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Human bone marrow stromal cells transplantation to regenerate central nervous system ; The translational research with novel technologies.

Research Project

Project/Area Number 20390377
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionHokkaido University

Principal Investigator

SHICHINOHE Hideo  Hokkaido University, 北海道大学・病院, 助教 (80374479)

Co-Investigator(Kenkyū-buntansha) KURODA Satoshi  北海道大学, 北海道大学病院, 講師 (10301904)
IWASAKI Yoshinobu  北海道大学, 大学院・医学研究科, 名誉教授 (00113522)
HIDA Kazutoshi  北海道大学, 大学院・医学研究科, 准教授 (10238305)
KOBAYASHI Hiroyuki  北海道大学, 北海道大学病院, 助教 (70374478)
矢野 俊介  北海道大学, 病院, 助教 (20374481)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords中枢神経再生医療 / 骨髄間質細胞 / 幹細胞移植 / 脳梗塞 / 脊髄損傷 / サイトカイン / バイオマテリアル / 光イメージング / PET
Research Abstract

This study was aimed to translate the regenerative medicine with human bone marrow stromal cells (BMSC) to the central nervous system disorders. The results were as follows; (1) the BMSC could be cultured with some bio-matrixes. (2) The addition of G-CSF (granulocyte-colony stimulating factor) to the culture medium could stimulate the cellular activity of the BMSC. On the other hand, the addition of human platelet lysate (PL) was useful for the animal serum-free cell culture. (3) The scaffold with fibrin matrix or Mebiol gelR was useful as a cell delivery system to the lesion. (4) The behavior of the transplanted BMSC could be monitored temporally and noninvasively using the optical imaging or MRI.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (80 results)

All 2011 2010 2009 2008 Other

All Journal Article (37 results) (of which Peer Reviewed: 21 results) Presentation (40 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Therapeutic Impact of Human Bone Marrow Stromal Cells (hBMSC) Expanded by Animal Serum-Free Medium for Cerebral Infarct in Rats2011

    • Author(s)
      Sugiyama T, Kuroda S, Takeda Y, Nishio M, Ito M, Shichinohe H, Koike T
    • Journal Title

      Neurosurg (in press)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Near-infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain2011

    • Author(s)
      Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M, Iwasaki Y
    • Journal Title

      Neurosurg (in press)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Autologous bone marrow stromal cell transplantation for central nervous system disorders-Recent progress and perspective for clinical application2011

    • Author(s)
      Kuroda S, Shichinohe H, Houkin K, Iwasaki Y
    • Journal Title

      J Stem Cell Regen Med 7

      Pages: 1-12

    • Related Report
      2010 Final Research Report
  • [Journal Article] Near-infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain.2011

    • Author(s)
      Sugiyama T, Kuroda S, et al.
    • Journal Title

      Neurosurgery

      Volume: (In Press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autologous bone marrow stromal cell transplantation for central nervou s system disorders-Recent progress and perspective for clinical application.2011

    • Author(s)
      Kuroda S, et al.
    • Journal Title

      J Stem Cell Regen Med

      Volume: 7 Pages: 1-12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Impact of Human Bone Marrow Stromal Cells (hBMSC) Expanded by Animal Serum-Free Medium for Cerebral Infarct in Rats.2011

    • Author(s)
      Sugiyama T, Kuroda S, et al.
    • Journal Title

      Neurosurgery

      Volume: (In Press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト骨髄間質細胞の安全で効率的な培養法-骨髄間質細胞移植による中枢神経再生の臨床応用に向けて-2011

    • Author(s)
      伊東雅基、黒田敏, ら
    • Journal Title

      再生医療

      Volume: 9 Pages: 72-79

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳梗塞再生医療の展望2011

    • Author(s)
      黒田敏, ら
    • Journal Title

      Medical Practice

      Volume: 28巻4号 Pages: 681-684

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats2010

    • Author(s)
      Shichinohe H, Kuroda S, Sugiyama T, Ito M, Kawabori M
    • Journal Title

      Dement Geriatr Cogn Disord 30

      Pages: 293-301

    • Related Report
      2010 Final Research Report
  • [Journal Article] Noninvasive transplantation of bone marrow stromal cells for ischemic stroke : preliminary study with a thermoreversible gelation polymer hydrogel2010

    • Author(s)
      Osanai T, Kuroda S, Yasuda H, Chiba Y, Maruichi K, Hokari M, Sugiyama T, Shichinohe H, Iwasaki Y
    • Journal Title

      Neurosurg 66

      Pages: 1140-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury.2010

    • Author(s)
      Chiba Y, Kuroda S, Shichinohe H, Hokari M, Osanai T, Maruichi K, Yano S, Hida K, Iwasaki Y
    • Journal Title

