Convection-enhanced delivery of ACNU with systemic administration of temozolomide

• Project/Area Number: 20390378
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: SONODA Yukihiko Tohoku University, 大学院・医学系研究科, 非常勤講師 (90302140)
• Co-Investigator(Kenkyū-buntansha): YAMASHITA Yoji 宮城県がんセンター研究所, 特任研究員 (30420045) ; 金森 政之 東北大学, 大学院・医学系研究科, 助教 (60420022)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 膠芽腫 / MGMT CED法 / 薬剤耐性 / MGMT / CED法 / ACNU / Temozolomide

Research Abstract

This study evaluated the efficacy of combined-modality treatments using CED of ACNU with systemic administration of temozolomide. CED of ACNU plus systemic administration of temozolomide significantly enhanced survival rate compared with each treatment alone (versus CED : p<0.001, versus systemic temozolomide : p<0.05). Multimodality treatment using CED of ACNU and systemic chemotherapy with temozolomide is a promising strategy for treatment of brain tumors.

Research Products

• [Journal Article] Regression of Recurrent Brain Stem Glioblastoma Infiltrating the Brainstem after Convection-enhanced Delivery of Nimustine Hydrochloride. (2011)
  • Author(s): Saito R, Sonoda Y, Kumabe T,Nagamatsu K, Watanabe M, Tominaga T.
  • Journal Title: Case report J Neurosurg in press
  • Peer Reviewed
• [Journal Article] O(6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma. (2010)
  • Author(s): Sonoda Y, Yokosawa M, Saito R, Kanamori M, Yamashita Y, Kumabe T, Watanabe M, Tominaga T.
  • Journal Title: Int J Clin Oncol. 4 Pages: 352-358
  • NAID: 10026601301
  • Peer Reviewed
• [Journal Article] O(6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma. (2010)
  • Author(s): Sonoda Y, Yokosawa M, Saito R, Kanamori M, Yamashita Y, Kumabe T, Watanabe M, Tominaga T.
  • Journal Title: Int J Clin Oncol. Volume: 4 Pages: 352-358
  • NAID: 10026601301
  • Peer Reviewed
• [Journal Article] O(6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma. (2010)
  • Author(s): Yukihiko Sonoda
  • Journal Title: Int J Clin Oncol. (In press)
  • NAID: 10026601301
  • Peer Reviewed
• [Journal Article] Long-term survivors of glioblastoma : clinical features and molecular analysis. (2009)
  • Author(s): Sonoda Y, Kumabe T, Watanabe M, Nakazato Y, Inoue T, Kanamori M, Tominaga T.
  • Journal Title: Acta Neurochir (Wien). 151 Pages: 1349-1358
  • Peer Reviewed
• [Presentation] テモゾロミド不応性再発神経膠腫に対するACNU局所投与 (2009)
  • Author(s): 斎藤竜太, 園田順彦, 他
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-08
• [Presentation] Convection enhanced delivery of nimustine hydrochloride(ACNU)with systhemic administration of temozolomide in recurrent glioma patients (2009)
  • Author(s): 園田順彦
  • Organizer: World Federation Of Neuro-Oncology 2009
  • Place of Presentation: 横浜
  • Year and Date: 2009-05-13
• [Remarks] ホームページ等