
  • Publisher: Springer
• [Book] Res. Adv. in Stroke 1 : Bone marrow stromal cell transplantation for cerebral infarction-Recent advances and perspective (2008)
  • Author(s): Hideo Shichinohe and Satoshi Kuroda
  • Publisher: Global Research Network (India)
• [Remarks] ホームページ
  • URL: http://www.neurosurgery-hokudai.jp/