      Neuropathol 30

      Pages: 241-50

    • NAID

      10029320824

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bone marrow stromal cells and bone marrow-derived mononuclear cells : which are suitable as cell source of transplantation for mice infarct brain?2010

    • Author(s)
      Shichinohe H, Kuroda S, Maruichi K, Osanai T, Sugiyama T, Chiba Y, Yamaguchi A, Iwasaki Y
    • Journal Title

      Neuropathol 30

      Pages: 113-22

    • NAID

      10029320219

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of biodegradable fibrin scaffold on survival, migration, and differentiation of transplanted bone marrow stromal cells after cortical injury in rats2010

    • Author(s)
      Yasuda H, Kuroda S, Shichinohe H, Kamei S, Kawamura R, Iwasaki Y
    • Journal Title

      J Neurosurg. 112

      Pages: 336-44

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats.2010

    • Author(s)
      Shichinohe H, et al.
    • Journal Title

      Dement Geriatr Cogn Disord.

      Volume: 30(4) Pages: 293-301

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳梗塞をターゲットとした再生医療における最適な細胞移植法2010

    • Author(s)
      川堀真人、黒田敏, ら
    • Journal Title

      再生医療

      Volume: 9 Pages: 477-486

    • NAID

      120006488412

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2010

    • Author(s)
      黒田敏, ら
    • Journal Title

      脳卒中

      Volume: 32 Pages: 532-537

    • NAID

      10027895546

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Biodegradable fibrin scaffold enhances survival, migration, and differentiation of transplanted bone marrow…2010

    • Author(s)
      Yasuda H, et al.
    • Journal Title

      J Neurosurg 112

      Pages: 336-344

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive transplantation of bone marrow stromal cells using a thermoreversible gelation polymer(TGP)hydrogel…2010

    • Author(s)
      Osanai T, et al.
    • Journal Title

      Neurosurgery (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経再生におけるバイオイメージング2010

    • Author(s)
      杉山拓, ら
    • Journal Title

      再生医療 (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in a rat spinal cord injury model2009

    • Author(s)
      Chiba Y, Kuroda S, Maruichi K, Osanai T, Hokari M, Yano S, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neurosurg 64

      Pages: 991-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation for mice cerebral infarct2009

    • Author(s)
      Hokari M, Kuroda S, Chiba Y, Maruichi K, Iwasaki Y
    • Journal Title

      Cytokine 46

      Pages: 260-6

    • Related Report
      2010 Final Research Report
  • [Journal Article] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neuropathol 29

      Pages: 422-32

    • NAID

      10028191635

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into injured spinal cord : A novel material for CNS tissue engineering2009

    • Author(s)
      Itosaka H, Kuroda S, Shichinohe H, Yasuda H, Yano S, Kamei S, Kawamura R, Hida K, Iwasaki Y
    • Journal Title

      Neuropathol 29

      Pages: 248-57

    • NAID

      10026609224

    • Related Report
      2010 Final Research Report
  • [Journal Article] Graded model of diffuse axonal injury for studying head injury-induced cognitive dysfunction in rats2009

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y
    • Journal Title

      Neuropathol 29

      Pages: 132-9

    • NAID

      10026608745

    • Related Report
      2010 Final Research Report
  • [Journal Article] Graded model of diffuse axonal injury for studying head Injury-induced cognitive dysfunction in rats.2009

    • Author(s)
      Maruichi K, et al.
    • Journal Title

      Neuropathology 29

      Pages: 132-139

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells improve cognitive dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      Maruichi K, et al.
    • Journal Title

      Neuropathology(E-pub) 29

      Pages: 422-432

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells promote axonal regeneration and improve motor function in rat…2009

    • Author(s)
      Chiba Y, et al.
    • Journal Title

      Neurosurgery 64

      Pages: 991-1000

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation…2009

    • Author(s)
      Hokari M, et al.
    • Journal Title

      Cytokine 46

      Pages: 260-266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cell & bone marrow mononuclear cells-Which are suitable as cell source of transplantation…2009

    • Author(s)
      Shichinohe H, et al.
    • Journal Title

      Neuropathology(E-pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of bone marrow stromal cells and a Rhokinase(ROCK)inhibitor, Fasudil on axon…2009

    • Author(s)
      Chiba Y, et al.
    • Journal Title

      Neuropathology(E-pub)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into…2009

    • Author(s)
      Itosaka H, et al.
    • Journal Title

      Neuropathology 29

      Pages: 248-257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of biodegradable fibrin scaffold on survival, migration, and differentiation of transplanted bone marrow stromal cells after cortical injury in rats2009

    • Author(s)
      Yasuda H, Kuroda S, Shichinohe H, et.al.
    • Journal Title

      Journal of Neurosurgery Mar 6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats2009

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, et.al.
    • Journal Title

      Neuropathology Jan 9(Epub ahead of print)

    • NAID

      10028191635

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Graded model of diffuse axonal injury for studying headinjury-induced cognitive dysfunction in rats2009

    • Author(s)
      Maruichi K, Kuroda S, Chiba Y, et.al.
    • Journal Title

      Neuropathology. 29(2)

      Pages: 132-9

    • NAID

      10026608745

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells promote neurite extension in organotypic spinal cord slice : significance for cell transplantation therapy2008

    • Author(s)
      Shichinohe H, Kuroda S, Tsuji S, Yamaguchi S, Yano S, Lee JB, Kobayashi H, Kikuchi S, Hida K, Iwasaki Y
    • Journal Title

      Neurorehabil Neural Repair 22

      Pages: 447-57

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into injured spinal cord : A novel material for CNS tissue engineering2008

    • Author(s)
      Itosaka H, Kuroda S, Shichinohe H, et.al.
    • Journal Title

      Neuropathology Oct 20(Epub ahead of print)

    • NAID

      10026609224

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow stromal cells promote neurite extension in organotypic spinal cord slice : significance for cell transplantation therapy2008

    • Author(s)
      Shichinohe H, Kuroda S, Tsuji S, et.al.
    • Journal Title

      Neurorehabilitation and Neural Repair. 22(5)

      Pages: 447-57

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Platelet lysateを用いたヒト骨髄間質細胞培養-安全な中枢神経再生の臨床応用を目指して2011

    • Author(s)
      七戸秀夫、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床用MRIを用いた鉄製剤で標識された骨髄間質細胞のファントム内検出2011

    • Author(s)
      七戸秀夫、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨髄間質細胞移植による脳卒中予防効果-発症前SHR-SPにおけるneuro-vascular unitの保護および脳損傷の軽減2011

    • Author(s)
      伊東雅基、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット脳凍結損傷モデルに対する骨髄間質細胞の経動脈的移植-生体蛍光イメージング法による評価2011

    • Author(s)
      長内俊也、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳梗塞ラットモデルに対するBMSC移植の投与経路に関しての検討2011

    • Author(s)
      川堀真人、黒田敏, ら
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transplanted Bone Marrow Stromal Cells Protect Neurovascular Units and Ameliorate Brain Damage in Stroke-Prone Spontaneously Hypertensive Rats (SHR-SP)2011

    • Author(s)
      Ito M, Kuroda S, et al.
    • Organizer
      国際脳卒中会議2011
    • Place of Presentation
      ロサンゼルス(USA)
    • Year and Date
      2011-02-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats.2011

    • Author(s)
      Shichinohe H, Kuroda S, et al.
    • Organizer
      国際脳卒中会識2011
    • Place of Presentation
      ロサンゼルス(USA)
    • Year and Date
      2011-02-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats2011

    • Author(s)
      Shichinohe H
    • Organizer
      国際脳卒中会議
    • Place of Presentation
      ロサンゼルス
    • Year and Date
      2011-02-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳神経外科疾患に対する骨髄間質細胞移植研究の現状と課題2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第69回日本脳神経外科学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Direct or Intravenous Delivery of Bone Marrow Stromal Cells-Which is Better Route for Ischemic Stroke2010

    • Author(s)
      Kawabori M, Kuroda S, et al.
    • Organizer
      第60回米国神経外科コングレス
    • Place of Presentation
      サンフランシスコ(USA)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serial Magnetic Resonance Tracking of Human Bone Marrow Stromal CellsTransplanted into Infarct Brain of Rats-Validity of Cell Expansion in Animal Serum-Free Medium2010

    • Author(s)
      Ito M, Kuroda S, et al.
    • Organizer
      第60回米国神経外科コングレス
    • Place of Presentation
      サンフランシスコ(USA)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Optimal delivery route of bone marrow stromal cells for rat infarct brain-Astudy using non-invasive optical imaging2010

    • Author(s)
      Kawabori M, Kuroda S, et al.
    • Organizer
      第5回日印再生医療研究会
    • Place of Presentation
      チェンナイ、インド
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transplantation of autologous bone marrow stromal cells (BMSC) for CNS disorders-Strategy and tactics for clinical application2010

    • Author(s)
      Kuroda S, et al.
    • Organizer
      第5回日印再生医療研究会
    • Place of Presentation
      チェンナイ、インド(招待講演)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transplantation of autologous bone marrow stromal cells (BMSC) for CNS disorders-Strategy and tactics for clinical application2010

    • Author(s)
      黒田敏
    • Organizer
      第5回日印再生医療研究会
    • Place of Presentation
      チェンナイ、インド
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2010

    • Author(s)
      黒田敏
    • Organizer
      第35回日本脳卒中学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Animal serum-free mediumで培養したヒト骨髄間質細胞の脳梗塞治療における有用性-in vivo study2010

    • Author(s)
      杉山拓、黒田敏, ら
    • Organizer
      第35回日本脳卒中学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] もやもや病の発症におけるendothelial progenitor cells(EPC)の役割;病理学的検討2010

    • Author(s)
      杉山拓、黒田敏, ら
    • Organizer
      第35回日本脳卒中学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2010

    • Author(s)
      黒田敏, ら
    • Organizer
      第35回日本脳卒中学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2010

    • Author(s)
      黒田敏
    • Organizer
      第10回脳血管疾患治療研究会
    • Place of Presentation
      東京都、如水会館
    • Year and Date
      2010-02-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bone marrow stromal cells and bone marrow-derived mononuclear cells : which are suitable as cell source of transplantation for mice infarct brain?2010

    • Author(s)
      Shichinohe H
    • Organizer
      国際脳卒中会議2010
    • Place of Presentation
      サンアントニオ
    • Year and Date
      2010-02-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性脳循環不全・骨髄間質細胞移植モデルにおける記憶学習障害の改善2010

    • Author(s)
      七戸秀夫, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット脳梗塞モデルへの骨髄間質細胞の最適な移植経路2010

    • Author(s)
      川堀真人, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルへの移植2010

    • Author(s)
      伊東雅基, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト骨髄間質細胞のラット脳梗塞モデルにおける治療効果の検討2010

    • Author(s)
      杉山拓, ら
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島市、広島国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bone marrow stromal cell transplantation for chronic cerebral ischemia2010

    • Author(s)
      Shichinohe H, et al
    • Organizer
      International Stroke Conference 2010
    • Place of Presentation
      San Antonio(USA), Convention Center
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏
    • Organizer
      第9回ブレインアタックカンファレンス研究会
    • Place of Presentation
      福岡市、西鉄グランドホテル
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄間質細胞による中枢神経再生の治療戦略2009

    • Author(s)
      黒田敏
    • Organizer
      第12回浜松脳神経障害とフリーラジカル研究会
    • Place of Presentation
      浜松市、オークラアクトシティホテル浜松
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 長波長蛍光物質で標識した骨髄間質細胞(BMSC)の頭蓋内光イメージング2009

    • Author(s)
      杉山拓
    • Organizer
      第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
    • Place of Presentation
      松江市
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス脳梗塞-骨髄間質細胞移植モデルにおける、SDF-1/CXCR4系の遊走・生着への関与2009

    • Author(s)
      七戸秀夫
    • Organizer
      第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
    • Place of Presentation
      松江市
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] GM1アナログMCC-257はBMSCからのneurotrophin分泌を促進する2009

    • Author(s)
      小林徹
    • Organizer
      第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
    • Place of Presentation
      松江市
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について2009

    • Author(s)
      長内俊也
    • Organizer
      第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
    • Place of Presentation
      松江市
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳卒中に対する骨髄間質細胞移植研究の現状と課題2009

    • Author(s)
      黒田敏
    • Organizer
      第34回日本脳卒中学会総会第38回日本脳卒中の外科学会
    • Place of Presentation
      松江市
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス脳梗塞-骨髄間質細胞移植モデルにおける、SDF-1/CXCR4系の遊走・生着への関与2009

    • Author(s)
      七戸秀夫
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄間質細胞移植のバイオマテリアルとしてのMebiol gelの有用性について2009

    • Author(s)
      長内俊也
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 塩酸ファスジルは脊髄損傷に対する骨髄間質細胞の移植効果を増強するか2009

    • Author(s)
      千葉泰弘
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄間質細胞の移植はびまん性軸索損傷による高次脳機能障害を改善する11C-FMZ PET/CTを用いた検討2009

    • Author(s)
      丸一勝彦
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 長波長蛍光物質で標識した骨髄間質細胞(BMSC)の頭蓋内光イメージング2009

    • Author(s)
      杉山拓
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bone marrow stromal cell transplantation for cerebral stroke-lab to bedside2008

    • Author(s)
      Shichinohe H
    • Organizer
      第35回北米神経科学大会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2008-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Bone marrow stromal cell transplantation for cerebral stroke-lab to bedside2008

    • Author(s)
      Hideo Shichinohe
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自己骨髄細胞による損傷脊髄の再生-分かってきたことと解明すべきこと2008

    • Author(s)
      黒田敏
    • Organizer
      第43回日本脊髄障害医学会
    • Place of Presentation
      札幌市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development2010

    • Author(s)
      Tamaki N, Kuge Y, et al.
    • Total Pages
      303
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Book] Res. Adv. in Stroke 1 : Bone marrow stromal cell transplantation for cerebral infarction-Recent advances and perspective2008

    • Author(s)
      Hideo Shichinohe and Satoshi Kuroda
    • Publisher
      Global Research Network (India)
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.neurosurgery-hokudai.jp/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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